Pattern of cortical thinning in logopenic progressive aphasia patients in Thailand
Background: Logopenic progressive aphasia (LPA) is an uncommon neurodegenerative disorder primarily characterized by word-finding difficulties and sentence repetition impairment. Prominent cortical atrophy around left temporo-parietal junction (TPJ) is a classical imaging feature of LPA. This study investigated cortical thinning pattern in clinically diagnosed LPA patients using non-demented subjects as a control group. We also aimed to explore whether there was prominent thinning of other cortical area additional to the well-recognized left TPJ.
Methods: Thicknesses of all cortical regions were measured from brain magnetic resonance images using an automated command on Freesurfer software. Cortical thickness of the LPA and control groups were compared by two methods: 1) using a general linear model (GLM) in SPSS software; and 2) using a vertex-by-vertex GLM, performed with Freesurfer’s QDEC interface.
Results: Besides the well-recognized left TPJ, cortical regions that were significantly thinner in the LPA group by both comparison methods included left caudal middle frontal gyrus (CMFG) (p=0.006 by SPSS, p=0.0003 by QDEC), left rostral middle frontal gyrus (p=0.001 by SPSS, p=0.0001 by QDEC), left parahippocampal gyrus (p=0.008 by SPSS, p=0.005 by QDEC) and right CMFG (p=0.005 by SPSS, p=0.0001 by QDEC).
Conclusions: Our results demonstrated that thinning of middle frontal gyri may be an additional feature in clinically diagnosed LPA patients. Involvement of left parahippocampal gyrus may reflect the underlying neuropathology of Alzheimer’s disease in majority of the LPA patients.
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Posted 12 Jan, 2021
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Pattern of cortical thinning in logopenic progressive aphasia patients in Thailand
Posted 12 Jan, 2021
On 13 Jan, 2021
On 27 Dec, 2020
On 16 Dec, 2020
On 16 Dec, 2020
On 16 Dec, 2020
On 07 Dec, 2020
On 05 Dec, 2020
Received 05 Dec, 2020
Invitations sent on 23 Nov, 2020
On 13 Oct, 2020
On 12 Oct, 2020
On 12 Oct, 2020
On 01 Oct, 2020
Received 08 Sep, 2020
On 30 Aug, 2020
Invitations sent on 29 Aug, 2020
On 26 Aug, 2020
On 25 Aug, 2020
On 25 Aug, 2020
On 18 Aug, 2020
Background: Logopenic progressive aphasia (LPA) is an uncommon neurodegenerative disorder primarily characterized by word-finding difficulties and sentence repetition impairment. Prominent cortical atrophy around left temporo-parietal junction (TPJ) is a classical imaging feature of LPA. This study investigated cortical thinning pattern in clinically diagnosed LPA patients using non-demented subjects as a control group. We also aimed to explore whether there was prominent thinning of other cortical area additional to the well-recognized left TPJ.
Methods: Thicknesses of all cortical regions were measured from brain magnetic resonance images using an automated command on Freesurfer software. Cortical thickness of the LPA and control groups were compared by two methods: 1) using a general linear model (GLM) in SPSS software; and 2) using a vertex-by-vertex GLM, performed with Freesurfer’s QDEC interface.
Results: Besides the well-recognized left TPJ, cortical regions that were significantly thinner in the LPA group by both comparison methods included left caudal middle frontal gyrus (CMFG) (p=0.006 by SPSS, p=0.0003 by QDEC), left rostral middle frontal gyrus (p=0.001 by SPSS, p=0.0001 by QDEC), left parahippocampal gyrus (p=0.008 by SPSS, p=0.005 by QDEC) and right CMFG (p=0.005 by SPSS, p=0.0001 by QDEC).
Conclusions: Our results demonstrated that thinning of middle frontal gyri may be an additional feature in clinically diagnosed LPA patients. Involvement of left parahippocampal gyrus may reflect the underlying neuropathology of Alzheimer’s disease in majority of the LPA patients.
Figure 1
Figure 2