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Research article
Gerd U. Auffarth
Department of Ophthalmology, University of Heidelberg
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6927-5251
License:
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The most recent version of this article is available here.
Background: The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistening formation. Methods: An in-vitro stress test for glistening induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm 2 ) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity. Results: In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm 2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm². The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm². Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero. Conclusion: In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.
Keywords
glistenings, hydrophobic acrylic, IOL material quality, IOL pathology, IOL material change, AcrySof, Eyecryl, IOL aging
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CURRENT STATUS: Under Review
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Editor assigned
On 06 Apr, 2020
Submission checks complete
On 05 Apr, 2020
Editor invited
On 05 Apr, 2020
Version 2
Posted 02 Mar, 2020
No comments provided
Editorial decision: Minor revision
On 03 Apr, 2020
Review #2 received
Received 27 Mar, 2020
Reviewer #2 agreed
On 13 Mar, 2020
Reviewer #1 agreed
On 10 Mar, 2020
Review #1 received
Received 10 Mar, 2020
Reviewers invited
Invitations sent on 08 Mar, 2020
Editor assigned
On 28 Feb, 2020
Submission checks complete
On 27 Feb, 2020
Editor invited
On 27 Feb, 2020
No comments provided
Editorial decision: Major revision
On 17 Feb, 2020
Review #2 received
Received 11 Feb, 2020
Review #1 received
Received 16 Nov, 2019
Reviewer #2 agreed
On 07 Nov, 2019
Reviewer #1 agreed
On 02 Nov, 2019
Reviewers invited
Invitations sent on 25 Oct, 2019
Editor assigned
On 17 Oct, 2019
Submission checks complete
On 16 Oct, 2019
Editor invited
On 16 Oct, 2019
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Subject Areas
Ophthalmology
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This preprint is under consideration at BMC Ophthalmology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Gerd U. Auffarth
Department of Ophthalmology, University of Heidelberg
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6927-5251
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
No community comments so far
Editor assigned
On 06 Apr, 2020
Submission checks complete
On 05 Apr, 2020
Editor invited
On 05 Apr, 2020
Version 2
Posted 02 Mar, 2020
No comments provided
Editorial decision: Minor revision
On 03 Apr, 2020
Review #2 received
Received 27 Mar, 2020
Reviewer #2 agreed
On 13 Mar, 2020
Reviewer #1 agreed
On 10 Mar, 2020
Review #1 received
Received 10 Mar, 2020
Reviewers invited
Invitations sent on 08 Mar, 2020
Editor assigned
On 28 Feb, 2020
Submission checks complete
On 27 Feb, 2020
Editor invited
On 27 Feb, 2020
No comments provided
Editorial decision: Major revision
On 17 Feb, 2020
Review #2 received
Received 11 Feb, 2020
Review #1 received
Received 16 Nov, 2019
Reviewer #2 agreed
On 07 Nov, 2019
Reviewer #1 agreed
On 02 Nov, 2019
Reviewers invited
Invitations sent on 25 Oct, 2019
Editor assigned
On 17 Oct, 2019
Submission checks complete
On 16 Oct, 2019
Editor invited
On 16 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Background: The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistening formation. Methods: An in-vitro stress test for glistening induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm 2 ) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity. Results: In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm 2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm². The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm². Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero. Conclusion: In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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