[1] United Nations. World Population Ageing 2020: Highlights. Department of Economic and Social Affairs, Population Division. http://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/undesa_pd-2020_world_population_ageing_highlights.pdf. (2020).
[2] EUROSTAT; Population structure and ageing. Explained, Statistics 2020. https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Population_structure_and_ageing. (2020).
[3] Administration for Community Living. 2020 Profile of older americans. Preprint at: https://acl.gov/sites/default/files/Aging%20and%20Disability%20in%20America/2020ProfileOlderAmericans.Final_.pdf. (2020).
[4] Instituto Brasileiro de Geografia e Estatística. Projeções e estimativas da população do Brasil e das Unidades da Federação. Preprint at: https://www.ibge.gov.br/apps/populacao/projecao/index.html. (2020).
[5] McKee, A. et al. Obesity in the Elderly. Preprint at: https://pubmed.ncbi.nlm.nih.gov/30379513/. (2018).
[6] DiMilia. P.R., Mittman, A.C., Batsis, J.A. Benefit-to-Risk Balance of Weight Loss Interventions in Older Adults with Obesity. Curr. Diab. Rep. 19, 114 (2019). doi: 10.1007/s11892-019-1249-8.
[7] Batsis, J.A, Zagaria, A.B. Addressing Obesity in Aging Patients. Med. Clin. N. 102, 65-85 (2018) doi: 10.1016/j.mcna.2017.08.007.
[8] Lauby-Secretan, B., Scoccianti, C., Loomis, D., Grosse, Y., Bianchini, F., Straif, K. Body Fatness and Cancer — Viewpoint of the IARC Working Group. NEJM. 375, 794 – 798 (2016). doi:10.1056/NEJMsr1606602.
[9] Caleyachetty, R. et al. Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women. J Am Coll Cardiol. 70, 1429 - 1437 (2017). doi: 10.1016/j.jacc.2017.07.763.
[10] Silveira, E.A., Kliemann, N., Noll, M., Sarrafzadegan, N., Oliveira, C. Visceral obesity and incident cancer and cardiovascular disease: An integrative review of the epidemiological evidence. Obes Rev. 22, 1-17 (2021). doi: 10.1111/obr.13088.
[11] Cheng, X. et al. Population ageing and mortality during 1990–2017: A global decomposition analysis. PLoS Med. 17, 1-17 (2020). doi: 10.1371/journal.pmed.1003138.
[12] de Almeida Roediger, M. et al. Body Composition Changes and 10-Year Mortality Risk in Older Brazilian Adults: Analysis of Prospective Data from the SABE Study. J Nutr Health Aging. 23, 51-59 (2019). doi: 10.1007/s12603-018-1118-1.
[13] Puzianowska-Kuznicka, M. et al. Obesity Paradox in Caucasian Seniors: Results of the PolSenior Study. J Nutr Health Aging. 23, 796-804 (2019). doi: 10.1007/s12603-019-1257-z.
[14] da Silva Alexandre, T., Scholes, S., Ferreira Santos, J.L., de Oliveira Duarte, Y. A., de Oliveira, C. Dynapenic Abdominal Obesity Increases Mortality Risk Among English and Brazilian Older Adults: A 10-Year Follow-Up of the ELSA and SABE Studies. J Nutr Health Aging. 22, 138-144 (2018). doi: 10.1007/s12603-017-0966-4.
[15] Bowman, K. et al. Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants. Am. J. Clin. Nutr. 106, 130-135 (2017). doi: 10.3945/ajcn.116.147157.
[16] Cheng, F. W. et al. Body mass index and all-cause mortality among older adults. Obesity. 24, 2232 – 2239 (2016). doi:10.1002/oby.21612.
[17] Chooi, Y. C., Ding, C., Magkos, F. The epidemiology of obesity. Metabolism. 92, 6-10 (2019). doi: 10.1016/j.metabol.2018.09.005.
[18] Silveira, E. A., Pagotto, V., Barbosa, L.S., Oliveira, C., de, Pena, G.G., Velasquez-Melendez, G. Accuracy of BMI and waist circumference cut-off points to predict obesity in older adults. Cien Saude Colet 25, 1075 – 1082 (2020). doi: 10.1590/1413-81232020253.13762018.
