Table 1 The significantly changed protein in hypothalamus of pigs under HS
|
|
Protein name
|
Accession number
|
Ratio
(Heat stress/Control)
|
Peptides
|
Functions
|
|
|
Down-regulated in Hypothalamus
|
|
Similar to V-type proton ATPase subunit F-like
|
gi|311275455
|
0.643
|
4
|
hydrogen ion transporting ATP synthase activity
|
|
Similar to microtubule-associated protein tau-like
|
gi|350590233
|
0.152
|
11
|
microtubule binding
|
|
Similar to neurofilament heavy polypeptide
|
gi|311270880
|
0.493
|
9
|
-
|
|
Similar to dynamin-1 isoform 1
|
gi|194033645
|
0.333
|
8
|
phospholipid binding
|
|
Similar to cytoplasmic dynein 1 heavy chain 1
|
gi|350587231
|
0.425
|
12
|
protein binding and microtubule motor activity
|
|
Similar to microtubule-associated protein 6
|
gi|350588280
|
0.27
|
11
|
-
|
|
Similar to annexin A6-like
|
gi|335304211
|
0.611
|
3
|
calcium ion binding
|
|
Similar to clathrin coat assembly protein AP180
|
gi|350578374|ref|XP_003121434.3|
|
0.21
|
5
|
binding
|
|
Similar to ankyrin-2
|
gi|350587861
|
0.543
|
15
|
spectrin binding
|
|
Similar to dihydropyrimidinase- related protein 1
|
gi|350587318
|
0.135
|
9
|
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
|
|
Similar to alpha-centractin
|
gi|194041937
|
0.52
|
5
|
ATP binding
|
|
Similar to beta-adducin isoform 1
|
gi|335285320
|
0.381
|
8
|
calmodulin binding
|
|
Muscle glycogen phosphorylase
|
gi|106073338
|
0.329
|
4
|
glycogen phosphorylase activity
|
|
RAB10, member RAS oncogene family
|
gi|340007402
|
0.455
|
3
|
GTP binding
|
|
Similar to tubulin beta-2C chain-like
|
gi|335281298
|
0.331
|
18
|
GTP binding and MHC class I protein binding
|
|
AP-2 complex subunit beta
|
gi|342187276
|
0.444
|
9
|
protein transporter activity
|
|
Similar to prefoldin subunit 5-like isoform 1
|
gi|335287837
|
0.492
|
2
|
transcription corepressor activity
|
|
Similar to septin-7-like isoform 1
|
gi|311275636
|
0.368
|
5
|
protein binding and structural molecule activity
|
|
Glia maturation factor beta
|
gi|346986485
|
0.401
|
2
|
protein kinase inhibitor activity
|
|
Similar to platelet-activating factor acetylhydrolase IB subunit beta-like
|
gi|311263970
|
0.509
|
2
|
1-alkyl-2-acetylglycerophosphocholine esterase activity
|
|
Similar to creatine kinase U-type, mitochondrial-like isoform 1
|
gi|311244870
|
0.284
|
9
|
creatine kinase activity
|
|
paralemmin-1
|
gi|84042928
|
0.356
|
7
|
D3 dopamine receptor binding
|
|
Similar to dihydropyrimidinase- related protein 3-like
|
gi|335283727
|
0.442
|
1
|
chondroitin sulfate binding
|
|
Extracellular signal-regulated kinase-2
|
gi|310789265
|
0.291
|
3
|
RNA polymerase II carboxy-terminal domain kinase activity
|
|
Proteolipid protein
|
gi|5679718
|
0.085
|
6
|
structural constituent of myelin sheath
|
|
Acylphosphatase
|
gi|353524
|
0.398
|
2
|
acylphosphatase activity
|
|
RTN4-Aw
|
gi|38488990
|
0.266
|
4
|
-
|
|
Heat shock 70 kDa protein 12A
|
gi|350593095
|
0.439
|
7
|
ATP binding
|
|
Peptidyl-prolyl cis-trans isomerase D
|
gi|346986322
|
0.559
|
3
|
peptide binding and heat shock protein
|
|
Unnamed protein product
|
gi|1900
|
0.428
|
5
|
sodium:potassium-exchanging ATPase activity
|
|
Similar to guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2-like isoform 3
|
gi|311245496
|
0.293
|
2
|
signal transducer activity
|
|
Glyceraldehyde-3-phosphate dehydrogenase;
|
gi|2506441
|
0.664
|
10
|
NAD binding and microtubule binding
|
|
Alpha-soluble NSF attachment protein
|
gi|346986315
|
0.537
|
5
|
aspartic-type endopeptidase activity
|
|
Similar to uncharacterized membrane protein C1orf95-like
|
gi|335296122
|
0.367
|
1
|
-
|
|
Similar to rab GDP dissociation inhibitor alpha-like isoform 1
|
gi|335306783
|
0.293
|
13
|
GTPase activator activit
|
|
Similar to septin-6-like isoform 2
|
gi|311276869
|
0.147
|
4
|
GTP binding
|
|
