1. Wilhelm P, Youngkyu P, Kevin W, Natalya NP, David AT, et al (2015) The utilization of extracellular proteins as nutrients is suppressed by mTORC1. Cell; 162(2):259-270. https://doi.org/10.1016/j.cell.2015.06.017.
2. Shawn MD, Oliver J, Mark AK, Han WH, Alba L, et al (2017) Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat Med; 23(2):235-241. https://doi.org/10.1038/nm.4256.
3. Jayashankar V, Edinger AL (2020) Macropinocytosis confers resistance to therapies targeting cancer anabolism. Nat Commun; 11(1):1121. https://doi.org/10.1038/ s41467-020-14928-3.
4. Kong B, Wu W, Cheng T, Schlitter AM, Qian C, et al (2020) Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition. Cell Rep; 30(8):2729-2742. https://doi.org/10.1016/j.celrep.2020.01.080.
5. Cosimo C, Shawn MD, Rengin GS, Seth JP, Jurre JK, et al (2013) Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature; 497(7451): 633-7.https://doi.org/10.1038/nature12138.
6. Palm W, Araki J, King B, DeMatteo RG, Thompson CB (2017) Critical role for PI3-kinase in regulating the use of proteins as an amino acid source. Proc Natl Acad Sci; 114(41):E8628-E8636. https:// doi.org/10.1073/ pnas.1712726114.
7. Seong MK, Tricia TN, Archna R, Peter Ku, Brendan TF, et al (2018) PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells. Cancer Discov; 8(7):866-883. https:// doi.org/10.1158/2159-8290.CD-17-1215.
8. Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, et al (2016) Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nat Cell Biol; 18:1090-1101. https:// doi.org/10.1038/ncb3410.
9. Lee SW, Alas B, Commisso C (2014) Determining the macropinocytic index of cells through a quantitative image-based assay. Nat Protoc; 9(1):182-92. https:// doi.org/10.1038/nprot.2014.004.
10. Kong B, Wu W, Cheng T, Schlitter AM, Qian C, et al (2020) Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition. Cell Rep; 30(8):2729-2742.e4. https:// doi.org/10.1016/j.celrep.2020.01.080.
11. Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, et al (2020) Statin induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. PNAS; 117(8):4158-4168. https:// doi.org/10.1073/pnas.1917938117.
12. Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D (2019) Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis. Nature; 576(7787):477-481. https:// doi.org/10.1038/s41586-019-1831-x.
13.Yang L, Venneti S, Nagrath D (2017) Glutaminolysis: a hallmark of cancer metabolism. Annu Rev Biomed Eng;19:163-194. https://doi:10.1146/annurev-bioeng-071516-044546.
14. Takano T, Lin JH, Arcuino G, Gao Q, Yang J, et al (2001) Glutamate release promotes growth of malignant gliomas. Nat Med; 7(9):1010-5. https://doi.org/10.1038/mm0901-1010.
15. Ralph JD, Anthony M, Evgueni D, Ilana N, Marc Y, et al (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci; 104(49):19345-50. https://doi.org/10.1073/ pnas.0709747104.
16. Tran TQ, Lowman XH, Reid MA, Mendez-Dorantes C, Pan M et al (2017) Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction. Oncogene;36(14):1991-2001. https://doi.org/10.1038/ onc.2016.360.
17. Michael AR, Wen-I W, Kimberly RR, Meng XW, Min Pan, et al (2013) The B55alpha subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation. Mol Cell; 50(2):200-11. https://doi.org/10.1016/j.molcel.2013.02.008.
18.Saverio T, Anaïs O, Shafiq UA, Fred F, Olivier K, et al (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nat Cell Biol;17(12):1556-68. https://doi.org/10.1038/ncb3272.
19. Lee SW, Zhang Y, Jung M, Cruz N, Alas B, et al (2019) EGFR-Pak signaling selectively regulates glutamine deprivation induced macropinocytosis. Dev. Cell; 50(3):381-392.e5. https://doi.org/10.1016/ j.devcel.2019.05.043.
20. Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, et al (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res; 75(3):544-53. https://doi.org/10.1158/0008-5472.CAN-14-2211.
21. Margaux C, Cédric D, Rekin's J, Anne-Sophie L, Gwendoline R, et al (2019) Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). Cancers (Basel); 11(3):411. https://doi.org/10. 3390/cancers11030411.
22. Müller-Greven G, Carlin CR, Burgett ME, Ahluwalia MS, Lauko A, et al (2017) Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival. Clin Cancer Res; 23(22):7059-7071. https://doi.org/10.1158/1078-0432.CCR-17-0249.