[19] World Health Organization. Physical Status: The Use and Interpretation of Anthropometry. Preprint at: https://apps.who.int/iris/handle/10665/37003?locale-attribute=pt&. (1995).
[20] Adab, P., Pallan, M., Whincup, P.H. Is BMI the best measure of obesity? BMJ. 361, 1-2 (2018)
doi: 10.1136/bmj.k1274.
[21] Peralta, M., Ramos, M., Lipert, A., Martins, J., Marques, A. Prevalence and trends of overweight and obesity in older adults from 10 European countries from 2005 to 2013. Scand. J. Public Health. 46, 522 – 529 (2018). doi:10.1177/1403494818764810.
[22] Reinders, I., Visser, M., Schaap, L. Body weight and body composition in old age and their relationship with frailty. Curr. Opin. Clin. Nutr. & Metab. Care. 20, 11 – 15 (2017). doi: 10.1097/MCO.0000000000000332.
[23] Javed, A. A., Aljied, R., Allison, D.J., Anderson, L.N., Ma, J., Raina, P. Body mass index and all‐cause mortality in older adults: A scoping review of observational studies. Obes. Rev. 21, 1 – 12 (2020). doi:10.1111/obr.13035.
[24] Winter, J.E., MacInnis, R.J., Wattanapenpaiboon, N., Nowson, C.A. BMI and all-cause mortality in older adults: a meta-analysis. Am. J. Clin. Nutr. 99, 875 – 890 (2014). doi: 10.3945/ajcn.113.068122.
[25] Flegal, K.M., Kit, B.K., Orpana H., Graubard, B.I. Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories. JAMA. 309, 71 – 82 (2013). doi:10.1001/jama.2012.113905.
[26] Chapman, I.M. Body Composition and Aging. S. Karger AG. 37, 20-36. (2010). https://doi.org/10.1159/000319992.
[27] David, C.N., de Mello, R.B, Bruscato, N.M., Moriguchi, E.H. Overweight and abdominal obesity association with all-cause and cardiovascular mortality in the elderly aged 80 and over: A cohort study. J Nutr Health Aging. 21, 597 – 603 (2017). doi:10.1007/s12603-016-0812-0.
[28] Wu, C-Y., Chou, Y-C., Huang, N., Chou, Y-J., Hu, H-Y., Li, C-P. Association of Body Mass Index with All-Cause and Cardiovascular Disease Mortality in the Elderly. PLoS One. 9, 1 – 10 (2014) doi: 10.1371/journal.pone.0102589.
[29] Rodgers, J.L. et al. Cardiovascular Risks Associated with Gender and Aging. J Cardiovasc Dev Dis 6, 1 - 18 (2019). doi:10.3390/jcdd6020019.
[30] Dorner, T.E., Rieder, A. Obesity paradox in elderly patients with cardiovascular diseases. Int J Cardiol. 23, 56 – 65 (2012). doi:10.1016/j.ijcard.2011.01.076.
[31] Elagizi, A. et al. An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases. Prog Cardiovasc Dis. 61, 142 – 150 (2018). doi: 10.1016/j.pcad.2018.07.003.
[32] Cifu, G., Arem, H. Adherence to lifestyle-related cancer prevention guidelines and breast cancer incidence and mortality. Ann. Epidemiol. 28, 767 – 773 (2018). doi:10.1016/j.annepidem.2018.09.002.
[33] Shaukat, A., Dostal, A., Menk, J., Church, T.R. BMI Is a Risk Factor for Colorectal Cancer Mortality. Dig. Dis. Sci.. 62, 2511 – 2517 (2017). doi:10.1007/s10620-017-4682-z.
[34] Freisling, H. et al. Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe. Br. J. Cancer. 116, 1486 - 1497 (2017). doi: 10.1038/bjc.2017.106.