Parvalbumin
|
gi|225877918
|
0.625
|
2
|
calcium ion binding
|
|
Similar to microtubule-associated protein RP/EB family member 3-like
|
gi|350582630
|
0.192
|
2
|
microtubule binding and small GTPase regulator activity
|
|
Similar to complexin-1-like
|
gi|335293102
|
0.226
|
2
|
neurotransmitter transporter activity
|
|
Similar to neuroplastin, partial
|
gi|350586844
|
0.299
|
1
|
cell adhesion molecule and 1 fibroblast growth factor receptor binding
|
|
Lipotropin gamma
|
gi|229326
|
0.322
|
4
|
-
|
|
Metallothionein-III
|
gi|2073002
|
0.195
|
2
|
-
|
|
Similar to V-type proton ATPase subunit E 1 isoform 2
|
gi|350584473
|
0.513
|
6
|
hydrogen-exporting ATPase activity, phosphorylative mechanism
|
|
Rab-3A
|
gi|115394766
|
0.116
|
2
|
protein C-terminus binding
|
|
Similar to annexin A6-like
|
gi|350594505
|
0.611
|
10
|
calcium ion binding
|
|
Similar to V-type proton ATPase 116 kDa subunit a isoform 1-like isoform 1
|
gi|350590297
|
0.52
|
8
|
hydrogen ion transmembrane transporter activity
|
|
Unnamed protein product
|
gi|1921
|
0.464
|
4
|
lutropin-choriogonadotropic hormone receptor binding
|
|
Similar to gamma-enolase isoform 1
|
gi|335288522
|
0.271
|
15
|
magnesium ion binding and protein heterodimerization activity
|
|
Similar to protein S100-B-like
|
gi|335310426
|
0.174
|
4
|
kinase inhibitor activity
|
|
Similar to secernin-1-like
|
gi|311275688
|
0.415
|
4
|
dipeptidase activity
|
|
Similar to synaptic vesicle membrane protein VAT-1 homolog
|
gi|350584838
|
0.639
|
9
|
oxidoreductase activity
|
|
Similar to microtubule-associated protein 1A
|
gi|350578745
|
0.423
|
11
|
-
|
|
Similar to endophilin-A2-like
|
gi|311248396
|
0.523
|
1
|
Phosphatase,lipid and GTPase binding
|
|
Similar to ADP/ATP translocase 1-like isoform 2
|
gi|311272309
|
0.612
|
8
|
ATP:ADP antiporter activity
|
|
fascin
|
gi|225382133
|
0.24
|
6
|
-
|
|
Similar to glycogen phosphorylase, brain form-like, partial
|
gi|335310649
|
7
|
0.665
|
glycogen phosphorylase activity and pyridoxal phosphate binding
|
|
Thymosin beta-4
|
gi|85700161
|
1
|
0.572
|
actin binding
|
|
Similar to tubulin alpha-1D chain
|
gi|194043861
|
17
|
0.121
|
GTP binding and protein heterodimerization activity
|
|
Prefoldin subunit 6
|
gi|297747282
|
3
|
0.516
|
chaperone binding
|
|
Similar to tubulin alpha-4A chain
|
gi|335303414
|
18
|
0.161
|
protein binding and GTP binding
|
|
OTUB1
|
gi|167888450
|
3
|
0.577
|
omega peptidase activity
|
|
Aspartate aminotransferase, cytoplasmic
|
gi|112976
|
5
|
0.562
|
phosphatidylserine decarboxylase activity
|
|
Protein carboxyl-o-methyltrans ferase
|
gi|19070126
|
2
|
0.259
|
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
|
|
Similar to protein-arginine deiminase type-2-like
|
gi|335290579
|
9
|
0.563
|
protein-arginine deiminase activity
|
|
Myelin P2 protein
|
gi|297307127
|
4
|
0.647
|
cholesterol binding and transporter activity
|
|
Similar to tubulin polymerization-promoting protein family member 3-like isoform 1
|
gi|311257146
|
4
|
0.349
|
tubulin binding and calcium ion binding
|
|
Similar to transcriptional activator protein Pur-alpha isoform 1
|
gi|335283572
|
5
|
0.629
|
translation repressor activity, nucleic acid binding
|
|
NADP-dependent malic enzyme, mitochondrial
|
gi|346716344
|
6
|
0.579
|
metal ion binding and NAD binding
|
|
Similar to bolA-like protein 2-like,
|
gi|335307557
|
1
|
0.653
|
Signal transduction mechanisms ;
|
|
Cofilin 2
|
gi|67634029
|
3
|
0.614
|
actin binding
|
|
Na+/K+ transporting alpha 3 polypeptide
|
gi|283443672
|
25
|
0.282
|
metal ion binding and sodium:potassium-exchanging ATPase activity
|
|
Similar to spectrin alpha chain, brain
|
gi|311246557
|
51
|
0.402
|
calcium ion binding and spectrin binding
|
|
Excitatory amino acid transporter 1
|
gi|346986408
|
1
|
0.32
|
