Background: RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population. Methods: We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Five RIPK1 genetic variants (rs6907943, rs3736724, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under multivariate logistic regression models. Results: The results showed rs3736724 and rs2077681 were significantly associated with cervical cancer risk under various genetic models ( p < 0.05). The stratified analysis indicated that the relationships of rs2077681 and rs17548629 with cervical cancer risk were statistically significant in the subgroups of elderly individuals (age > 43 years) and stage. Additional, rs3736724 decreased the cervical cancer risk among the subjects aged ≤ 43 years in codominant model ( p = 0.043). Rs6907943 and rs9503400 could influence the susceptibility of cervical cancer for the patients with different stage ( p < 0.05). Conclusion: Our findings demonstrated that RIPK1 polymorphisms are associated with cervical cancer susceptibility among the Uyghur population in China, and may be involved in the development of cervical cancer.