[35] Calle, E.E., Rodriguez, C., Walker-Thurmond, K., Thun, M.J. Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults. NEJM. 348, 1625 – 1638 (2003). doi:10.1056/NEJMoa021423
[36] Taghizadeh, N. et al. BMI and lifetime changes in BMI and cancer mortality risk. PLoS One. 10, 1 – 16 (2015). doi:10.1371/journal.pone.0125261
[37] Lee, D.H., Giovannucci, E.L. The Obesity Paradox in Cancer: Epidemiologic Insights and Perspectives. Curr. Nutr. Rep. 8, 175 – 181 (2019) doi:10.1007/s13668-019-00280-6.
[38] Shachar, S.S., Williams, G.R. The Obesity Paradox in Cancer—Moving Beyond BMI. Cancer Epidemiol Biomarkers Prev. 26, 13 – 16 (2017). doi:10.1158/1055-9965.
[39] Lennon, H., Sperrin, M., Badrick, E., Renehan, A.G. The Obesity Paradox in Cancer: a Review. Curr. Oncol. Rep. 18, 1 – 8 (2016). doi:10.1007/s11912-016-0539-4.
[40] Myint, P.K., Kwok, C.S., Luben, R.N., Wareham, N.J., Khaw, K-T. Body fat percentage, body mass index and waist-to-hip ratio as predictors of mortality and cardiovascular disease. Heart. 100, 1613 – 1619 (2014). doi:10.1136/heartjnl-2014-305816.
[41] Lee, D.H. et al. Predicted lean body mass, fat mass, and all cause and cause specific mortality in men: prospective US cohort study. BMJ. 362, 1 - 10 (2018). doi:10.1136/bmj.k2575.
[42] Wang, S., Ren, J. Obesity Paradox in Aging: From Prevalence to Pathophysiology. Prog. Cardiovasc. Dis.. 61, 182 – 189 (2018). doi:10.1016/j.pcad.2018.07.011.4
[43] Silveira, E. A., Dalastra, L., Pagotto. V. Polypharmacy, chronic diseases and nutritional markers in community-dwelling older. Rev. bras. epidemiol. 17, 818 – 829 (2014). doi: 10.1590/1809-4503201400040002.
[44] Pagotto, V., Silveira, E.A., Velasco, W.D. The profile of hospitalizations and associated factors among elderly users of the Brazilian Unified Health System. 18, 3061 – 3069. Cien Saude Colet (2013). doi: 10.1590/S1413-81232013001000031.
[45] Pagotto, V., Nakatani, A.Y.K., Silveira, E.A. Factors associated with poor self-rated health in elderly users of the Brazilian Unified National Health System. Cad. Saúde Pública. 27, 1593 – 1602 (2011). doi:10.1590/S0102-311X2011000800014.
[46] Pagotto, V., Santos, K.F. dos, Malaquias, S.G., Bachion, M.M., Silveira, E.A. Calf circumference: clinical validation for evaluation of muscle mass in the elderly. Rev. Bras. Enferm. 71, 322 - 328 (2018). doi: 10.1590/0034-7167-2017-0121.
[47] Silveira, E.A., Vieira, L.L., Souza, J.D. de. High prevalence of abdominal obesity among the elderly and its association with diabetes, hypertension and respiratory diseases. Cien Saude Colet. 23, 903 – 912 (2018). doi: 10.1590/1413-81232018233.01612016.
[48] Associação Brasileira de Empresas de Pesquisas. Critério de Classificação Econômica Brasil. https://www.abep.org/criterio-brasil. (2008).
[49] MINISTÉRIO DA SAÚDE. INSTITUTO NACIONAL DE CÂNCER. Abordagem e tratamento do fumante – consenso. https://www.inca.gov.br/publicacoes/livros/abordagem-e-tratamento-do-fumante-consenso. (2001).
[50] American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. Diabetes Care. 41, S13-S27(2018). doi: 10.2337/dc18-S002.
[51] Drozda, Jr. J. et al. ACCF/AHA/AMA–PCPI 2011 Performance Measures for Adults With Coronary Artery Disease and Hypertension. Circulation. 124, 248 – 270 (2011). doi: 10.1161/CIR.0b013e31821d9ef2
[52] National Cholesterol Education Program Expert Panel on Detection, Evaluation and T of HBC in A Adult TPI. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 106, 3143 – 3421 (2002). doi: 10.1161/CIR.0b013e31821d9ef2.
