1 Shaffer EA. (2006 ) Gallstone disease: Epidemiology of gallbladder stone disease. Best practice & research Clinical gastroenterology 20:981-996. https:// doi.org/ 10.1016/j.bpg.2006.05.004
2 Pak M, Lindseth G. (2016 Jul-Aug) Risk Factors for Cholelithiasis. Gastroenterol Nurs 39:297-309. https:// doi.org/10.1097/SGA.0000000000000235.
3 Gosavi S, Mishra RR, Kumar VP. (2017 Mar) Study on the Relation between Colorectal Cancer and Gall Bladder Disease. J Clin Diagn Res 11:OC25-OC27. https:// doi.org/ 10.7860/JCDR/2017/22954.9485.
4 Russo MW, Wei JT, Thiny MT, Gangarosa LM, Brown A, Ringel Y. (2004 May) Digestive and liver diseases statistics, 2004. Gastroenterology 126:1448-1453. https:// doi.org/ 10.1053/j.gastro.2004.01.025
5 Chen JY, Hsu CT, Liu JH, Tung TH. (2014 Apr) Clinical predictors of incident gallstone disease in a Chinese population in Taipei, Taiwan. BMC gastroenterology 14:83. https:// doi.org/ 10.1186/1471-230X-14-83
6 Kim SB, Kim KH, Kim TN, Heo J, Jung MK, Cho CM, Lee YS, et al. (2017 Mar) Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee: A retrospective analysis of a multicenter study. Medicine (Baltimore) 96:e6477. https:// doi.org/ 10.1097/MD.0000000000006477
7 Editorial Board of Chinese Digestive Journal, Collaborative Group of Hepatobiliary Diseases, Society of Digestive Diseases, Chinese Medical Association. (2019 Feb) Chinese consensus on diagnosis and treatment of chronic cholecystitis and gallstones (2018). Chin J Dig. 39: 73-79. https:// doi.org/10.3760/cma.j.issn.0254- 1432.2019.02.001
8 Bonfrate L, Wang DQ, Garruti G, Portincasa P. (2014 Aug) Obesity and the risk and prognosis of gallstone disease and pancreatitis. Best practice & research Clinical gastroenterology 28:623-635. https:// doi.org/10.1016/j.bpg.2014.07.013.
9 Di Ciaula A, Garruti G, Frühbeck G, De Angelis M, de Bari O, Wang DQ, Lammert F, et al. (2019 ) The Role of Diet in the Pathogenesis of Cholesterol Gallstones. Curr Med Chem. 26:3620-3638. https:// doi.org/ 10.2174/0929867324666170530080636.
10 Portincasa P, Di Ciaula A, Grattagliano I: Preventing a Mass Disease. (2016 Jul) The Case of Gallstones Disease: Role and Competence for Family Physicians. Korean journal of family medicine 37:205-213. https:// doi.org/ 10.4082/kjfm.2016.37.4.205.
11 Chen LY, Qiao QH, Zhang SC, Chen YH, Chao GQ, Fang LZ. (2012 Aug) Metabolic syndrome and gallstone disease. World J Gastroenterol 18:4215-4220. https:// doi.org/ 10.3748/wjg.v18.i31.4215
12 Kharga B, Sharma BK, Singh VK, Nishant K, Bhutia P, Tamang R. (2016 Oct) Obesity Not Necessary, Risk of Symptomatic Cholelithiasis Increases as a Function of BMI. Journal of clinical and diagnostic research : JCDR 10:PC28-PC32. https:// doi.org/10.7860/JCDR/2016/22098.8736
13 Liu T, Wang W, Ji Y, Wang Y, Liu X, Cao L. (2018 May) Association between different combination of measures for obesity and new-onset gallstone disease. PloS one 13:e0196457. https:// doi.org/ 10.1371/journal.pone.0196457.
14 Aune D, Norat T, Vatten LJ. (2015 Sep) Body mass index, abdominal fatness and the risk of gallbladder disease. Eur J Epidemiol 30:1009-1019. https:// doi.org/ 10.1007/s10654-015-0081-y
15 Radmard AR, Merat S, Kooraki S, Ashraf M, Keshtkar A, Sharafkhah M. (2015 Sep-Oct) Gallstone disease and obesity: a population-based study on abdominal fat distribution and gender differences. Annals of hepatology 14:702-709. PMID: 26256899
16 Shi X, Jin S, Wang S, Tao W, Wang G. (2018 May) Gallbladder perforation in a patient with alcoholic liver cirrhosis and asymptomatic gallstones: A case report. Medicine (Baltimore). 97:e0414. https:// doi.org/ 10.1097/MD.0000000000010414.
