1. Quinlan, E.B., et al., Psychosocial Stress and Brain Function in Adolescent Psychopathology. Am J Psychiatry, 2017. 174(8): p. 785–794.
2. Salam, A.P., A. Borsini, and P.A. Zunszain, Trained innate immunity: a salient factor in the pathogenesis of neuroimmune psychiatric disorders. Mol Psychiatry, 2018. 23(2): p. 170–176.
3. Zhu, Y., et al., Neuroinflammation caused by mental stress: the effect of chronic restraint stress and acute repeated social defeat stress in mice. Neurol Res, 2019. 41(8): p. 762–769.
4. Tynan, R.J., et al., Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions. Brain Behav Immun, 2010. 24(7): p. 1058-68.
5. Delpech, J.C., et al., Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain Behav Immun, 2016. 57: p. 79–93.
6. Nie, X., et al., The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation. Neuron, 2018. 99(3): p. 464-+.
7. Yue, N., et al., Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors. J Neuroinflammation, 2017. 14(1): p. 102.
8. Ishikawa, H. and G.N. Barber, STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling (vol 455, pg 674, 2008). Nature, 2008. 456(7219): p. 274–274.
9. Konno, H., K. Konno, and G.N. Barber, Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell, 2013. 155(3): p. 688 − 98.
10. Hara, M.R., et al., A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Nature, 2011. 477(7364): p. 349 − 53.
11. Burdette, D.L., et al., STING is a direct innate immune sensor of cyclic di-GMP. Nature, 2011. 478(7370): p. 515-8.
12. Radoshevich, L. and O. Dussurget, Cytosolic Innate Immune Sensing and Signaling upon Infection. Frontiers in Microbiology, 2016. 7.
13. Li, N., et al., STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. Redox Biol, 2019. 24: p. 101215.
14. Sun, L.J., et al., Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway. Science, 2013. 339(6121): p. 786–791.
15. Mathur, V., et al., Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. Neuron, 2017. 96(6): p. 1290–1302 e6.
16. Xie, Y., et al., Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors. J Biomed Sci, 2012. 19: p. 14.
17. York, E.M., et al., 3DMorph Automatic Analysis of Microglial Morphology in Three Dimensions from Ex Vivo and In Vivo Imaging. eNeuro, 2018. 5(6).
18. Ohkuri, T., et al., STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res, 2014. 2(12): p. 1199 − 208.
19. Sliter, D.A., et al., Parkin and PINK1 mitigate STING-induced inflammation. Nature, 2018. 561(7722): p. 258–262.
20. Gui, X., et al., Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature, 2019. 567(7747): p. 262-+.
21. Ahn, J., et al., STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci U S A, 2012. 109(47): p. 19386-91.
22. Reinert, L.S., et al., Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. Nature Communications, 2016. 7.
23. Jeffries, A.M. and I. Marriott, Human microglia and astrocytes express cGAS-STING viral sensing components. Neurosci Lett, 2017. 658: p. 53–56.
24. Gulen, M.F., et al., Signalling strength determines proapoptotic functions of STING. Nat Commun, 2017. 8(1): p. 427.
25. Feng, X., et al., Bioactive modulators targeting STING adaptor in cGAS-STING pathway. Drug Discov Today, 2020. 25(1): p. 230–237.
26. Wu, J.J., et al., Agonists and inhibitors of the STING pathway: Potential agents for immunotherapy. Med Res Rev, 2020. 40(3): p. 1117–1141.
27. Cai, X., Y.H. Chiu, and Z.J. Chen, The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol Cell, 2014. 54(2): p. 289 − 96.
28. Cohen, D., et al., Cyclic GMP-AMP signalling protects bacteria against viral infection. Nature, 2019. 574(7780): p. 691–695.
29. Xu, Q., et al., Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2. Brain Behav Immun, 2019. 81: p. 495–508.
30. Nazmi, A., et al., Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression. Glia, 2019. 67(7): p. 1254–1276.
31. Zhao, Q., et al., STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis. Gastroenterology, 2018. 154(6): p. 1822–1835 e2.
32. Zhao, Q.L., et al., STING signalling protects against chronic pancreatitis by modulating Th17 response. Gut, 2019. 68(10): p. 1827-+.
33. Tejera, D. and M.T. Heneka, United Again: STING and the Police. Neuron, 2017. 96(6): p. 1207–1208.
34. Kemeny, M.E. and M. Schedlowski, Understanding the interaction between psychosocial stress and immune-related diseases: A stepwise progression. Brain Behavior and Immunity, 2007. 21(8): p. 1009–1018.
35. Aryal, U.K., et al., Global Proteomic Analyses of STING-Positive and -Negative Macrophages Reveal STING and Non-STING Differentially Regulated Cellular and Molecular Pathways. Proteomics Clin Appl, 2020: p. e1900109.
36. Deczkowska, A., K. Baruch, and M. Schwartz, Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology. Trends Immunol, 2016. 37(3): p. 181–192.
37. Hosmane, S., et al., Toll/interleukin-1 receptor domain-containing adapter inducing interferon-beta mediates microglial phagocytosis of degenerating axons. J Neurosci, 2012. 32(22): p. 7745-57.
38. Scheu, S., et al., Interferon -Mediated Protective Functions of Microglia in Central Nervous System Autoimmunity. International Journal of Molecular Sciences, 2019. 20(1).
39. Karimi, Y., et al., IFN-beta signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity. Innate Immun, 2020. 26(3): p. 172–182.
40. Murray, C., et al., Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C. Brain Behav Immun, 2015. 48: p. 274 − 86.
41. Han, Y., et al., Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis. Brain Behav Immun, 2020. 87: p. 568–578.
42. Zhao, X.J., et al., Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus. Brain Res Bull, 2017. 130: p. 146–155.
43. Hasan, M., et al., Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism. Proc Natl Acad Sci U S A, 2017. 114(4): p. 746–751.
44. Watson, R.O., P.S. Manzanillo, and J.S. Cox, Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell, 2012. 150(4): p. 803 − 15.
45. Liang, Q.M., et al., Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses. Cell Host & Microbe, 2014. 15(2): p. 228–238.
46. Lei, Z., et al., cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING. Am J Physiol Gastrointest Liver Physiol, 2018. 314(6): p. G655-G667.