The Impact Of Frailty On Admission To Home Care Services And Nursing Homes: Eight-Year Follow-Up Of A Community-Dwelling, Older Adult, Spanish Cohort

doi:10.21203/rs.2.16436/v2

Background

The aim of this study is to identify the factors that anticipate the future inclusion of community-dwelling individuals aged ≥ 70 years in home care programmes (HC) and nursing homes (NH), and to develop the corresponding prediction models.

Methods

Study design: prospective, multicenter, cohort study in 23 primary healthcare centers located in Catalonia, Spain, with an eight-year follow-up (2005-2013).

Participants: the cohort was made up of 616 individuals.

Data collection: baseline interview included a multidimensional assessment carried out by primary health care professionals. Outcome variables were collected during follow-up by consulting electronic healthcare records, telephone contacts, and the Central Registry of Catalonia for mortality.

Statistical analysis: a prognostic index for a HC and NH at eight years was estimated for each patient. Death prior to these events was considered a competing risk event, and Fine–Gray regression models were used. The internal validity of the predictive models was tested for 150 bootstrap re-samples.

Results

At baseline, mean age was 76.4 years, 55.5% were women, and 22% lived alone. During follow-up, 19.2% entered a HC program, 8.2% a NH, and 15.4% died without presenting an event. Of those who entered a NH, 31.5% had previously been in a HC program.

Multivariate competitive risk models for a HC and NH showed that the risk of a HC entry was associated with older age, dependence on the Instrumental Activities of the Daily Living, and slow gait measured by Timed-up-and-go test. An increased risk of being admitted to a NH was associated with older age, dependence on the Instrumental Activities of the Daily Living, augmented number of prescriptions, and the presence of social risk.

Conclusions

Prognostic models based on comprehensive geriatric assessments can predict the need for the commencement of HC and NH admission in community-dwelling older adults. Our findings underline the necessity to measure functional capacity, mobility, number of prescriptions, and social aspects of older adults in primary healthcare centers. In such a setting they can be offered longitudinal holistic assessments so as to benefit from preventive actions in order to remain independent in the community for as long as possible.

Geriatrics & Gerontology

cohort study

frail elderly

primary health care

risk prediction models

long-term home care

long-term institutional care.

Worldwide, progressive population aging presents increasingly multiple health, social, and economic consequences for systems with inadequate planning and resources. This demographic change is leading to an augmented prevalence of chronic diseases and frailty in older adults, resulting in loss of autonomy and placing a heavier burden on health and social care^1-4.

In Spain, 17% of the inhabitants are currently >65 years, and projections for 2050 indicate that the figure will reach 33% compared to the expected 29% in neighbouring European countries⁴. Many older individuals are, or will become, frail. Such a condition in the elderly is a multidimensional clinical entity that represents a state of vulnerability to stressors⁵, including a reduction in physical, mental, and social functions, and predicts adverse events such as hospitalization⁶, institutionalization⁷, and death⁸.

There are different ways to measure frailty, the most common measurements are the frailty phenotype⁹ and the deficit accumulation model¹⁰. Other tools include performance tests (such as the Short Physical Performance Battery and the Timed-Up-and-go Test) and scales that assess the instrumental activities of daily life^11,12. In addition, there is the comprehensive geriatric assessment (CGA), considered the gold standard approach for community evaluation. It is usually conducted following existing national strategies in supporting individuals living with frailty^13-15. The CGA is a multidimensional process that can be performed in a number of healthcare settings to identify medical, social, and functional needs and develop a care plan^16,17.

Primary Health Care (PHC), with its community perspective and longitudinal approach, is the ideal scenario for the early detection of frailty in older adults. Nevertheless, simple evaluation tests need to be incorporated into usual care practice. Early identification would allow targeted support from health and social services to help older individuals improve their quality of life and live autonomously in their homes for as long as possible. In addition to respecting the preferences of most of them¹⁸, it would provide a more cost-effective alternative to institutionalization.

Adverse outcomes in the progression of frailty include dependency and institutionalization. In Spain, one of the primary care resources available for these individuals is the Home Care programme (HC). It offers comprehensive, continuous health and social attention to individuals in situations of functional decline and/or dependency who cannot attend health centers with the aim of keeping them as long as possible in their home with the corresponding autonomy. The HC programmes offered by the Spanish PHC cover some 6% of individuals >65 years, the population generally considered to be at a state of advanced frailty or disability¹⁹.

Nevertheless, as frailty advances the complexity of medical attention augments and the caregiver and/or social support may have difficulties maintaining the quality of care. At this point, nursing home (NH) services become the most appropriate resource, despite the considerable financial outlay for both the public health system and the family economy. In our region NH services cover 3% of those >65 years of age²⁰.

Most studies have focused on validating instruments to identify and describe the characteristics of frail older individuals^11,21,22whilst other authors have established the determinants of HC and NH use²³. The aim of this study is to characterize the factors that will lead to the future inclusion of older, community-dwelling subjects into HC programmes/NH institutionalization, and to develop the corresponding risk prediction models. Both events are related to the progression of frailty, functional decline, and loss of autonomy all of which could be delayed/prevented by an adequate and timely approach to those at risk. These individuals can then benefit from personalized preventive actions in order to remain independent in the community for as long as possible.

Study design and setting

We conducted an eight-year follow-up, multicentre, cohort study in 23 PHC centers in Catalonia, Spain. The 23 PHC were not randomly selected, although special care was taken to include PHC with different socioeconomic status as well as urban and rural health centers. Out of the 50 PHC which were invited to participate, a final sample of 23 accepted (20 in urban areas and 3 in rural ones). These PHC belong to the National Health System in Catalonia and are distributed geographically in 3 of the 4 Catalonia provinces, (Barcelona, Lleida and Girona). They serve an assigned population, which varies from 1179 to 29214 individuals from middle-low to middle-high socioeconomic status. The inclusion period was from October 2004 to June 2005.

Participants

The cohort was made up of a random sample of 616 subjects ≥70 years of age. Interview participation was turned down by 75 individuals (73% women) with no age differences compared to the study members. Exclusion criteria included subjects already receiving HC and NH services, those presenting severe mental disorders/terminal illness, and non-residents in the reference area.

Data collection and study variables:

Subjects were randomly selected from the daily schedule of the healthcare professionals taking part in the study, and were included once the informed consent was signed.

Participants were programmed for the interview and the CGA in their corresponding PHC center. The healthcare professionals (nurses and doctors) carried out both the interview and the CGA. The main information collected in interviews through standardized questionnaires included sociodemographic data, physical activity, body mass index (BMI), self-reported health²⁴, number of hospitalization and falls in the previous year, and prescribed drugs.

The CGA included:

Functional Assessment:

Basic Activities of Daily Living (BADL) with the Barthel Index²⁵ (from 0 to 100 points), <60 represents moderate/severe dependence.
Instrumental Activities of Daily Living (IADL) with the Lawton and Brody Index²⁶, the cut-off points for moderate/severe dependence are <6 points for women and <4 points for men, respectively.
Mobility was evaluated with the Timed-up-and-go test (TUGT)²⁷. It measures in seconds the time to rise from a chair, walk a distance of 3m, return to the chair and sit down. It includes aspects of gait, strength, balance, and speed. A score of > 10 seconds is usually considered as altered.