high-affinity glutamate transmembrane transporter activity
|
|
Similar to protein arginine N-methyltransferase 1 isoform 1
|
gi|335290012
|
1
|
0.621
|
histone methyltransferase activity (H4-R3 specific)
|
|
Similar to 26S proteasome non-ATPase regulatory subunit 12-like
|
gi|350590194
|
2
|
0.56
|
Posttranslational modification, protein turnover, chaperones ;
|
|
Similar to dihydropyrimidinase- related protein 5
|
gi|311252980
|
4
|
0.371
|
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
|
|
Similar to syntaxin-1A-like
|
gi|335284236
|
3
|
0.267
|
myosin head/neck binding and SNAP receptor activity
|
|
Similar to syntaxin-1B-like
|
gi|350581587
|
5
|
0.212
|
extracellular-glutamate-gated ion channel activity
|
|
Mitochondrial NAD+isocitrate dehydrogenase 3 beta variant 1
|
gi|98283612
|
2
|
0.504
|
NAD binding and isocitrate dehydrogenase (NAD+) activity;
|
|
Similar to cysteine and glycine-rich protein 1-like isoform 1
|
gi|335296245
|
4
|
0.48
|
protein binding and zinc ion binding
|
|
Beta-synuclein
|
gi|144227406
|
6
|
0.228
|
calcium ion binding and alpha-tubulin binding
|
|
Synapsin Ib
|
gi|212525788
|
13
|
0.205
|
ATP binding and actin binding
|
|
HPCA
|
gi|115394790
|
7
|
0.151
|
actin binding and calcium ion binding
|
|
Similar to mitochondrial 2-oxoglutarate/malate carrier protein
|
gi|335298430
|
6
|
0.623
|
transporter activity
|
|
Similar to transgelin-3-like
|
gi|350591990
|
5
|
0.165
|
Cytoskeleton ;
|
|
Putative V-ATPase G subunit
|
gi|6624727
|
2
|
0.203
|
hydrogen-exporting ATPase activity, phosphorylative mechanism
|
|
Similar to protein phosphatase inhibitor 2-like
|
gi|335300158
|
2
|
0.417
|
protein serine/threonine phosphatase inhibitor activity
|
|
Galectin-1
|
gi|47716872
|
7
|
0.431
|
signal transducer activity and laminin binding
|
|
Heat shock 90kD protein 1, beta
|
gi|346986428
|
15
|
0.666
|
GTP, CTP binding and UTP binding, chaperones
|
|
Similar to 14-3-3 protein eta
|
gi|194043292
|
5
|
0.252
|
sodium channel regulator activity
|
|
Similar to protein kinase C and casein kinase substrate in neurons protein 1-like
|
gi|335292069
|
7
|
0.179
|
cytoskeletal protein binding
|
|
Protein,myelin basic
|
gi|224358
|
4
|
0.083
|
structural constituent of myelin sheath
|
|
Similar to alpha-internexin
|
gi|350593043
|
11
|
0.28
|
structural constituent of cytoskeleton
|
|
Protein phosphatase 1 regulatory subunit 1B
|
gi|2499741
|
4
|
0.225
|
receptor binding and protein kinase inhibitor activity
|
|
Similar to synaptic vesicle glycoprotein 2A
|
gi|194036298
|
6
|
0.325
|
Receptor and transmembrane transporter activity
|
|
hexokinase 1
|
gi|342187282
|
15
|
0.637
|
hexokinase activity
|
|
CDC37 cell division cycle 37 protein
|
gi|51870491
|
5
|
0.608
|
Hsp90 protein binding -
|
|
Similar to contactin-1-like isoform 2
|
gi|350584500
|
12
|
0.343
|
glycoprotein binding and carbohydrate binding
|
|
HN1
|
gi|54151071
|
1
|
0.387
|
-
|
|
Prostaglandin D synthase
|
gi|1064940
|
1
|
0.443
|
retinoid binding and prostaglandin-D synthase activity
|
|
Endorphin gamma
|
gi|229600
|
2
|
0.202
|
-
|
|
RTN4-C
|
gi|38327590
|
1
|
0.31
|
protein complex binding
|
|
Similar to cell adhesion molecule 3
|
gi|350583264
|
2
|
0.212
|
protein homodimerization activity
|
|
somatostatin
|
gi|46850198
|
2
|
0.44
|
hormone activity
|
|
Rho GDP dissociation inhibitor alpha
|
gi|315321426
|
4
|
0.625
|
Rho GDP-dissociation inhibitor activity
|
|
Similar to LanC lantibiotic synthetase component C-like 1
|
gi|335307003
|
2
|
0.444
|
G-protein coupled receptor activity
|
|
Similar to synaptotagmin-1
|
gi|350584732
|
4
|
0.235
|
1-phosphatidylinositol and metal ion binding
|
|
Similar to myosin-10-like
|
gi|350590878
|
26
|
0.503
|
nucleotide binding
|
|
Similar to 14-3-3 protein beta/alpha isoform 1
|
gi|194044626
|
6
|
0.352
|
transcription corepressor activity and histone deacetylase binding
