Discontinuation and switching of postpartum contraceptive methods over twelve months in Burkina Faso and the DRC: a secondary analysis of the Yam-Daabo trial

doi:10.21203/rs.3.rs-63481/v2

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Discontinuation and switching of postpartum contraceptive methods over twelve months in Burkina Faso and the DRC: a secondary analysis of the Yam-Daabo trial

https://doi.org/10.21203/rs.3.rs-63481/v2

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published 23 Nov, 2020

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Introduction : Women who use contraceptive methods sometimes stop early, use methods intermittently or switched contraceptive methods. All these events (discontinuations and switching) contribute to the occurrence of unwanted and close pregnancies. This study aimed to explore contraceptive discontinuation and switching during the Yam-Daabo project to measure the effect of interventions on the continuation of contraceptive methods use.

Methods: We conducted a secondary analysis of the Yam-Daabo trial data. We choose the discontinuation and switching of a modern contraceptive method as outcome measures. We performed a survival analysis by using the Stata software package to estimate the effect of the interventions on contraceptive discontinuation. We also studied the main reasons for discontinuation and switching.

Results: In total, 637 out of the 1,120 women used at least one contraceptive method (of any type), with 267 women in the control and 370 in the intervention group. Modern methods were used by 179 women of control group compared to 279 women of intervention group with 24 and 32 who discontinued, respectively. We observed no statistically significant association between interventions and modern methods discontinuation and switching. However, the discontinuation of modern methods was higher in pills and injectables users than implants and IUDs users. The pooled data comparison showed that, in reference to the women who had not switched while using a modern method, the likelihood of switching to a less or equal effectiveness method among the women of the control group was 3.8(95% CI: 1.8-8.0) times the likelihood of switching to a less or equal effectiveness method among the women of the intervention group. And this excess was statistically significant (p<0.001). The main reason for discontinuation and switching was method-related (141 over 199), followed by partner opposition with 20 women.

Conclusion: The results of this study show no statistically significant association between interventions and modern methods discontinuation. Discontinuation is more related to the methods themselves than to any other factor. It is also important to set up specific actions targeting women's partners and influential people in the community to counter inhibiting beliefs.

Trial registration: Pan African Clinical Trials Registry (PACTR201609001784334, https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=1784).

Sexual & Reproductive Medicine

contraceptive methods

injectables

Contraceptive use is very low in many developing countries. According to the United Nations Statistics Division (Africa Economic Commission) in 2012, Africa had the second lowest contraceptive prevalence (44.3%) in the world, after Oceania (37.3%). More than 70% of African countries have a prevalence rate of less than 50%, which is part of the reasons why maternal mortality is high in Africa [1]. To improve the use of postpartum contraceptive methods, in 2015, we implemented a set of interventions in two African countries, Burkina Faso and the Democratic Republic of Congo (DRC), and tested them in a cluster-randomized trial called Yam-Daabo described previously [2,3]. The main results showed a significant increase in the use of contraceptive methods among women receiving interventions compared to women in the control group in both countries [4,5].

Contraceptive discontinuation and switching to a less effective method, increase the risk of unwanted and closely-spaced pregnancies. In developing countries, short-term methods such as pills and injectables have discontinuation rates about 40% at 12 months [6,7]. The method-related concerns [8] and side-effects were the most commonly reported reasons of the discontinuation of these methods. There are also other factors which were reported by previous authors as influencing contraceptive continuation. Among these factors we have the use of a short-acting method, the desire for pregnancy within two years [9], little or no sexual relations [10] and other socio-economic and demographic factors such as age, marital status, income, mass media-exposure, and partner involvement in decision making, and service quality [11–13].

In the literature, few studies focused on the effect of family planning interventions on discontinuation and switching. We found three systematic reviews which concluded to a low level of evidence on the effect of the strategies to improve continuation of hormonal methods of contraception [14–16]. Halpern et al., in 2013, reported that only three trials showed some benefit of strategies to improve adherence and continuation. Several studies included in the review had a small sample size and six had high number of lost to follow up [14]. The overall quality of evidence was considered moderate. For Mack et al., 2019, intensive counseling and reminders (with or without educational information) may be associated with the improved continuation of shorter‐term hormonal contraceptive methods when compared with usual family planning care. However, this should be interpreted with caution due to the low certainty of the evidence [15]. Cavallaro et al., in 2013, conducted a systematic review of the strategies to improve adherence and acceptability of hormonal methods of contraception. A total of 63 publications corresponding to 61 studies met their inclusion criteria. There was substantial heterogeneity in study settings, interventions and outcome measures. Interventions targeting women initiating a method (including structured counselling on side effects) tended to show positive effects on contraceptive continuation. In contrast, the majority of studies on providers training and decision-making tools for method choice did not find evidence of an effect [16].

