[1] R.M. Tuder, S.L. Archer, P. Dorfmuller, S.C. Erzurum, C. Guignabert, E. Michelakis, M. Rabinovitch, R. Schermuly, K.R. Stenmark, N.W. Morrell, Relevant issues in the pathology and pathobiology of pulmonary hypertension, J Am Coll Cardiol 62(25 Suppl) (2013) D4-12.
[2] V.V. McLaughlin, S.L. Archer, D.B. Badesch, R.J. Barst, H.W. Farber, J.R. Lindner, M.A. Mathier, M.D. McGoon, M.H. Park, R.S. Rosenson, L.J. Rubin, V.F. Tapson, J. Varga, D. American College of Cardiology Foundation Task Force on Expert Consensus, A. American Heart, P. American College of Chest, I. American Thoracic Society, A. Pulmonary Hypertension, ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association, J Am Coll Cardiol 53(17) (2009) 1573-619.
[3] A. Vonk-Noordegraaf, F. Haddad, K.M. Chin, P.R. Forfia, S.M. Kawut, J. Lumens, R. Naeije, J. Newman, R.J. Oudiz, S. Provencher, A. Torbicki, N.F. Voelkel, P.M. Hassoun, Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology, J Am Coll Cardiol 62(25 Suppl) (2013) D22-33.
[4] N. Hatton, J.J. Ryan, Sex Differences in Response to Pulmonary Arterial Hypertension Therapy : Is What's Good for the Goose, Good for the Gander?, Chest 145(6) (2014) 1184-1186.
[5] R. Condliffe, D.G. Kiely, A.J. Peacock, P.A. Corris, J.S. Gibbs, F. Vrapi, C. Das, C.A. Elliot, M. Johnson, J. DeSoyza, C. Torpy, K. Goldsmith, D. Hodgkins, R.J. Hughes, J. Pepke-Zaba, J.G. Coghlan, Connective tissue disease-associated pulmonary arterial hypertension in the modern treatment era, Am J Respir Crit Care Med 179(2) (2009) 151-7.
[6] R.D. Machado, L. Southgate, C.A. Eichstaedt, M.A. Aldred, E.D. Austin, D.H. Best, W.K. Chung, N. Benjamin, C.G. Elliott, M. Eyries, C. Fischer, S. Graf, K. Hinderhofer, M. Humbert, S.B. Keiles, J.E. Loyd, N.W. Morrell, J.H. Newman, F. Soubrier, R.C. Trembath, R.R. Viales, E. Grunig, Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects, Hum Mutat 36(12) (2015) 1113-27.
[7] M.M. Hoeper, C. Apitz, E. Grunig, M. Halank, R. Ewert, H. Kaemmerer, H.J. Kabitz, C. Kahler, H. Klose, H. Leuchte, S. Ulrich, K.M. Olsson, O. Distler, S. Rosenkranz, H.A. Ghofrani, Targeted therapy of pulmonary arterial hypertension: Updated recommendations from the Cologne Consensus Conference 2018, International journal of cardiology 272s (2018) 37-45.
[8] B. Vogelstein, N. Papadopoulos, V.E. Velculescu, S. Zhou, L.A. Diaz, Jr., K.W. Kinzler, Cancer genome landscapes, Science 339(6127) (2013) 1546-58.
[9] M. Mura, M. Anraku, Z. Yun, K. McRae, M. Liu, T.K. Waddell, L.G. Singer, J.T. Granton, S. Keshavjee, M. de Perrot, Gene expression profiling in the lungs of patients with pulmonary hypertension associated with pulmonary fibrosis, Chest 141(3) (2012) 661-673.
[10] A.R. Hemnes, E.L. Brittain, A.W. Trammell, J.P. Fessel, E.D. Austin, N. Penner, K.B. Maynard, L. Gleaves, M. Talati, T. Absi, T. Disalvo, J. West, Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension, Am J Respir Crit Care Med 189(3) (2014) 325-34.
[11] Y. Zhao, J. Peng, C. Lu, M. Hsin, M. Mura, L. Wu, L. Chu, R. Zamel, T. Machuca, T. Waddell, M. Liu, S. Keshavjee, J. Granton, M. de Perrot, Metabolomic heterogeneity of pulmonary arterial hypertension, PLoS One 9(2) (2014) e88727.