|
|
Similar to dynactin subunit 2-like isoform 3
|
gi|335310032
|
8
|
0.579
|
motor activity
|
|
Similar to gamma-soluble NSF attachment protein-like
|
gi|350596353
|
3
|
0.416
|
-
|
|
peptidyl-Pro cis trans isomerase
|
gi|226256
|
6
|
0.629
|
Posttranslational modification, protein turnover, chaperones ;
|
|
Similar to endophilin-A1-like
|
gi|311245746
|
2
|
0.209
|
identical protein binding and lipid binding
|
|
Dihydrolipoamide acetyltransferase
|
gi|14587786
|
4
|
0.62
|
dihydrolipoyllysine-residue acetyltransferase activity
|
|
Similar to ubiquitin-conjugating enzyme E2 N-like
|
gi|335288894
|
4
|
0.649
|
ubiquitin binding and ubiquitin-protein ligase activity
|
|
Similar to neurofilament medium polypeptide-like isoform 1
|
gi|350592300
|
24
|
0.497
|
structural molecule activity
|
|
Tubulin polymerization promoting protein p25 alpha
|
gi|170178280
|
7
|
0.225
|
microtubule binding and calcium ion binding
|
|
Similar to rap1 GTPase-GDP dissociation stimulator 1
|
gi|350587954
|
4
|
0.281
|
GTPase activator activity
|
|
Tubulin beta-2B chain
|
gi|343478189
|
16
|
0.154
|
structural molecule activity
|
|
Clathrin heavy chain
|
gi|224492556
|
38
|
0.362
|
ankyrin binding and structural molecule activity
|
|
Gamma-synuclein
|
gi|132269870
|
7
|
0.548
|
-
|
|
FKBP1A-like
|
gi|61098747
|
3
|
0.628
|
type I transforming growth factor beta receptor binding
|
|
Similar to astrocytic phosphoprotein PEA-15
|
gi|194035847
|
5
|
0.262
|
protein kinase C binding
|
|
Stathmin-1
|
gi|49615355
|
5
|
0.523
|
signal transducer activity
|
|
Glutaminase
|
gi|1583522
|
3
|
0.438
|
glutaminase activity
|
|
Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1
|
gi|197130945
|
2
|
0.54
|
phospholipid binding and protein kinease B binding
|
|
Similar to myristoylated alanine-rich C-kinase substrate
|
gi|335279372
|
3
|
0.362
|
protein kinase C binding and actin filament binding
|
|
Similar to erythrocyte membrane protein band 4.1-like 1 isoform 1
|
gi|335304751
|
9
|
0.601
|
actin binding and structural molecule activity
|
|
Similar to dynamin 1
|
gi|350584292
|
3
|
0.5
|
GTP binding and ubiquitin protein ligase binding
|
|
Similar to neural cell adhesion molecule 2
|
gi|350592100
|
2
|
0.307
|
-
|
|
Similar to pyruvate kinase isozymes M1/M2 isoform 1
|
gi|194038728
|
17
|
0.4
|
pyruvate kinase activity
|
|
CD90 protein
|
gi|224697007
|
3
|
0.376
|
GPI anchor binding and integrin binding
|
|
Neuromodulin
|
gi|346716243|ref|NP_001231264.1|
|
4
|
0.1
|
protein binding
|
|
Nucleoside diphosphate kinase A
|
gi|325652098
|
4
|
0.394
|
nucleoside diphosphate kinase activity
|
|
Similar to dihydropyrimidinase- related protein 3
|
gi|350581250
|
5
|
0.234
|
chondroitin sulfate binding and phosphoprotein binding
|
|
Similar to NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like
|
gi|311275515
|
2
|
0.598
|
oxidoreductase activity, acting on NADH or NADPH
|
|
Similar to MARCKS-related protein-like isoform 2
|
gi|311258852
|
2
|
0.382
|
-
|
|
Similar to sodium/potassium-transporting ATPase subunit beta-2-like
|
gi|311268313
|
2
|
0.172
|
sodium:potassium-exchanging ATPase activity
|
|
Similar to neural cell adhesion molecule 1-like
|
gi|311263926
|
10
|
0.256
|
-
|
|
Similar to guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2-like isoform 2
|
gi|311251041
|
5
|
0.474
|
signal transducer activity
|
|
Similar to mu-crystallin homolog
|
gi|335284508
|
4
|
0.439
|
thyroid hormone binding and thiomorpholine-carboxylate dehydrogenase
|
|
Hexokinase II
|
gi|90820093
|
2
|
0.482
|
Carbohydrate transport and metabolism ;
|
|
Similar to NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10-like
|
gi|335310935
|
2
|
0.608
|
/hexokinase activity and glucose binding
|
|
Similar to AP-2 complex subunit alpha-1 isoform 1
|
gi|311258000
|
5
|
0.416
|