After showing that family planning interventions had low evidence on contraceptive discontinuation, Halpern et al., in 2013, suggested that high-quality randomized controlled trials, with adequate power, and well-designed interventions, could help to identify ways to improve women's adherence to hormonal contraceptive methods [14]. Furthermore, Cavallaro et al., mentioned the need to improve reporting of studies, and to develop and evaluate novel interventions in different settings. Therefore, this secondary analysis of Yam-Daabo data which had been implemented in predominantly rural context for Burkina Faso and urban context for the DR Congo can contribute to addressing these evidence gaps. So, we aimed to explore contraceptive discontinuation and switching among the postpartum intervention women by assessing if during the first 12 months postpartum, contraceptive users in the intervention group continued their method of choice for a longer time, or switched to an equally or more effective method, compared to those in the control group. In this study, we also aimed to explore the reasons of contraceptive switching among postpartum women.

We performed a secondary analysis of the Yam Daabo study, which was a two-group, multi-intervention, single-blinded, cluster-randomized controlled trial with health centres as the randomization units. It was a study that involved two countries: Burkina Faso and the Demographic Republic of Congo (DRC). Health centres in each country were randomized into two groups: intervention and control. The intervention group's health centres offered a set of six postpartum family planning (PPFP) interventions that were identified as solutions to the barriers identified during the planning phase of the project [3]. The control group health centres provided the usual care PPFP. The study had the statistical power to detect a 15-point difference between the intervention and control groups in terms of the proportion of women adopting an effective PPFP method at 6-month. In each country, 8 health centres were selected (4 intervention and 4 controls) for the study, and, taking into account the loss to follow-up, each centre had to include 70 women (refer to the published protocol [2]).

The project interventions can be categorized into two broad groups: the supply-side interventions were the improvement of the availability of the PPFP services seven days a week and training/updating the clinical skills of health providers on the PPFP, including capacity building support supervision for service providers; and the demand-side interventions such as the PPFP counselling tool (new intervention tool taking into account all of WHO's new recommendations for offering FP services), appointment cards for women, and invitation letters for partners [3]. We included a total of 1,147 women in both countries, and 1,120 women had follow-up data.

The trial was approved by the WHO Research Ethics Review Committee, the ethics committee for health research in Burkina Faso and the School of Public Health ethics committee in DR Congo. Moreover, the trial was registered in the Pan African Clinical Trials Registry (PACTR201609001784334).

For the analysis of switching of the different methods, we adopted the classification of Trussels et al., which considered the switching between four groups (from the less effective to the more effective) [17] which are :

First group: spermicide (correct use: at every sex), abstain, collier, other methods
Second group: condoms, diaphragm, sponge, withdrawal (correct use: at every sex)
Third group: Injections (repeat injections on time), Lactational Amenorrhea Method (LAM) until six months, Pills, patch, ring
Fourth group: vasectomy (with the use of another method for the first three months), implant, IUD and female sterilization

We had no data on adherence to the method, hence we assumed that women used them correctly (especially for pills and injectables).

Discontinuation is defined as starting modern contraceptive use within 12 months postpartum and then stopping for any reason while still at risk of unintended pregnancy. If the woman stops using the second after switching the first one, the duration of use is that of the second method.

An episode of switching occurred when a woman, using a given contraceptive method, change for any reason to another contraceptive method. We excluded the women who stopped the first method because we were not able to classify them according to the chosen classification. So, for discontinuation and switching analysis, we only considered those who used pills or IUDs or injectables or implants at least once during the follow-up. The condom was not considered because it was used in combination with other methods (17 women). LAM was also not considered because it is ineffective after 6 months postpartum and therefore, necessarily leads to another more effective method.

