Lung Mechanics in Type L CoVID-19 Pneumonia: A Pseudo-Normal ARDS.
This study was conceived to provide systematic data about lung mechanics during early phases of CoVID-19 pneumonia, as long as to explore its variations during prone positioning.
We enrolled four patients hospitalized in the Intensive Care Unit of “M. Bufalini” hospital, Cesena (Italy); after the positioning of an esophageal balloon, we measured mechanical power, respiratory system and transpulmonary parameters and arterial blood gases every 6 hours, just before decubitus change and 1 hour after prono-supination.
Both respiratory system and transpulmonary compliance and driving pressure confirmed the pseudo-normal respiratory mechanics of early CoVID-19 pneumonia (respectively, CRS 40.8 ml/cmH2O and DPRS 9.7 cmH2O; CL 53.1 ml/cmH2O and DPL 7.9 cmH2O). Interestingly, prone positioning involved a worsening in respiratory mechanical properties (CRS,SUP 56.3 ml/cmH2O and CRS,PR 41.5 ml/cmH2O – P 0.37; CL,SUP 80.8 ml/cmH2O and CL,PR 53.2 ml/cmH2O – P 0.23).
Despite the severe ARDS pattern, respiratory system and lung mechanical properties during CoVID-19 pneumonia are pseudo-normal and tend to worsen during pronation.
Restrospectively registered.
Figure 1
Posted 18 Sep, 2020
On 21 Dec, 2020
On 21 Oct, 2020
Received 20 Oct, 2020
Received 18 Oct, 2020
Received 25 Sep, 2020
On 24 Sep, 2020
On 21 Sep, 2020
On 20 Sep, 2020
Invitations sent on 20 Sep, 2020
On 16 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
Lung Mechanics in Type L CoVID-19 Pneumonia: A Pseudo-Normal ARDS.
Posted 18 Sep, 2020
On 21 Dec, 2020
On 21 Oct, 2020
Received 20 Oct, 2020
Received 18 Oct, 2020
Received 25 Sep, 2020
On 24 Sep, 2020
On 21 Sep, 2020
On 20 Sep, 2020
Invitations sent on 20 Sep, 2020
On 16 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
This study was conceived to provide systematic data about lung mechanics during early phases of CoVID-19 pneumonia, as long as to explore its variations during prone positioning.
We enrolled four patients hospitalized in the Intensive Care Unit of “M. Bufalini” hospital, Cesena (Italy); after the positioning of an esophageal balloon, we measured mechanical power, respiratory system and transpulmonary parameters and arterial blood gases every 6 hours, just before decubitus change and 1 hour after prono-supination.
Both respiratory system and transpulmonary compliance and driving pressure confirmed the pseudo-normal respiratory mechanics of early CoVID-19 pneumonia (respectively, CRS 40.8 ml/cmH2O and DPRS 9.7 cmH2O; CL 53.1 ml/cmH2O and DPL 7.9 cmH2O). Interestingly, prone positioning involved a worsening in respiratory mechanical properties (CRS,SUP 56.3 ml/cmH2O and CRS,PR 41.5 ml/cmH2O – P 0.37; CL,SUP 80.8 ml/cmH2O and CL,PR 53.2 ml/cmH2O – P 0.23).
Despite the severe ARDS pattern, respiratory system and lung mechanical properties during CoVID-19 pneumonia are pseudo-normal and tend to worsen during pronation.
Restrospectively registered.
Figure 1