Mental health Assessment:

Cognitive assessment was measured with the Lobo Mini Cognitive Examination (MCE)²⁸, the Spanish validated version of the Folstein Mini-mental state examination²⁹ (From 0 to 30 points), the cut-off point for cognitive deterioration is ≤ 23.
For evaluation of the affective state, the Yesavage Geriatric Depression Scale (GDS)³⁰(from 0 to 15 points) was employed with a cut-off point for probable depression of > 5.

Biomedical assessment:

Nutritional status was measured using the Mini Nutritional Assessment Short Form (MNA-SF)³¹ questionnaire (from 0 to 14 points), with a cut-off point ≤ 11 for risk of malnutrition.
Near vision was evaluated with the Jaeger Card³²with a cut-off point of > 20/40 for visual acuity deficit.
Hearing was assessed with the Handicap Hearing Impairment in the Elderly Screening Version (HHIE-S)³³ (from 0 to 40 points). A cut-off point ≥10 was considered auditory limitation.
Urinary incontinence was measured with the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF)³⁴ (from 0 to 21 points) with a cut-off point ≥ 1 for the diagnosis of urinary incontinence.
Morbidities, selected following literature review and consensus by the original study group. The selection criteria were for those conditions most related to the development of frailty, functional limitations, and disability^35,36: osteoarticular diseases, cerebrovascular accident with sequelae, Parkinson's disease, acute myocardial infarction or heart failure, chronic obstructive pulmonary disease, severe visual deficit, severe deafness, dementia, recurrent falls or fractures and chronic depression.

Social Assessment:

Social vulnerability was evaluated with the Socio-Family Rating Scale of the Elderly (SFRSE)³⁷ (from 0 to 25 points). It assesses the family, economic situation, housing, social relations, and social support, with a cut-off point ≥10 for social risk.

We gathered the outcome variables during the eight-year follow-up by consulting the electronic primary healthcare records; telephone contacts were made in the case of incomplete information. In addition, we consulted the Central Registry of Catalonia for mortality.

Main outcome variables were:

Inclusion in an HC program of the PHC: encoded in the electronic primary healthcare records when the service is requested by either the patient or healthcare professional, mainly due to considerable mobility difficulties.
Inclusion in a NH: this encompasses all types of institutions such as nursing homes, long-term care institutions, private or public. It is encoded in the electronic primary healthcare records when a patient is institutionalized with the care relationship usually transferred from the PHC to the institution.
Mortality: date of death registered in the PHC record and the Central Registry of Catalonia.

Statistical analysis

Continuous variables were expressed as mean and standard deviation, or as median and interquartile (IQ) range, whenever appropriate. For HC and NH outcomes, death prior to these events was considered as a competing risk event, therefore the cumulative incidence function (CIF) of HC/NH risk was calculated taking it into consideration. To analyse the effect of baseline predictors for the CIF, we used the Fine–Gray³⁸ regression model for the sub-distribution hazard (sHR). Clinically meaningful variables showing a significant level in the univariate analysis (P<0.05) were thereafter included in the multivariate model. A backward stepwise method was used to identify independent risk predictors with P<0.05 for the inclusion or deletion criterion. The proportionality assumption of the models was verified using time-dependent variables. The discriminative ability of the models was assessed by Harrell’s C-index³⁹. The internal validity of the final predictive models was tested for 150 bootstrap re-samples. The calibration of models was checked by plotting the observed and predicted probabilities of the model in groups defined by the quartiles of the predicted event probabilities. We estimated a prognostic index for home confinement and institutionalization at eight years for each patient as the sum of the variables included in the final model multiplied by the log of the respective sHR. We classified patients using the CIF approach into three groups according to their risk of a HC/NH: low, medium, and high, by splitting the index according to tertiles. Data analysis was performed using the statistical R-3.5.1 package. The discrimination and calibration analyses were carried out with the pec package⁴⁰.

Baseline characteristics of the cohort and assessment of frailty dimensions are shown in Tables 1 and 2. The mean baseline age was 76.4 years, 55.5% were women, 73.5% did not have complete primary education, and 22% lived alone (32% women vs 9.6% men). Mean BMI was 28.5 and 4.5% smoked. Health was rated as good by 47.4% and bad by 6.7%. Patients on average took 5 drugs a day, and 32% consumed psychotropic ones. At the functional level, the mean Barthel index score was 96.5, the majority were independent for the BADL (62.5%), and only 15.3% had moderate/severe dependence. The IADL, measured with the Lawton index, showed that 76.7% were independent, and only 6.5% presented moderate/severe dependence. Mobility, measured with TUGT, was 13 seconds on average, and 14.4% of the participants led a sedentary life. At the mental level, the average MCE score was 27/30 points, and the GDS scores showed 19.8% probable depression.

During follow-up 19.2% (n=118) of the 616 participants entered a HC programme (30.6 incidence per 1000 person-years), while 8.2% (n=51) were admitted to a NH one (13.1 incidence per 1000 person-years). Of those admitted to a NH, 31.5% (n=17) had previously been in a HC. Of the 616, mortality during follow-up was 15.4% (n=95) for participants presenting no event, and 46.2% (n=78) for those who were in either a HC or NH programme. During follow-up 4.5% (n=28) was lost with a greater proportion of men (64%, p<0.05). However, there were no statistically significant differences in the rest of the main variables between those who completed the study and those who did not (Figure 1).

The median follow-up was 91.8 months (IQ: 58.1-97.7) and 92.3 months (IQ: 59.7-97.9) for the HC and NH subjects, respectively.

Table 1 shows the bivariate sHRs of admission to HC and NC programmes during the eight-year follow-up period according to baseline variables.

Comparing those who entered a HC programme with those who did not, HC incidence increased with age (78.9 years versus 75.2 years, sHR = 1.1), sedentary life style (22.9% versus 11.3%, sHR = 2.4), and poor self-perceived health (12.7% versus 6.7%, sHR = 2.3).

Table 2 shows the bivariate sHRs of admission to HC and NC programmes during the eight-year follow-up period according to the geriatric assessment.

Comparing those who entered a HC programme with those who did not, HC incidence increased with worse functional status, Barthel index (94.1 versus 97.5, sHR = 1.0), and Lawton and Brody index, in light (22.2% versus 13.4% , sHR = 1.7) and moderate dependence (15.4% versus 3.2%, sHR = 4.8). It also augmented in individuals with worse mobility (mean TUGT 16.2 versus 11.8, sHR = 1.1); worse cognitive scores (mean score 26.2 versus 27.4, sHR = 0.9); worse affective state (mean 4.3 versus 3.6, sHR = 1.1); urinary incontinence (59.3% versus 40.5%, sHR = 1.8); and higher social risk (mean 9.4 versus 8.7, sHR = 1.1).

Admission to a NH programme was associated with age (mean 78.7 versus 75.8, sHR = 1.1); living alone (47.1% versus 19.4%, sHR = 2.8); and greater drug consumption (mean 6.6 versus 4.6, sHR = 1.2).

Functional impairment in BADL was related to NH and the Barthel index (mean 93.1 versus 97.1, sHR = 1.0). Unlike a HC, however, NH entry was only associated with the highest degree of dependence in the Lawton and Brody index (moderate/severe dependence, with 15.7% versus 4.9%, sHR = 4.5). It was also related to worse mobility (longer TUGT time, mean 15.5 versus 12.4, sHR = 1.1); worse cognitive scores (mean 25.6 versus 27.3, sHR = 0.9) and risk of depression (mean 5.1 versus 3.6, sHR = 1.1).