We chose the discontinuation (for modern contraceptive methods) and the switching (for any method) as outcome measures. To compute the durations of the two outcomes, we listed different situations:

Women started by using a method not classified in this analysis (abstain, collier, condoms, diaphragm, sponge, withdrawal, LAM until six months and other methods) and haven't used another one. These women were ignored in the statistical analysis.
Women started by using a method not classified in this analysis and switched to pills, injectables, implants or IUDs. The duration of use was the time between second the method initiation and the end of the study (or the date of the last follow-up if the woman was lost-to-follow-up).
Women started by using pills, injectables, implants or IUDs and switched to pills, injectables, implants or IUDs and then stopped the second method. The duration of use was the duration of the use of the second method.
Women started contraception with pills, injectables, implants or IUDs and switched to a method not classified in this analysis (abstain, collier, condoms, diaphragm, sponge, withdrawal, LAM until six months and other methods) and then stopped the second method. The duration of use was the duration of the use of the first method.

We used survival analysis to estimate the effect of postpartum interventions on contraceptive discontinuation and switching. This technique allowed to include censored episodes in the estimation procedures. In this study, we defined an episode as a period of uninterrupted use of a contraceptive method that may or may not has ended. If the episode ended without switching to another method, then it was a discontinuation. One woman may report several episodes of contraceptive use. If another method was used after the first episode, then it was switching. The woman was right-censored if she started a method and did not stop it for the rest of the follow-up. She was left-censored if she started a method other than those excluded in the operational definitions given above.

The statistical significance and the effect of postpartum interventions of each outcome of interest were assessed using multivariate Cox regression modelling. We performed maximum likelihood estimation for parametric regression survival-time models. 95% CI and P value less or equal to 0.05 were set to determine the level of statistical significance.

After comparing the different models using the Akaike's Information Criteria (AIC), the best model was the Weibull survival distribution model (streg Stata's command) and therefore was selected to estimate the effect of the interventions on contraceptive discontinuation or switching. We opted for a hazard ratio (HR) estimate for our exposure variable and for the covariables.

A bivariate analysis with cluster effect correction was conducted initially to measure the possible association between interventions and the discontinuation or switching of the contraceptive methods, with primary health centres as clusters. Then, we adjusted the estimates by introducing into the model the type of method used. We analyzed each country separately and pooled data of both countries because they are different settings (urban in the DRC, primarily rural in Burkina Faso).

For switching, we use a multinomial logit model to estimate the effect of interventions on switching to a less or equal effectiveness method or to a more effective method. The reference group was that of the women who did not switch the first method.

We also reported the reasons of switching by method type on the one hand and also by the interventions group on the other hand.

In total, 637 (56.8%) out of the 1,120 women used at least one contraceptive method (of any type), with 47.8% (267/558) of users in the control group and 65.8% (370/562) in the intervention group.

Discontinuation of modern methods: Hormonal methods (pills, injectables, and implants) and intrauterine devices were used by 179 women of the control group with 24 discontinuations compared to 279 women of the intervention group with 32 discontinuations. The incidence rate of discontinuation of hormonal contraceptives was 6.91 in the control group compared to 5.14 per 10,000 women-days in the intervention group for the pooled data. The country-specific and pooled results are expressed in Table 1.

Table 1

Episodes of contraceptive use (pills, injectables, implants, and intra-uterine devices) by study group and country
	Burkina Faso		DR Congo		Pooled data
	Control	Intervention	Control	Intervention	Control	Intervention
Number of episodes	99	181	80	98	179	279
Total time at risk (days)	22747	40839	11981	21418	34728	62257
Number of discontinuations	17	28	7	4	24	32
Incidence rate (per 10000 women-days)	7.474	6.856	5.843	1.868	6.911	5.140
Mean time of use (days)	230	226	150	219	194	223
Median time	251	252	140	235	193	249
Hazard ratio	0.92(0.43–1.96)		0.32(0.05-2.00)		0.69(0.32–1.50)

No statistically significant difference was observed between study groups in terms of modern method discontinuation in either the bivariate or multivariate analyses. However, the discontinuation of modern methods was explained mainly by the type of method used. Compared to users of long-acting and reversible contraceptives (implants and IUD), women using injectables and pills were 13 and 10 times, respectively, more likely to discontinue its use during the first postpartum 12 months (95% CI=4.5-38.0 and 3.7-28.7, respectively). All the other covariables, such as the number of pregnancies, abortion, living children, woman's education, woman's occupation, showed no significant association with our variable of interest (Table 2).