protein C-terminus binding
|
|
calbindin 2
|
gi|300827489
|
5
|
0.231
|
calcium ion binding
|
|
Up-regulated protein in hypothalamus
|
|
Annexin A2
|
gi|52631987
|
14
|
2.322
|
phosphatidylinositol-4,5-bisphosphate binding
|
|
Small acidic protein
|
gi|349585075
|
1
|
2.098
|
-
|
|
Apolipoprotein B-100
|
gi|350597081
|
3
|
2.815
|
low-density lipoprotein particle receptor binding
|
|
Antioxidant protein 1 homolog
|
gi|262036932
|
3
|
1.979
|
copper-dependent protein binding and copper chaperone activity
|
|
Hsp27
|
gi|55668280
|
6
|
2.771
|
protein kinase C binding and protein kinase C inhibitor activity
|
|
Nuclease-sensitive element-binding protein 1-like
|
gi|350586335
|
4
|
1.745
|
p53 binding and single-stranded DNA binding
|
|
78 kDa glucose-regulated protein
|
gi|350579657
|
22
|
1.634
|
chaperone binding and unfolded protein binding
|
|
L-3-hydroxyacyl-CoA dehydrogenase
|
gi|4454537
|
6
|
4.784
|
3-hydroxyacyl-CoA dehydrogenase activity
|
|
Isocitrate dehydrogenase [NADP] cytoplasmic isoform 1
|
gi|350593816
|
4
|
3.448
|
NAD and receptor binding; isocitrate dehydrogenase (NADP+)
|
|
Histone H2B type 1-like
|
gi|194039814
|
2
|
1.574
|
DNA binding
|
|
Flavin reductase-like
|
gi|335289705
|
5
|
3.028
|
riboflavin reductase (NADPH) activity
|
|
immunoglobulin lambda-chain
|
gi|164511
|
5
|
4.454
|
-
|
|
Stress-70 protein, mitochondrial
|
gi|311250237
|
16
|
2.105
|
ATP binding and unfolded protein binding, testosterone 17-beta-dehydrogenase (NADP+)
|
|
17-beta-hydroxysteroid Dehydrogenase 14-like
|
gi|311257850
|
3
|
3.992
|
estradiol 17-beta-dehydrogenase activity
|
|
Synaptosomal-associated protein
|
gi|347800627
|
2
|
1.958
|
syntaxin binding
|
|
Ppk 98; a protein kinase
|
gi|431944
|
20
|
1.783
|
virion and calcium ion binding
|
|
Aldehyde reductase
|
gi|1185557
|
3
|
5.13
|
electron carrier activity
|
|
Argininosuccinate synthase
|
gi|335281104
|
9
|
19.913
|
protein and toxin binding; argininosuccinate synthase activity;
|
|
Immunoglobulin heavy chain variable region
|
gi|119663061
|
1
|
1.985
|
-
|
|
Ribosomal protein L6
|
gi|56384243
|
4
|
1.956
|
structural constituent of ribosome
|
|
Soluble epoxide hydrolase
|
gi|45551399
|
2
|
3.051
|
10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
|
|
Alpha-1B-glycoprotein-like
|
gi|311259609
|
4
|
3.927
|
-
|
|
V-type proton ATPase subunit G 1
|
gi|298104120
|
2
|
3.062
|
hydrogen-exporting ATPase activity, phosphorylative mechanism
|
|
Electron transfer flavoprotein beta subunit precursor
|
gi|35384838
|
6
|
2.808
|
electron carrier activity
|
|
Cathepsin D protein
|
gi|56417363
|
8
|
4.76
|
aspartic-type endopeptidase activity
|
|
Similar to protein disulfide-isomerase A4-like
|
gi|311264773
|
11
|
1.889
|
electron carrier activity and protein binding
|
|
Serpin H1 precursor
|
gi|346421378
|
8
|
3.195
|
serine-type endopeptidase inhibitor activity
|
|
IgG heavy chain precursor
|
gi|5052050
|
8
|
5.141
|
-
|
|
Prolyl 4-hydroxylase beta polypeptide
|
gi|358009193
|
9
|
1.926
|
protein disulfide isomerase activity
|
|
Solute carrier family 25 member 3
|
gi|255964672
|
3
|
1.595
|
symporter activity
|
|
Similar to ezrin
|
gi|350578005
|
9
|
4.869
|
cell adhesion molecule binding and actin filament binding
|
|
Similar to calcium-regulated heat stable protein 1-like isoform 2
|
gi|350581733
|
1
|
3.533
|
mRNA 3'-UTR and DNA binding
|
|
Similar to ribonuclease UK114-like isoform 1
|
gi|194037005
|
4
|
5.011
|
endonuclease activity
|
|
Similar to prohibitin
|
gi|3a50590415
|
6
|
1.519
|
sequence-specific DNA binding RNA polymerase II transcription factor activity
|
|
Alternative Pig Liver Esterase
|
gi|164414678
|
4
|
5.891
|
hydrolase activity
|
|
Similar to proenkephalin-A
|
gi|311253816
|
4
|
1.63
|
neuropeptide hormone activity
|
|
Sorbitol dehydrogenase
|
gi|346421435
|
3
|
2.822
|