We found a higher risk of NH admission for urinary incontinence (66.74% versus 42.4%, sHR = 2.5); higher number of specific morbidities (mean 1.0 versus 0.7, sHR = 1.3); and social risk (higher score on the socio-familial assessment scale of the elderly, mean 10.7 versus 8.7, sHR = 1.2).

A complementary, bivariate sub-analysis was carried out between the participant’s social risk and the occurrence of any events (NH, HC; data not shown). We observed a dose-response association between increasing social risk and being first admitted to a HC programme; with a still higher baseline social risk, entering a NH one: Finally, the highest baseline social risk was associated with first a HC programme and later a NH facility.

The multivariate adjusted model showed that the incidence risk of a HC entry was associated with older age, dependence on the IADL (moderate/severe dependence), and slow gait measured by TUGT. There was a significant association between the risk of being admitted to a NH programme and older age, dependence on the IADL (moderate/severe), more prescriptions, and the presence of social risk, see Table 3.

Based on the results of the multivariate analyses, we constructed two prediction models according to the risk of inclusion in a HC/NH. Subjects with a HC risk were classified into three groups: lower risk with a prognostic index (PI) between 7.5 and 8.3; medium risk, between 8.4 and 8.9; and higher risk > 9.0. The NH model was also categorized into three groups: lower risk between 7.9 and 9.5; medium risk between 9.6 and 10.2; and higher risk PI > 10.3, see Table 3.

The calibration plot showed that both models (HC and NH) presented a good calibration for predicting risk outcomes. In addition, discrimination was good for a HC (C-index=0.7) and moderate for a NH (C-index=0.7), see Figure 2.

Figure 3 depicts the cumulative incidence for each of these prognostic groups for the two events. For a HC in the lower risk group the cumulative incidence was 10.0 per 1000 patients-year; for the medium risk one it was 25.6 per 1000 patients-year; and for the higher risk one 63.1 per 1000 patients-year (p <0.001). For a NH in the lower risk group the incidence was 1.9 per 1000 patients-year; the medium risk one was 4.2 per 1000 patients-year; and the higher risk one was 32.9 per 1000 patients-year (p <0.001).

Incidence of Home Care and Nursing Home entry

In this eight-year cohort study, a follow-up of more than 95% participants was obtained, with 19% entering home care programmes, and 8% geriatric nursing homes, outcomes that are generally associated with advanced frailty, especially when not addressed promptly and adequately. Health service utilization is influenced by numerous aspects, including sociodemographic, organizational, and sociocultural ones. Nevertheless, it is beyond the scope of this paper to compare HC/NH rates among countries or different health systems. We used, instead, these events as measures of health outcomes associated with the loss of functionality and independence. However, regarding HC, although difficult to compare, similar rates were observed between homebound incidence in Japan⁴¹(32.1 per 1000 individuals/year) and that of our study (30.6 per individual/year). With respect to NH entry, we found lower rates than those reported by the USA⁴², 16.1% in two years; but closer to Germany, with rates of 4.7% in a three-year follow-up⁴³. Again, institutionalization rates differ among countries, depending on organizational aspects, the availability of long-term beds and the responsibility for the care of disabled older individuals by different actors. Our rates of institutionalization are low, this could be explained by the fact that in southern European cultures the involvement of the family in the care of older adults is considerable, whether for cultural or economic reasons ^44,45.

Risk factors

Age and sex

In our results, increasing age was the main predisposing factor associated with frailty and both an HC and NH placement. Although women had a higher incidence of NH inclusion, it was not a statistically significant predictor. The higher life expectancy of women, and the greater percentage of their living alone, could explain this trend ⁴⁶.

Functional status

We observed that IADL deterioration was associated with both a HC and NH. The ability to perform instrumental activities of daily life autonomously is essential to live at home independently. It is, therefore, a relevant measure to take into account when predicting the path to functional decline and dependence. We found that even mild dependence in the IADL was associated with a future HC, and moderate to severe dependence with NH entry. IADL impairment has been described as a potential marker of frailty⁴⁷, implying losses in different functioning domains ⁴⁸. There is, however, controversy with respect to disability and its inclusion in the definition of frailty ⁴⁹. Nevertheless, early stages of IADL impairment could be useful in detecting individuals at risk, it is an easy measure to collect and has a long-established tradition in PHC settings. Our sample included very few subjects with dependence in basic activities of daily living as it was composed of community-dwelling, independent individuals. BADL thus had no impact on the prediction models.

Mobility

We measured mobility with the TUGT. It has been shown to have high sensitivity for identifying frailty⁵⁰, moreover, as it is a simple test requiring little equipment and space, the TUGT is a valuable tool in a clinical setting. Savva et al⁵¹ found that a cut-off point of more than 16 seconds was optimum to identify the frail population. Our results concur, we observed a mean score of 16.2 seconds for subjects entering a HC programme, and 15.5 seconds for a NH one. Due to the fact that the TUGT has been used as a proxy measure of frailty⁵² and subsequent functional decline, it is a relevant factor in a HC prediction model.

Polypharmacy

Polypharmacy is a measure of medication-associated frailty, irrespective of the number of comorbidities and their severity⁵³. It is associated with increased rates of falls⁵⁴ and hospitalization, disability, and mortality⁵⁵. In our sample, polypharmacy, collected from the electronic primary healthcare records, was a prevailing factor. Some 52% of the participants had more than 4 prescribed drugs which was higher than in other studies reporting a prevalence based on health surveys of between 26 and 40%⁵⁶. It was, however, closer to those authors employing electronic healthcare records⁵⁷ who observed over 50%. In our study, polypharmacy predicted NH entry, a fact that might be related to multimorbidity in addition to adverse drug reactions/interactions, and greater risk of falls, and negative health outcomes⁵⁸.

Particular emphasis should be placed on psychoactive drugs as 50% of those entering a NH were taking them. Moreover, inappropriate polypharmacy is a key issue to address in order to improve outcomes in older adults⁵⁹ by means of active medication reviews and deprescription processes with tools such as STOPP START criteria and other available strategies⁶⁰.

Social vulnerability

We observed that whilst living alone had no effect on the need for an HC it did influence NH entry (sHR=2.8), a finding that has been already described in other countries^61-64. Employing an exhaustive socio-family situation measure, the SFRSE scale, we found a strong association between greater social risk and a higher institutionalization rate, irrespective of functional status or comorbidities. It appears as one of the predictors in a NH entry equation highlighting the importance of social support and environment in maintaining the capacity to live in the community in one’s home. Social and caregiver networks could help circumvent institutionalization, as has been observed in various studies that only take either living arrangements or caregiver networks into account^65,66. The need to assess the social sphere of frail older adults is evident⁶⁷. Indeed, as the issue of social frailty is increasingly conceptualized⁶⁸, the design of interventions to improve social support resources and promote inclusion of older adults will become essential in granting their preferences for living in the community, and thus improving quality of life.

Other factors

Cognitive impairment and dementia are factors classically described as being related to NH placement⁶⁹. Whilst we observed a bivariate association between cognitive status and adverse events it was not included in the final model. This was due to the low prevalence of dementia in our free-living, community-dwelling population. As we lacked a longitudinal measure of the incidence of cognitive impairment in our sample, we could not test the association with enough statistical power. The same pattern of bivariate association was also reported for depression, nutritional risk, and urinary incontinence. The latter is additionally usually found as a strong gender-specific predictor⁷⁰, negatively affecting daily life although our final model did not include it.

