See the published version of this preprint at Translational Medicine Communications.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Lorenzo Viola
Ospedale Maurizio Bufalini
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8959-8357
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background.
This study was conceived to provide systematic data about lung mechanics during early phases of CoVID-19 pneumonia, as long as to explore its variations during prone positioning.
Methods.
We enrolled four patients hospitalized in the Intensive Care Unit of “M. Bufalini” hospital, Cesena (Italy); after the positioning of an esophageal balloon, we measured mechanical power, respiratory system and transpulmonary parameters and arterial blood gases every 6 hours, just before decubitus change and 1 hour after prono-supination.
Results.
Both respiratory system and transpulmonary compliance and driving pressure confirmed the pseudo-normal respiratory mechanics of early CoVID-19 pneumonia (respectively, CRS 40.8 ml/cmH2O and DPRS 9.7 cmH2O; CL 53.1 ml/cmH2O and DPL 7.9 cmH2O). Interestingly, prone positioning involved a worsening in respiratory mechanical properties (CRS,SUP 56.3 ml/cmH2O and CRS,PR 41.5 ml/cmH2O – P 0.37; CL,SUP 80.8 ml/cmH2O and CL,PR 53.2 ml/cmH2O – P 0.23).
Conclusions.
Despite the severe ARDS pattern, respiratory system and lung mechanical properties during CoVID-19 pneumonia are pseudo-normal and tend to worsen during pronation.
Trial registration.
Restrospectively registered.
Keywords
CoVID-19 pneumonia, transpulmonary pressure, prone positioning, mechanical power
Figure 1
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CURRENT STATUS: Published
View the published article at Translational Medicine Communications.
Version 1
Posted 18 Sep, 2020
No community comments so far
Editorial decision: Minor revision
On 21 Oct, 2020
Review #1 received
Received 20 Oct, 2020
Review #2 received
Received 18 Oct, 2020
Review #3 received
Received 25 Sep, 2020
Reviewer #3 agreed
On 24 Sep, 2020
Reviewer #2 agreed
On 21 Sep, 2020
Reviewer #1 agreed
On 20 Sep, 2020
Reviewers invited
Invitations sent on 20 Sep, 2020
Editor assigned
On 16 Sep, 2020
First submitted
On 15 Sep, 2020
Submission checks complete
On 15 Sep, 2020
Editor invited
On 15 Sep, 2020
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Subject Areas
Translational Medicine
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See the published version of this preprint at Translational Medicine Communications.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Lorenzo Viola
Ospedale Maurizio Bufalini
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8959-8357
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Translational Medicine Communications.
Version 1
Posted 18 Sep, 2020
No community comments so far
Editorial decision: Minor revision
On 21 Oct, 2020
Review #1 received
Received 20 Oct, 2020
Review #2 received
Received 18 Oct, 2020
Review #3 received
Received 25 Sep, 2020
Reviewer #3 agreed
On 24 Sep, 2020
Reviewer #2 agreed
On 21 Sep, 2020
Reviewer #1 agreed
On 20 Sep, 2020
Reviewers invited
Invitations sent on 20 Sep, 2020
Editor assigned
On 16 Sep, 2020
First submitted
On 15 Sep, 2020
Submission checks complete
On 15 Sep, 2020
Editor invited
On 15 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Translational Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Translational Medicine Communications.
Background.
This study was conceived to provide systematic data about lung mechanics during early phases of CoVID-19 pneumonia, as long as to explore its variations during prone positioning.
Methods.
We enrolled four patients hospitalized in the Intensive Care Unit of “M. Bufalini” hospital, Cesena (Italy); after the positioning of an esophageal balloon, we measured mechanical power, respiratory system and transpulmonary parameters and arterial blood gases every 6 hours, just before decubitus change and 1 hour after prono-supination.
Results.
Both respiratory system and transpulmonary compliance and driving pressure confirmed the pseudo-normal respiratory mechanics of early CoVID-19 pneumonia (respectively, CRS 40.8 ml/cmH2O and DPRS 9.7 cmH2O; CL 53.1 ml/cmH2O and DPL 7.9 cmH2O). Interestingly, prone positioning involved a worsening in respiratory mechanical properties (CRS,SUP 56.3 ml/cmH2O and CRS,PR 41.5 ml/cmH2O – P 0.37; CL,SUP 80.8 ml/cmH2O and CL,PR 53.2 ml/cmH2O – P 0.23).
Conclusions.
Despite the severe ARDS pattern, respiratory system and lung mechanical properties during CoVID-19 pneumonia are pseudo-normal and tend to worsen during pronation.
Trial registration.
Restrospectively registered.
Figure 1
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