See the published version of this preprint at Gynecological Surgery.
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Original Article
marjan ghaemi
Tehran University of Medical Sciences
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to describe the efficacy of hysteroscopy in the management of women with persistent gestational trophoblastic disease to decrease the chemotherapy need.
Materials and methods: This prospective, single-arm, clinical trial study was conducted at a tertiary educational referral hospital between September 2018 and September 2019. In the follow-up of the patients diagnosed with hydatidiform mole and managed by uterine evacuation, 30 cases developed low risk persistent gestational trophoblastic disease. Hysteroscopy was performed for removal of persisted trophoblastic tissue, before chemotherapy. Serum beta-hCG titer was measured before and 7 days after the procedure.
Results: Mean±SD age of the participants was 31.4±4.6 years. There was a significantly difference (p=0.06) between that mean±SD of beta-hCG titer before (8168.4±1758) and after (2648.8±5888) treatment. Two (6.6%) cases needed chemotherapy due to no decrease in beta-hCG titer.
Conclusion: Although, hysteroscopy may play a significant role in the management of persistent gestational trophoblastic disease but requires validation in larger prospective randomized studies and longer follow-up.
Keywords
Hysteroscopy, Persistent Gestational Trophoblastic Disease, Molar Pregnancy, Beta-hCG, Chemotherapy, Hydatidiform mole
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CURRENT STATUS: Published
View the published article at Gynecological Surgery.
Version 1
Posted 25 Aug, 2020
No community comments so far
Review #2 received
Received 15 Feb, 2021
Editorial decision: Major revision
On 15 Feb, 2021
Reviewer #2 agreed
On 06 Feb, 2021
Review #1 received
Received 22 Oct, 2020
Reviewer #1 agreed
On 16 Oct, 2020
Reviewers invited
Invitations sent on 14 Oct, 2020
Editor assigned
On 21 Aug, 2020
First submitted
On 20 Aug, 2020
Submission checks complete
On 20 Aug, 2020
Editor invited
On 20 Aug, 2020
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See the published version of this preprint at Gynecological Surgery.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Original Article
marjan ghaemi
Tehran University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Gynecological Surgery.
Version 1
Posted 25 Aug, 2020
No community comments so far
Review #2 received
Received 15 Feb, 2021
Editorial decision: Major revision
On 15 Feb, 2021
Reviewer #2 agreed
On 06 Feb, 2021
Review #1 received
Received 22 Oct, 2020
Reviewer #1 agreed
On 16 Oct, 2020
Reviewers invited
Invitations sent on 14 Oct, 2020
Editor assigned
On 21 Aug, 2020
First submitted
On 20 Aug, 2020
Submission checks complete
On 20 Aug, 2020
Editor invited
On 20 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Gynecological Surgery.
Background: This study aimed to describe the efficacy of hysteroscopy in the management of women with persistent gestational trophoblastic disease to decrease the chemotherapy need.
Materials and methods: This prospective, single-arm, clinical trial study was conducted at a tertiary educational referral hospital between September 2018 and September 2019. In the follow-up of the patients diagnosed with hydatidiform mole and managed by uterine evacuation, 30 cases developed low risk persistent gestational trophoblastic disease. Hysteroscopy was performed for removal of persisted trophoblastic tissue, before chemotherapy. Serum beta-hCG titer was measured before and 7 days after the procedure.
Results: Mean±SD age of the participants was 31.4±4.6 years. There was a significantly difference (p=0.06) between that mean±SD of beta-hCG titer before (8168.4±1758) and after (2648.8±5888) treatment. Two (6.6%) cases needed chemotherapy due to no decrease in beta-hCG titer.
Conclusion: Although, hysteroscopy may play a significant role in the management of persistent gestational trophoblastic disease but requires validation in larger prospective randomized studies and longer follow-up.
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