[12] Y.D. Zhao, H.Z.H. Yun, J. Peng, L. Yin, L. Chu, L. Wu, R. Michalek, M. Liu, S. Keshavjee, T. Waddell, J. Granton, M. de Perrot, De novo synthesize of bile acids in pulmonary arterial hypertension lung, Metabolomics 10(6) (2014) 1169-1175.
[13] G. Marsboom, P.T. Toth, J.J. Ryan, Z. Hong, X. Wu, Y.H. Fang, T. Thenappan, L. Piao, H.J. Zhang, J. Pogoriler, Y. Chen, E. Morrow, E.K. Weir, J. Rehman, S.L. Archer, Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension, Circ Res 110(11) (2012) 1484-97.
[14] C. Hong, M. Hauskrecht, MCODE: Multivariate Conditional Outlier Detection, Computer Science (2015).
[15] W. Steudel, F. Ichinose, P.L. Huang, W.E. Hurford, R.C. Jones, J.A. Bevan, M.C. Fishman, W.M. Zapol, Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene, Circ Res 81(1) (1997) 34-41.
[16] J.J. Ryan, G. Marsboom, Y.H. Fang, P.T. Toth, E. Morrow, N. Luo, L. Piao, Z. Hong, K. Ericson, H.J. Zhang, M. Han, C.R. Haney, C.T. Chen, W.W. Sharp, S.L. Archer, PGC1alpha-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension, Am J Respir Crit Care Med 187(8) (2013) 865-78.
[17] P. Herve, J.M. Launay, M.L. Scrobohaci, F. Brenot, G. Simonneau, P. Petitpretz, P. Poubeau, J. Cerrina, P. Duroux, L. Drouet, Increased plasma serotonin in primary pulmonary hypertension, Am J Med 99(3) (1995) 249-54.
[18] H.L. Reeve, E. Michelakis, D.P. Nelson, E.K. Weir, S.L. Archer, Alterations in a redox oxygen sensing mechanism in chronic hypoxia, J Appl Physiol (1985) 90(6) (2001) 2249-56.
[19] H.C. Thomas, M.W. Lame, D.W. Wilson, H.J. Segall, Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA, Toxicol Appl Pharmacol 141(1) (1996) 319-29.
[20] K. Shimokado, K. Umezawa, J. Ogata, Tyrosine kinase inhibitors inhibit multiple steps of the cell cycle of vascular smooth muscle cells, Exp Cell Res 220(2) (1995) 266-73.
[21] H.C. Thomas, M.W. Lame, D. Morin, D.W. Wilson, H.J. Segall, Prolonged cell-cycle arrest associated with altered cdc2 kinase in monocrotaline pyrrole-treated pulmonary artery endothelial cells, Am J Respir Cell Mol Biol 19(1) (1998) 129-42.
[22] Q. Xi, M. Huang, Y. Wang, J. Zhong, R. Liu, G. Xu, L. Jiang, J. Wang, Z. Fang, S. Yang, The expression of CDK1 is associated with proliferation and can be a prognostic factor in epithelial ovarian cancer, Tumour Biol 36(7) (2015) 4939-48.
[23] A. Satyanarayana, M.B. Hilton, P. Kaldis, p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint, Mol Biol Cell 19(1) (2008) 65-77.
[24] R. Liu, M. Fan, D. Candas, L. Qin, X. Zhang, A. Eldridge, J.X. Zou, T. Zhang, S. Juma, C. Jin, R.F. Li, J. Perks, L.Q. Sun, A.T. Vaughan, C.X. Hai, D.R. Gius, J.J. Li, CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance, Mol Cancer Ther 14(9) (2015) 2090-102.
[25] G. Sutendra, E.D. Michelakis, Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology, Front Oncol 3 (2013) 38.
[26] K. Bednarek, K. Kiwerska, M. Szaumkessel, M. Bodnar, M. Kostrzewska-Poczekaj, A. Marszalek, J. Janiszewska, A. Bartochowska, J. Jackowska, M. Wierzbicka, R. Grenman, K. Szyfter, M. Giefing, M. Jarmuz-Szymczak, Recurrent CDK1 overexpression in laryngeal squamous cell carcinoma, Tumour Biol 37(8) (2016) 11115-26.
