[1] Hill P, Austin A, Forsyth J, et al. British Society of Gastroenterology guidelines on the diagnosis and management of coeliac disease[J]. Gut, 2015,64(4):691-692.
[2] Silberg D G, Sullivan J, Kang E, et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice[J]. Gastroenterology, 2002,122(3):689-696.
[3] Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018,68(6):394-424.
[4] Wang Quan, Han renqiang, Li Ying, et al. Epidemiological status and trend analysis of gastric cancer in Jiangsu Province in 2015 [J]. China cancer, 2019,28 (11): 838-844
[5] Correa P. A human model of gastric carcinogenesis[J]. Cancer Res, 1988,48(13):3554-3560.
[6] Wang Yibo, Huang Pingqing, Du Yuanyuan, et al. Analysis and thinking based on the first batch of classic prescriptions [J]. Chinese Journal of traditional Chinese medicine, 2019, 44 (11): 2191 - 2196.
[7] Li H, Zhao L, Zhang B, et al. A network pharmacology approach to determine active compounds and action mechanisms of ge-gen-qin-lian decoction for treatment of type 2 diabetes[J]. Evid Based Complement Alternat Med, 2014,2014:495840.
[8] Li S. [Network target: a starting point for traditional Chinese medicine network pharmacology][J]. Zhongguo Zhong Yao Za Zhi, 2011,36(15):2017-2020.
[9] Li S, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application[J]. Chin J Nat Med, 2013,11(2):110-120.
[10] Ru J, Li P, Wang J, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines[J]. J Cheminform, 2014,6:13.
[11] Xue R, Fang Z, Zhang M, et al. TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis[J]. Nucleic Acids Res, 2013,41(Database issue):D1089-D1095.
[12] Xu X, Zhang W, Huang C, et al. A novel chemometric method for the prediction of human oral bioavailability[J]. Int J Mol Sci, 2012,13(6):6964-6982.
[13] Tao W, Xu X, Wang X, et al. Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease[J]. J Ethnopharmacol, 2013,145(1):1-10.
[14] Wishart D S, Feunang Y D, Guo A C, et al. DrugBank 5.0: a major update to the DrugBank database for 2018[J]. Nucleic Acids Res, 2018,46(D1):D1074-D1082.
[15] Smoot M E, Ono K, Ruscheinski J, et al. Cytoscape 2.8: new features for data integration and network visualization[J]. Bioinformatics, 2011,27(3):431-432.
[16] Szklarczyk D, Morris J H, Cook H, et al. The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible[J]. Nucleic Acids Res, 2017,45(D1):D362-D368.
[17] Szklarczyk D, Gable A L, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets[J]. Nucleic Acids Res, 2019,47(D1):D607-D613.
[18] Su G, Morris J H, Demchak B, et al. Biological network exploration with Cytoscape 3[J]. Curr Protoc Bioinformatics, 2014,47:8-13.
[19] Trott O, Olson A J. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading[J]. J Comput Chem, 2010,31(2):455-461.
[20] Ahmad K M, Sarwar A, Rahat R, et al. Stigmasterol protects rats from collagen induced arthritis by inhibiting proinflammatory cytokines[J]. Int Immunopharmacol, 2020,85:106642.
[21] Hu Yaqin, Wang Jiajia, Wu Hao, et al. Berberine regulates ERK / NF- κ B signal pathway improves the abnormal proliferation of mesangial cells induced by high glucose [J]. Journal of Anhui Medical University, 2021 (05): 671-675
[22] Gao X, Zhang C, Wang Y, et al. Berberine and Cisplatin Exhibit Synergistic Anticancer Effects on Osteosarcoma MG-63 Cells by Inhibiting the MAPK Pathway[J]. Molecules, 2021,26(6).
[23] Zhi H J, Zhu H Y, Zhang Y Y, et al. In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus[J]. Phytomedicine, 2019,57:105-116.
[24] Welch A A, Shakya-Shrestha S, Lentjes M A, et al. Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of α-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort[J]. Am J Clin Nutr, 2010,92(5):1040-1051.
