The clinical features of chronic intestinal schistosomiasis-related intestinal lesions
Chronic intestinal schistosomiasis has been reported to be associated with colonic polyps, colorectal cancer and ulcerative colitis. We aim to investigate the clinical characteristics of intestinal-related lesions caused by chronic intestinal schistosomiasis japonicum.
Patients with and without chronic intestinal schistosomiasis were retrospectively enrolled from the endoscopy center of Wuhan Union Hospital from September 1, 2014, to June 30, 2019 with a ratio of 4:1. The characteristics of infected intestinal segments were analyzed in patients with chronic intestinal schistosomiasis. We also compared the characteristics of intestinal-related lesions, including colorectal. polyps, colorectal cancer (CRC), ulceration or erosion of the intestinal mucosa and hemorrhoids, between the two groups.
A total of 248 patients with chronic intestinal schistosomiasis and 992 patients without chronic intestinal schistosomiasis were analyzed. The most common sites of chronic intestinal schistosomiasis were the sigmoid colon (79.0%) and rectum (84.7%). The frequency of intestinal polyps (64.5%vs42.8%, p < 0.001), especially rectal polyps (62.5%vs45.0%, p = 0.002), in the intestinal schistosomiasis group was significantly higher than that in the control group. Morphologically, type IIa polyps were more common in the schistosomiasis enteropathy group (68.5%vs60.7%, p = 0.001). Female patients with intestinal schistosomiasis had a higher detection rate of CRC than women in the control group (13.8%vs5.4%, p = 0.017). There was no significant difference in the incidence of ulcerative colitis between the two groups (0.8%vs0.6%, p = 0.664). In addition, the schistosomiasis enteropathy patients had a higher detection rate of internal hemorrhoids (58.9%vs51.0%, p = 0.027).
Chronic intestinal schistosomiasis mainly involved the rectum and sigmoid colon and was more likely to induce intestinal polyps, especially rectal polyps and internal hemorrhoids. Women with chronic schistosomiasis have a higher risk of colorectal cancer.
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Posted 18 Sep, 2020
On 06 Jan, 2021
On 06 Jan, 2021
Received 22 Oct, 2020
On 22 Oct, 2020
On 19 Oct, 2020
Received 04 Oct, 2020
On 03 Oct, 2020
Invitations sent on 17 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
On 31 Aug, 2020
The clinical features of chronic intestinal schistosomiasis-related intestinal lesions
Posted 18 Sep, 2020
On 06 Jan, 2021
On 06 Jan, 2021
Received 22 Oct, 2020
On 22 Oct, 2020
On 19 Oct, 2020
Received 04 Oct, 2020
On 03 Oct, 2020
Invitations sent on 17 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
On 31 Aug, 2020
Chronic intestinal schistosomiasis has been reported to be associated with colonic polyps, colorectal cancer and ulcerative colitis. We aim to investigate the clinical characteristics of intestinal-related lesions caused by chronic intestinal schistosomiasis japonicum.
Patients with and without chronic intestinal schistosomiasis were retrospectively enrolled from the endoscopy center of Wuhan Union Hospital from September 1, 2014, to June 30, 2019 with a ratio of 4:1. The characteristics of infected intestinal segments were analyzed in patients with chronic intestinal schistosomiasis. We also compared the characteristics of intestinal-related lesions, including colorectal. polyps, colorectal cancer (CRC), ulceration or erosion of the intestinal mucosa and hemorrhoids, between the two groups.
A total of 248 patients with chronic intestinal schistosomiasis and 992 patients without chronic intestinal schistosomiasis were analyzed. The most common sites of chronic intestinal schistosomiasis were the sigmoid colon (79.0%) and rectum (84.7%). The frequency of intestinal polyps (64.5%vs42.8%, p < 0.001), especially rectal polyps (62.5%vs45.0%, p = 0.002), in the intestinal schistosomiasis group was significantly higher than that in the control group. Morphologically, type IIa polyps were more common in the schistosomiasis enteropathy group (68.5%vs60.7%, p = 0.001). Female patients with intestinal schistosomiasis had a higher detection rate of CRC than women in the control group (13.8%vs5.4%, p = 0.017). There was no significant difference in the incidence of ulcerative colitis between the two groups (0.8%vs0.6%, p = 0.664). In addition, the schistosomiasis enteropathy patients had a higher detection rate of internal hemorrhoids (58.9%vs51.0%, p = 0.027).
Chronic intestinal schistosomiasis mainly involved the rectum and sigmoid colon and was more likely to induce intestinal polyps, especially rectal polyps and internal hemorrhoids. Women with chronic schistosomiasis have a higher risk of colorectal cancer.
Figure 1
Figure 2
Figure 3
Figure 4