[27] S.J. Kim, S. Nakayama, K. Shimazu, Y. Tamaki, K. Akazawa, F. Tsukamoto, Y. Torikoshi, T. Matsushima, M. Shibayama, H. Ishihara, S. Noguchi, Recurrence risk score based on the specific activity of CDK1 and CDK2 predicts response to neoadjuvant paclitaxel followed by 5-fluorouracil, epirubicin and cyclophosphamide in breast cancers, Ann Oncol 23(4) (2012) 891-7.
[28] J. Ryan, A. Dasgupta, J. Huston, K.H. Chen, S.L. Archer, Mitochondrial dynamics in pulmonary arterial hypertension, J Mol Med (Berl) 93(3) (2015) 229-42.
[29] A. Takemoto, K. Kimura, S. Yokoyama, F. Hanaoka, Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin, J Biol Chem 279(6) (2004) 4551-9.
[30] Y. Murakami-Tonami, S. Kishida, I. Takeuchi, Y. Katou, J.M. Maris, H. Ichikawa, Y. Kondo, Y. Sekido, K. Shirahige, H. Murakami, K. Kadomatsu, Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells, Cell Cycle 13(7) (2014) 1115-31.
[31] D. Allegra, V. Bilan, A. Garding, H. Dohner, S. Stilgenbauer, F. Kuchenbauer, D. Mertens, M. Zucknick, Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia, Leukemia 28(1) (2014) 98-107.
[32] V. Davalos, L. Suarez-Lopez, J. Castano, A. Messent, I. Abasolo, Y. Fernandez, A. Guerra-Moreno, E. Espin, M. Armengol, E. Musulen, A. Ariza, J. Sayos, D. Arango, S. Schwartz, Jr., Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target, J Biol Chem 287(52) (2012) 43472-81.
[33] A. Hutterer, M. Glotzer, M. Mishima, Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody, Curr Biol 19(23) (2009) 2043-9.
[34] L. Seguin, C. Liot, R. Mzali, R. Harada, A. Siret, A. Nepveu, J. Bertoglio, CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase, Mol Cell Biol 29(2) (2009) 570-81.
[35] T. Kato, D. Lee, L. Wu, P. Patel, A.J. Young, H. Wada, H.P. Hu, H. Ujiie, M. Kaji, S. Kano, S. Matsuge, H. Domen, K. Kaga, Y. Matsui, H. Kanno, Y. Hatanaka, K.C. Hatanaka, Y. Matsuno, M. de Perrot, K. Yasufuku, Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma, Int J Oncol 49(2) (2016) 448-56.
[36] L. Sun, C. Zhang, Z. Yang, Y. Wu, H. Wang, Z. Bao, T. Jiang, KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4, Oncotarget 7(17) (2016) 24646-55.
[37] Y. Mao, A. Desai, D.W. Cleveland, Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling, J Cell Biol 170(6) (2005) 873-80.
[38] B.A. Sullivan, S. Schwartz, Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres, Hum Mol Genet 4(12) (1995) 2189-97.
[39] Y. Kim, A.J. Holland, W. Lan, D.W. Cleveland, Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E, Cell 142(3) (2010) 444-55.
[40] L. Shan, M. Zhao, Y. Lu, H. Ning, S. Yang, Y. Song, W. Chai, X. Shi, CENPE promotes lung adenocarcinoma proliferation and is directly regulated by FOXM1, Int J Oncol 55(1) (2019) 257-266.
[41] O. Rath, F. Kozielski, Kinesins and cancer, Nat Rev Cancer 12(8) (2012) 527-39.
[42] Z.H. McMahan, T.R. Cottrell, F.M. Wigley, B. Antiochos, E.T. Zambidis, T.S. Park, M.K. Halushka, L. Gutierrez-Alamillo, R. Cimbro, A. Rosen, L. Casciola-Rosen, Enrichment of Scleroderma Vascular Disease-Associated Autoantigens in Endothelial Lineage Cells, Arthritis Rheumatol 68(10) (2016) 2540-9.
[43] J.R. Thomson, R.D. Machado, M.W. Pauciulo, N.V. Morgan, M. Humbert, G.C. Elliott, K. Ward, M. Yacoub, G. Mikhail, P. Rogers, J. Newman, L. Wheeler, T. Higenbottam, J.S. Gibbs, J. Egan, A. Crozier, A. Peacock, R. Allcock, P. Corris, J.E. Loyd, R.C. Trembath, W.C. Nichols, Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family, J Med Genet 37(10) (2000) 741-5.
