Background: Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR.
Methods: This will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates and high-quality embryo rates. The safety of acupuncture will also be assessed.
Discussion: The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians.
Trial registration: AMCTR-IPR-18000198. Registered on 10 August 2018, http://www.acmctr.org/showproj.aspx?proj=289
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Posted 07 Aug, 2020
On 10 Sep, 2020
On 16 Aug, 2020
On 30 Jul, 2020
On 29 Jul, 2020
On 17 Jul, 2020
Invitations sent on 18 May, 2020
On 16 May, 2020
On 15 May, 2020
On 16 Apr, 2020
On 15 Apr, 2020
Received 06 Feb, 2020
On 16 Jan, 2020
Received 21 Dec, 2019
On 15 Dec, 2019
Invitations sent on 28 Nov, 2019
On 28 Oct, 2019
On 18 Oct, 2019
On 29 Sep, 2019
Posted 07 Aug, 2020
On 10 Sep, 2020
On 16 Aug, 2020
On 30 Jul, 2020
On 29 Jul, 2020
On 17 Jul, 2020
Invitations sent on 18 May, 2020
On 16 May, 2020
On 15 May, 2020
On 16 Apr, 2020
On 15 Apr, 2020
Received 06 Feb, 2020
On 16 Jan, 2020
Received 21 Dec, 2019
On 15 Dec, 2019
Invitations sent on 28 Nov, 2019
On 28 Oct, 2019
On 18 Oct, 2019
On 29 Sep, 2019
Background: Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR.
Methods: This will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates and high-quality embryo rates. The safety of acupuncture will also be assessed.
Discussion: The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians.
Trial registration: AMCTR-IPR-18000198. Registered on 10 August 2018, http://www.acmctr.org/showproj.aspx?proj=289
Figure 1
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