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Research Article
Physiological Effects of the Electrogenic Current Generated by the Na /K Pump in Mammalian Articular Chondrocytes
Mary M Maleckar
Simula Research Laboratory, Inc., Oslo, Norway
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7012-3853
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Declarations:
Declarations
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
Background: Although the chondrocyte is a non-excitable cell, there is strong interest in gaining detailed knowledge of its ion pumps, channels, exchangers and transporters. In combination, these transport mechanisms set the resting potential, regulate cell volume and strongly modulate responses of the chondrocyte to endocrine agents and physicochemical alterations in the surrounding extracellular micro-environment.
Materials and Methods: Mathematical modeling was used to assess the functional roles of energy-requiring active transport, the Na+/K+ pump, in chondrocytes.
Results: Our findings illustrate plausible physiological roles for the Na+/K+ pump in regulating the resting membrane potential and suggest ways in which specific molecular components of pump can respond to the unique electrochemical environment of the chondrocyte.
Conclusion: This analysis provides a basis for linking chondrocyte electrophysiology to metabolism and yields insights into novel ways of manipulating or regulating responsiveness to external stimuli both under baseline conditions and in chronic diseases such as osteoarthritis (OA).
Keywords
Articular cartilage, Chondrocyte, Na+/K+ pump, Na+-K+-ATPase, Electrogenic Pumps, Ion Channels, Mathematical Model, Osteoarthritis (OA), Rheumatoid Arthritis (RA)
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- SupplementaryInformationrev1August.13.docx
Supplementary Information
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This is a preprint. It has not completed peer review.
Research Article
Physiological Effects of the Electrogenic Current Generated by the Na /K Pump in Mammalian Articular Chondrocytes
Mary M Maleckar
Simula Research Laboratory, Inc., Oslo, Norway
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7012-3853
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 19 Aug, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Declarations:
Declarations
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
Background: Although the chondrocyte is a non-excitable cell, there is strong interest in gaining detailed knowledge of its ion pumps, channels, exchangers and transporters. In combination, these transport mechanisms set the resting potential, regulate cell volume and strongly modulate responses of the chondrocyte to endocrine agents and physicochemical alterations in the surrounding extracellular micro-environment.
Materials and Methods: Mathematical modeling was used to assess the functional roles of energy-requiring active transport, the Na+/K+ pump, in chondrocytes.
Results: Our findings illustrate plausible physiological roles for the Na+/K+ pump in regulating the resting membrane potential and suggest ways in which specific molecular components of pump can respond to the unique electrochemical environment of the chondrocyte.
Conclusion: This analysis provides a basis for linking chondrocyte electrophysiology to metabolism and yields insights into novel ways of manipulating or regulating responsiveness to external stimuli both under baseline conditions and in chronic diseases such as osteoarthritis (OA).
Figure 1
Figure 2
Figure 3
Figure 4