Pathways
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No of hub genes
Involved
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Genes
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Immune System
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237
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TIMP1,HGF,CTSD, LYZ,VWF,EGF,SERPING1 ,CLU,C1R, HSPA5,CFH, CFB,C1S,B2M,
,QSOX1,RHOA, CFD , VEGFA,FN1, BCL2, CD44 ,ITPR3, FCGR2A, VCAM1,PAK2, LCK, ACTB, SYK,HCK,LYN,ITGB1,VAV1, CYFIP1, ATIC, CCL2, CCR2, CXCL8,CCL19, CCL5, CXCL1,ANXA1,CCL20, FCGR2B, CASP8, LAMP2, LPCAT1, CASP3, VCL, COL1A1, IRF1, TLR2, ITGAV, SAMHD1, ICAM1,TLR3, COL1A2, PDIA3 ,CD28, P4HB, CASP9, HMGB1, ANXA2,TLR7, CD63, KRT8, STAT1, CYBB, ALOX5,ITGAM,PTEN ,VIM, SQSTM1, PTPRC, PECAM1, MX1
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|
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ALOX5,ITGAM,PTEN ,VIM, SQSTM1, PTPRC, PECAM1, MX1 ,PPIA, HSP90AB1, RPLP0, MYC, YWHAZ, ITGB3, IRF2, ILF2, ITGB2,CAPN1,CD59, HLA- DQB2, ,C3, PYCARD, AGA,CD3D, IL7R, PANX1,CDA, ADAM10, STK10,CMTM6, MICB, SNAP25, MYD88,ADAM17, FCER1G, LILRB2, CKAP4, C3AR1,CD36,RAP2B, CD53, CD47, TNFRSF1B, PRKCB,SELL, COL3A1, CTSK, IL18, BST2, HLA-F,IRF8, DDX58,HLA-G, HLA-E, HLA-A,HLA-C,HLA-B,GBP2, IFITM3, PSMB8, OAS1, IRF9, GNB5, PSAP, FPR1, CD14, EDA, RAB27A, NLRP3, XRCC5, CLEC7A, JAK1, TYROBP, CD86, NCF2, LCP2, C1QB, CTSS, LY86, CSF2RB, CSTB, MID1, CD209, SLPI, GZMB, TNFSF10,EPO,BIRC3, IL7,CSF1R,CD1D, ATG12,CASP4, IL15, CASP1, JAK2, CFLAR,APAF1, FGL2, LY96,CD74, SEC24D, SEC24C, SIGLEC1, BCL10, CARD8, TRIM5, TRIM22,DDOST, SKP2, CDC27, IL10RA, DOCK2, PRKDC, GAB2, MAP2K4, QPCT, TXNIP,RET,IKBKB,NFATC1, LTF,TNFAIP6, LILRA2, SP100, TAP1, TRIM38, PSMB10, CD247, TLR1, CD1C, FCGR1B, GBP1, LCN2, PSMB9,NEU1, LAT, TAPBP, TNFAIP3,TRAF3,CYLD, C7,IL11, TNFRSF11B, IFI16, GLIPR1, CPNE1,C1QA, C2,C4BPA,FCGR3B, MRC1, CLEC10A,IL10RB, IFNGR1, MEF2C, IL33, EIF4G3,
IL1R1,IL32, FNTA, TEK,KLRB1,INPP5D
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Innate Immune System
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140
|
CTSD , LYZ ,SERPING1,CLU ,C1R ,CFH ,CFB ,C1S ,B2M ,QSOX1 , RHOA , CFD
,BCL2 , CD44 , ITPR3 , FCGR2A,PAK2 , LCK , ACTB , SYK ,HCK ,LYN ,VAV1 , CYFIP1,ATIC , CCR2 , CXCL1 , FCGR2B , CASP8 , LAMP2 , LPCAT1 , VCL ,TLR2 , ITGAV , TLR3 , CASP9 , HMGB1 , ANXA2 , TLR7 , CD63 ,KRT8 , CYBB , ALOX5 , ITGAM , PTPRC , PECAM1 , PPIA , HSP90AB1, ILF2 , ITGB2 , CAPN1 , CD59 , C3
