Abou Khouzam, R., Brodaczewska, K., Filipiak, A., Zeinelabdin, N. A., Buart, S., Szczylik, C., et al. (2020). Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies. Front Immunol, 11, 613114. doi:10.3389/fimmu.2020.613114.
Abourbih, S., Sircar, K., Tanguay, S., Kassouf, W., Aprikian, A., Mansure, J., et al. (2013). Aldehyde dehydrogenase 1 expression in primary and metastatic renal cell carcinoma: an immunohistochemistry study. World J Surg Oncol, 11, 298. doi:10.1186/1477-7819-11-298.
Bertout, J. A., Majmundar, A. J., Gordan, J. D., Lam, J. C., Ditsworth, D., Keith, B., et al. (2009). HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A, 106(34), 14391-6. doi:10.1073/pnas.0907357106.
Bradley, J. R., Wang, J., Pacey, S., Warren, A. Y., Pober, J. S., & Al-Lamki, R. S. (2020). Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133. FASEB Bioadv, 2(2), 126-144. doi:10.1096/fba.2019-00071.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 68(6), 394-424. doi:10.3322/caac.21492.
Caglar, H. O., & Biray Avci, C. (2020). Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells. Mol Biol Rep, 47(4), 3065-3076. doi:10.1007/s11033-020-05341-6.
Carreau, A., El Hafny-Rahbi, B., Matejuk, A., Grillon, C., & Kieda, C. (2011). Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J Cell Mol Med, 15(6), 1239-53. doi:10.1111/j.1582-4934.2011.01258.x.
Casanovas, O., Hicklin, D. J., Bergers, G., & Hanahan, D. (2005). Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell, 8(4), 299-309. doi:10.1016/j.ccr.2005.09.005.
Cheon, D. J., & Orsulic, S. (2011). Mouse models of cancer. Annu Rev Pathol, 6, 95-119. doi:10.1146/annurev.pathol.3.121806.154244.
Cho, H., Du, X., Rizzi, J. P., Liberzon, E., Chakraborty, A. A., Gao, W., et al. (2016). On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature, 539(7627), 107-111. doi:10.1038/nature19795.
Collet, G., Skrzypek, K., Grillon, C., Matejuk, A., El Hafni-Rahbi, B., Lamerant - Fayel, N., et al. (2012). Hypoxia control to normalize pathologic angiogenesis: Potential role for endothelial precursor cells and miRNAs regulation. Vascular Pharmacology, 56(5-6), 252-261. doi:10.1016/j.vph.2012.03.001.
Cowey, C. L., & Rathmell, W. K. (2009). VHL gene mutations in renal cell carcinoma: role as a biomarker of disease outcome and drug efficacy. Curr Oncol Rep, 11(2), 94-101. doi:10.1007/s11912-009-0015-5.
Das, P. K., Islam, F., & Lam, A. K. (2020). The Roles of Cancer Stem Cells and Therapy Resistance in Colorectal Carcinoma. Cells, 9(6). doi:10.3390/cells9061392.
Debeb, B. G., Zhang, X., Krishnamurthy, S., Gao, H., Cohen, E., Li, L., et al. (2010). Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells. Mol Cancer, 9, 180. doi:10.1186/1476-4598-9-180.
Debnath, S., Mukherjee, A., Saha, D., Dash, J., & Chatterjee, T. K. (2021). Poly-l-Lysine inhibits VEGF and c-Myc mediated tumor-angiogenesis and induces apoptosis in 2D and 3D tumor microenvironment of both MDA-MB-231 and B16F10 induced mice model. Int J Biol Macromol, 183, 528-548. doi:10.1016/j.ijbiomac.2021.04.109.
Dolinsek, T., Sersa, G., Prosen, L., Bosnjak, M., Stimac, M., Razborsek, U., et al. (2015). Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects. Cancers (Basel), 8(1). doi:10.3390/cancers8010003.
Duval, K., Grover, H., Han, L. H., Mou, Y., Pegoraro, A. F., Fredberg, J., et al. (2017). Modeling Physiological Events in 2D vs. 3D Cell Culture. Physiology (Bethesda), 32(4), 266-277. doi:10.1152/physiol.00036.2016.
