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Research article
Ultrasonographic features of medullary thyroid carcinoma nodules less than 1 cm compare with papillary thyroid microcarcinomas: a retrospective analysis
Weiwei Zhan
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Objective: The aim of this study was to retrospectively analyze the ultrasonographic characteristics of medullary thyroid carcinomas (MTCs) with size less than 1 cm (MTMCs) compared with those of papillary thyroid microcarcinomas (PTMCs).
Materials and Methods: This study included 41 patients with 46 MTMCs between January 2008 to April 2017 and 104 consecutive patients with 136 PTMCs between January to June 2015. All thyroid carcinoma nodules were surgically and histologically proved. Age and nodules size were analyzed by independent sample t test. Sex, multiplicity and cervical lymph node metastases were evaluated by χ2 or Fisher’s exact tests. Univariate analysis and multivariate logistic regression analysis were performed on the sonographic features of thyroid carcinoma nodules, including location, composition, echogenicity, shape, margin, boundary, calcifications and vascularization degree.
Results: More MTMCs presented cervical lymph node metastases than PTMCs (36.59% vs 20.19%, p = 0.040). Compared with PTMCs, MTMCs tended to have an ovoid to round shape (P = 0.000, odds ratio [OR], 4.018; 95% CI, 1.295-12.473), more commonly showed solid composition (P = 0.004, OR, 0.13; 95% CI, 0.020-0.842), and macrocalcifications (P = 0.001, OR, 0.085; 95% CI, 0.016-0.454) and hypervascularity (P=0.000, OR, 10.778; 95% CI, 3.939-29.488). There were no significant differences in the location, margin, boundary, echogenicity, peripheral halo ring, the present of calcifications, microcalcifications and between MTMCs and PTMCs.
Conclusion: MTMCs have the ultrasonographic features of general malignant nodules, such as hypoechoic or markedly hypoechoic solid lesions with unique characteristics including ovoid to round shape, macrocalcifications and hypervascularity.
Keywords
medullary thyroid carcinoma, papillary thyroid carcinoma, ultrasound
Figure 1
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Editor assigned
On 31 Mar, 2020
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On 30 Mar, 2020
Editor invited
On 30 Mar, 2020
No comments provided
Editorial decision: Minor revision
On 12 Mar, 2020
Review #2 received
Received 09 Mar, 2020
Reviewer #2 agreed
On 24 Feb, 2020
Reviewer #1 agreed
On 23 Feb, 2020
Review #1 received
Received 23 Feb, 2020
Reviewers invited
Invitations sent on 20 Feb, 2020
Editor assigned
On 19 Feb, 2020
Submission checks complete
On 18 Feb, 2020
Editor invited
On 18 Feb, 2020
Version 1
Posted 01 Nov, 2019
No comments provided
Editorial decision: Major revision
On 16 Dec, 2019
Review #2 received
Received 26 Nov, 2019
Reviewer #2 agreed
On 12 Nov, 2019
Reviewers invited
Invitations sent on 11 Nov, 2019
Reviewer #1 agreed
On 11 Nov, 2019
Review #1 received
Received 11 Nov, 2019
Submission checks complete
On 29 Oct, 2019
Editor assigned
On 29 Oct, 2019
Editor invited
On 28 Oct, 2019
First submitted
On 27 Oct, 2019
Metrics
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Subject Areas
Nuclear Medicine & Medical Imaging
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This preprint is under consideration at BMC Medical Imaging. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Ultrasonographic features of medullary thyroid carcinoma nodules less than 1 cm compare with papillary thyroid microcarcinomas: a retrospective analysis
Weiwei Zhan
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
No community comments so far
Editor assigned
On 31 Mar, 2020
Submission checks complete
On 30 Mar, 2020
Editor invited
On 30 Mar, 2020
No comments provided
Editorial decision: Minor revision
On 12 Mar, 2020
Review #2 received
Received 09 Mar, 2020
Reviewer #2 agreed
On 24 Feb, 2020
Reviewer #1 agreed
On 23 Feb, 2020
Review #1 received
Received 23 Feb, 2020
Reviewers invited
Invitations sent on 20 Feb, 2020
Editor assigned
On 19 Feb, 2020
Submission checks complete
On 18 Feb, 2020
Editor invited
On 18 Feb, 2020
Version 1
Posted 01 Nov, 2019
No comments provided
Editorial decision: Major revision
On 16 Dec, 2019
Review #2 received
Received 26 Nov, 2019
Reviewer #2 agreed
On 12 Nov, 2019
Reviewers invited
Invitations sent on 11 Nov, 2019
Reviewer #1 agreed
On 11 Nov, 2019
Review #1 received
Received 11 Nov, 2019
Submission checks complete
On 29 Oct, 2019
Editor assigned
On 29 Oct, 2019
Editor invited
On 28 Oct, 2019
First submitted
On 27 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nuclear Medicine & Medical Imaging
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Objective: The aim of this study was to retrospectively analyze the ultrasonographic characteristics of medullary thyroid carcinomas (MTCs) with size less than 1 cm (MTMCs) compared with those of papillary thyroid microcarcinomas (PTMCs).
Materials and Methods: This study included 41 patients with 46 MTMCs between January 2008 to April 2017 and 104 consecutive patients with 136 PTMCs between January to June 2015. All thyroid carcinoma nodules were surgically and histologically proved. Age and nodules size were analyzed by independent sample t test. Sex, multiplicity and cervical lymph node metastases were evaluated by χ2 or Fisher’s exact tests. Univariate analysis and multivariate logistic regression analysis were performed on the sonographic features of thyroid carcinoma nodules, including location, composition, echogenicity, shape, margin, boundary, calcifications and vascularization degree.
Results: More MTMCs presented cervical lymph node metastases than PTMCs (36.59% vs 20.19%, p = 0.040). Compared with PTMCs, MTMCs tended to have an ovoid to round shape (P = 0.000, odds ratio [OR], 4.018; 95% CI, 1.295-12.473), more commonly showed solid composition (P = 0.004, OR, 0.13; 95% CI, 0.020-0.842), and macrocalcifications (P = 0.001, OR, 0.085; 95% CI, 0.016-0.454) and hypervascularity (P=0.000, OR, 10.778; 95% CI, 3.939-29.488). There were no significant differences in the location, margin, boundary, echogenicity, peripheral halo ring, the present of calcifications, microcalcifications and between MTMCs and PTMCs.
Conclusion: MTMCs have the ultrasonographic features of general malignant nodules, such as hypoechoic or markedly hypoechoic solid lesions with unique characteristics including ovoid to round shape, macrocalcifications and hypervascularity.
Figure 1