,PYCARD , AGA ,CD3D ,PANX1 , CDA ,ADAM10 , STK10 , CMTM6 , SNAP25 , MYD88 , FCER1G , LILRB2 , CKAP4 , C3AR1 , CD36 , RAP2B , CD53 , CD47 , TNFRSF1B ,SELL , CTSK , BST2 , DDX58 , HLA-E , HLA-A , HLA-C , HLA-B ,PSMB8
, PSAP , FPR1 , CD14 , RAB27A , NLRP3 , XRCC5 , CLEC7A,TYROBP , NCF2 , LCP2 , C1QB , CTSS , LY86 , CSTB , CD209 ,SLPI , GZMB , EPO ,BIRC3 , ATG12 , CASP4 , CASP1 , CFLAR ,APAF1 , FGL2 , LY96 , BCL10 , CARD8 , DDOST , DOCK2 , PRKDC , GAB2 , MAP2K4 , QPCT , TXNIP , IKBKB , NFATC1 , LTF ,TNFAIP6, PSMB10 , CD247 , TLR1 , LCN2 , PSMB9 , NEU1 , LAT ,TNFAIP3,TRAF3 , CYLD , C7 ,IFI16 ,
GLIPR1 , CPNE1 , C1QA , C2 , C4BPA , FCGR3B , CLEC10A,MEF2C
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Cytokine Signaling in Immune system
|
116
|
TIMP1,HGF,VWF,EGF,B2M,VEGFA,FN1, BCL2, CD44, VCAM1,PAK2, LCK,ACTB, SYK, HCK,LYN, ITGB1,VAV1, CCL2, CCR2, CXCL8, CCL19,CCL5, CXCL1, ANXA1
,CCL20,CASP3,VCL, IRF1, SAMHD1, ICAM1,COL1A2, P4HB, HMGB1,ANXA2, STAT1, ALOX5,ITGAM,VIM,SQSTM1, MX1,PPIA, RPLP0, MYC,YWHAZ,ITGB3, IRF2, ITGB2,HLA-DQB2, HLA-DPA1,HLA-DPB1, HLA-DQB1, HLA-DRA,IL7R, SNAP25, MYD88, ADAM17, CD36, TNFRSF1B,IL18, BST2, HLA-F,IRF8,DDX58, GBP2,IFITM3, PSMB8,OAS1, IRF9, FPR1, EDA, JAK1,CD86, CSF2RB, MID1, GZMB, TNFSF10, BIRC3,IL7, CSF1R,IL15, CASP1,JAK2, TRIM5,TRIM22, IL10RA ,GAB2, MAP2K4, RET,IKBKB, SP100,TRIM38, PSMB10,
FCGR1B, GBP1, LCN2, PSMB9, LAT,TRAF3,IL11, TNFRSF11B, IL10RB, IFNGR1, MEF2C,IL33, EIF4G3, IL1R1,IL32, FNTA, TEK,INPP5D
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Adaptive Immune System
|
85
|
CTSD , HSPA5 , B2M ,ITPR3 , VCAM1 , PAK2 , LCK ,SYK , LYN ,ITGB1 , VAV1 , FCGR2B , COL1A1 , TLR2 , ITGAV , ICAM1 , COL1A2 , PDIA3 , CD28 , CYBB , PTEN
, PTPRC , PPIA , YWHAZ ,ITGB2 , HLA-DQB2,HLA-DPA1,HLA-DPB1,HLA-DMB, HLA-DMA,HLA-DQB1,HLA-DRA,C3 ,CD3D , MICB , SNAP25 , MYD88 , LILRB2 , CD36 , PRKCB ,SELL , COL3A1 , CTSK , HLA-F , , PSMB8 , GNB5 , FPR1 , CD14 , TYROBP , CD86 , NCF2 ,LCP2 , CTSS , CD209 ,TNFSF10,CD1D , LY96 , CD74 , SEC24D, SEC24C , SIGLEC1,BCL10 , SKP2 ,
CDC27 , IKBKB , NFATC1 , LILRA2 ,TAP1 , PSMB10 , CD247 , TLR1 , CD1C , FCGR1B , PSMB9 , LAT , TAPBP , MRC1 , IFNGR1 , KLRB1 , INPP5D,
