Malapposition of Graft-host Interface after Keratoplasty: an Optical Coherence Tomography Study
Background: Previous studies of internal graft-host malappositions have not dealt with the precise ways in which each wound malapposition affected post-keratoplasty visual outcomes. In this study, reviewing our postsurgical keratoconic patients using anterior segment optical coherence tomography (AS-OCT) to evaluate the correlation between characteristics of the graft-host interface (GHI) and visual outcomes was aimed.
Methods: Correlations between characteristics of GHI and the postsurgical visual outcomes, including logarithm of minimum angle of resolution best-corrected visual acuity (logMAR BCVA), spherical equivalent diopter (SE), diopter of spherical power (DS), diopter of cylindrical power (DC), and keratometric astigmatism, were evaluated of 45 eyes (patients).
Results: The graft-host touch (GHT) varied with different alignment patterns. LogMAR BCVA correlated positively with GHT (r=0.32, P=0.030) and junctional graft thickness (Tg) (r=0.49, P=0.001). SE had positive correlation with frequency of step [F (step)] (r=0.46, P=0.001), graft step [F (graft step)] (r=0.40, P=0.028), total prevalence of malapposition proportion (Pm) (r=0.35, P=0.018), size of malapposition (Sm) (r=0.31, P=0.037), Tg (r=0.03, P=0.022), disparity between junctional graft and host thickness (|Tg-Th|) (r=0.40, P=0.007), and correlated negatively with GHT (r=-0.34, P=0.021). Similar results were acquired in DS. Keratometric astigmatism was found to correlate positively with Sm (r=0.30, P=0.047).
Conclusion: In keratoconic eyes, corneal keratometric astigmatism increased by 0.017 with Sm. LogMAR BCVA increased by 0.001 with both GHT and Tg. Investigation of the visions for keratoconus patients. Our study might have potential reference value for future technological promotion.
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On 31 Jan, 2020
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Received 10 Oct, 2019
On 08 Oct, 2019
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On 07 Oct, 2019
Posted 12 Dec, 2018
On 29 Aug, 2019
Received 06 Aug, 2019
On 31 Jul, 2019
Received 20 Jul, 2019
On 24 Apr, 2019
Received 28 Mar, 2019
On 07 Mar, 2019
Invitations sent on 16 Jan, 2019
On 07 Jan, 2019
On 10 Dec, 2018
On 10 Dec, 2018
Malapposition of Graft-host Interface after Keratoplasty: an Optical Coherence Tomography Study
On 31 Jan, 2020
On 04 Jan, 2020
On 03 Jan, 2020
On 19 Dec, 2019
On 16 Dec, 2019
On 15 Dec, 2019
On 15 Dec, 2019
On 15 Nov, 2019
Received 16 Oct, 2019
On 10 Oct, 2019
On 10 Oct, 2019
Invitations sent on 10 Oct, 2019
Received 10 Oct, 2019
On 08 Oct, 2019
On 07 Oct, 2019
On 07 Oct, 2019
Posted 12 Dec, 2018
On 29 Aug, 2019
Received 06 Aug, 2019
On 31 Jul, 2019
Received 20 Jul, 2019
On 24 Apr, 2019
Received 28 Mar, 2019
On 07 Mar, 2019
Invitations sent on 16 Jan, 2019
On 07 Jan, 2019
On 10 Dec, 2018
On 10 Dec, 2018
Background: Previous studies of internal graft-host malappositions have not dealt with the precise ways in which each wound malapposition affected post-keratoplasty visual outcomes. In this study, reviewing our postsurgical keratoconic patients using anterior segment optical coherence tomography (AS-OCT) to evaluate the correlation between characteristics of the graft-host interface (GHI) and visual outcomes was aimed.
Methods: Correlations between characteristics of GHI and the postsurgical visual outcomes, including logarithm of minimum angle of resolution best-corrected visual acuity (logMAR BCVA), spherical equivalent diopter (SE), diopter of spherical power (DS), diopter of cylindrical power (DC), and keratometric astigmatism, were evaluated of 45 eyes (patients).
Results: The graft-host touch (GHT) varied with different alignment patterns. LogMAR BCVA correlated positively with GHT (r=0.32, P=0.030) and junctional graft thickness (Tg) (r=0.49, P=0.001). SE had positive correlation with frequency of step [F (step)] (r=0.46, P=0.001), graft step [F (graft step)] (r=0.40, P=0.028), total prevalence of malapposition proportion (Pm) (r=0.35, P=0.018), size of malapposition (Sm) (r=0.31, P=0.037), Tg (r=0.03, P=0.022), disparity between junctional graft and host thickness (|Tg-Th|) (r=0.40, P=0.007), and correlated negatively with GHT (r=-0.34, P=0.021). Similar results were acquired in DS. Keratometric astigmatism was found to correlate positively with Sm (r=0.30, P=0.047).
Conclusion: In keratoconic eyes, corneal keratometric astigmatism increased by 0.017 with Sm. LogMAR BCVA increased by 0.001 with both GHT and Tg. Investigation of the visions for keratoconus patients. Our study might have potential reference value for future technological promotion.
Figure 1
Figure 2
Figure 3