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Volume of Tidal Gas Movement in the Nonventilated Lung during One-lung Ventilation and its Relevant Factors
Weidong Gu
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3014-5839
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View the published version at BMC Anesthesiology.
Background: The passive ventilation of nonventilated lung results in tidal gas movement (TGM) and thus affects lung collapse. The present study aimed to measure the volume of TGM and to analyse the relevant factors of the TGM index (TGM/body surface area).Methods: One hundred eight patients scheduled for elective thoracoscopic surgeries were enrolled. Lung isolation was achieved with a double-lumen endobronchial tube (DLT). The paediatric spirometry sensor was connected to the double-lumen connector of the nonventilated lung to measure the volume of TGM during one-lung ventilation (OLV) in the lateral position. The TGM index was calculated. The multiple linear regression was analysed using the TGM index as the dependent variables. Independent variables were also recorded: 1) age, sex, body mass index (BMI); 2) forced vital capacity (FVC), FEV1/FVC, minute ventilation volume (MVV); 3) dynamic lung compliance (Cdyn) and peak inspiratory pressure (PIP) during dual lung ventilation; 4) the side of OLV; and 5) whether lung puncture for localization of the pulmonary nodule was performed on the day of surgery. The oxygen concentration in the nonventilated lung was measured at 5 min after OLV, and its correlation with the TGM index was analysed.Results: The volume of TGM in the nonventilated lung during OLV was 78 37 mL. The TGM index was 45 20 mL/m2 and was negatively correlated with the oxygen concentration in the nonventilated lung at 5 min after OLV. The multiple linear regression model for the TGM index was deduced as follows: TGM index (mL/m2)=C+12.770×a-3.987×b-1.237×c-2.664×d, where C is a constant 95.621 mL/m2, a is 1 for males and 0 for females, b is 1 for right OLV and 0 for left OLV, c is BMI (kg/m2), and d is PIP (cmH2O).Conclusions: The TGM index is negatively correlated with the oxygen concentration of the nonventilated lung at 5 min after OLV. Sex, side of OLV, BMI and PIP are independently correlated with the TGM index.Trial registration: This study was registered at ChiCTR (www.chictr.org.cn, ChiCTR1900024220) on July 1, 2019.Key Words: tidal gas movement, TGM index, one-lung ventilation, lung collapse, double-lumen endobronchial tube, dynamic lung compliance, thoracoscopy
Keywords
tidal gas movement, one-lung ventilation, lung collapse, double-lumen endobronchial tube, dynamic lung compliance, thoracoscopy
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CURRENT STATUS: Published
Published
On 22 Jan, 2020
No community comments so far
Submission checks complete
On 14 Jan, 2020
Editorial decision: Accept
On 13 Jan, 2020
Version 3
Posted 13 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 06 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 23 Dec, 2019
Editor assigned
On 22 Dec, 2019
Submission checks complete
On 21 Dec, 2019
Editor invited
On 21 Dec, 2019
No comments provided
Review #2 received
Received 31 Oct, 2019
Editorial decision: Major revision
On 31 Oct, 2019
Reviewer #2 agreed
On 30 Oct, 2019
Review #1 received
Received 28 Oct, 2019
Editor assigned
On 18 Oct, 2019
Reviewers invited
Invitations sent on 18 Oct, 2019
Reviewer #1 agreed
On 18 Oct, 2019
Editor invited
On 15 Oct, 2019
Submission checks complete
On 14 Oct, 2019
First submitted
On 07 Oct, 2019
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Subject Areas
Anesthesiology & Pain Medicine
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This preprint is under consideration at BMC Anesthesiology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Volume of Tidal Gas Movement in the Nonventilated Lung during One-lung Ventilation and its Relevant Factors
Weidong Gu
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3014-5839
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Published
On 22 Jan, 2020
No community comments so far
Submission checks complete
On 14 Jan, 2020
Editorial decision: Accept
On 13 Jan, 2020
Version 3
Posted 13 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 06 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 23 Dec, 2019
Editor assigned
On 22 Dec, 2019
Submission checks complete
On 21 Dec, 2019
Editor invited
On 21 Dec, 2019
No comments provided
Review #2 received
Received 31 Oct, 2019
Editorial decision: Major revision
On 31 Oct, 2019
Reviewer #2 agreed
On 30 Oct, 2019
Review #1 received
Received 28 Oct, 2019
Editor assigned
On 18 Oct, 2019
Reviewers invited
Invitations sent on 18 Oct, 2019
Reviewer #1 agreed
On 18 Oct, 2019
Editor invited
On 15 Oct, 2019
Submission checks complete
On 14 Oct, 2019
First submitted
On 07 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Anesthesiology & Pain Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Anesthesiology.
Background: The passive ventilation of nonventilated lung results in tidal gas movement (TGM) and thus affects lung collapse. The present study aimed to measure the volume of TGM and to analyse the relevant factors of the TGM index (TGM/body surface area).Methods: One hundred eight patients scheduled for elective thoracoscopic surgeries were enrolled. Lung isolation was achieved with a double-lumen endobronchial tube (DLT). The paediatric spirometry sensor was connected to the double-lumen connector of the nonventilated lung to measure the volume of TGM during one-lung ventilation (OLV) in the lateral position. The TGM index was calculated. The multiple linear regression was analysed using the TGM index as the dependent variables. Independent variables were also recorded: 1) age, sex, body mass index (BMI); 2) forced vital capacity (FVC), FEV1/FVC, minute ventilation volume (MVV); 3) dynamic lung compliance (Cdyn) and peak inspiratory pressure (PIP) during dual lung ventilation; 4) the side of OLV; and 5) whether lung puncture for localization of the pulmonary nodule was performed on the day of surgery. The oxygen concentration in the nonventilated lung was measured at 5 min after OLV, and its correlation with the TGM index was analysed.Results: The volume of TGM in the nonventilated lung during OLV was 78 37 mL. The TGM index was 45 20 mL/m2 and was negatively correlated with the oxygen concentration in the nonventilated lung at 5 min after OLV. The multiple linear regression model for the TGM index was deduced as follows: TGM index (mL/m2)=C+12.770×a-3.987×b-1.237×c-2.664×d, where C is a constant 95.621 mL/m2, a is 1 for males and 0 for females, b is 1 for right OLV and 0 for left OLV, c is BMI (kg/m2), and d is PIP (cmH2O).Conclusions: The TGM index is negatively correlated with the oxygen concentration of the nonventilated lung at 5 min after OLV. Sex, side of OLV, BMI and PIP are independently correlated with the TGM index.Trial registration: This study was registered at ChiCTR (www.chictr.org.cn, ChiCTR1900024220) on July 1, 2019.Key Words: tidal gas movement, TGM index, one-lung ventilation, lung collapse, double-lumen endobronchial tube, dynamic lung compliance, thoracoscopy
Figure 1
Figure 2