Table 2

Univariate and multivariate analysis of interventions’ effects on method discontinuation
	Crude Hazard Ratio (95% CI)	p	Adjusted Hazard Ratio (95% CI)	p
Group
Control	Ref		Ref
Intervention	0.7(0.3–1.5)	0.351	0.9(0.4–1.9)	0.701
Method type
Injectables	13.3(4.8–36.9)	0.000	13.0(4.5–38.0)	0.000
Pills	10.5(3.8–28.8)	0.000	10.3(3.7–28.7)	0.000
Implants/IUD	Ref		Ref

Switching of contraceptives methods: Table 3 compares the method switching risks between the control and intervention groups in DR Congo, Burkina Faso, and both countries combined.

Table 3

multinomial logit estimates, comparing risks of switching between study group by country
	Burkina Faso			DRC			Pooled Data
	n(%)	HR(95%CI)	p	n(%)	HR(95%CI)	p	n(%)	HR(95%CI)	p
No switching
Control	74(90.2)			50(48.5)			124(67.0)
Intervention	120(72.7)			88(88.9)			208(78.8)
Switching to less or equally effective methods
Control	2(2.4)	0.5(0.1–2.7)	0.458	23(22.3)	8.1(2.9–22.6)	0.000	25(13.5)	3.8(1.8-8.0)	0.000
Intervention	6(3.6)	Ref		5(5.1)	Ref		11(4.2)	Ref
Switching to more effective methods
Control	6(7.3)	0.2(0.1–0.6)	0.003	30(29.1)	8.8(3.4–22.6)	0.000	36(19.5)	1.3(0.8–2.2)	0.241
Intervention	39(23.6)	Ref		6(6.1)	Ref		45(17.0)	Ref

In DR Congo, in reference to the women who had not switched while using a modern method, the likelihood of switching to a less or equally effective method among women of the control group was 8.1(95% CI: 2.9-22.6) times higher than that among women of the intervention group (p<0.001). This result is similar to that comparing the likelihood of switching to a more effective method among the women of the control group to the likelihood of switching to a more effective method among the women of the intervention group (RRR=8.8(95% CI: 3.4-22.6)) in reference to the women who had not switched while using a modern method.

In Burkina, in reference to the women who had not switched while using a modern method, none difference was found between the likelihood of switching to a less or equally effective method among women of the control group and that among women of the intervention group (p=0.458). But, in reference to the women who had not switched while using a modern method, we found a reduction of 80% in the likelihood of switching to a more effective method among women in the control group compared to that among women of the intervention group (RRR=0.2(95% CI: (0.1-0.6)). In other words, the women in the intervention group in Burkina likely switched to a more effective method than women in the control group.

The pooled data comparison showed, in reference to the women who had not switched while using a modern method, the likelihood of switching to a less or equally effective method among the women of the control group was 3.8(95% CI: 1.8-8.0) times higher than that the likelihood of switching to a less or equal effectiveness method among the women of the intervention group. And this excess was statistically significant (p<0.001).

Main reasons for first adopted method discontinuation or switching: Out of 199 women who switched, 141were interrupted due to a method-related reason (mainly lactational amenorrhea method). The second and third reason was partner opposition and unknown reason in respectively 20 and 17 cases. Table 4 shows these results.

Table 4

Main reasons for discontinuation or switching of first adopted methods by contraceptive type
	LAM	Injectable	Daily Pill	Implant/IUD	Condom	Other methods	Total
	n(%)	n(%)	n(%)	n(%)	n(%)	n(%)	n(%)
Method-related reason†	64(45.4)	20(14.2)	12(8.5)	5(3.5)	14(9.9)	26(18.4)	141(100.0)
Partner opposition	0(0.0)	3(15.0)	2(10.0)	0(0.0)	6(30.0)	9(45)	20(100.0)
Unknown	1(5.9)	6(35.3)	1(5.9)	1(5.9)	6(35.3)	2(11.8)	17(100.0)
Reduced need‡	0(0.0)	5(62.5)	2(25.0)	0(0.0)	0(0.0)	1(12.5)	8(100.0)
Desire for a child	0(0.0)	2(40.0)	1(20.0)	1(20.0)	0(0.0)	1(20.0)	5(100.0)
Pregnancy	0(0.0)	0(0.0)	2(50.0)	1(25.0)	1(25.0)	0(0.0)	4(100.0)
Financial problem	0(0.0)	4(100.0)	0(0.0)	0(0.0)	0(0.0)	0(0.0)	4(100.0)
Total	65(32.7)	40(20.1)	20(10.1)	8(4.0)	27(13.6)	39(19.6)	199(100.0)
†: Fear of side effects, side effects experienced, switching to a more effective method, switching to a more convenient method, method ineffective, noncompliance
‡: Reduced need included partner traveling and no partner (deceased or separated)

The proportions of the main reasons were not different between the two groups of women (significance not statistically evaluated) excepted for the partner opposition. Indeed, in the control group, there were 14 women (16.3%) stopped using their first method or changed it because of their partner disapproval against 6 (5.3%) in the intervention group. Table 5 expressed all these results.

