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Learn more about In Review
Study protocol
yigong Fang
China Academy of Chinese Medical Sciences Institute of Acupuncture and Moxibustion
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Trials.
Background: Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR.
Methods: This will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates and high-quality embryo rates. The safety of acupuncture will also be assessed.
Discussion: The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians.
Trial registration: AMCTR-IPR-18000198. Registered on 10 August 2018, http://www.acmctr.org/showproj.aspx?proj=289
Keywords
Acupuncture; Poor ovarian response; Number of retrieved oocytes; In vitro fertilization-embryo transfer; Randomized controlled trial
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Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 07 Aug, 2020
Published
On 10 Sep, 2020
No community comments so far
Editorial decision: Accept
On 16 Aug, 2020
Editor assigned
On 30 Jul, 2020
Submission checks complete
On 29 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 17 Jul, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Editor assigned
On 16 May, 2020
Submission checks complete
On 15 May, 2020
No comments provided
Editorial decision: Major revision
On 16 Apr, 2020
Reviewer #3 agreed
On 15 Apr, 2020
Review #2 received
Received 06 Feb, 2020
Reviewer #2 agreed
On 16 Jan, 2020
Review #1 received
Received 21 Dec, 2019
Reviewer #1 agreed
On 15 Dec, 2019
Reviewers invited
Invitations sent on 28 Nov, 2019
Editor assigned
On 28 Oct, 2019
Submission checks complete
On 18 Oct, 2019
First submitted
On 29 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
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This preprint is under consideration at Trials. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Study protocol
yigong Fang
China Academy of Chinese Medical Sciences Institute of Acupuncture and Moxibustion
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 07 Aug, 2020
Published
On 10 Sep, 2020
No community comments so far
Editorial decision: Accept
On 16 Aug, 2020
Editor assigned
On 30 Jul, 2020
Submission checks complete
On 29 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 17 Jul, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Editor assigned
On 16 May, 2020
Submission checks complete
On 15 May, 2020
No comments provided
Editorial decision: Major revision
On 16 Apr, 2020
Reviewer #3 agreed
On 15 Apr, 2020
Review #2 received
Received 06 Feb, 2020
Reviewer #2 agreed
On 16 Jan, 2020
Review #1 received
Received 21 Dec, 2019
Reviewer #1 agreed
On 15 Dec, 2019
Reviewers invited
Invitations sent on 28 Nov, 2019
Editor assigned
On 28 Oct, 2019
Submission checks complete
On 18 Oct, 2019
First submitted
On 29 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Trials.
Background: Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR.
Methods: This will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates and high-quality embryo rates. The safety of acupuncture will also be assessed.
Discussion: The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians.
Trial registration: AMCTR-IPR-18000198. Registered on 10 August 2018, http://www.acmctr.org/showproj.aspx?proj=289
Figure 1
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