Goding, C. R., & Arnheiter, H. (2019). MITF-the first 25 years. Genes Dev, 33(15-16), 983-1007. doi:10.1101/gad.324657.119.
Goundiam, O., Nagel, M. D., & Vayssade, M. (2010). Growth and survival signalling in B16F10 melanoma cells in 3D culture. Cell Biol Int, 34(4), 385-91. doi:10.1042/CBI20090147.
Hinshaw, D. C., & Shevde, L. A. (2019). The Tumor Microenvironment Innately Modulates Cancer Progression. Cancer Res, 79(18), 4557-4566. doi:10.1158/0008-5472.CAN-18-3962.
Hoarau-Véchot, J., Rafii, A., Touboul, C., & Pasquier, J. (2018). Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions? Int J Mol Sci, 19(1). doi:10.3390/ijms19010181.
Jeon, S., Lee, H. S., Lee, G. Y., Park, G., Kim, T. M., Shin, J., et al. (2017). Shift of EMT gradient in 3D spheroid MSCs for activation of mesenchymal niche function. Sci Rep, 7(1), 6859. doi:10.1038/s41598-017-07049-3.
Joseph, J. P., Harishankar, M. K., Pillai, A. A., & Devi, A. (2018). Hypoxia induced EMT: A review on the mechanism of tumor progression and metastasis in OSCC. Oral Oncol, 80, 23-32. doi:10.1016/j.oraloncology.2018.03.004.
Khacho, M., Mekhail, K., Pilon-Larose, K., Payette, J., & Lee, S. (2008). Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor. Mol Cell Biol, 28(1), 302-14. doi:10.1128/MCB.01044-07.
Klimkiewicz, K., Weglarczyk, K., Collet, G., Paprocka, M., Guichard, A., Sarna, M., et al. (2017). A 3D model of tumour angiogenic microenvironment to monitor hypoxia effects on cell interactions and cancer stem cell selection. Cancer Lett, 396, 10-20. doi:10.1016/j.canlet.2017.03.006.
Leo, C., Cotic, C., Pomp, V., Fink, D., & Varga, Z. (2018). Overexpression of Lox in triple-negative breast cancer. Ann Diagn Pathol, 34, 98-102. doi:10.1016/j.anndiagpath.2018.03.009.
Li, C., Lu, J., & Zhang, B. (2012). Development of a novel chronic intermittent hypoxia chamber. Sleep Breath, 16(1), 177-9. doi:10.1007/s11325-010-0470-0.
Melissaridou, S., Wiechec, E., Magan, M., Jain, M. V., Chung, M. K., Farnebo, L., et al. (2019). The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer. Cancer Cell Int, 19, 16. doi:10.1186/s12935-019-0733-1.
Pan, Y., Ma, S., Cao, K., Zhou, S., Zhao, A., Li, M., et al. (2018). Therapeutic approaches targeting cancer stem cells. J Cancer Res Ther, 14(7), 1469-1475. doi:10.4103/jcrt.JCRT_976_17.
Pastushenko, I., & Blanpain, C. (2019). EMT Transition States during Tumor Progression and Metastasis. Trends Cell Biol, 29(3), 212-226. doi:10.1016/j.tcb.2018.12.001.
Quail, D. F., & Joyce, J. A. (2013). Microenvironmental regulation of tumor progression and metastasis. Nat Med, 19(11), 1423-37. doi:10.1038/nm.3394.
Rathmell, W. K., & Chen, S. (2008). VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment. Expert Rev Anticancer Ther, 8(1), 63-73. doi:10.1586/14737140.8.1.63.
Ravi, M., Paramesh, V., Kaviya, S. R., Anuradha, E., & Solomon, F. D. (2015). 3D cell culture systems: advantages and applications. J Cell Physiol, 230(1), 16-26. doi:10.1002/jcp.24683.
Riffle, S., & Hegde, R. S. (2017). Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids. J Exp Clin Cancer Res, 36(1), 102. doi:10.1186/s13046-017-0570-9.
