This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Mary M Maleckar
Simula Research Laboratory, Inc., Oslo, Norway
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7012-3853
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This work is licensed under a CC BY 4.0 License. Read Full License
Declarations:
Declarations
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
Background: Although the chondrocyte is a non-excitable cell, there is strong interest in gaining detailed knowledge of its ion pumps, channels, exchangers and transporters. In combination, these transport mechanisms set the resting potential, regulate cell volume and strongly modulate responses of the chondrocyte to endocrine agents and physicochemical alterations in the surrounding extracellular micro-environment.
Materials and Methods: Mathematical modeling was used to assess the functional roles of energy-requiring active transport, the Na+/K+ pump, in chondrocytes.
Results: Our findings illustrate plausible physiological roles for the Na+/K+ pump in regulating the resting membrane potential and suggest ways in which specific molecular components of pump can respond to the unique electrochemical environment of the chondrocyte.
Conclusion: This analysis provides a basis for linking chondrocyte electrophysiology to metabolism and yields insights into novel ways of manipulating or regulating responsiveness to external stimuli both under baseline conditions and in chronic diseases such as osteoarthritis (OA).
Keywords
Articular cartilage, Chondrocyte, Na+/K+ pump, Na+-K+-ATPase, Electrogenic Pumps, Ion Channels, Mathematical Model, Osteoarthritis (OA), Rheumatoid Arthritis (RA)
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- SupplementaryInformationrev1August.13.docx
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Mary M Maleckar
Simula Research Laboratory, Inc., Oslo, Norway
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7012-3853
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
View the published article at Bioelectricity.
Version 1
Posted 19 Aug, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Declarations:
Declarations
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
View the published article at Bioelectricity.
Background: Although the chondrocyte is a non-excitable cell, there is strong interest in gaining detailed knowledge of its ion pumps, channels, exchangers and transporters. In combination, these transport mechanisms set the resting potential, regulate cell volume and strongly modulate responses of the chondrocyte to endocrine agents and physicochemical alterations in the surrounding extracellular micro-environment.
Materials and Methods: Mathematical modeling was used to assess the functional roles of energy-requiring active transport, the Na+/K+ pump, in chondrocytes.
Results: Our findings illustrate plausible physiological roles for the Na+/K+ pump in regulating the resting membrane potential and suggest ways in which specific molecular components of pump can respond to the unique electrochemical environment of the chondrocyte.
Conclusion: This analysis provides a basis for linking chondrocyte electrophysiology to metabolism and yields insights into novel ways of manipulating or regulating responsiveness to external stimuli both under baseline conditions and in chronic diseases such as osteoarthritis (OA).
Figure 1
Figure 2
Figure 3
Figure 4
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryInformationrev1August.13.docx
Supplementary Information
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