[53] LIPSCHITZ, D.A. Screening for nutritional status in the elderly. Prim. Care. 21, 55-67 (1994).Silveira, E. A., Dalastra, L., Pagotto. V. Polypharmacy, chronic diseases and nutritional markers in community-dwelling older. Rev. bras. epidemiol. 17, 818 – 829 (2014). doi: 10.1590/1809-4503201400040002.
[54] Pagotto, V., Silveira, E.A., Velasco, W.D. The profile of hospitalizations and associated factors among elderly users of the Brazilian Unified Health System. 18, 3061 – 3069. Cien Saude Colet (2013). doi: 10.1590/S1413-81232013001000031.
[55] Pagotto, V., Nakatani, A.Y.K., Silveira, E.A. Factors associated with poor self-rated health in elderly users of the Brazilian Unified National Health System. Cad. Saúde Pública. 27, 1593 – 1602 (2011). doi:10.1590/S0102-311X2011000800014.
[56] Pagotto, V., Santos, K.F. dos, Malaquias, S.G., Bachion, M.M., Silveira, E.A. Calf circumference: clinical validation for evaluation of muscle mass in the elderly. Rev. Bras. Enferm. 71, 322 - 328 (2018). doi: 10.1590/0034-7167-2017-0121.
[57] Silveira, E.A., Vieira, L.L., Souza, J.D. de. High prevalence of abdominal obesity among the elderly and its association with diabetes, hypertension and respiratory diseases. Cien Saude Colet. 23, 903 – 912 (2018). doi: 10.1590/1413-81232018233.01612016.
[58] Associação Brasileira de Empresas de Pesquisas. Critério de Classificação Econômica Brasil. https://www.abep.org/criterio-brasil. (2008).
[59] MINISTÉRIO DA SAÚDE. INSTITUTO NACIONAL DE CÂNCER. Abordagem e tratamento do fumante – consenso. https://www.inca.gov.br/publicacoes/livros/abordagem-e-tratamento-do-fumante-consenso. (2001).
[60] American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. Diabetes Care. 41, S13-S27(2018). doi: 10.2337/dc18-S002.
[61] Drozda, Jr. J. et al. ACCF/AHA/AMA–PCPI 2011 Performance Measures for Adults With Coronary Artery Disease and Hypertension. Circulation. 124, 248 – 270 (2011). doi: 10.1161/CIR.0b013e31821d9ef2.
[62] National Cholesterol Education Program Expert Panel on Detection, Evaluation and T of HBC in A Adult TPI. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 106, 3143 – 3421 (2002). doi: 10.1161/CIR.0b013e31821d9ef2.
[63] LIPSCHITZ, D.A. Screening for nutritional status in the elderly. Prim. Care. 21, 55-67 (1994).
[64] Peralta, M., Ramos, M., Lipert, A., Martins, J., Marques, A. Prevalence and trends of overweight and obesity in older adults from 10 European countries from 2005 to 2013. Scand. J. Public Health. 46, 522 – 529 (2018). doi:10.1177/1403494818764810.
[65] Reinders, I., Visser, M., Schaap, L. Body weight and body composition in old age and their relationship with frailty. Curr. Opin. Clin. Nutr. & Metab. Care. 20, 11 – 15 (2017). doi: 10.1097/MCO.0000000000000332.
[66] Javed, A. A., Aljied, R., Allison, D.J., Anderson, L.N., Ma, J., Raina, P. Body mass index and all‐cause mortality in older adults: A scoping review of observational studies. Obes. Rev. 21, 1 – 12 (2020). doi:10.1111/obr.13035.
[67] Winter, J.E., MacInnis, R.J., Wattanapenpaiboon, N., Nowson, C.A. BMI and all-cause mortality in older adults: a meta-analysis. Am. J. Clin. Nutr. 99, 875 – 890 (2014). doi: 10.3945/ajcn.113.068122.
[68] Flegal, K.M., Kit, B.K., Orpana H., Graubard, B.I. Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories. JAMA. 309, 71 – 82 (2013). doi:10.1001/jama.2012.113905.
