1 ] American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders(DSM5).5thed.Arlighton,VA:American Psychiatric Association,2013:8
2 ] Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P. An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol. 2000;42(7):436-447. doi:10.1017/s0012162200000839
3 ] Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein L,Serlachius E,et al. Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study. Mol Psychiatry. 2018;23(5):1189-1197. doi:10.1038/mp.2017.31
4 ] Robertson MM, Eapen V, Singer HS, Martino D, Scharf JM,Paschou P,et al. Gilles de la Tourette syndrome. Nat Rev Dis Primers. 2017;3:16097. doi:10.1038/nrdp.2016.97.
5 ] Ganos C, Roessner V, Munchau A.The functional anatomy of Gilles de la Tourette syndrome. Neurosci. Biobehav. 2013. 37(6):1050-1062 .doi:10.1016/j.neubiorev.2012.11.004.
6 ] Hartmann A, Worbe Y. Tourette syndrome: clinical spectrum, mechanisms and personalized treatments. Curr Opin Neurol. 2018;31(4):504-509.
doi:10.1097/WCO.0000000000000575.
7 ] Pagliaroli L, Vető B, Arányi T, Barta C. From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research. Front Neurosci. 2016;10:277.doi:10.3389/fnins.2016.00277
8 ] Paschou P, Müller-Vahl K. Editorial: The Neurobiology and Genetics of Gilles de la Tourette Syndrome: New Avenues through Large-Scale Collaborative Projects. Front Psychiatry. 2017;8:197. Published 2017 Oct 11. doi:10.3389/fpsyt.2017.00197.
9 ] Párraga HC, Harris KM, Párraga KL, Balen GM, Cruz C. An overview of the treatment of Tourette's disorder and tics. J Child Adolesc Psychopharmacol. 2010;20(4):249-262. doi:10.1089/cap.2010.0027.
10 ] Alvarez-Chaver P, Otero-Estévez O, Páez de la Cadena M, Rodríguez-Berrocal FJ, Martínez-Zorzano VS. Proteomics for discovery of candidate colorectal cancer biomarkers. World J Gastroenterol. 2014;20(14):3804-3824. doi:10.3748/wjg.v20.i14.3804.
11 ] Mallick P, Kuster B. Proteomics: a pragmatic perspective. Nat Biotechnol. 2010;28(7):695-709. doi:10.1038/nbt.1658.
12 ] Anderson NL, Anderson NG, Pearson TW, Borchers CH,Paulovich AG,Patterson SD,et al. A human proteome detection and quantitation project. Mol Cell Proteomics. 2009;8(5):883-886. doi:10.1074/mcp.R800015-MCP200.
13 ] Liao QL,Chen XD,Ding YQ.Advance in serum proteomics research and technology[J].CHINESE JOURNAL OF PATHOPHYSIOLOGY,2008,24(2):402-407. DOI:10.3321/j.issn:1000-4718.2008.02.045.
[14] Yang J, Chen YN, Xiong XF, Zhou XB,Han L,Ni L,et al. Peptidome Analysis Reveals Novel Serum Biomarkers for Children with Autism Spectrum Disorder in China. Proteomics Clin Appl. 2018;12(5):e1700164. doi:10.1002/prca.201700164.
[15] Jiang W.Application of Serum Protein Markers from Patients with Schizophrenia in Clinic.Luzhou, China: Luzhou Medical College, 2008.
[16] Shen G, He P, Du Y, Zhang S. Identification of Biomarkers by Proteomics for Prenatal Screening for Neural Tube Defects. Tohoku J Exp Med. 2016;238(2):123-129. doi:10.1620/tjem.238.123.
[17] Bao WX, He FP, Yu LH,Gao J, Meng FX,Ding YH,et al. Complement cascade on severe traumatic brain injury patients at the chronic unconscious stage: implication for pathogenesis. Expert Rev Mol Diagn. 2018;18(8):761-766. doi: 10.1080/ 14737159.2018.147 1985.
[18] Bennett S, Grant M, Creese AJ, Mangialasche F, Cecchetti R, Cooper HJ,et al.Plasma levels of complement 4a protein are increased in Alzheimer's disease. Alzheimer Dis Assoc Disord. 2012;26(4):329-334. doi:10.1097/WAD.0b013e318239dcbd
[19] Craig-Schapiro R, Perrin RJ, Roe CM,Xiong Cj,Carter D,Cairns NJ,et al. YKL-40: a novel prognostic fluid biomarker for p Alreclinicalzheimer's disease [published correction appears in Biol Psychiatry. 2011 Feb 15;69(4):389]. Biol Psychiatry. 2010;68(10):903-912. doi:10.1016/j.biopsych.2010.08.025.