Strengths and limitations

Few longitudinal studies can be found in the literature analysing the transition of frail older adults from the commencement of their requiring home care to later nursing home placement, both outcomes related to functional decline and loss of autonomy. Our cohort had an excellent follow-up rate, up to 95% of the sample, and was representative of the older patients attended in primary healthcare in Catalonia, around 12.6% of the total patient population. Although our external validity was limited to those who sought medical assistance at the PHC it should be noted that this was not a health survey aimed at representing all the older population in this region. Moreover, most of these individuals in Spain seek medical assistance in the public health sector.

Despite the fact that our models included the main CGA variables there might have been other factors influencing an HC/NH admission. Nevertheless, the CGA is comprised of the most important known dimensions, and they were measured using standardised, validated questionnaires and scales. Finally, although an extensive follow-up was performed, changes in baseline variables during follow-up were not analyzed as it was a prediction model based on the initial situation of the sample.

Prognostic models established with comprehensive geriatric assessments can predict the commencement of the need for HC and subsequent NH entry in community-dwelling, older adults. Our findings underline the necessity to measure functional capacity, mobility, inappropriate prescriptions, and social aspects of older adults in primary care settings where they can be offered holistic, longitudinal assessments, and tailored interventions.

Such models could also be useful for the risk classification of frail older adults and in the planning of health care policies.

Recommendations

Due to the relevance of mobility and instrumental activities of daily living in the prediction of adverse outcomes, community interventions based on physical and functional exercises should be prioritised to improve/maintain independence and quality of life in older adults^70,71.
Tackling polypharmacy and inappropriate prescriptions through deprescription processes at the primary care level should also be prioritised⁷².
Interventions to improve social resources and promote social support networks and inclusion in the community would improve the quality of life of older adults. Moreover, they would enhance the efficiency of the health system and, given the high cost of residential centres, ease the financial burden for both for families and society⁷².

BADL Basic Activities of the Daily Living

BMI Body mass index

CIF Cumulative incidence function

CGA Comprehensive Geriatric Assessment

GDS Geriatric Depression Scale

HC Home care

HHIE-S Handicap Hearing Impairment in the Elderly Screening Version

IADL Instrumental Activities of the Daily Living

ICIQ-SF International Consultation on Incontinence Questionnaire Short Form

IQ Interquartile

MCE Mini Cognitive Examination

MNA-SF Mini Nutritional Assessment Short Form

NH Nursing home

PHC Primary Health Care

SFRSE Socio-Family Rating Scale of the Elderly

sHR Subdistribution hazard

TUGT Timed-up-and-go test

Ethics approval and consent to participate

Research was performed in accordance with the Declaration of Helsinki. Ethics approval for the study was received from: The Ethical Committee on Clinical Research IDIAP Jordi Gol, approval number P11/75. All study participants gave written informed consent.

Consent for publication

Not applicable

Availability of data and materials

The dataset supporting the conclusions of this article is available in the Open Science Framework repository, in [https://osf.io/sqty8/].

Competing interests

None declared.

Funding

This work was supported by the Carlos III Health Institute (Ministry of Economy and Competitiveness, Spain) with a grant for research projects on health (PI031655) and the 7th Primary Care Research of Barcelona Region Award.

Authors’ contributions

FC, FO coordinated the study. FC, FO were involved in the study conduct. RA, FO, FC, MP were involved in the analyses and interpretation. FC, FO, MP, RA were involved in drafting the manuscript. All authors read and approved the final manuscript.

Acknowledgments

We would like to thank the study participants and the healthcare professionals who helped us contact them.

Authors’ Information

Francisco Cegri, Email: [email protected]

Francesc Orfila, Email: [email protected]

Rosa María Abellana, Email: [email protected]

María Pastor-Valero, Email: [email protected]