[69] Chapman, I.M. Body Composition and Aging. S. Karger AG. 37, 20-36. (2010). https://doi.org/10.1159/000319992.
[70] David, C.N., de Mello, R.B, Bruscato, N.M., Moriguchi, E.H. Overweight and abdominal obesity association with all-cause and cardiovascular mortality in the elderly aged 80 and over: A cohort study. J Nutr Health Aging. 21, 597 – 603 (2017). doi:10.1007/s12603-016-0812-0.
[71] Wu, C-Y., Chou, Y-C., Huang, N., Chou, Y-J., Hu, H-Y., Li, C-P. Association of Body Mass Index with All-Cause and Cardiovascular Disease Mortality in the Elderly. PLoS One. 9, 1 – 10 (2014) doi: 10.1371/journal.pone.0102589.
[72] Rodgers, J.L. et al. Cardiovascular Risks Associated with Gender and Aging. J Cardiovasc Dev Dis 6, 1 - 18 (2019). doi:10.3390/jcdd6020019.
[73] Dorner, T.E., Rieder, A. Obesity paradox in elderly patients with cardiovascular diseases. Int J Cardiol. 23, 56 – 65 (2012). doi:10.1016/j.ijcard.2011.01.076.
[74] Elagizi, A. et al. An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases. Prog Cardiovasc Dis. 61, 142 – 150 (2018). doi: 10.1016/j.pcad.2018.07.003.
[75] Cifu, G., Arem, H. Adherence to lifestyle-related cancer prevention guidelines and breast cancer incidence and mortality. Ann. Epidemiol. 28, 767 – 773 (2018). doi:10.1016/j.annepidem.2018.09.002.
[76] Shaukat, A., Dostal, A., Menk, J., Church, T.R. BMI Is a Risk Factor for Colorectal Cancer Mortality. Dig. Dis. Sci.. 62, 2511 – 2517 (2017). doi:10.1007/s10620-017-4682-z.
[77] Freisling, H. et al. Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe. Br. J. Cancer. 116, 1486 - 1497 (2017). doi: 10.1038/bjc.2017.106.
[78] Lee, D.H., Giovannucci, E.L. The Obesity Paradox in Cancer: Epidemiologic Insights and Perspectives. Curr. Nutr. Rep. 8, 175 – 181 (2019) doi:10.1007/s13668-019-00280-6.
[79] Shachar, S.S., Williams, G.R. The Obesity Paradox in Cancer—Moving Beyond BMI. Cancer Epidemiol Biomarkers Prev. 26, 13 – 16 (2017). doi:10.1158/1055-9965.
[80] Lennon, H., Sperrin, M., Badrick, E., Renehan, A.G. The Obesity Paradox in Cancer: a Review. Curr. Oncol. Rep. 18, 1 – 8 (2016). doi:10.1007/s11912-016-0539-4.
[81] Myint, P.K., Kwok, C.S., Luben, R.N., Wareham, N.J., Khaw, K-T. Body fat percentage, body mass index and waist-to-hip ratio as predictors of mortality and cardiovascular disease. Heart. 100, 1613 – 1619 (2014). doi:10.1136/heartjnl-2014-305816.
[82] Lee, D.H. et al. Predicted lean body mass, fat mass, and all cause and cause specific mortality in men: prospective US cohort study. BMJ. 362, 1 - 10 (2018). doi:10.1136/bmj.k2575.
[83] Wang, S., Ren, J. Obesity Paradox in Aging: From Prevalence to Pathophysiology. Prog. Cardiovasc. Dis.. 61, 182 – 189 (2018). doi:10.1016/j.pcad.2018.07.011.4
[84] Calle, E.E., Rodriguez, C., Walker-Thurmond, K., Thun, M.J. Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults. NEJM. 348, 1625 – 1638 (2003). doi:10.1056/NEJMoa021423
[85] Taghizadeh, N. et al. BMI and lifetime changes in BMI and cancer mortality risk. PLoS One. 10, 1 – 16 (2015). doi:10.1371/journal.pone.0125261