1. Südhof, T. C. Synaptotagmins: Why so many? J. Biol. Chem. 277, 7629–7632 (2002).
2. Rickman, C., Craxton, M., Osborne, S. & Davletov, B. Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family. Biochem. J. 378, 681–6 (2004).
3. Dai, H. et al. Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4. Nat. Struct. Mol. Biol. 11, 844–849 (2004).
4. Sugita, S. et al. Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis. 30, 459–473 (2001).
5. Bhalla, A., Tucker, W. C. & Chapman, E. R. Synaptotagmin Isoforms Couple Distinct Ranges of Ca 2+ , Ba 2+ , and Sr 2+ Concentration to SNARE-mediated Membrane Fusion. Mol. Biol. Cell 16, 4755–4764 (2005).
6. Li, C. et al. Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins. Nature 375, 594–599 (1995).
7. Wolfes, A. C. & Dean, C. The diversity of synaptotagmin isoforms. Curr. Opin. Neurobiol. 63, 198–209 (2020).
8. Yoo, E. S., Yu, J. & Sohn, J. W. Neuroendocrine control of appetite and metabolism. Experimental and Molecular Medicine 53, 505–516 (2021).
9. Moghadam, P. K. & Jackson, M. B. The Functional Significance of Synaptotagmin Diversity in Neuroendocrine Secretion. Front. Endocrinol. (Lausanne). 4, (2013).
10. Von Poser, C., Ichtchenko, K., Shao, X., Rizo, J. & Südhof, T. C. The evolutionary pressure to inactivate: A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding. J. Biol. Chem. 272, 14314–14319 (1997).
11. von Poser, C. & Südhof, T. C. Synaptotagmin 13: structure and expression of a novel synaptotagmin. Eur. J. Cell Biol. 80, 41–47 (2001).
12. Fukuda, M. & Mikoshiba, K. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Biochem Biophys Res Commun 281, 1226–1233 (2001).
13. Willmann, S. J. et al. The global gene expression profile of the secondary transition during pancreatic development. Mech. Dev. 139, 51–64 (2016).
14. Han, S. et al. Altered expression of synaptotagmin 13 mRNA in adult mouse brain after contextual fear conditioning. Biochem. Biophys. Res. Commun. 425, 880–5 (2012).
15. Nizzardo, M. et al. Synaptotagmin 13 is neuroprotective across motor neuron diseases. Acta Neuropathol. 139, 837–853 (2020).
16. Kanda, M. et al. Synaptotagmin XIII expression and peritoneal metastasis in gastric cancer. Br. J. Surg. 105, 1349–1358 (2018).
17. Li, Q., Zhang, S., Hu, M., Xu, M. & Jiang, X. Silencing of synaptotagmin 13 inhibits tumor growth through suppressing proliferation and promoting apoptosis of colorectal cancer cells. Int. J. Mol. Med. 45, 237–244 (2020).
18. Zhang, L. et al. Identification SYT13 as a novel biomarker in lung adenocarcinoma. J. Cell. Biochem. 121, 963–973 (2020).
19. Hitz, C., Wurst, W. & Kühn, R. Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference. Nucleic Acids Res. 35, e90 (2007).
20. Gronostajski, R. M. & Sadowski, P. D. The FLP recombinase of the Saccharomyces cerevisiae 2 microns plasmid attaches covalently to DNA via a phosphotyrosyl linkage. Mol. Cell. Biol. 5, 3274–3279 (1985).
21. Mittelsteadt, T. et al. Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain. J. Comp. Neurol. 512, 514–528 (2009).
22. Böttcher, A. et al. Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates. Nat. Cell Biol. 23, (2021).
23. Huang, C. et al. Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev. Cell 45, 347–361 (2018).
24. Dolai, S. et al. Synaptotagmin-7 functions to replenish insulin granules for exocytosis in human islet β-cell. 1–49 (2016).
25. Andersson, S. A. et al. Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes. Mol. Cell. Endocrinol. 364, 36–45 (2012).
26. Bastidas-Ponce, A. et al. Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development (2019). doi:10.1242/dev.173849
27. Salinno, C. et al. CD81 marks immature and dedifferentiated pancreatic β-cells. Mol. Metab. 49, 101188 (2021).