United Nations, Department of Economic and Social Affairs, Population Division. World Population Prospects 2019: Highlights. ST/ESA/SER.A/423. Available from: https://population.un.org/wpp/Publications/Files/WPP2019_Highlights.pdf. Accessed 7 Jul 2019.
Kojima G. Frailty as a predictor of disabilities among community-dwelling older people: a systematic review and meta-analysis. Disabil Rehabil.2017 Sep;39(19):1897-1908. doi:1080 / 09638288.2016.1212282.
Abellán A, Ayala A, Pérez J, Pujol R. Un perfil de las personas mayores en España, 2018. Indicadores estadísticos básicos. Madrid, 2018. Informes Envejecimiento en red nº 17, 34p. Available from: http://envejecimiento.csic.es/documentos/documentos/enred-indicadoresbasicos18.pdf. Accessed 7 Jul 2019.
Albarrán I, Alonso P. La población dependiente en España: estimación del número y coste global asociado a su cuidado. Estudios de Economía, 2009;36 (2):127-163. Available from: http://www.redalyc.org/html/221/22111975001/. Accessed 7 Jul 2019.
Rodríguez-Mañas L, Féart C, Mann G, Viña J, Chatterji S, Chodzko-Zajko W, et al. Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2013;68(1):62-67. doi: 10.1093/gerona/gls119.
Victor CR, Healy J, Thomas A, Seargeant J. Older patients and delayed discharge from hospital. Health Soc Care Community. 2000 Nov;8(6):443-452. doi: 10.1046/j.1365-2524.2000.00270.
Luppa M, Luck T, Weyerer S, König HH, Brähler E, Riedel-Heller SG. Prediction of institutionalization in the elderly. A systematic review. Age Ageing. 2010 Jan;39(1):31-8. doi: 10.1093/ageing/afp202.
Ahmad R, Bath PA. Identiﬁcation of risk factors for 15-year mortality among community-dwelling older people using Cox regression and a genetic algorithm. J Gerontol A Biol Sci Med Sci 2005;60(8):1052–8. doi: 10.1093/gerona/60.8.1052.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146
Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62:722-7. doi: 10.1093/gerona/62.7.722.
Clegg A, Rogers L, Young J. Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review. Age Ageing. 2015 Jan;44(1):148-52. doi: 10.1093/ageing/afu157.
Apostolo J, Cooke R, Bobrowicz-Campos E, Santana S, Marcucci M, Cano A, et al. Predicting risk and outcomes for frail older adults: an umbrella review of frailty screening tools. JBI Database System Rev Implement Rep. 2017;15:1154-208.
NHS England/LTC Team. Toolkit for General Practice in Supporting Older People Living With Frailty. Update to 2014 document. Available from: https://www.england.nhs.uk/wp-content/uploads/2017/03/toolkit-general-practice-frailty-1.pdf Accessed 7 Jul 2019.
Documento de consenso sobre prevención de fragilidad y caídas en la persona mayor. Estrategia de Promoción de la Salud y Prevención en el SNS. Madrid: Ministerio de Sanidad, Servicios Sociales e Igualdad; 2014. Available from: https://www.mscbs.gob.es/profesionales/saludPublica/prevPromocion/Estrategia/docs/FragilidadyCaidas_personamayor.pdf. Accessed 7 jul 2019. Accessed 7 Jul 2019.
Supporting routine frailty identification and frailty through the GP Contract 2017/2018. NHS England. Available from: https://www.england.nhs.uk/publication/supporting-routine-frailty-identification-and-frailty-through-the-gp-contract-20172018/. Accessed 7 Jul 2019.
Parker SG, McCue P, Phelps K, McCleod A, Arora S, Nockels K, et al. What is Comprehensive Geriatric Assessment (CGA)? An umbrella review. Age Ageing. 2018 Jan 1;47(1):149-55. doi:10.1093/ageing/afx166.
Pilotto A, Cella A, Pilotto A, Daragjati J, Veronese N, Musacchio C, et al. Three Decades of Comprehensive Geriatric Assessment: Evidence Coming From Different Healthcare Settings and Specific Clinical Conditions. J Am Med Dir Assoc. 2017 Feb 1;18(2):192.e1-192.e11. doi: 10.1016/j.jamda.2016.11.004.
Primero las personas: Cuidar como nos gustaría ser cuidados. Resultados de la Encuesta sobre cuidados. Obra social “la Caixa”. Fundación Matia Instituto Gerontológico. 2016. Available from: https://prensa.lacaixa.es/obrasocial/show_annex.html?id=54093. Accessed 7 Jul 2019.
Generalitat de Catalunya. CatSalut. Ús de recursos i despesa sanitària dels pacients en atenció domiciliària. Any 2016. Informes breus. Número 13. Març 2018. Available from: http://catsalut.gencat.cat/web/.content/minisite/catsalut/publicacions/informes_breus/infor mes_breus_n13.pdf. Accessed 7 Jul 2019.
Las Personas Mayores en España. Informe 2016. Datos Estadísticos Estatales y por Comunidades Autónomas. Ministerio de Sanidad, Servicios Sociales e Igualdad 2017. 518p. Available from: http://feafesgalicia.org/img/documentacion/estudios/Informe_2016_personas_mayores.pdf. Accessed 7 Jul 2019.
Hollander MJ, Chappell NL. A comparative analysis of costs to government for home care and long‐term residential care services, standardized for client care needs. Canadian Journal on Aging. 2007;26:149‐61. doi: 10.3138/cja.26.suppl_1.149.
Slobbe LCJ, Wong A, Verheij RA, van Oers HAM, Polder JJ. Determinants of first-time utilization of long-term care services in the Netherlands: an observational record linkage study. BMC Health Services Research. 2017;17:626. Available from: https://bmchealthservres.biomedcentral.com/track/pdf/10.1186/s12913-017-2570-z. Accessed 7 Jul 2019.
Young C, Hall AM, Gonçalves-Bradley DC, Quinn TJ, Hooft L, van Munster BC, Stott DJ. Home or foster home care versus institutional long-term care for functionally dependent older people. Cochrane Database Syst Rev. 2017 Apr 3;4:CD009844. doi: 10.1002/14651858.CD009844.pub2.
Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, et al. Cross validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. International Quality of Life Assessment. J Clin Epidemiol. 1998;51:1171-8. doi: 10.1016/S0895-4356(98)00109-7.
Mahoney FI, Barthel DW. Functional evaluation: The Barthel Index. Md State Med J- 1965;14-61-5.
Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental actvities of daily living. Gerontologist. 1969;9:179-86.
Podsiadlo D, Richardson S: The Timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991, 39 (2): 142-148.
Lobo A, Saz P, Marcos G, Día JL, De la Cámara C, Ventura T, et al. Revalidación y normalización del miniexamen cognoscitivo (primera versión en castellano del Minimental State Examination) en la población general geriátrica. Med Clin (Barc). 1999;112: 767-74.
Folstein MF, Folstein SE, McHugh PR. Minimental State. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12: 189-98.
Sheikh JL, Yesavage JA. Geriatric Depression Scales (GDS): Recent evidence and development of a shorter version. Brink TL, editors. Clinical Gerontology: A guide to assessment and intervention. New York: Haworth Press. 1986, p. 165.
Kaiser MJ, Bauer JM, Ramsch C, et al. Validation of the Mini Nutritional Assessment Short-Form (MNA®-SF): A practical tool for identification of nutritional status. J Nutr Health Aging. 2009;13: 782-788. Available from:
https://www.researchgate.net/profile/Maria_Dolores_Ruiz-Lopez/publication/258516598_Validation_of_the_Mini_Nutritional_Assessment_Short-Form_MNAr-SF_A_practical_tool_for_identification_of_nutritional_status/links/004635338025915898000000.pdf. Accessed 7 Jul 2019.
Jaeger E. Über Staar und Staaroperationen nebst anderer Beobachtungen und Erfahrungen. Wien: Seidel und Sohn. 1854.
Lichtenstein MJ, Bess FH, Logan SA. Validation of Screening Tools for Identifying Hearing-Impaired Elderly in Primary Care. JAMA: The Journal of the American Medical Association. 1988;259(19), 2875. doi: 10.1001/jama.1988.03720190043029.
Avery K, Donovan J, Peters TJ, Shaw C, Gotoh M, Abrams P. ICIQ: A brief and robust measure for evaluating the Symptoms and Impact of Urinary Incontinence. Neurourol Urodyn. 2004;23: 322-30. doi: 10.1002/nau.20041.
García JV, Díaz E, Salamea A, Cabrera D, Menéndez A, Fernández A, Acebal V. Evaluación de la fiabilidad y validez de una escala de valoración social en el anciano. Atención Primaria. Vol. 23. Núm. 7. 30 de abril 1999. Available from: https://www.siis.net/documentos/ficha/518344.pdf. Accessed 7 Jul 2019.
