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Estimating the potential impact of Attractive Targeted Sugar Baits (ATSBs) as a new vector control tool for Plasmodium falciparum malaria
Keith James Fraser
Imperial College London
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8933-9750
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Attractive targeted sugar baits (ATSBs) are a promising new tool for malaria control as they can target outdoor-feeding mosquito populations, in contrast to current vector control tools which predominantly target indoor-feeding mosquitoes.
Methods: We sought to estimate the potential impact of these new tools on Plasmodium falciparum malaria prevalence in African settings by combining data from a recent entomological field trial of ATSBs undertaken in Mali with mathematical models of malaria transmission.
Results: The entomological study showed a significant reduction of 55.4% (95 % CI 33.7-77.1%) in mosquito catch numbers, and a larger reduction of ~91% (95% CI 75-100%) in the entomological inoculation rate due to the fact that, in the presence of ATSBs, most mosquitoes do not live long enough to transmit malaria. The key parameter determining impact on the mosquito population is the excess mortality due to ATSBs, which we estimate from the observed reduction in mosquito catch numbers to be lower (mean 0.13 per mosquito per day, seasonal range 0.10-0.16 per day) than the bait feeding rate obtained from one-day staining tests (mean 0.34 per mosquito per day, seasonal range 0.28-0.38 per day). Using a mathematical model capturing the lifecycle of P. falciparum malaria in mosquitoes and humans and incorporating the excess mortality, we predict that ATSBs could result in large reductions (>30% annually) in prevalence and clinical incidence of malaria, even in regions with an existing high malaria burden.
Conclusions: Results suggest that this new tool could provide a promising addition to existing vector control tools and result in significant reductions in malaria burden across a range of malaria-endemic settings.
Keywords
malaria, mosquito, vector control
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CURRENT STATUS: Under Revision
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Posted 08 Sep, 2020
No community comments so far
Editorial decision: Minor Revision
On 11 Dec, 2020
Review #2 received
Received 09 Dec, 2020
Reviewer #2 agreed
On 18 Oct, 2020
Review #1 received
Received 07 Oct, 2020
Reviewer #1 agreed
On 22 Sep, 2020
Reviewers invited
Invitations sent on 21 Sep, 2020
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On 08 Sep, 2020
Editor invited
On 07 Sep, 2020
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On 05 Sep, 2020
First submitted
On 02 Sep, 2020
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This preprint is under consideration at Malaria Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Estimating the potential impact of Attractive Targeted Sugar Baits (ATSBs) as a new vector control tool for Plasmodium falciparum malaria
Keith James Fraser
Imperial College London
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8933-9750
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 08 Sep, 2020
No community comments so far
Editorial decision: Minor Revision
On 11 Dec, 2020
Review #2 received
Received 09 Dec, 2020
Reviewer #2 agreed
On 18 Oct, 2020
Review #1 received
Received 07 Oct, 2020
Reviewer #1 agreed
On 22 Sep, 2020
Reviewers invited
Invitations sent on 21 Sep, 2020
Editor assigned
On 08 Sep, 2020
Editor invited
On 07 Sep, 2020
Submission checks complete
On 05 Sep, 2020
First submitted
On 02 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Attractive targeted sugar baits (ATSBs) are a promising new tool for malaria control as they can target outdoor-feeding mosquito populations, in contrast to current vector control tools which predominantly target indoor-feeding mosquitoes.
Methods: We sought to estimate the potential impact of these new tools on Plasmodium falciparum malaria prevalence in African settings by combining data from a recent entomological field trial of ATSBs undertaken in Mali with mathematical models of malaria transmission.
Results: The entomological study showed a significant reduction of 55.4% (95 % CI 33.7-77.1%) in mosquito catch numbers, and a larger reduction of ~91% (95% CI 75-100%) in the entomological inoculation rate due to the fact that, in the presence of ATSBs, most mosquitoes do not live long enough to transmit malaria. The key parameter determining impact on the mosquito population is the excess mortality due to ATSBs, which we estimate from the observed reduction in mosquito catch numbers to be lower (mean 0.13 per mosquito per day, seasonal range 0.10-0.16 per day) than the bait feeding rate obtained from one-day staining tests (mean 0.34 per mosquito per day, seasonal range 0.28-0.38 per day). Using a mathematical model capturing the lifecycle of P. falciparum malaria in mosquitoes and humans and incorporating the excess mortality, we predict that ATSBs could result in large reductions (>30% annually) in prevalence and clinical incidence of malaria, even in regions with an existing high malaria burden.
Conclusions: Results suggest that this new tool could provide a promising addition to existing vector control tools and result in significant reductions in malaria burden across a range of malaria-endemic settings.
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