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The effect of comorbidities for the prognosis of community-acquired pneumonia: an epidemiologic study using a hospital surveillance in Japan
Yukiko Wagatsuma
University of Tsukuba
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8056-9998
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Research Notes.
Objective
Pneumonia is a common but serious illness that continues to present significant morbidity and mortality. Although the effect of severity at admission on outcome has been well reported, the role of comorbidity is still not widely understood. The Charlson Comorbidity Index measures comorbidity with a well-established history of predicting long-term outcome but its utility in pneumonia prognosis is still limited. Here, we use the Charlson Comorbidity Index and hospital surveillance data to investigate associations between comorbidities and in-hospital mortality due to community-acquired pneumonia.
Results
Among the 535 eligible adult patients (69.0% male, median [IQR] age, 79 [70-84] years), 100 (18.7%) acquired severe to extremely severe pneumonia. The median [IQR] CCI was 1[1-3]. Malignancy (129 of 535, 24.1%), chronic pulmonary diseases (113 of 535, 21.1%) and congestive heart failure (103 of 535, 19.3%) were frequent. Higher Charlson Comorbidity Index scores were associated with higher risk of in-hospital mortality (OR 1.28; 95% CI 1.07-1.53). These results support the inclusion of comorbid burden in predicting community-acquired pneumonia outcome.
Keywords
community-acquired pneumonia, mortality, comorbidity, Charlson Comorbidity Index
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CURRENT STATUS: Published
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Posted 18 Dec, 2019
Published
On 19 Dec, 2019
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On 08 Dec, 2019
Editorial decision: Accept
On 06 Dec, 2019
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Editorial decision: Minor revision
On 04 Dec, 2019
Editor assigned
On 29 Nov, 2019
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On 28 Nov, 2019
Editor invited
On 28 Nov, 2019
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Editorial decision: Major revision
On 15 Nov, 2019
Review #1 received
Received 22 Oct, 2019
Submission checks complete
On 11 Oct, 2019
Editor invited
On 11 Oct, 2019
Editor assigned
On 11 Oct, 2019
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Reviewer #1 agreed
On 11 Oct, 2019
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This preprint is under consideration at BMC Research Notes. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
The effect of comorbidities for the prognosis of community-acquired pneumonia: an epidemiologic study using a hospital surveillance in Japan
Yukiko Wagatsuma
University of Tsukuba
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8056-9998
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 18 Dec, 2019
Published
On 19 Dec, 2019
No community comments so far
Submission checks complete
On 08 Dec, 2019
Editorial decision: Accept
On 06 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 04 Dec, 2019
Editor assigned
On 29 Nov, 2019
Submission checks complete
On 28 Nov, 2019
Editor invited
On 28 Nov, 2019
No comments provided
Editorial decision: Major revision
On 15 Nov, 2019
Review #1 received
Received 22 Oct, 2019
Submission checks complete
On 11 Oct, 2019
Editor invited
On 11 Oct, 2019
Editor assigned
On 11 Oct, 2019
Reviewers invited
Invitations sent on 11 Oct, 2019
Reviewer #1 agreed
On 11 Oct, 2019
First submitted
On 04 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Research Notes.
Objective
Pneumonia is a common but serious illness that continues to present significant morbidity and mortality. Although the effect of severity at admission on outcome has been well reported, the role of comorbidity is still not widely understood. The Charlson Comorbidity Index measures comorbidity with a well-established history of predicting long-term outcome but its utility in pneumonia prognosis is still limited. Here, we use the Charlson Comorbidity Index and hospital surveillance data to investigate associations between comorbidities and in-hospital mortality due to community-acquired pneumonia.
Results
Among the 535 eligible adult patients (69.0% male, median [IQR] age, 79 [70-84] years), 100 (18.7%) acquired severe to extremely severe pneumonia. The median [IQR] CCI was 1[1-3]. Malignancy (129 of 535, 24.1%), chronic pulmonary diseases (113 of 535, 21.1%) and congestive heart failure (103 of 535, 19.3%) were frequent. Higher Charlson Comorbidity Index scores were associated with higher risk of in-hospital mortality (OR 1.28; 95% CI 1.07-1.53). These results support the inclusion of comorbid burden in predicting community-acquired pneumonia outcome.