NAD binding and zinc ion binding
|
|
Similar to branched-chain -amino-acid aminotransferase, mitochondrial isoform 2
|
gi|335289923
|
3
|
7.182
|
L-valine and L-isoleucine transaminase activity
|
|
Hemoglobin alpha
|
gi|229176
|
3
|
3.057
|
oxygen transporter activity and iron ion binding
|
|
Lumican precursor
|
gi|343183420
|
7
|
2.116
|
extracellular matrix structural constituent
|
|
Thioredoxin
|
gi|14326453
|
3
|
1.604
|
protein disulfide oxidoreductase activity
|
|
Transaldolase
|
gi|349732238
|
5
|
1.532
|
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate
|
|
Lysosome membrane protein 2 precursor
|
gi|346421419
|
4
|
2.332
|
receptor activity and enzyme binding
|
|
Bcl-2-like protein 13
|
gi|350584479
|
4
|
2.387
|
cysteine-type endopeptidase activator activity involved in apoptotic process
|
|
Glycerol-3-phosphate dehydrogenase 1
|
gi|283765396
|
3
|
2.003
|
NAD binding and glycerol-3-phosphate dehydrogenase activity
|
|
Similar to transgelin-2-like isoform 1
|
gi|335286672
|
6
|
5.511
|
protein binding
|
|
protein SET
|
gi|346644699
|
3
|
2.047
|
histone and DNA binding, protein phosphatase inhibitor activity
|
|
Similar to annexin A5
|
gi|335293906
|
12
|
2.117
|
calcium ion binding; binding, bridging
|
|
tumor protein D52
|
gi|346986324
|
4
|
1.576
|
protein heterodimerization activity
|
|
Dihydropyrimidinase
|
gi|311253507
|
3
|
3.762
|
dihydropyrimidinase activity and zinc ion binding
|
|
Isovaleryl Coenzyme A dehydrogenase
|
gi|262204892
|
5
|
2.146
|
flavin adenine dinucleotide binding
|
|
Sterol carrier protein 2
|
gi|262263195
|
4
|
1.851
|
propanoyl-CoA C-acyltransferase activity
|
|
Formiminotransferase-cyclodeaminase
|
gi|433003
|
2
|
1.723
|
folic acid and intermediate filament binding
|
|
Enoyl-CoA hydratase, mitochondrial
|
gi|298104076
|
8
|
2.514
|
protein binding and enoyl-CoA hydratase activity
|
|
Long-chain acyl-CoA dehydrogenase
|
gi|1695729
|
2
|
2.921
|
fatty-acyl-CoA binding and palmitoyl-CoA oxidase activity
|
|
Similar to glyoxalase domain-containing protein 4-like
|
gi|335298275
|
7
|
1.616
|
Amino acid transport and metabolism ;
|
|
APEX nuclease 1
|
gi|210062866
|
3
|
2.152
|
transcription corepressor activity
|
|
CArG-binding factor A
|
gi|160858224
|
5
|
1.718
|
sequence-specific DNA binding transcription factor activity
|
|
Similar to 40S ribosomal protein S24 isoform 4
|
gi|194042179
|
2
|
1.72
|
Translation, ribosomal structure and biogenesis ;
|
|
Similar to kynurenine--oxoglutarate transaminase 3 isoform 2
|
gi|311254836
|
2
|
2.85
|
kynurenine-glyoxylate transaminase activity, cysteine-S-conjugate beta-lyase activity, kynurenine-oxoglutarate transaminase activity, protein homodimerization activity
|
|
prohibitin 2
|
gi|343780941
|
8
|
1.594
|
estrogen receptor binding
|
|
Similar to 3-hydroxybutyrate dehydrogenase type 2-like isoform 1
|
gi|335294000
|
3
|
3.361
|
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
|
|
Annexin A4
|
gi|4033507
|
4
|
3.162
|
phospholipase inhibitor activity
|
|
Similar to vimentin
|
gi|335296459
|
22
|
1.906
|
protein C-terminus binding, structural constituent of eye lens
|
|
Cytochrome b5 fragment
|
gi|229384
|
2
|
6.781
|
cytochrome-c oxidase activity
|
|
Succinyl-CoA synthetase beta-subunit, partial
|
gi|164669
|
6
|
4.231
|
succinate-CoA ligase (GDP-forming) activity
|
|
Histidine-rich glycoprotein precursor
|
gi|347582595
|
5
|
1.891
|
heparin binding
|
|
Eukaryotic translation elongation factor 1 alpha
|
gi|110287842
|
9
|
1.53
|
protein kinase binding and translation elongation factor activity
|
|
Similar to alpha-actinin-4-like isoform 2
|
gi|335289608|ref|XP_003355931.1|
|
13
|
2.541
|
integrin binding
|
|
unconventional myosin
|
gi|516155
|
8
|
2.048
|
minus-end directed microfilament motor activity
|
|
aminoacylase I
|
gi|1845|emb|CAA48565.1|
|
6
|
