Background The use of social networks in the field of education has also accelerated and has become a powerful source of learning for transformation and empowerment in different fields. This questionnaire addresses the standardization of the attitude to professionalism in using social networks in Iranian medical science students . Methods In this questionnaire, with the aim of standardizing the attitude toward social networks, we used a questionnaire with 10 questions in 5 fields by Ness etal , 2013 . The fields include Accountability, Hiring decisions, Profile edits, Professionalism and Privacy setting . In this study, the questionnaire was first checked by validity in content . In the next step, construct validity was performed by exploratory factor analysis .Also reliability checked by test – retest in one group of students . Results By examining the correlation matrix between the variables, correlation between the variables and total score of questionnaire were appropriate.The result of factor analysis by principal component method and Varimax rotation with 3 factors is approved .The reliability of the test was obtained 0.940 through test-retest method, and internal consistency were good . Conclusion Perspectives on e-professionalism and social media questionnire by Ness etal , 2013 , is a reliable and valid instrument for assessing perspectives on e-professionalism and social media in Iranian medical students.