Fried LP, Bandeen-Roche K, Kasper JD, Guralnik JM. Association of comorbidity with disability in older women: the Women's Health and Aging Study. J Clin Epidemiol. 1999 Jan;52(1):27-37.
Valderrama-Gama E, Damián J, Ruigómez A, Martín-Moreno JM. Chronic disease, functional status, and self-ascribed causes of disabilities among noninstitutionalized older people in Spain. J Gerontol A Biol Sci Med Sci. 2002 Nov;57(11):M716-21.
Fine JP and Gray RJ. A proportional hazards model for the subdistribution of a competing risk. JASA. 1999;94:496-509. doi: 10.1080/01621459.1999.10474144.
Pencina MJ, D’agostino RB. Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation. Statistics in medicine. 2004;23: 2109-2123. doi: 10.1002/sim.1802.
Gerds TA. Prediction Error Curves for Risk Prediction Models in Survival Analysis. Package “pec”. Version 2018.07.26. Available from: https://cran.r-project.org/web/packages/pec/pec.pdf. Accessed 7 Jul 2019.
Xiang X, Chen J, Kim M. Trajectories of Homebound Status in Medicare Beneficiaries Aged 65 and Older. Gerontologist. 2019 Mar 13. pii: gnz023. doi:10.1093/geront/gnz023.
Wolff JL, MulcahyJ, Roth DL, Cenzer IS, Kasper JD, Huang J et al. Long‐Term Nursing Home Entry: A Prognostic Model for Older Adults with a Family or Unpaid Caregiver. J Am Geriatr Soc. 2018;66: 1887-1894. doi: 10.1111/jgs.15447.
Luppa M, Riedel-Heller SG, Luck T, Wiese B, Van den Bussche H, Haller F et al. Age-related predictors of institutionalization: results of the German study on ageing, cognition and dementia in primary care patients (AgeCoDe). Soc Psychiatry Psychiatr Epidemiol. 2012 Feb;47(2):263-70. doi: 10.1007/s00127-010-0333-9.
AGE Platform Europe. Older people also suffer because of the crisis. November 2012. Brusells. Available from:
https://www.age-platform.eu/sites/default/files/AGE_IntergenerationalSolidarity_Position_on_Structural_Ageism2016.pdf. Accessed 7 Jul 2019.
Analysing equity in the use of long-term care in Europe. Research note 9/2014. Rodrigues R, Ilinca S, Schmidt A, European Centre for Social Welfare Policy and Research. Available from: https://ec.europa.eu/social/BlobServlet?docId=13627&langId=en. Accessed 7 Jul 2019.
Instituto Nacional de Estadística. Tablas de mortalidad, año 2017. 2018. Available from: http://www.ine.es/dyngs/INEbase/es/operacion.htm?c=Estadistica_C&cid=1254736177004&menu=ultiDatos&idp=1254735573002. Accessed 7 Jul 2019.
Ourhashémi F, Andrieu S, Gillette-Guyonnet S, Vellas B, Albarède JL, Grandjean H. Instrumental activities of daily living as a potential marker of frailty: a study of 7364 community-dwelling elderly women (the EPIDOS study). J Gerontol A Biol Sci Med Sci. 2001 Jul;56(7):M448-53. doi: 10.1093/gerona/56.7.m448.
Schuurmans H, Steverink N, Lindenberg S, Frieswijk N, Slaets JP. Old or frail:what tells us more? J Gerontol A Biol Sci Med Sci. 2004 Sep;59(9):M962-5. doi: 1093/gerona/59.9.m962
Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008 Jan;12(1):29-37.
Clegg A, Rogers L, Young J. Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review. Age Ageing. 2015 Jan;44(1):148-52. doi: 10.1093/ageing/afu157.
Savva GM, Donoghue OA, Horgan F, O’Regan C, Cronin H, Kenny RA. Using timed up-and-go to identify frail members of the older population. J Gerontol A Biol Sci Med Sci. 2013; 68: 441–6. doi: 1093/gerona/gls190.
Saum KU, Schöttker B, Meid AD, Holleczek B, Haefeli WE, Hauer K, Brenner H. Is Polypharmacy Associated with Frailty in Older People? Results From the ESTHER Cohort Study. J Am Geriatr Soc. 2017 Feb;65(2):e27-e32. doi: 10.1111/jgs.14718.
Dhalwani NN, Fahami R, Sathanapally H, Seidu S, Davies MJ, Khunti K. Association between polypharmacy and falls in older adults: a longitudinal study from England. BMJ Open. 2017 Oct 16;7(10):e016358. doi:10.1136/bmjopen-2017-016358.
Bonaga B, Sánchez-Jurado PM, Martínez-Reig M, Ariza G, Rodríguez-Mañas L, Gnjidic D, et al. Frailty, Polypharmacy, and Health Outcomes in Older Adults: The Frailty and Dependence in Albacete Study. J Am Med Dir Assoc. 2018 Jan;19(1):46-52. doi: 10.1016/j.jamda.2017.07.008.
Midão L, Giardini A, Menditto E, Kardas P, Costa E. Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch Gerontol Geriatr. 2018 Sep - Oct;78:213-220. doi:10.1016/j.archger.2018.06.018.
Freund J, Meiman J, Kraus C. Using electronic medical record data to characterize the level of medication use by age-groups in a network of primary care clinics. J Prim Care Community Heal. 2013;4(4):286–293. doi: 10.1177/2150131913495243.
Fried TR, O'Leary J, Towle V, Goldstein MK, Trentalange M, Martin DK. Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review. J Am Geriatr Soc. 2014 Dec;62(12):2261-72. doi:10.1111/jgs.13153.
Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013 Jun;14(6):392-7. doi: 10.1016/j.jamda.2013.03.022.
Kaufmann CP, Tremp R, Hersberger KE, Lampert ML. Inappropriate prescribing: a systematic overview of published assessment tools. Eur J Clin Pharmacol. 2014 Jan;70(1):1-11. doi: 10.1007/s00228-013-1575-8.
Steinbach U. Social networks, institutionalization, and mortality among elderly people in the United States. J Gerontol. 1992 Jul;47(4):S183-90. doi: 1093/geronj/47.4.s183.
Takeuchi M, Showa S, Kitazawa K, Mori M. Living alone is associated with an increased risk of institutionalization in older men: A follow-up study in Hamanaka Town of Hokkaido, Japan. Geriatr Gerontol Int. 2018 Jun;18(6):867-872. doi: 10.1111/ggi.13267.
Hajek A, Brettschneider C, Lange C, Posselt T, Wiese B, Steinmann S, et al. AgeCoDe Study Group. Longitudinal Predictors of institutionalization in Old Age. PLoS One. 2015 Dec 14;10(12):e0144203. doi: 10.1371/journal.pone.0144203.
Pimouguet C, Rizzuto D, Schön P, Shakersain B, Angleman S, Lagergren M, et al. Impact of living alone on institutionalization and mortality: a population-based longitudinal study. Eur J Public Health. 2016 Feb;26(1):182-7. doi: 10.1093/eurpub/ckv052.
Lesende M. Crisis económica y vulnerabilidad social en personas mayores. Aten Primaria. 2014;46(2):55-57. doi: 10.1016/j.aprim.2013.11.001.
O'Caoimh R, Cornally N, Svendrovski A, Weathers E, FitzGerald C, Healy E, et al. Measuring the Effect of Carers on Patients' Risk of Adverse Healthcare Outcomes Using the Caregiver Network Score. J Frailty Aging. 2016;5(2):104-10. doi: 10.14283/jfa.2016.86.
Makizako H, Shimada H, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, et al. Social Frailty Leads to the Development of Physical Frailty among Physically Non-Frail Adults: A Four-Year Follow-Up Longitudinal Cohort Study. Int J Environ Res Public Health. 2018 Mar 10;15(3). pii: E490. doi: 10.3390/ijerph15030490.
Bunt S, Steverink N, Olthof J, van der Schans CP, Hobbelen JSM. Social frailty in older adults: a scoping review. Eur J Ageing. 2017 Jan 31;14(3):323-334. doi: 10.1007/s10433-017-0414-7.
Hajek A, Brettschneider C, Lange C, Posselt T, Wiese B, Steinmann S et al. AgeCoDe Study Group. Longitudinal Predictors of institutionalization in Old Age. PLoS One. 2015 Dec 14;10(12):e0144203. doi: 10.1371/journal.pone.0144203.
Luppa M, Luck T, Weyerer S, König HH, Riedel-Heller SG. Gender differences in predictors of nursing home placement in the elderly: a systematic review. Int Psychogeriatr. 2009 Dec;21(6):1015-25. doi: 10.1017/S1041610209990238.
Romera-Liebana L, Orfila F, Segura JM, Real J, Fabra ML, Möller M et al. Effects of a Primary Care-Based Multifactorial Intervention on Physical and Cognitive Function in Frail, Elderly Individuals: A Randomized Controlled Trial, The Journals of Gerontology: Series A, Volume 73, Issue 12, December 2018, Pages 1668–1674. doi: 10.1093/gerona/glx259
Inzitari M, Pérez LM, Enfedaque MB, Soto L, Díaz F, Gual N, et al. Integrated primary and geriatric care for frail older adults in the community: Implementation of a complex intervention into real life. Eur J Intern Med. 2018 Oct;56:57-63. doi: 10.1016/j.ejim.2018.07.022.
Gené L, Navarro M, Kostov B, Ortega M, Colungo C, Carpallo M, et al. Pre Frail 80: Multifactorial Intervention to Prevent Progression of Pre-Frailty to Frailty in the Elderly. J Nutr Health Aging. 2018;22(10):1266-1274. doi: 10.1007/s12603-018-1089-2.