9.061
|
metal ion binding and aminoacylase activity
|
|
Similar to putative aminopeptidase C13A
|
gi|350587379
|
3
|
2.756
|
manganese ion binding and metalloexopeptidase activity
|
|
Glutathione S-transferase
|
gi|1185280
|
2
|
18.659
|
glutathione transferase activity
|
|
Histidine triad nucleotide-binding protein 2, mitochondrial isoform 1 precursor
|
gi|346716222
|
4
|
2.219
|
hydrolase activity
|
|
Apolipoprotein A-I
|
gi|164359
|
14
|
4.284
|
phospholipid binding, phosphatidylcholine-sterol O-acyltransferase activator activity
|
|
Epididymal secretory protein E4
|
gi|22535477
|
2
|
1.859
|
serine-type endopeptidase inhibitor activity
|
|
Antithrombin protein
|
gi|106647532
|
5
|
3.182
|
Posttranslational modification, protein turnover, chaperones ;
|
|
Similar to annexin A11
|
gi|194042189
|
6
|
2.757
|
serine-type endopeptidase inhibitor activity
|
|
Aldose 1-epimerase
|
gi|11611545
|
3
|
5.151
|
carbohydrate binding and aldose 1-epimerase activity
|
|
Similar to aldehyde dehydrogenase
|
gi|350597032
|
1
|
5.491
|
aldehyde dehydrogenase [NAD(P)+] activity
|
|
family 1 member A3
|
|
Similar to alpha-2-macroglobulin
|
gi|311256211
|
7
|
1.728
|
endopeptidase inhibitor activity
|
|
Apolipoprotein A-II precursor
|
gi|297747304
|
2
|
5.64
|
protein homodimerization activity
|
|
2,4-dienoyl-CoA reductase 1
|
gi|295442674
|
3
|
3.733
|
oxidoreductase activity, acting on NADH or NADPH
|
|
Similar to selenium-binding protein 1
|
gi|194036227
|
20
|
2.677
|
selenium and protein binding
|
|
Monoamine oxidase A
|
gi|45551418
|
4
|
1.979
|
primary amine oxidase activity
|
|
Similar to ganglioside GM2 activator-like isoform 1
|
gi|311274101
|
1
|
14.478
|
phospholipase activator activity
|
|
Similar to hypothetical protein LOC100038023
|
gi|311245732
|
2
|
1.724
|
protein kinase bindingand structural constituent of ribosome
|
|
Similar to methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
|
gi|194038542
|
15
|
5.125
|
thiolester hydrolase activity
|
|
SMP-30
|
gi|115371745
|
2
|
5.202
|
zinc ion binding, enzyme regulator
|
|
Complement component 4A
|
gi|147780441
|
2
|
1.581
|
endopeptidase inhibitor activity
|
|
Similar to hepatoma-derived growth factor
|
gi|335286747
|
7
|
2.187
|
growth factor activity
|
|
Gastrin-binding protein
|
gi|433066
|
9
|
2.614
|
acetyl-CoA C-acetyltransferase activity
|
|
Protein canopy homolog 2 precursor
|
gi|297307133
|
6
|
1.89
|
protein binding
|
|
Alpha-1 acid glycoprotein, partial
|
gi|164302
|
8
|
6.08
|
-
|
|
Similar to glutaredoxin-related protein 5, mitochondrial
|
gi|194038359
|
2
|
2.363
|
metal ion binding and electron carrier activity
|
|
G-beta like protein
|
gi|495144
|
3
|
2.11
|
protein kinase C binding
|
|
Apolipoprotein C-III
|
gi|164361
|
4
|
4.813
|
phospholipid binding and lipase inhibitor activity
|
|
Catechol-O-methyltransferase
|
gi|285818436
|
6
|
2.321
|
catechol O-methyltransferase activity
|
|
Phosphotriesterase-related protein
|
gi|3466448441177.1|
|
4
|
4.447
|
hydrolase activity, acting on ester bonds
|
|
Chromogranin B
|
gi|10121853
|
25
|
3.564
|
-
|
|
Adipocyte fatty acid-binding protein
|
gi|4160392
|
5
|
324.583
|
transporter activity
|
|
Similar to TP53-regulated inhibitor of apoptosis 1
|
gi|350592546
|
2
|
3.42
|
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
|
|
Similar to peroxiredoxin-1 isoform 5
|
gi|311259408
|
7
|
1.631
|
thioredoxin peroxidase activity
|
|
Similar to alpha-aminoadipic semialdehyde dehydrogenase-like
|
gi|350581057
|
3
|
1.551
|
betaine-aldehyde dehydrogenase activity
|
|
3-hydroxyanthranilate 3,4-dioxy genase
|
gi|349732262
|
2
|
3.249
|
3-hydroxyanthranilate 3,4-dioxygenase activity
|
|
Transgelin
|
gi|346421409
|
9
|
2.033
|
actin binding
|
|
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
|
gi|356582295
|
7
|
3.568
|
electron carrier activity
