Funding: The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. The authors are grateful to the study participants, the staff from the Rotterdam Study and the participating general practitioners and pharmacists. This project further received funding from ZonMw, project number: 10430022010016.
Conflicts of interest/Competing interests: not applicable,none of the authors report conflicts of interest.
Data and Code Availability: Data can be obtained upon request. Requests should be directed towards the management team of the Rotterdam Study ([email protected]), which has a protocol for approving data requests. Because of restrictions based on privacy regulations and informed consent of the participants, data cannot be made freely available in a public repository.
Author Contributions: Conceptualization: Natalie Terzikhan, Brenda C.T. Kieboom, M. ArfanIkram.Data curation:Natalie Terzikhan, Frank J.A. van Rooij, Jolande Verkroost-van Heemst, Sven Geurts, Michelle M.J. Mens, Niels van der Schaft, Maud de Feijter. Formal analysis: SilvanLicher, Marije J. Splinter.Fundingacquisition: SilvanLicher, M. ArfanIkram.Investigation: SilvanLicher, Marije J. Splinter, Natalie Terzikhan, PremyslVelek, Annechien E.G. Haarman, Eric Thee, Sven Geurts, Michelle M.J. Mens, Niels van der Schaft, Maud de Feijter, LubaM. Pardo.Paper methodology: SilvanLicher, M. ArfanIkram.Project administration: Brenda C.T. Kieboom, Jolande Verkroost-van Heemst,Natalie Terzikhan, Frank J. A. van Rooij, M. ArfanIkram. Resources: M. ArfanIkram, Supervision: M. ArfanIkram.Visualization: Silvan Licher, PremyslVelek. Writing – original draft: Silvan Licher, Annet E.G. Haarman, Eric Thee, M. ArfanIkram.Writing – review & editing: all authors.
Ethics approval: The Rotterdam Study complies with the declaration of Helsinki and has been has been approved by the Medical Ethics Committee of the Erasmus MC (registration number MEC 02.1015) and by the Dutch Ministry of Health, Welfare and Sport (Population Screening Act WBO, license number 1071272-159521-PG). The Rotterdam Study Personal Registration Data collection is filed with the Erasmus MC Data Protection Officer under registration number EMC1712001. The Rotterdam Study has been entered into the Netherlands National Trial Register (NTR; www.trialregister.nl) and into the WHO International Clinical Trials Registry Platform (ICTRP; www.who.int/ictrp/network/primary/en/) under shared catalogue number NTR6831. All participants provided written informed consent to participate in the study and to have their information obtained from treating physicians.
Acknowledgements: We acknowledge the dedication, commitment, and contribution of inhabitants, general practitioners, and pharmacists of the Ommoord district who took part in the Rotterdam Study. We thank dr. Frank J. Wolters for his valuable contribution to cleaning of the data.