Table 1. Frequency and bivariate sub-hazard ratios of admission into a Home Care programme or a Nursing Home during the 8-year follow-up in relation to the baseline characteristics of the cohort.

VARIABLES	N	ALL N=616	Death² n=95	HOME CARE			NURSING HOME
VARIABLES	N	ALL N=616	Death² n=95	No HC n=403	HC n=118	Sub-hazard Ratio³ [IC95%]	No NH n=470	NH n=51	Sub-hazard Ratio³[IC95%]
Age, years, mean (SD)	616	76.4 (4.8)	78.0 (4.9)	75.2 (4.3)	78.9 (4.8)	1.4[1.1;1.2]	75.8 (4.6)	78.7(5.1)	1.1[1.1;1.2]
Gender, female, n (%)	616	342 (55.5%)	41 (43.2%)	233(57.8%)	68 (57.6%)	1.0[0.7;1.5]	267(56.8%)	34 (66.7%)	1.5[0.8;2.7]
Educational level, n (%):	599
Illiterate		52 (8.6%)	7 (7.5%)	33 (8.3%)	12 (10.3%)	Ref.	39 (8.4%)	6 (12.0%)		Ref.
Incomplete primary		395 (65.0%)	71 (76.3%)	251(63.1%)	73 (62.4%)	0.8[0.4;1.5]	290(62.4%)	34(68.0%)		0.7[0.3;1.8]
Primary		112 (18.4%)	9 (9.7%)	78 (19.6%)	25 (21.4%)	1.0[0.5;2.0]	99 (21.3%)	4 (8.0%)		0.3[0.1;1.1]
Secondary		29 (4.8%)	3 (3.2%)	24 (6.0%)	2 (1.7%)	0.3[0.1;1.3]	23 (4.95%)	3 (6.0%)		0.8[0.2;3.3]
University		11 (1.8%)	1 (1.1%)	7 (1.8%)	3 (2.6%)	1.2[0.4;3.7]	9 (1.9%)	1 (2.0%)		0.7[0.1;6.0]
Living arrangements, n (%):	613
Family		167 (27.2%)	30 (31.9%)	106(26.4%)	31 (26.5%)	Ref.	126(26.9%)	11 (21.6%)		Ref.
Partner		311 (50.7%)	44 (46.8%)	206(51.2%)	61 (52.1%)	1.05[0.7;1.6]	251(53.6%)	16 (31.4%)		0.8[0.4;1.7]
Living alone		135 (22.0%)	20 (21.3%)	90 (22.4%)	25 (21.4%)	1.04[0.6;1.8]	91 (19.4%)	24 (47.1%)		2.8[1.4;5.8]
Physical activity, n (%):	610
Active (≥30 minutes/day)		352 (57.7%)	37 (39.4%)	262(65.8%)	53 (44.9%)	Ref.	292(62.8%)	23 (45.1%)		Ref.
<30 minutes/day		171 (28.0%)	42 (44.7%)	91 (22.9%)	38 (32.2%)	1.5[1.0;2.2]	110(23.7%)	19 (37.3%)		1.7[0.9;3.1]
Sedentary		87 (14.3%)	15 (16.0%)	45 (11.3%)	27 (22.9%)	2.4[1.5;3.8]	63 (13.5%)	9 (17.6%)		1.8[0.9;3.9]
Body mass index, mean (SD)	592	28.5 (4.2)	28.3 (4.7)	28.2 (3.9)	29.6 (4.4)	1.1[1.0;1.1]	28.5 (3.92)	28.9(5.1)		1.0[0.9;1.1]
Body mass index, n (%):	592
< 22 Low weight		36 (6.1%)	8 (8.8%)	22 (5.7%)	6 (5.2%)	Ref.	22 (4.9%)	6 (12.0%)		Ref.
22-26.9 Norm weight		144 (24.3%)	26 (28.6%)	98 (25.5%)	20 (17.2%)	0.8[0.3;2.0]	111(24.6%)	7 (14.0%)		0.3[0.1;0.8]
27-29.9 Over weight		169 (28.5%)	26 (28.6%)	96 (24.9%)	47 (40.5%)	1.5[0.6;3.6]	123(27.3%)	20 (40.0%)		0.7[0.3;1.6]
≥ 30 Obesity		243 (41.0%)	31 (34.1%)	169 (43.9%)	43 (37.1%)	0.9[0.4;2.2]	195(43.2%)	17 (34.0%)		0.4[0.1;0.9]
Perceived health¹, n (%):	616
Good or +		259 (42%)	31 (32.6%)	191 (47,4%)	37 (31.4%)	Ref.	211(44.9%)	17 (33%)		Ref.
Fair		305 (49.5%)	54 (56.8%)	185 (45.9%)	66 (55.9%)	1.6[1.1;2.4]	226(48.1%)	25 (49.0%)		1.3 [0.7;2.5]
Bad		52 (8.4%)	10 (10.5%)	27 (6.70%)	15 (12.7%)	2.3[1.3;4.2]	33(37.0%)	9 (17.6%)		3.0[1.3;6.7]
Hospitalization/previous year, n (%), ≥1	616	78 (12.7%)	19 (20.0%)	46 (11.4%)	13 (11.0%)	0.8[0.5;1.5]	53 (11.3%)	6 (11.8%)		0.9 [0.4;2.1]
Falls / previous year, n (%) ≥1	615	149 (24.2%)	25 (26.3%)	101 (25.1%)	23 (19.5%)	0.8[0.5;1.2]	108 (23%)	16 (31.4%)		1.5[0.8;2.6]
Number of drugs, mean (SD)	582	5.0 (3.1)	6.1 (3.3)	4.6 (2.9)	5.4 (3.1)	1.1[1.0;1.1]	4.6 (2.9)	6.6(3.2)		1.2[1.1;1.2]
Psychoactive drugs, n (%), ≥1	563	180 (32.0%)	27 (32.5%)	115 (30.7%)	38 (36.2%)	1.2[0.8;1.8]	130(30.0%)	23 (50.0%)		2.1[1.2;3.8]

SD: Standard deviation; HC: Home Care; NH: Nursing Home; IC95%: 95% confidence interval

¹Perceived health, question: "In general, would you say that your health is excellent, very good, good, fair, or bad?. ²Death, prior to both HC/ NH outcomes. ³Fine–Gray regression model for the sub-distribution hazard.

Table 2. Frequency and bivariate sub-hazard ratios of admission into a Home Care programme or a Nursing Home during the 8-year follow-up in relation to the baseline Comprehensive Geriatric Assessment.