Saeednejad Zanjani, L., Madjd, Z., Abolhasani, M., Shariftabrizi, A., Rasti, A., & Asgari, M. (2018). Expression of CD105 cancer stem cell marker in three subtypes of renal cell carcinoma. Cancer Biomark, 21(4), 821-837. doi:10.3233/CBM-170755.
Sakashita, M., Tanaka, T., & Nangaku, M. (2019). Hypoxia-Inducible Factor-Prolyl Hydroxylase Domain Inhibitors to Treat Anemia in Chronic Kidney Disease. Contributions to Nephrology, 198, 112-123. doi:10.1159/000496531.
Schafer, K. A. (1998). The cell cycle: a review. Vet Pathol, 35(6), 461-78. doi:10.1177/030098589803500601.
Schödel, J., Grampp, S., Maher, E. R., Moch, H., Ratcliffe, P. J., Russo, P., et al. (2016). Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer. Eur Urol, 69(4), 646-657. doi:10.1016/j.eururo.2015.08.007.
Semenza, G. L. (2001). HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol, 13(2), 167-71.
Shi, D., Che, J., Yan, Y., Peng, B., Yao, X., & Guo, C. (2019). Expression and clinical value of CD105 in renal cell carcinoma based on data mining in The Cancer Genome Atlas. Exp Ther Med, 17(6), 4499-4505. doi:10.3892/etm.2019.7493.
Simbulan-Rosenthal, C. M., Dougherty, R., Vakili, S., Ferraro, A. M., Kuo, L. W., Alobaidi, R., et al. (2019). CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis. Cancers (Basel), 11(10). doi:10.3390/cancers11101490.
Singh, S. K., Abbas, S., Saxena, A. K., Tiwari, S., Sharma, L. K., & Tiwari, M. (2020). Critical role of three-dimensional tumorsphere size on experimental outcome. Biotechniques, 69(5), 333-338. doi:10.2144/btn-2020-0081.
Taylor, L. A., Abraham, R. M., Tahirovic, E., van Belle, P., Li, B., Huang, L., et al. (2017). High ALDH1 expression correlates with better prognosis in tumorigenic malignant melanoma. Mod Pathol, 30(5), 634-639. doi:10.1038/modpathol.2016.226.
Tazawa, H., Kagawa, S., & Fujiwara, T. (2016). p53 Replacement Therapy for Cancer. Recent Results Cancer Res, 209, 1-15. doi:10.1007/978-3-319-42934-2_1.
Ulukan, B., Bihorac, A., Sipahioglu, T., Kiraly, R., Fesus, L., & Telci, D. (2020). Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression. ACS Omega, 5(43), 28273-28284. doi:10.1021/acsomega.0c04226.
Verjans, E. T., Doijen, J., Luyten, W., Landuyt, B., & Schoofs, L. (2018). Three-dimensional cell culture models for anticancer drug screening: Worth the effort? J Cell Physiol, 233(4), 2993-3003. doi:10.1002/jcp.26052.
Vlashi, E., & Pajonk, F. (2015). Cancer stem cells, cancer cell plasticity and radiation therapy. Semin Cancer Biol, 31, 28-35. doi:10.1016/j.semcancer.2014.07.001.
Yamada, T., Oshima, T., Yoshihara, K., Tamura, S., Kanazawa, A., Inagaki, D., et al. (2010). Overexpression of MMP-13 gene in colorectal cancer with liver metastasis. Anticancer Res, 30(7), 2693-9.
Zhang, G., Miyake, M., Lawton, A., Goodison, S., & Rosser, C. J. (2014). Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors. BMC Cancer, 14, 310. doi:10.1186/1471-2407-14-310.
Zhang, J., & Zhang, Q. (2018). VHL and Hypoxia Signaling: Beyond HIF in Cancer. Biomedicines, 6(1). doi:10.3390/biomedicines6010035.
Zhang, Y., Sun, B., Zhao, X., Liu, Z., Wang, X., Yao, X., et al. (2013). Clinical significances and prognostic value of cancer stem-like cells markers and vasculogenic mimicry in renal cell carcinoma. J Surg Oncol, 108(6), 414-9. doi:10.1002/jso.23402.