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Association of Maternal Ethnicity and Urbanicity on Severe Pediatric Disease: A Nationwide Cohort Study
Lai-Chu See
Chang Gung University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1379-8969
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Pediatrics.
Background: A healthy migrant effect on birth outcomes has been reported, however, whether this protective effect persists throughout childhood is unknown. The effect of urbanicity on child health among an immigrant population is unclear. The objective of this study was to compare the incidence rate and cumulative incidence of severe diseases among urban children of Taiwan-born mothers, rural children of Taiwan-born mothers, urban children of foreign-born mothers, and rural children of foreign-born mothers. Methods: A nationwide cohort study was conducted for children born in Taiwan during 2004-2011 and follow-up till age 4 to 11 years old by linkage the Taiwan Birth Registry 2004-2011, Taiwan Death Registry 2004-2015, and National Health Insurance Research Database 2004-2015. Cox proportional hazards model (multivariable) was used to examine differences among the four study groups. Results: There were 682,982 urban children of Taiwan-born mothers, 662,818 rural children of Taiwan-born mothers, 61,570 urban children of foreign-born mothers, 87,473 rural children of foreign-born mothers. Children of foreign-born mothers had a lower incidence of vasculitis, mainly Kawasaki disease. The incidences of congenital disorders did not differ between children of foreign-born mothers and children of Taiwan-born mothers. The incidence of psychotic disorders was higher in urban children. However, children in rural areas had a higher incidence of major trauma/burn and a higher mortality rate. Conclusions: A healthy migrant effect was only seen for Kawasaki disease. The mental health of urban children born to immigrant mothers warrants concern.
Keywords
severe diseases, children, transnational marriage, urban–rural
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CURRENT STATUS: Published
Version 3
Posted 19 Dec, 2019
Published
On 23 Dec, 2019
No community comments so far
Submission checks complete
On 12 Dec, 2019
Editorial decision: Accept
On 12 Dec, 2019
Editor assigned
On 11 Dec, 2019
Editor invited
On 10 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 28 Nov, 2019
Reviewer #2 agreed
On 21 Nov, 2019
Review #2 received
Received 21 Nov, 2019
Editor assigned
On 19 Nov, 2019
Reviewers invited
Invitations sent on 19 Nov, 2019
Reviewer #1 agreed
On 19 Nov, 2019
Submission checks complete
On 18 Nov, 2019
Editor invited
On 18 Nov, 2019
No comments provided
Review #2 received
Received 12 Nov, 2019
Editorial decision: Major revision
On 12 Nov, 2019
Reviewer #2 agreed
On 29 Oct, 2019
Review #1 received
Received 29 Oct, 2019
Reviewer #1 agreed
On 27 Oct, 2019
Reviewers invited
Invitations sent on 25 Oct, 2019
Submission checks complete
On 17 Oct, 2019
Editor assigned
On 12 Sep, 2019
Editor invited
On 11 Sep, 2019
First submitted
On 10 Sep, 2019
Metrics
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PDF Downloads: ...
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Subject Areas
Pediatrics
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This preprint is under consideration at BMC Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Association of Maternal Ethnicity and Urbanicity on Severe Pediatric Disease: A Nationwide Cohort Study
Lai-Chu See
Chang Gung University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1379-8969
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 19 Dec, 2019
Published
On 23 Dec, 2019
No community comments so far
Submission checks complete
On 12 Dec, 2019
Editorial decision: Accept
On 12 Dec, 2019
Editor assigned
On 11 Dec, 2019
Editor invited
On 10 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 28 Nov, 2019
Reviewer #2 agreed
On 21 Nov, 2019
Review #2 received
Received 21 Nov, 2019
Editor assigned
On 19 Nov, 2019
Reviewers invited
Invitations sent on 19 Nov, 2019
Reviewer #1 agreed
On 19 Nov, 2019
Submission checks complete
On 18 Nov, 2019
Editor invited
On 18 Nov, 2019
No comments provided
Review #2 received
Received 12 Nov, 2019
Editorial decision: Major revision
On 12 Nov, 2019
Reviewer #2 agreed
On 29 Oct, 2019
Review #1 received
Received 29 Oct, 2019
Reviewer #1 agreed
On 27 Oct, 2019
Reviewers invited
Invitations sent on 25 Oct, 2019
Submission checks complete
On 17 Oct, 2019
Editor assigned
On 12 Sep, 2019
Editor invited
On 11 Sep, 2019
First submitted
On 10 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Pediatrics.
Background: A healthy migrant effect on birth outcomes has been reported, however, whether this protective effect persists throughout childhood is unknown. The effect of urbanicity on child health among an immigrant population is unclear. The objective of this study was to compare the incidence rate and cumulative incidence of severe diseases among urban children of Taiwan-born mothers, rural children of Taiwan-born mothers, urban children of foreign-born mothers, and rural children of foreign-born mothers. Methods: A nationwide cohort study was conducted for children born in Taiwan during 2004-2011 and follow-up till age 4 to 11 years old by linkage the Taiwan Birth Registry 2004-2011, Taiwan Death Registry 2004-2015, and National Health Insurance Research Database 2004-2015. Cox proportional hazards model (multivariable) was used to examine differences among the four study groups. Results: There were 682,982 urban children of Taiwan-born mothers, 662,818 rural children of Taiwan-born mothers, 61,570 urban children of foreign-born mothers, 87,473 rural children of foreign-born mothers. Children of foreign-born mothers had a lower incidence of vasculitis, mainly Kawasaki disease. The incidences of congenital disorders did not differ between children of foreign-born mothers and children of Taiwan-born mothers. The incidence of psychotic disorders was higher in urban children. However, children in rural areas had a higher incidence of major trauma/burn and a higher mortality rate. Conclusions: A healthy migrant effect was only seen for Kawasaki disease. The mental health of urban children born to immigrant mothers warrants concern.
Figure 1
Figure 2
Figure 3