Table 5

Main reasons for first adopted method discontinuation or switching by study group
	Control	Intervention	Total
	n(%)	n(%)	n(%)
Method-related reason	58(67.4)	83(73.5)	141(70.9)
Partner opposition	14(16.3)	6(5.3)	20(10.1)
Unknown	7(8.1)	10(8.8)	17(8.5)
Reduced need	1(1.2)	7(6.2)	8(4.0)
Pregnancy	0(0.0)	4(3.5)	4(2.0)
Financial problem	4(4.7)	0(0.0)	4(2.0)
Desire for a child	2(2.3)	3(2.7)	5(2.5)
Total	86(100.0)	113(100.0)	199(100.0)

Regarding the discontinuation among women who were using injectables, thirteen women (total of 20) who discontinued the use gave the method-related reason to explain it in the control group against seven women (total of 20 also) in the intervention group (results not shown in the table).

At the end of this analysis, we noted that postpartum interventions (Yam Daabo project) did not have a significant effect on modern contraceptive method discontinuation and switching. We also noted different results between the two countries. Indeed, while women in the intervention group in Burkina Faso switched contraceptive methods less than those in the control group, in the DRC the situation was the opposite (more frequent method switching in the intervention group). The main reported reason of the first method switching was method-related reasons, although some women also cited partner opposition as a reason for discontinuation or switching contraceptive methods.

Effect of PP interventions on contraceptive methods discontinuation and associated factors: the results showed no effect of PP (Yam Daabo) interventions on contraceptive methods discontinuation. Instead, these events were associated with the type of contraceptive methods used. Weldemariam et al, showed that the method related problems were found to contribute for more than half of the contraceptive use discontinuation by studying the reasons and multilevel factors associated with unscheduled contraceptive use discontinuation in Ethiopia [8]. In their study, they found that IUD and implant discontinuation rates were lowest compared to others. In our study, we had the same finding. Indeed, compared to implants or IUDs, we noticed many discontinuations among women using pills and injectables, which could be explained by the complexity of their intake (daily intake). The woman may either forget to take the pull several times or not be able to take the pill at the specified times. These types of events can lead to a switch to a method that is more practical to use, especially to long-acting methods (implant and IUD), but also to injectables (to a lesser extent). These results, obtained in the multivariate analysis, are consistent with the reasons given by women to explain the discontinuation of the methods. According to them, the method-related issues were the main reason for discontinuation of the first method with 141 episodes stopped over 199 (70.8%). The periodicity of injectable renewal exposes women to the forgetfulness in the same way as pills. So, this can lead to switching or discontinuation. The other reason for the low likelihood of women using a long-acting method to switch or stop is the fact that these methods are administered by qualified staff, and discontinuing or switching also requires the same type of staff. Women who return to interrupt her long-acting method could receive explanations (discussions on the reasons for the discontinuation) from health workers. They may convince her not to stop the method; this is unlike the pill or injectables, for which a woman does not need to see a health worker stop the method. All of these reasons explain why, in almost all studies, such as the Casey et al., study in the DRC (86.1% versus 78.0%) the rate of continuation of methods is higher in users of long-acting methods (implants and IUDs) than in users of short-acting methods (pills and injectables) [18]. In Senegal, in 2015, a study of 6927 women of childbearing age living in six urban sites showed that implants had the lowest 12-month discontinuation rate (6.3%), followed by intrauterine devices (IUDs) (18.4%). Higher rates were observed for injectable contraceptives (32.7%), pills (38%), and condoms (62.9%) [11]. Similar results were reported by the Diedrich's study, which, after adjustment, showed a risk of discontinuation that was three times higher among users of other methods compared to long-acting methods users (HRa =3.08, 95% CI=2.80-3.39) [19].