17 Inah GB, Ekanem EE. (2019 Jan) Sonographic Diagnosis and Clinical Correlates of Gallbladder Stones in Patients with Sickle Cell Disease in Calabar, Nigeria. Open Access Maced J Med Sci. 7:68-72. https:// doi.org/10.3889/oamjms.2019.015.
18 Rosenthal TC, Siepel T, Zubler J, Horwitz M. (1994 Apr) The use of ultrasonography to scan the abdomen of patients presenting for routine physical examinations. J Fam Pract. 8:380-385. PMID: 8163963
19 Anuurad E, Shiwaku K, Nogi A, Kitajima K, Enkhmaa B, Shimono K. (2003 Nov) The new BMI criteria for asians by the regional office for the western pacific region of WHO are suitable for screening of overweight to prevent metabolic syndrome in elder Japanese workers. Journal of occupational health 45:335-343. https:// doi.org/ 10.1539/joh.45.335
20 Zhu L, Aili A, Zhang C, Saiding A, Abudureyimu K. (2014 Oct) Prevalence of and risk factors for gallstones in Uighur and Han Chinese. World J Gastroenterol 20:14942-14949. https:// doi.org/10.3748/wjg.v20.i40.14942.
21 Fan JG, Wei L, Zhuang H, National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association; Fatty Liver Disease Expert Committee, Chinese Medical Doctor Association. (2019 Apr) Guidelines of prevention and treatment of nonalcoholic fatty liver disease (2018, China). J Dig Dis. 20(4):163-173. https:// doi.org/ 10.1111/1751-2980.12685. Epub 2018 Dec 11.
22 Zhang J, Ma M, Nan X, Sheng B. (2016 Jul) Obesity inversely correlates with prostate-specific antigen levels in a population with normal screening results of prostate cancer in northwestern China. Braz J Med Biol Res 49. https:// doi.org/10.1590/1414-431X20165272
23 Arrese M, Cortes V, Barrera F, Nervi F. (2018 Mar) Nonalcoholic fatty liver disease, cholesterol gallstones, and cholecystectomy: new insights on a complex relationship. Curr Opin Gastroenterol 34:90-96. https:// doi.org/ 10.1097/MOG.0000000000000416
24 Frybova B, Drabek J, Lochmannova J, Douda L, Hlava S, Zemkova D. (2018 May) Cholelithiasis and choledocholithiasis in children; risk factors for development. PloS one 13:e0196475. https:// doi.org/ 10.1371/journal.pone.0196475.
25 Tsai CJ. (2009 Sep) Steatocholecystitis and fatty gallbladder disease. Dig Dis Sci 54:1857-1863. https:// doi.org/ 10.1007/s10620-008-0578-2.
26 Everhart JE. (1993 Nov) Contributions of obesity and weight loss to gallstone disease. Ann Intern Med 119:1029-1035. https:// doi.org/10.7326/0003-4819-119-10-199311150-00010
27 Bouchard G, Johnson D, Carver T, Paigen B, Carey MC. (2002 Jul) Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. Journal of lipid research 43:1105-1113. https:// doi.org/10.1194/jlr.m200102-jlr200
28 Tran KQ, Goldblatt MI, Swartz-Basile DA, Svatek C, Nakeeb A, Pitt HA. (2003 Nov) Diabetes and hyperlipidemia correlate with gallbladder contractility in leptin-related murine obesity. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 7:857-862; discussion 863. https:// doi.org/10.1007/s11605-003-0030-z
29 Grundy SM. (1998 Feb) Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome. The American journal of cardiology 81:18B-25B. https:// doi.org/10.1016/s0002-9149(98)00033-2
30 Jonkers IJ, Smelt AH, Ledeboer M, Hollum ME, Biemond I, Kuipers F. (2003 Jan) Gall bladder dysmotility: a risk factor for gall stone formation in hypertriglyceridaemia and reversal on triglyceride lowering therapy by bezafibrate and fish oil. Gut 52:109-115. https:// doi.org/10.1136/gut.52.1.109
31 Smelt AH. (2010 Nov) Triglycerides and gallstone formation. Clin Chim Acta 411:1625-1631. https:// doi.org/10.1016/j.cca.2010.08.003
32 Kutsunai M, Kanemoto H, Fukushima K, Fujino Y, Ohno K, Tsujimoto H. (2014 Jan) The association between gall bladder mucoceles and hyperlipidaemia in dogs: a retrospective case control study. Vet J 199:76-79. https:// doi.org/ 10.1016/j.tvjl.2013.10.019
33 Villareal DT, Apovian CM, Kushner RF, Klein S, American Society for N, Naaso TOS. (2005 Mar) Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. The American journal of clinical nutrition 82:923-934. https:// doi.org/10.1038/oby.2005.228
34 Banim PJ, Luben RN, Bulluck H, Sharp SJ, Wareham NJ, Khaw KT. (2011 Aug) The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk. Epidemiological and biomarker data from a UK prospective cohort study (EPIC-Norfolk). European journal of gastroenterology & hepatology 23:733-740. https:// doi.org/10.1097/MEG.0b013e3283477cc9.
