Background: Evaluation of the safety and efficacy of the Drain Fluid Cryo-Explant (DFCE) technique for management of uncomplicated superior bullous rhegmatogenous retinal detachment (RRD). Methods: A retrospective interventional case series study that included eyes with uncomplicated superior bullous RRD and a duration less than one month. The DFCE technique which involved sequential drainage of subretinal fluid (SRF), intravitreal fluid injection, cryotherapy and placement of a scleral explant(s). The primary outcome measure was the anatomical reposition of the retina after a single surgery. Secondary outcome measures included improvement in visual acuity and any reported complication related to the procedure. Results: The study included 52 eyes (52 patients) with a mean duration of retinal detachment 19.7±6.4 days. A single retinal break was found in 31 eyes (59.6%) and more than one break were found in 21 eyes (40.4%). The mean detached area per eye was 6.3±2.8 clock hours, and the macula was detached in 23 eyes (44.2%). The mean number of breaks per eye was 1.72±1.04. Flattening of the retina and closure of all retinal breaks were achieved in all eyes. Late recurrence of RD occurred in 2 eyes (3.9%) due to PVR. No retinal incarceration or retinal folding were reported. Conclusions: DFCE is an economic technique that could be effectively used for treatment of uncomplicated superior bullous RRD. It provides good visualization during surgery that allows accurate localization of all retinal breaks, proper placement of a relatively low buckle and precise application of cryotherapy to all margins of the retinal break(s).