Lentinan Administration Alleviates Diarrhea of Rotavirus-Infected Weaned Pigs via Regulating Intestinal Immunity
Background
This study aimed to verify whether lentinan (LNT) administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs.
Methods
Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d (n = 14). RV infection was executed on d 15.
Results
Dietary LNT supplementation supported normal function of piglets even when infected with RV, as reflected by reduced growth performance loss and diarrhea prevalence, and maintained gut immunity (P < 0.05). The polysaccharide was isolated from LNT product, whose molecular weight was 5303 Da, and major monosaccharides included glucose, arabinose and galactose. In RV-infected IPEC-J2 cells, this polysaccharide significantly increased cell viability (P < 0.05), and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides (P < 0.05).
Conclusion
Those results suggest that LNT administration increases the piglets’ resistance to RV-induced stress, likely by supporting intestinal immunity.
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Posted 16 Dec, 2020
On 16 Dec, 2020
Received 13 Dec, 2020
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Posted 18 Sep, 2020
Received 15 Nov, 2020
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On 01 Nov, 2020
Received 15 Oct, 2020
On 02 Oct, 2020
Invitations sent on 17 Sep, 2020
On 16 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
Lentinan Administration Alleviates Diarrhea of Rotavirus-Infected Weaned Pigs via Regulating Intestinal Immunity
Posted 16 Dec, 2020
On 16 Dec, 2020
Received 13 Dec, 2020
Invitations sent on 12 Dec, 2020
On 12 Dec, 2020
On 09 Dec, 2020
On 09 Dec, 2020
On 09 Dec, 2020
Posted 18 Sep, 2020
Received 15 Nov, 2020
On 15 Nov, 2020
On 01 Nov, 2020
Received 15 Oct, 2020
On 02 Oct, 2020
Invitations sent on 17 Sep, 2020
On 16 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
Background
This study aimed to verify whether lentinan (LNT) administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs.
Methods
Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d (n = 14). RV infection was executed on d 15.
Results
Dietary LNT supplementation supported normal function of piglets even when infected with RV, as reflected by reduced growth performance loss and diarrhea prevalence, and maintained gut immunity (P < 0.05). The polysaccharide was isolated from LNT product, whose molecular weight was 5303 Da, and major monosaccharides included glucose, arabinose and galactose. In RV-infected IPEC-J2 cells, this polysaccharide significantly increased cell viability (P < 0.05), and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides (P < 0.05).
Conclusion
Those results suggest that LNT administration increases the piglets’ resistance to RV-induced stress, likely by supporting intestinal immunity.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6