35 Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. (2004 Jul) Prospective study of abdominal adiposity and gallstone disease in US men. The American journal of clinical nutrition 80:38-44. https:// doi.org/10.1093/ajcn/80.1.38
36 Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. (2006 May) Central adiposity, regional fat distribution, and the risk of cholecystectomy in women. Gut 55:708-714. https:// doi.org/10.1136/gut.2005.076133
37 Wang W, Li N. (2015 Jun) [Correlation of retinol binding protein 4 with metabolic indexes of glucose and lipid, bile cholesterol saturation index]. Zhong nan da xue xue bao Yi xue ban = Journal of Central South University Medical sciences 40:657-665. https:// doi.org/ 10.11817/j.issn.1672-7347.2015.06.014.
38 Li S, Brown MS, Goldstein JL. (2010 Feb) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America 107: 3441-3446. https:// doi.org/ 10.1073/pnas.0914798107.
39 Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. (2014 Mar) Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 146:726-735. https:// doi.org/ 10.1053/j.gastro.2013.11.049.
40 Ahmed F, Baloch Q, Memon ZA, Ali I. (2017 Mar) An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy. Ann Med Surg (Lond) 17:7-13. https:// doi.org/ 10.1016/j.amsu.2017.03.015.
41 Park M, Song DY, Je Y, Lee JE. (2014 Aug) Body mass index and biliary tract disease: a systematic review and meta-analysis of prospective studies. Preventive medicine 65:13-22. https:// doi.org/ 10.1016/j.ypmed.2014.03.027
42 Field AE, Coakley EH, Must A, Spadano JL, Laird N, Dietz WH. (2001 Jul) Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Archives of internal medicine 161:1581-1586. https:// doi.org/10.1001/archinte.161.13.1581
43 Tirziu S, Bel S, Bondor CI, Acalovschi M. (2008 Jan) Risk factors for gallstone disease in patients with gallstones having gallstone heredity. A case-control study. Romanian journal of internal medicine = Revue roumaine de medecine interne 46:223-228. PMID:19366081
44 Stampfer MJ, Maclure KM, Colditz GA, Manson JE, Willett WC. (1992 Mar) Risk of symptomatic gallstones in women with severe obesity. The American journal of clinical nutrition 55:652-658. https:// doi.org/10.1093/ajcn/55.3.652
45 Lamri-Senhadji MY, Mekki K, El Kebir B, Bachir-Bouiadjra N, Bouchenak M, Belleville J. (2002) Effect of dietary consumption, advanced age and overweight on the physical characteristics of cholesterol gallstones and biliary lipid composition in west Algerian women. Annals of nutrition & metabolism 46:139-146. https:// doi.org/10.1159/000063077
46 Cha BH, Lee BS, Lee SH, Kang SJ, Park MJ. (2017 Mar) A Study of Alcohol Consumption and Obesity as Main Risk Factor for Symptomatic Gallbladder Stone: a Case-Control Study. Asian Pacific journal of cancer prevention : APJCP 18:715-719. https:// doi.org/10.22034/APJCP.2017.18.3.715
47 van Kruijsdijk RC, van der Wall E, Visseren FL. (2009 Oct) Obesity and cancer: the role of dysfunctional adipose tissue. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18:2569-2578. https:// doi.org/ 10.1158/1055-9965.
48 Kano M, Shoda J, Irimura T, Ueda T, Iwasaki R, Urasaki T. (1998 Aug) Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones. Hepatology 28:302-313. https:// doi.org/10.1002/hep.510280204
49 Ogiyama H, Kamada Y, Kiso S, Araki H, Yamada T, Nishihara T. (2010 Aug) Lack of adiponectin promotes formation of cholesterol gallstones in mice. Biochemical and biophysical research communications 2010;399:352-358. https:// doi.org/10.1016/j.bbrc.2010.07.075