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Research article
Jikui Deng
Shenzhen Children's Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0040-1491
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Previous studies have demonstrated an association between adenovirus viremia and disease severity in immunocompromised children. However, few studies focused on the use of this approach in immunocompetent children. This study explored the association between adenovirus viremia and adenovirus pneumonia severity in immunocompetent children.
Methods: We did a retrospective, observational study of immunocompetent children with adenovirus pneumonia admitted in Shenzhen Children’s hospital in Shenzhen, China. Pneumonia was classified as severe or mild, based on the Chinese guideline of pneumonia severity classification. The serum of all the children in the study was tested for adenovirus DNA with quantitative polymerase chain reaction (PCR). Clinical manifestations, laboratory examinations, and disease severity were compared between these two groups.
Results: A total of 111 immunocompetent children with adenovirus pneumonia (60 severe, 51 mild) were included. The median age was 40 months and 64 patients were male. Five patients were admitted to intensive care unit and two were endotracheal intubated. All the patients were discharged with recovery or improvement. Univariate analysis and binary logistic regression analysis showed leukocytosis (OR = 1.1; 95% CI: 1.0 to 1.2; P = 0.033), co-infection of mycoplasma pneumoniae (OR = 5.0; 95% CI: 2.1 to 12.3; P < 0.001), and high blood viral load (OR = 1.5; 95% CI: 1.2 to 2.0; P = 0.001) were risk factors for severe adenovirus pneumonia.
Conclusions: Leukocytosis, co-infection of mycoplasma pneumoniae, and high blood viral load are risk factors for severe adenovirus pneumonia in immunocompetent children. Blood viral load predicts pneumonia severity.
Keywords
Adenovirus, Viremia, Pneumonia, Immunocompetent children
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CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
Version 2
Posted 23 Nov, 2020
No community comments so far
Editorial decision: Major revision
On 12 Jan, 2021
Review #1 received
Received 27 Dec, 2020
Review #2 received
Received 05 Dec, 2020
Reviewer #2 agreed
On 03 Dec, 2020
Reviewers invited
Invitations sent on 01 Dec, 2020
Reviewer #1 agreed
On 01 Dec, 2020
Editor assigned
On 14 Nov, 2020
Submission checks complete
On 14 Nov, 2020
Editor invited
On 14 Nov, 2020
No comments provided
Editorial decision: Major revision
On 16 Oct, 2020
Review #1 received
Received 25 Sep, 2020
Review #2 received
Received 25 Sep, 2020
Reviewers invited
Invitations sent on 22 Sep, 2020
Reviewer #1 agreed
On 22 Sep, 2020
Reviewer #2 agreed
On 22 Sep, 2020
Editor assigned
On 28 Aug, 2020
Submission checks complete
On 27 Aug, 2020
Editor invited
On 27 Aug, 2020
First submitted
On 26 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
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A new preprint design is coming!
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See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Jikui Deng
Shenzhen Children's Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0040-1491
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
Version 2
Posted 23 Nov, 2020
No community comments so far
Editorial decision: Major revision
On 12 Jan, 2021
Review #1 received
Received 27 Dec, 2020
Review #2 received
Received 05 Dec, 2020
Reviewer #2 agreed
On 03 Dec, 2020
Reviewers invited
Invitations sent on 01 Dec, 2020
Reviewer #1 agreed
On 01 Dec, 2020
Editor assigned
On 14 Nov, 2020
Submission checks complete
On 14 Nov, 2020
Editor invited
On 14 Nov, 2020
No comments provided
Editorial decision: Major revision
On 16 Oct, 2020
Review #1 received
Received 25 Sep, 2020
Review #2 received
Received 25 Sep, 2020
Reviewers invited
Invitations sent on 22 Sep, 2020
Reviewer #1 agreed
On 22 Sep, 2020
Reviewer #2 agreed
On 22 Sep, 2020
Editor assigned
On 28 Aug, 2020
Submission checks complete
On 27 Aug, 2020
Editor invited
On 27 Aug, 2020
First submitted
On 26 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Infectious Diseases.
Background: Previous studies have demonstrated an association between adenovirus viremia and disease severity in immunocompromised children. However, few studies focused on the use of this approach in immunocompetent children. This study explored the association between adenovirus viremia and adenovirus pneumonia severity in immunocompetent children.
Methods: We did a retrospective, observational study of immunocompetent children with adenovirus pneumonia admitted in Shenzhen Children’s hospital in Shenzhen, China. Pneumonia was classified as severe or mild, based on the Chinese guideline of pneumonia severity classification. The serum of all the children in the study was tested for adenovirus DNA with quantitative polymerase chain reaction (PCR). Clinical manifestations, laboratory examinations, and disease severity were compared between these two groups.
Results: A total of 111 immunocompetent children with adenovirus pneumonia (60 severe, 51 mild) were included. The median age was 40 months and 64 patients were male. Five patients were admitted to intensive care unit and two were endotracheal intubated. All the patients were discharged with recovery or improvement. Univariate analysis and binary logistic regression analysis showed leukocytosis (OR = 1.1; 95% CI: 1.0 to 1.2; P = 0.033), co-infection of mycoplasma pneumoniae (OR = 5.0; 95% CI: 2.1 to 12.3; P < 0.001), and high blood viral load (OR = 1.5; 95% CI: 1.2 to 2.0; P = 0.001) were risk factors for severe adenovirus pneumonia.
Conclusions: Leukocytosis, co-infection of mycoplasma pneumoniae, and high blood viral load are risk factors for severe adenovirus pneumonia in immunocompetent children. Blood viral load predicts pneumonia severity.
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