Background Post immune response again VHB after immunization have been slowly reported in health personal in limited setting country. We aimed to evaluate the post-vaccination immune response against the hepatitis B virus in health personal at CHUSS Bobo-Dioulasso.
Methods This was a prospective cohort study that was conducted from March 2014 to January 2015 at CHUSS. Thus, 84 vaccinated subjects were included. Whole blood was collected from each subject for antibody determination. CMIA technology was used for the determination of anti-HBs antibodies. Subjects with a titer of less than 100 mIU / ml were considered non-protective in the hospital setting.
Results The average age of the subjects is 40.38 ± 9.82 years. The sex ratio is 2.23. Of these, 47.6% had an Ac titre greater than 100 mIU / ml, and considered very well immunized. Also, 52.4% had an Ac titer less than 100 mIU / ml; and considered as unprotected subject in a hospital setting. Of these, 27.38% had a titer of between 10 and 99 mIU / ml and 30% had a titer of less than 10 mIU / ml. Comparing the different proportions of non-responders by age, we find that there is no statistically significant difference between non-responders aged ≤ 40 years compared to those aged> 40 years (p = 0.8). Comparing the different proportions of non-responders by sex, we find that there is a statistically significant difference between male and female non-responders (p = 0.044).
Conclusion We found that about half of the subjects had satisfactory protection, which indicates a good efficacy of SHANVAC B®. Research on immunological non-responders should be pursued to identify possible causes.