[25] Liu Weiliang, Ji Yu, Huang Aixiang β- Research and development progress of sitosterol [J]. Agricultural products processing, 2019 (01): 77-79
[26] Huang Ye, Liao Yang, Shen Yang Bing, et al. Quercetin enhances the apoptosis inducing activity of 5-fluorouracil on gastric cancer cells by inhibiting the expression level of c-jun [J]. Chinese Journal of pathophysiology, 2018,34 (02): 206-211
[27] Gengwei, Huiying, Li Lin, et al. The regulatory effect and mechanism of quercetin on the proliferation and invasion of gastric cancer cells [j]. Chinese Journal of Gerontology, 2018,38 (01): 34-36
[28] Shen X, Si Y, Wang Z, et al. Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling[J]. Int J Mol Med, 2016,38(2):619-626.
[29] Zhang cancan, Tan Zhijun, Xu Min, et al. Effects of quercetin combined with si-fscn1 on proliferation, invasion and apoptosis of gastric cancer MKN45 cells [J]. Chinese Journal of clinical pharmacology, 2020,36 (09): 1132-1135.
[30] Huang Zuliang, Wei Qihou, Tang Chunrong, Li Honglei. Study on analgesic and anti-inflammatory effects of hydroberberine [J]. Journal of Jiangxi University of traditional Chinese medicine, 2002 (01): 33-34.
[31] Khan N M, Ahmad I, Ansari M Y, et al. Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes[J]. Chem Biol Interact, 2017,274:13-23.
[32] Khan N M, Haseeb A, Ansari M Y, et al. Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes[J]. Free Radic Biol Med, 2017,106:288-301.
[33] Seong R K, Kim J A, Shin O S. Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways[J]. Acta Virol, 2018,62(1):78-85.
[34] Waltl I, Käufer C, Bröer S, et al. Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis[J]. Neurobiol Dis, 2018,110:192-205.
[35] Huang Y, Luo X, Li X, et al. Wogonin inhibits LPS-induced vascular permeability via suppressing MLCK/MLC pathway[J]. Vascul Pharmacol, 2015,72:43-52.
[36] Ku S K, Bae J S. Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation[J]. Fitoterapia, 2014,98:27-35.
[37] EghbaliFeriz S, Taleghani A, Tayarani-Najaran Z. Scutellaria: Debates on the anticancer property[J]. Biomed Pharmacother, 2018,105:1299-1310.
[38] Baek J S, Na Y G, Cho C W. Sustained Cytotoxicity of Wogonin on Breast Cancer Cells by Encapsulation in Solid Lipid Nanoparticles[J]. Nanomaterials (Basel), 2018,8(3).
[39] Xu Lin, Wang Ying, Chen Fuxing, et al. Effect of baicalein on human NK cells killing gastric cancer MKN45 cells and its mechanism [J]. Journal of immunology, 2014,30 (09): 804-808
[40] Wang Xiaohui, Wei Yingfang, Cheng Hong. Effects of wogonin on apoptosis, invasion, migration and Wnt of gastric cancer cell line SGC7901/ β- Study on the influence of catenin signaling pathway [J]. Traditional Chinese medicine, 2016,39 (06): 1372-1376
[41] Xiao W, Wu K, Yin M, et al. Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity[J]. J Immunother, 2015,38(5):167-184.
[42] Yu Z, Zhang C, Zhou M, et al. Mycobacterium tuberculosis PPE44 (Rv2770c) is involved in response to multiple stresses and promotes the macrophage expression of IL-12 p40 and IL-6 via the p38, ERK, and NF-κB signaling axis[J]. Int Immunopharmacol, 2017,50:319-329.
[43] Plotnikov A, Zehorai E, Procaccia S, et al. The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation[J]. Biochim Biophys Acta, 2011,1813(9):1619-1633.
[44] Liu Yu. Protective effect of Banxia Xiexin Decoction on gastric mucosa of HP infected mice and its effect on ERK signal transduction mechanism [D]. Hunan University of traditional Chinese medicine, 2015.
[45] Guo Chunxiu. Experimental study on the prevention and treatment of stress-induced gastric mucosal injury and anti apoptosis mechanism of Pinellia and Xinxin Decoction [D]. Hunan University of traditional Chinese medicine, 2014.