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Research article
Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in Korea
Hyeon-Jong Yang
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Infectious Diseases.
Background: Community–acquired pneumonia (CAP) is one of the leading worldwide causes of childhood morbidity and mortality and its disease burden is affected by age and etiologies with time-dependent changes. We aimed to investigate the annual and seasonal patterns in etiologies of pediatric CAP requiring hospitalization. Methods: We conducted a retrospective study in 30,994 children (0-18 years old) with CAP between 2010 and 2015 at 23 nationwide hospitals in Korea. Mycoplasma pneumoniae (MP) pneumonia was clinically classified into macrolide-sensitive MP, macrolide-less effective MP (MLEP) and macrolide-refractory MP (MRMP) based on fever duration after initiation of macrolide treatment, regardless of the results of in vitro macrolide sensitivity tests.
Results: MP and respiratory syncytial virus (RSV) were the two most commonly identified pathogens of CAP. With the two epidemics of MP pneumonia (2011 and 2015), the rates of clinical MLEP and MRMP pneumonia showed increasing trends of 36.36% of the total MP pneumonia. In children less than 2 years of age, RSV (34.01%) was the most common cause of CAP, followed by MP (9.44%), whereas MP was the most common cause of CAP in children 2-18 years of age. Systemic corticosteroid was most commonly administered in MP pneumonia. The rate of hospitalization in intensive care unit was highest for RSV pneumonia, and ventilator care was most commonly needed in cases of adenovirus pneumonia.
Conclusions: The present study provides fundamental data for establishment of public health policies to decrease disease burden due to CAP as well as for improvement of pediatric health.
Keywords
Children, Pneumonia, Respiratory virus, Mycoplasma pneumoniae, Macrolide- refractory, Macrolide-sensitive, Macrolide less-effective
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On 12 Feb, 2020
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Editor assigned
On 08 Jan, 2020
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On 07 Jan, 2020
Editor invited
On 07 Jan, 2020
Version 1
Posted 06 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 18 Dec, 2019
Review #2 received
Received 08 Dec, 2019
Reviewer #2 agreed
On 26 Nov, 2019
Review #1 received
Received 23 Nov, 2019
Reviewer #1 agreed
On 17 Nov, 2019
Reviewers invited
Invitations sent on 11 Nov, 2019
Submission checks complete
On 31 Oct, 2019
Editor assigned
On 24 Oct, 2019
First submitted
On 23 Oct, 2019
Editor invited
On 23 Oct, 2019
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Subject Areas
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This preprint is under consideration at BMC Infectious Diseases. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in Korea
Hyeon-Jong Yang
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Published
On 12 Feb, 2020
No community comments so far
Editor assigned
On 08 Jan, 2020
Submission checks complete
On 07 Jan, 2020
Editor invited
On 07 Jan, 2020
Version 1
Posted 06 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 18 Dec, 2019
Review #2 received
Received 08 Dec, 2019
Reviewer #2 agreed
On 26 Nov, 2019
Review #1 received
Received 23 Nov, 2019
Reviewer #1 agreed
On 17 Nov, 2019
Reviewers invited
Invitations sent on 11 Nov, 2019
Submission checks complete
On 31 Oct, 2019
Editor assigned
On 24 Oct, 2019
First submitted
On 23 Oct, 2019
Editor invited
On 23 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Infectious Diseases.
Background: Community–acquired pneumonia (CAP) is one of the leading worldwide causes of childhood morbidity and mortality and its disease burden is affected by age and etiologies with time-dependent changes. We aimed to investigate the annual and seasonal patterns in etiologies of pediatric CAP requiring hospitalization. Methods: We conducted a retrospective study in 30,994 children (0-18 years old) with CAP between 2010 and 2015 at 23 nationwide hospitals in Korea. Mycoplasma pneumoniae (MP) pneumonia was clinically classified into macrolide-sensitive MP, macrolide-less effective MP (MLEP) and macrolide-refractory MP (MRMP) based on fever duration after initiation of macrolide treatment, regardless of the results of in vitro macrolide sensitivity tests.
Results: MP and respiratory syncytial virus (RSV) were the two most commonly identified pathogens of CAP. With the two epidemics of MP pneumonia (2011 and 2015), the rates of clinical MLEP and MRMP pneumonia showed increasing trends of 36.36% of the total MP pneumonia. In children less than 2 years of age, RSV (34.01%) was the most common cause of CAP, followed by MP (9.44%), whereas MP was the most common cause of CAP in children 2-18 years of age. Systemic corticosteroid was most commonly administered in MP pneumonia. The rate of hospitalization in intensive care unit was highest for RSV pneumonia, and ventilator care was most commonly needed in cases of adenovirus pneumonia.
Conclusions: The present study provides fundamental data for establishment of public health policies to decrease disease burden due to CAP as well as for improvement of pediatric health.
Figure 1
Figure 2
Figure 3