Ethics approval and consent to participate:
The study was conducted according to the principles expressed in the Declaration of
Helsinki and was approved by the local university (Duisburg-Essen) institutional review
board.
Consent for publication:
Written informed consent was obtained from the patient for publication of this Case
Report and any accompanying images and videos. A copy of the written consent is available
for review by the Editor of this journal.
Availability of data and materials:
The datasets analyzed during the current study are not publicly available due protection
of privacy of the patient.
Funding:
Competing interests:
Tim Sinnecker has received travel support from Roche and Actelion, and is employee
of the Medical Image Analysis Center in Basel, Switzerland.
Jeffrie Hadisurya has received travel funding from Novartis, Teva, Bayer and Biogen.
Tilman Schneider-Hohendorf has received research and travel support from Biogen and
Novartis.
Nicholas Schwab has received travel funding from Novartis, and Biogen.
Karsten Wrede reports no disclosures.
Oliver Gembruch reports no disclosures.
Ralf Gold received speaker’s and board honoraria from Baxter, Bayer Schering, Biogen
Idec, CLB Behring, Genzyme, Merck Serono, Novartis, Roche, Stendhal, Talecris, TEVA.
His department received grant support from Bayer Schering, BiogenIdec, Genzyme, Merck
Serono, Novartis, TEVA. He possesses stock options from Merck Serono and Roche.
Kerstin Hellwig reports grants and honoriaria from Biogen, Novartis, Roche, Bayer
Healthcare, Teva, Sanofi and Merck.
Sara Pilgram-Pastor reports no disclosures.
Ortwin Adams reports no disclosures.
Philipp Albrecht reports grants, personal fees and non-financial support from Allergan,
Biogen, Ipsen, Merz Pharmaceuticals, Novartis, and Roche, personal fees and non-financial
support from Bayer Healthcare, and Merck, and non-financial support from Sanofi-Aventis/Genzym
Hans-Peter Hartung has received fees for serving on steering commitees from Biogen
Idec, GeNeuro, Sanofi Genzyme, Merck, Novartis Pharmaceuticals, Octapharma, Opexa
Therapeutics, Teva Pharmaceuticals, MedImmune, Bayer HealthCare, Forward Pharma, and
Roche, fees for serving on advisory boards from Biogen Idec, Sanofi Genzyme, Merck,
Novartis Pharmaceuticals, Octapharma, Opexa Therapeutics, Teva Pharmaceuticals, and
Roche, and lecture fees from Biogen Idec, Sanofi Genzyme, Merck, Novartis Pharmaceuticals,
Octapharma, Opexa Therapeutics, Teva Pharmaceuticals, MedImmune, and Roche.
Orhan Aktas has received, with approval by the Heinrich Heine University, advisor
fees or honoraria from Almirall, Bayer HealthCare, Biogen, MedImmune, Merck, Novartis,
and Teva; research support from Bayer HealthCare, Biogen, Novartis, Roche, and Teva
Markus Kraemer has received, by approval by his hospital, honoria from Bayer Schering,
Biogen Idec, Merck Pharma Novartis Pharma, Teva Pharma, Roche Pharma und Shire Deutschland.
Author´ contributions:
TS performed data acquisition and analysis and drafted the manuscript.
JH performed data acquisition and analysis and drafted the manuscript.
TSH performed data acquisition and analysis and drafted the manuscript.
NS performed data acquisition and analysis and revised the manuscript.
KW performed data acquisition and analysis and revised the manuscript.
OG performed data acquisition and analysis and revised the manuscript.
RG revised the manuscript for intellectual content and helped with the interpretation
of the data.
KH revised the manuscript for intellectual content and helped with the interpretation
of the data.
SPP performed data acquisition and analysis and revised the manuscript.
OAd performed data acquisition and analysis and revised the manuscript.
PA revised the manuscript for intellectual content and helped with the interpretation
of the data.
HPH revised the manuscript for intellectual content and helped with the interpretation
of the data.
OAk revised the manuscript for intellectual content and helped with the interpretation
of the data.
MK conceived the study, performed data acquisition and analysis and drafted the manuscript.
All authors read and approved the manuscript.
Acknowledgments:
Authors´ information: