Ultrasonographic features of medullary thyroid carcinoma nodules less than 1 cm compare with papillary thyroid microcarcinomas: a retrospective analysis
Objective: The aim of this study was to retrospectively analyze the ultrasonographic characteristics of medullary thyroid carcinomas (MTCs) with size less than 1 cm (MTMCs) compared with those of papillary thyroid microcarcinomas (PTMCs).
Materials and Methods: This study included 41 patients with 46 MTMCs between January 2008 to April 2017 and 104 consecutive patients with 136 PTMCs between January to June 2015. All thyroid carcinoma nodules were surgically and histologically proved. Age and nodules size were analyzed by independent sample t test. Sex, multiplicity and cervical lymph node metastases were evaluated by χ2 or Fisher’s exact tests. Univariate analysis and multivariate logistic regression analysis were performed on the sonographic features of thyroid carcinoma nodules, including location, composition, echogenicity, shape, margin, boundary, calcifications and vascularization degree.
Results: More MTMCs presented cervical lymph node metastases than PTMCs (36.59% vs 20.19%, p = 0.040). Compared with PTMCs, MTMCs tended to have an ovoid to round shape (P = 0.000, odds ratio [OR], 4.018; 95% CI, 1.295-12.473), more commonly showed solid composition (P = 0.004, OR, 0.13; 95% CI, 0.020-0.842), and macrocalcifications (P = 0.001, OR, 0.085; 95% CI, 0.016-0.454) and hypervascularity (P=0.000, OR, 10.778; 95% CI, 3.939-29.488). There were no significant differences in the location, margin, boundary, echogenicity, peripheral halo ring, the present of calcifications, microcalcifications and between MTMCs and PTMCs.
Conclusion: MTMCs have the ultrasonographic features of general malignant nodules, such as hypoechoic or markedly hypoechoic solid lesions with unique characteristics including ovoid to round shape, macrocalcifications and hypervascularity.
Figure 1
On 31 Mar, 2020
On 30 Mar, 2020
On 30 Mar, 2020
On 12 Mar, 2020
Received 09 Mar, 2020
On 24 Feb, 2020
On 23 Feb, 2020
Received 23 Feb, 2020
Invitations sent on 20 Feb, 2020
On 19 Feb, 2020
On 18 Feb, 2020
On 18 Feb, 2020
Posted 01 Nov, 2019
On 16 Dec, 2019
Received 26 Nov, 2019
On 12 Nov, 2019
Invitations sent on 11 Nov, 2019
On 11 Nov, 2019
Received 11 Nov, 2019
On 29 Oct, 2019
On 29 Oct, 2019
On 28 Oct, 2019
On 27 Oct, 2019
Ultrasonographic features of medullary thyroid carcinoma nodules less than 1 cm compare with papillary thyroid microcarcinomas: a retrospective analysis
On 31 Mar, 2020
On 30 Mar, 2020
On 30 Mar, 2020
On 12 Mar, 2020
Received 09 Mar, 2020
On 24 Feb, 2020
On 23 Feb, 2020
Received 23 Feb, 2020
Invitations sent on 20 Feb, 2020
On 19 Feb, 2020
On 18 Feb, 2020
On 18 Feb, 2020
Posted 01 Nov, 2019
On 16 Dec, 2019
Received 26 Nov, 2019
On 12 Nov, 2019
Invitations sent on 11 Nov, 2019
On 11 Nov, 2019
Received 11 Nov, 2019
On 29 Oct, 2019
On 29 Oct, 2019
On 28 Oct, 2019
On 27 Oct, 2019
Objective: The aim of this study was to retrospectively analyze the ultrasonographic characteristics of medullary thyroid carcinomas (MTCs) with size less than 1 cm (MTMCs) compared with those of papillary thyroid microcarcinomas (PTMCs).
Materials and Methods: This study included 41 patients with 46 MTMCs between January 2008 to April 2017 and 104 consecutive patients with 136 PTMCs between January to June 2015. All thyroid carcinoma nodules were surgically and histologically proved. Age and nodules size were analyzed by independent sample t test. Sex, multiplicity and cervical lymph node metastases were evaluated by χ2 or Fisher’s exact tests. Univariate analysis and multivariate logistic regression analysis were performed on the sonographic features of thyroid carcinoma nodules, including location, composition, echogenicity, shape, margin, boundary, calcifications and vascularization degree.
Results: More MTMCs presented cervical lymph node metastases than PTMCs (36.59% vs 20.19%, p = 0.040). Compared with PTMCs, MTMCs tended to have an ovoid to round shape (P = 0.000, odds ratio [OR], 4.018; 95% CI, 1.295-12.473), more commonly showed solid composition (P = 0.004, OR, 0.13; 95% CI, 0.020-0.842), and macrocalcifications (P = 0.001, OR, 0.085; 95% CI, 0.016-0.454) and hypervascularity (P=0.000, OR, 10.778; 95% CI, 3.939-29.488). There were no significant differences in the location, margin, boundary, echogenicity, peripheral halo ring, the present of calcifications, microcalcifications and between MTMCs and PTMCs.
Conclusion: MTMCs have the ultrasonographic features of general malignant nodules, such as hypoechoic or markedly hypoechoic solid lesions with unique characteristics including ovoid to round shape, macrocalcifications and hypervascularity.
Figure 1