[44] R.D. Machado, M.A. Aldred, V. James, R.E. Harrison, B. Patel, E.C. Schwalbe, E. Gruenig, B. Janssen, R. Koehler, W. Seeger, O. Eickelberg, H. Olschewski, C.G. Elliott, E. Glissmeyer, J. Carlquist, M. Kim, A. Torbicki, A. Fijalkowska, G. Szewczyk, J. Parma, M.J. Abramowicz, N. Galie, H. Morisaki, S. Kyotani, N. Nakanishi, T. Morisaki, M. Humbert, G. Simonneau, O. Sitbon, F. Soubrier, F. Coulet, N.W. Morrell, R.C. Trembath, Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension, Hum Mutat 27(2) (2006) 121-32.
[45] M.J. Goumans, Z. Liu, P. ten Dijke, TGF-beta signaling in vascular biology and dysfunction, Cell Res 19(1) (2009) 116-27.
[46] M.J. Goumans, G. Valdimarsdottir, S. Itoh, F. Lebrin, J. Larsson, C. Mummery, S. Karlsson, P. ten Dijke, Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling, Mol Cell 12(4) (2003) 817-28.
[47] R. Johnson, G. Halder, The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment, Nat Rev Drug Discov 13(1) (2014) 63-79.
[48] T.V. Kudryashova, D.A. Goncharov, A. Pena, N. Kelly, R. Vanderpool, J. Baust, A. Kobir, W. Shufesky, A.L. Mora, A.E. Morelli, J. Zhao, K. Ihida-Stansbury, B. Chang, H. DeLisser, R.M. Tuder, S.M. Kawut, H.H. Sillje, S. Shapiro, Y. Zhao, E.A. Goncharova, HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension, Am J Respir Crit Care Med 194(7) (2016) 866-877.
[49] Y. Luan, X. Zhang, F. Kong, G.H. Cheng, T.G. Qi, Z.H. Zhang, Mesenchymal stem cell prevention of vascular remodeling in high flow-induced pulmonary hypertension through a paracrine mechanism, Int Immunopharmacol 14(4) (2012) 432-7.
[50] L. Gautier, L. Cope, B.M. Bolstad, R.A. Irizarry, affy--analysis of Affymetrix GeneChip data at the probe level, Bioinformatics 20(3) (2004) 307-15.
[51] A. Suyundikov, J.R. Stevens, C. Corcoran, J. Herrick, R.K. Wolff, M.L. Slattery, Accounting for dependence induced by weighted KNN imputation in paired samples, motivated by a colorectal cancer study, PLoS One 10(4) (2015) e0119876.
[52] J.T. Leek, W.E. Johnson, H.S. Parker, A.E. Jaffe, J.D. Storey, The sva package for removing batch effects and other unwanted variation in high-throughput experiments, Bioinformatics 28(6) (2012) 882-3.
[53] M.E. Ritchie, B. Phipson, D. Wu, Y. Hu, C.W. Law, W. Shi, G.K. Smyth, limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Res 43(7) (2015) e47.
[54] G. Bindea, B. Mlecnik, H. Hackl, P. Charoentong, M. Tosolini, A. Kirilovsky, W.H. Fridman, F. Pages, Z. Trajanoski, J. Galon, ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks, Bioinformatics 25(8) (2009) 1091-3.
[55] P. Shannon, A. Markiel, O. Ozier, N.S. Baliga, J.T. Wang, D. Ramage, N. Amin, B. Schwikowski, T. Ideker, Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res 13(11) (2003) 2498-504.
[56] G.D. Bader, C.W. Hogue, An automated method for finding molecular complexes in large protein interaction networks, BMC Bioinformatics 4 (2003) 2.
[57] C.H. Chin, S.H. Chen, H.H. Wu, C.W. Ho, M.T. Ko, C.Y. Lin, cytoHubba: identifying hub objects and sub-networks from complex interactome, BMC Syst Biol 8 Suppl 4 (2014) S11.
[58] D. Sun, X. Wan, B.B. Pan, Q. Sun, X.B. Ji, F. Zhang, H. Zhang, C.C. Cao, Bioinformatics Analysis of Genes and Pathways of CD11b(+)/Ly6C(intermediate) Macrophages after Renal Ischemia-Reperfusion Injury, Curr Med Sci 38(1) (2018) 70-77.