In this study, discontinuation and switching were more frequently observed among women using LAM. Indeed, this method is ineffective after six months postpartum, and the women who were using are supposed to know that they must change to another method after six months postpartum. The counselling made with our new tool could have contributed to reassure the women for these switching. Also, regarding the data on discontinuation among injectables users, we noted that the control group had many women who gave method-related reasons to discontinue the method compared to the intervention group, that could also be explained by the counselling tool. Indeed, before adopting the given method, health workers had to explain the side effects to a woman so that she was prepared to accept any symptom that she might experience while using the method. Health care providers might be updated on contraceptives side-effects, indications, contraindications, and mechanisms of action.

Effect of PP (Yam Daabo) interventions on contraceptive methods switching: regarding the switching of methods, we noted that switching of methods varied according to the study group. Being part of the control group was associated with a decreased likelihood of switching to a less or equal effectiveness method, especially in RD Congo. This shows a beneficial effect of PP interventions on switching.

Reason of contraception discontinuation or switching: lastly, regarding the reason of contraception discontinuation or switching, some women did not indicate their reasons for the discontinuation and switching of methods (17 women in total, similar repartition between the study's group). This lack of clear reason raises questions, especially in an African context, marked by misconceptions about contraception, as shown in the first phase of this trial [20]. A literature review by Blackstone et al., published in 2017 regarding factors influencing contraceptive use in sub-Saharan Africa between 2005 and 2015 showed that negative factors prohibiting or reducing contraceptive use were women’s misconceptions of contraceptive side–effects, male partner disapproval, and social/cultural norms surrounding fertility. Positive factors included education, employment, and communication with male partner [21]. So, one of the common reason for discontinuation given by women is their partner's opposition. This has already been reported in several studies [20–24] as one of the inhibitors for contraception use by women in general and especially by married women. The opposition from partners calls for more targeted action towards men to gain a better commitment from them to facilitate the use of contraceptive methods by women. In particular, family planning is part of women's rights, and husbands should not prevent them from adopting the method of their choice. In this study, we noted a different distribution of women who gave their partner's opposition as the reason for discontinuation even if the statistical significance was not explored (in the control group, 14 women (16.3%) against 6(5.3%) in the intervention group).

Limitations: for the analysis of switching, we did not consider the time for which women used the first modern methods if they used more one modern contraceptive method.

Conclusion: we noted that postpartum interventions did not have a significant effect on modern contraceptive method discontinuation and switching. Discontinuation and switching are much more related to the methods themselves than to any other factor. It is also important to set up specific actions targeting women's partners and influential people in the community to counter inhibiting beliefs. The capacity to build on health care providers' knowledge of the indications, contraindications and mechanisms of action of the various contraceptive methods could also help to improve the adherence of women.

Ethics approval

The trial was approved by WHO Research Ethics Review Committee, the ethics committee for health research in Burkina Faso and the School of Public Health ethics committee in DR Congo. Moreover, the trial was registered in the Pan African Clinical Trials Registry (PACTR201609001784334).

Consent for publication

Not applicable

Availability of data and materials

Requests for the anonymised, coded trial data can be made to the Department of Reproductive Health and Research, World Health Organization ([email protected]). Data sharing is subject to WHO data sharing policies and data use agreements with the participating research centres.

Competing Interests

The authors declare that they have no competing interests.

Funding

The study funder (Government of France) had no role in study design, data collection, data analysis, data interpretation, or writing the Article.

Authors contribution

AC, TM, NTT, AS, AC-K, BT, SL, JK, RY participated in all phases of the project (from design to data collection) and revised the article.

AC analyzed this article data and wrote the first draft with the important contributions from AB, TM, NTT and SK to data analysis and drafting.

DM and SK were the main investigators of the project in BF and in DR Congo. As such, they participated in all phases of the project and revised the article. All other authors contributed toward data analysis, drafting, and revising the paper and agreed to be accountable for all aspects of the work.

Acknowledgments

This work was carried out as part of the epidemiology thesis of the corresponding author. Special thanks go to the World Health Organization for agreeing to provide us the database for secondary analyzes and for offering the scholarship of doctoral studies in epidemiology. We also thank the Government of France generously provided funding for this research grant in the context of the Muskoka Initiative on Maternal and Child Health.

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Discontinuation and switching of postpartum contraceptive methods over twelve months in Burkina Faso and the DRC: a secondary analysis of the Yam-Daabo trial

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