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Neutrophil degranulation
|
78
|
CTSD , LYZ ,C1R ,B2M ,QSOX1 , RHOA , CFD ,CD44 , FCGR2A , CYFIP1 , ATIC , CXCL1 , LAMP2 , LPCAT1 , VCL ,TLR2 , ITGAV , HMGB1 , ANXA2 , CD63 , KRT8 , CYBB , ALOX5 , ITGAM ,PTPRC , PECAM1 , PPIA , HSP90AB1,ILF2 , ITGB2 , CAPN1
, CD59 ,C3 ,PYCARD , AGA ,CDA ,ADAM10 , STK10 , CMTM6 , SNAP25 ,FCER1G , LILRB2 , CKAP4 , C3AR1 , CD36 , RAP2B , CD53 , CD47 ,TNFRSF1B, SELL , BST2 , , PSAP , FPR1 ,CD14 , RAB27A , XRCC5 , TYROBP , CTSS , CSTB , SLPI , GZMB ,EPO , APAF1 , FGL2 , DDOST , DOCK2 , QPCT , LTF ,TNFAIP6, LCN2 , NEU1 , GLIPR1 , CPNE1 , C4BPA , FCGR3B
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Signaling by Interleukins
|
69
|
TIMP1 , HGF ,VEGFA , FN1 ,BCL2 , VCAM1 , PAK2 , LCK , SYK ,HCK ,LYN ,ITGB1 , VAV1 , CCL2 , CCR2 , CXCL8 ,CCL19 , CCL5 , CXCL1 , ANXA1 , CCL20 , CASP3 , ICAM1 , COL1A2, P4HB , HMGB1 , ANXA2 , STAT1 , ALOX5 , ITGAM , VIM , SQSTM1, PPIA , RPLP0 , MYC ,YWHAZ , ITGB2 , IL7R , SNAP25 , MYD88 ,CD36 , TNFRSF1B,IL18 , PSMB8 , FPR1 , JAK1 , CD86 , CSF2RB, GZMB , IL7 ,CSF1R , IL15 , CASP1 , JAK2 , IL10RA , GAB2 ,MAP2K4 , IKBKB , PSMB10 , LCN2 , PSMB9 ,IL11 ,
IL10RB , IFNGR1, MEF2C , IL33 , IL1R1 , IL32 , INPP5D,
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Extracellular matrix organization
|
60
|
A2M ,TIMP1 , SPARC , CTSD , MMP7 , THBS1 , VWF ,ACTN1 ,TGFB2 , FN1 ,CD44 , VCAM1 , ITGB1 , COMP , CASP3 , ITGB8 , COL1A1 , ITGAV , ICAM1 , ITGA2 , COL1A2 , P4HB , SPP1 , ITGAM ,PECAM1 , ITGB3 , ADAM12 , ITGB2 , CAPN1 , ADAM10 , LAMB1 , LAMC1 ,ADAMTS5,ADAMTS3,ADAM17 , TNC ,SDC2 , VCAN , MATN3 , CD47 , FBN1 , COL5A1 , MMD , DCN ,FMOD , BGN ,COL3A1 , LUM ,CTSK , BMP7 , CTSS , GZMB , CAST , SERPINH1,CAPN6 , LAMC2 ,IKBKB , NID1 , COL4A1,
LTBP3,
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Platelet activation, signaling and aggregation
|
52
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A2M ,TIMP1 , HGF ,SPARC , HRG ,SRGN , THBS1 , VWF ,KNG1 , EGF ,SERPING1, CLU , HSPA5 , TOR4A , QSOX1 , RHOA , TMSB4X , CFD ,ACTN1 , VEGFA , F5
,TGFB2 , FN1 ,ITPR3 ,LCK ,SYK ,LYN ,VAV1 , LAMP2 , VCL ,COL1A1 , ANXA5
,COL1A2 ,CD63 , PECAM1 , PPIA , YWHAZ , ITGB3 , PLEK , FCER1G, CALU , CD36 , PRKCB , GNB3 , GNB5 , ADRA2A , PSAP , GNB1 , PLA2G4A,LCP2 , LAT ,LGALS3BP
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