[20] Wang D,HE L,Zhang J,Zhao XY, Xiong XF,He WX,et al.Screening of serum related proteins of different TCM syndromes with tic disorders by proteomic techniques.Chinese Journal of Woman and Child Health Research.2018,29(2):149-153. DOI: 10.3969/ j.issn.1673 -5293.2018.02.005.
[21] Neurology Group, Pediatrics Branch of Chinese Medical Association.Expert consensus on the diagnosis and treatment of tic disorders in children (2017 practical edition).Chinese Journal of Applied Clinical Pediatrics.2017,32(15):1137-1140.doi:10.3760/cma.j.issn.2095-42
8X20 17.15.005.
[22] Weisel JW, Litvinov RI. Fibrin Formation, Structure and Properties. Subcell Biochem. 2017;82:405-456. doi:10.1007/978-3-319-49674-0_13.
[23] TP U, DA S, L Z, et al. Identification of a novel recognition sequence for integrin alphaM beta2 within the gamma-chain of fibrinogen.[J]. Journal of Biological Chemistry, 1998,273(35): 22519-22527.
[24] Hsieh JY, Smith TD, Meli VS, Tran TN, Botvinick EL, Liu WF. Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. Acta Biomater. 2017;47:14- doi:10.1016/j.actbio.2016.09.024.
[25] Liu Z,Ji JP,Chen H,Li J,Zhang Y,Kang JJ.Correlation study between T-lymphocyte subsets and emotion in children with Tourette syndrome.China Journal of Modern Medicine,2013,23(27):101-105.
[26] Li N,Du JJ,Zheng H,Ji WD.Study on relationship between Tourette's syndrome and ASO, IL-6, IL-8.Chinese Journal of Child Health Care,2013,21(7):688-690.
[27] Cheng YH, Zheng Y, He F, Yang JH,Li WB, Wang ML,et al. Detection of autoantibodies and increased concentrations of interleukins in plasma from patients with Tourette's syndrome. J Mol Neurosci. 2012;48(1):219-224. doi:10.1007/s12031-012-9811-8.
[28] Leckman JF,Katsovich L,Kawikova I,Lin HQ,Zhang HP,Krönig H,et al. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome.Biol Psychiatry. 2005;57(6):667-673. doi:10.1016/j.biopsych.2004.12.004.
[29] Kawikova I, Grady BP, Tobiasova Z,Zhang Y, Vojdani A, Katsovich L, et al. Children with Tourette's syndrome may suffer immunoglobulin A dysgammaglobulinemia: preliminary report. Biol Psychiatry. 2010;67(7):679-683. doi:10.1016/j.biopsych.2009.09.034.
[30] Bos-Veneman NG, Olieman R, Tobiasova Z,Hoekstra PJ , Katsovich L, Bothwell AL,et al. Altered immunoglobulin profiles in children with Tourette syndrome. Brain Behav Immun. 2011;25(3):532-538. doi:10.1016/j.bbi.2010.12.003.
[31] Landau YE, Steinberg T, Richmand B, Leckman JF, Apter A. Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette's syndrome. J Neural Transm (Vienna). 2012;119(5):621-626. doi:10.1007/s00702-011-0739-x.
[32] Dey P, Kundu A, Sachan R,Park JH,Ahn MY,Yoon K,et al. PKM2 Knockdown Induces Autophagic Cell Death via AKT/mTOR Pathway in Human Prostate Cancer Cells. Cell Physiol Biochem. 2019;52(6):1535-1552. doi:10.33594/000000107.
[33] Hsu MC, Hung WC. Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling. Mol Cancer. 2018;17(1):35. Published 2018 Feb 19. doi:10.1186/s12943-018-0791-3.
[34] Bas-Orth C, Tan YW, Lau D, Bading H. Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect. J Biol Chem. 2017;292(13):5183-5194. doi:10.1074/jbc.M116.761106.
[35] Afaf El-Ansary. Activities of key glycolytic enzymes in the plasma of Saudi autistic patients.J Open Access Journal of Clinical Trials,2010,2010(NULL).
[36] Lopes C, Ribeiro M, Duarte AI, Humbert S,Saudou F,Almeida LPet al. IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice. Mol Neurobiol. 2014;49(3):1126-1142. doi:10.1007/s12035-013-8585-5.
[37] Naia L, Ferreira IL, Cunha-Oliveira T,Duarte AI,Ribeiro M,Rosenstock TR,et al. Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts. Mol Neurobiol. 2015;51(1):331-348. doi:10.1007/s12035-014-8735-4.
[38] Regenold WT, Pratt M, Nekkalapu S, Shapiro PS, Kristian T, Fiskum G. Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: implications for brain energy metabolism and neurotrophic signaling.J Psychiatr Res.2012;46(1):95-104.doi:10.1016/j.jps ychires.2011.09.01.