VARIABLES	N	ALL N=616	Death¹² n=95	HOME CARE			NURSING HOME
VARIABLES	N	ALL N=616	Death¹² n=95	No HC n=403	HC n=118	Sub-hazard Ratio¹³ [CI95%]	No NH n=470	NH n=51	Sub-hazard Ratio¹³ [CI95%]
BADL (Barthel¹), mean (SD)	616	96.5 (7.0)	95.5 (9.8)	97.5 (5.7)	94.1 (7.7)	1.0[1.0;1.0]	97.1 (5.30)	93.1(12.1)	1.0[1.0;0.98]
IADL (Lawton & Brody²), n (%)	615
Independent		472 (76.7%)	63 (66.3%)	336(83.4%)	73 (62.4%)	Ref.	373(79.5%)	36 (70.6%)	Ref.
Mild Dependence		103 (16.7%)	23 (24.2%)	54 (13.4%)	26 (22.2%)	1.7[1.1;2.6]	73 (15.6%)	7 (13.7%)	0.9[0.4;2.1]
Moderate + Severe Dependence		40 (6.5%)	9 (9.47%)	13 (3.23%)	18 (15.4%)	4.82[2.8;8.3]	23 (4.9%)	8 (15.7%)	4.5[2.0;9.9]
Mobility assessment (Timed-up-and-go test³), mean (SD)	599	13.0 (6.8)	14.6 (7.4)	11.8 (5.5)	16.2 (9.0)	1.1[1.0;1.1]	12.4 (6.4)	15.5(8.4)	1.1[1.0;1.1]
Cognitive status (MEC⁴), mean (SD)	614	27.0 (3.7)	26.6 (3.6)	27.4 (3.6)	26.2 (3.9)	0.9[0.9;1.0]	27.3 (3.6)	25.6(3.8)	0.9[0.9;1.0]
Affective status (GDS⁵) mean (SD)	607	3.79 (3.3)	4.15 (3.2)	3.55 (3.3)	4.3 (3.1)	1.1[1.0;1.1]	3.6 (3.2)	5.1(3.8)	1.1[1.0;1.2]
Nutritional assessment (MNA-SF⁶), mean (SD)	604	12.9 (1.6)	12.6 (1.8)	13.0 (1.6)	12.8 (1.6)	0.94[0.9;1.0]	13.0 (1.6)	12.6(1.8)	0.9[0.8;1.0]
Visual impairment (Jaeger Card⁷), n (%)	611	195 (31.9%)	34 (35.8%)	112(28.0%)	49 (42.2%)	1.7[1.2;2.4]	143(30.6%)	18 (36.7%)	1.3[0.7;2.4]
Hearing impairment (HHIE-S⁸), n (%)	612	121 (19.8%)	21 (22.1%)	71 (17.7%)	29 (25.0%)	1.4[0.9;2.1]	89 (19.1%)	11 (21.6%)	1.2[0.6;2.3]
Urinary incontinence (ICIQ-SF⁹), n (%)	615	277 (45.0%)	44 (46.3%)	163 (40.5%)	70 (59.3%)	1.8[1.3; 2.7]	199(42.4%)	34 (66.7%)	2.5[1.4;4.5]
Number of morbidities¹⁰, mean (SD)	616	0.8 (0.9)	0.9 (1.1)	0.7 (0.9)	0.9 (0.8)	1.1[1.0;1.3]	0.7 (0.8)	1.0(1.3)	1.3[1.1;1.6]
Social risk (Social-familial evaluation scale¹¹), mean (SD)	614	8.8 (2.7)	8.7 (2.8)	8.7 (2.7)	9.4 (2.7)	1.1[1.0;1.2]	8.7 (2.6)	10.7(3.2)	1.2[1.1;1.3]

SD: Standard deviation; HC: Home Care; NH: Nursing Home; CI95%: 95% confidence interval.

¹Basic Activities of the Daily Living (BADL) Barthel Index (from 0 to 100 points), below 60 represents moderate/ severe dependence.²Instrumental Activities of the Daily Living (IADL) Lawton and Brody Index, with dependence cut-off points for women <8 points (from 0 to 8 points) and men <5 points (from 0 to 5 points). ³Timed-up-and-go test (TUGT) The score of> 10 seconds was considered altered. ⁴Mini Cognitive Examination (MEC), (from 0 to 30 points), cut-off point for cognitive deterioration ≤ 23. ⁵Geriatric Depression Scale (GDS) Yesavage Scale (from 0 to 15 points), cut-off point for probable depression> 5. ⁶Mini Nutritional Assessment Short Form (MNA-SF) (from 0 to 14 points), cut-off point ≤ 11 for risk of malnutrition. ⁷Jaeger Card, point > 20/40 visual acuity deficit. ⁸Handicap Hearing Impairment in the Elderly Screening Version (HHIE-S) (from 0 to 40 points) (ref). The cut-off point ≥10 was considered an auditory limitation. ⁹International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) (from 0 to 21 points) with a cut-off point ≥ 1 for the diagnosis of urinary incontinence. ¹⁰Morbidities related to frailty, including: cerebrovascular accident with sequelae, Parkinson's disease, osteoarticular diseases, severe visual deficit, dementia, acute myocardial infarction or heart failure, chronic obstructive pulmonary disease, recurrent falls or fractures, severe deafness and chronic depression. ¹¹Socio-Family Rating Scale of the Elderly (SFRSE) (from 0 to 25 points) which assesses family, economic situation, housing, social relations, and social support, with a cut-off point ≥10 for social risk. ¹²Death, previous to both HC/NH outcomes. ¹³Fine–Gray regression model for the sub-distribution hazard.

Table 3: Multivariate Competitive Risk Models for a Home Care and Nursing Home admission, prognostic index functions, and risk classification.


HOME CARE (HC)			NURSING HOME (NH)
	Sub Hazard Ratio [CI95%]	p-value		Sub Hazard Ratio [CI95%]	p-value
Age (years)	1.1 [1.1-1.2]	<0.001	Age (years)	1.1 [1.0-1.2]	0.002
IADL: Independent	1		IADL: Independent	1
IADL: Mild Dependence	1.5 [1.0-2.4]	0.083	IADL: MIld Dependence	0.6 [0.2-1.5]	0.250
IADL: Moderate Dependence or +	2.8 [1.4-5.6]	0.005	IADL: Moderate Dependence or +	2.6 [1.0-6.8]	0.045
TUGT (seconds)	1.0 [1.0-1.1]	0.024	-	-	-
-	-	-	Number of drugs	1.1 [1.0-1.2]	0.019
			SFRSE (points)	1.2 [1.1-1.2]	<0.001
PROGNOSTIC INDEX FUNCTION (PI)
HC PI			NH PI
PI: 0,107Age (years)+0.412 Mild instrumental dependence (IADL) +1,013* Moderate instrumental dependence (includes severe and total) (IADL) + 0,0331*TUGT (seconds)			PI: 0,106Age (years)-0.551 Mild instrumental dependence (IADL) +0.971* Moderate instrumental dependence (includes severe and total) (IADL) + 0.097* Number of drugs + 0.165 *SFRSE (points)
Risk group			Risk group
Lower risk group: PI 7.5 - 8.3 Medium risk group: PI 8.4 - 8.9 Higher risk: PI ≥ 9.0			Lower risk group: PI 7.9 - 9.5 Medium risk group: PI 9.6 - 10.2 Higher risk: PI ≥ 10.3

IADL: Instrumental Activities of Daily Living; TUGT: Timed Get Up and Go Test; SFRSE: Socio-Family Rating Scale of the Elderly; HC: Home Care; NH: Nursing Home; CI95%: 95% confidence interval.

The Impact Of Frailty On Admission To Home Care Services And Nursing Homes: Eight-Year Follow-Up Of A Community-Dwelling, Older Adult, Spanish Cohort

Status:

Journal Publication

Version 2

Abstract

Figures

Background

Methods

Results

Discussion

Conclusions

List of Abbreviations

Declarations

References

Tables

Status:

Journal Publication

Version 2