|
|
Similar to carbonic anhydrase 2
|
gi|194037097
|
6
|
1.943
|
carbonate dehydratase activity
|
|
Leukotriene A4 hydrolase
|
gi|262204898
|
3
|
3.469
|
aminopeptidase activity zinc ion binding
|
|
Similar to histone H2A type 1
|
gi|194039812
|
2
|
1.797
|
DNA binding and enzyme binding
|
|
Myosin light chain isoform LC17b
|
gi|253578
|
7
|
2.162
|
structural constituent of muscle
|
|
uncoupling protein 3
|
gi|4165892
|
1
|
1481.875
|
oxidative phosphorylation uncoupler activity
|
|
Heat shock 10kD protein
|
gi|30525868
|
7
|
10.249
|
chaperone binding
|
|
Mitochondrial aldehyde dehydrogenase 2
|
gi|81295909
|
6
|
7.509
|
aldehyde dehydrogenase [NAD(P)+] activity
|
|
Similar to cytosol aminopeptidase-like
|
gi|350587377
|
2
|
2.194
|
metalloexopeptidase activity
|
|
Similar to adipocyte plasma membrane-associated protein
|
gi|335308355
|
2
|
2.602
|
Arylesterase and strictosidine synthase activity
|
|
Similar to hemoglobin subunit beta-like
|
gi|311263245
|
5
|
2.37
|
oxygen transporter activity
|
|
Ribophorin I
|
gi|9857227
|
4
|
1.592
|
dolichyl-diphosphooligosaccharide-protein glycotransferase activity
|
|
superoxide dismutase [Mn], mitochondrial
|
gi|312283580
|
3
|
1.959
|
manganese ion binding
|
|
Similar to hypothetical protein LOC100516841
|
gi|350595403
|
3
|
2.421
|
3-hydroxyisobutyrate dehydrogenase activity
|
|
Proteasome activator 28 beta subunit
|
gi|30315381
|
4
|
1.865
|
-
|
|
Lon peptidase 1, mitochondrial
|
gi|342349346
|
10
|
3.016
|
mitochondrial heavy strand promoter anti-sense binding
|
|
Ig heavy chain variable VDJ region, partial
|
gi|558859
|
1
|
2.341
|
-
|
|
Glutathione peroxidase 3 precursor
|
gi|169646366
|
3
|
7.594
|
glutathione peroxidase activity
|
|
Signal sequence receptor, alpha
|
gi|297632426
|
1
|
2.434
|
-
|
|
S-adenosylhomocysteine hydrolase
|
gi|40644231
|
4
|
2.286
|
NAD binding and copper ion binding
|
|
Similar to 4-trimethylaminobutyral dehyde dehydrogenase
|
gi|194036835
|
4
|
4.833
|
1-pyrroline dehydrogenase activity
|
|
Hexosaminidase A alpha polypeptide
|
gi|169117926
|
3
|
2.462
|
beta-N-acetylhexosaminidase activity
|
|
Similar to ig kappa chain V-II region RPMI 6410
|
gi|350582129
|
3
|
2.706
|
-
|
|
Similar to fumarylacetoacetate hydrolase domain-containing protein 2
|
gi|311252000
|
5
|
2.18
|
metal ion binding
|
|
Similar to acyl-coenzyme A thioesterase 6
|
gi|194038528
|
3
|
1.836
|
carboxylesterase and thiolester hydrolase activity
|
|
Thioredoxin-dependent peroxide reductase, mitochondrial
|
gi|347300323
|
3
|
3.05
|
protein C-terminus binding and peroxiredoxin activity
|
|
Beta 2-microglobulin
|
gi|309795
|
1
|
1.862
|
-
|
|
Rho GDP dissociation inhibitor (GDI) beta
|
gi|346716314
|
2
|
2.344
|
GTPase activator activity
|
|
Glucosidase 2 subunit beta precursor
|
gi|347446687
|
6
|
1.733
|
phosphatidylinositol binding
|
|
Similar to caldesmon
|
gi|311275365
|
5
|
2.353
|
Calmodulin, actin and myosin binding
|
|
Similar to purine nucleoside phosphorylase
|
gi|194038973
|
5
|
2.615
|
drug and phosphate ion binding
|
|
Similar to fumarylacetoacetase
|
gi|335292272
|
5
|
6.573
|
fumarylacetoacetase activity and metal ion binding
|
|
Similar to eukaryotic translation initiation factor 3 subunit A
|
gi|194042126
|
2
|
1.961
|
translation initiation factor activity
|
|
Similar to apoptosis-inducing factor 1, mitochondrial isoform 1
|
gi|311276941
|
2
|
3.164
|
flavin adenine dinucleotide binding
|
|
Similar to ES1 protein homolog, mitochondrial-like
|
gi|335300836
|
4
|
1.726
|
Secondary metabolites biosynthesis, transport and catabolism
|
|
Non-selenium glutathione phospholipid hydroperoxide peroxidase (PHGPx)
|
gi|6689393
|
7
|
2.148
|
glutathione peroxidase activity
|
|
Cytochrome b5 type B
|
gi|227430316
|
2
|
5.38
|
metal ion binding
|
|
Similar to chromobox protein homolog 3-like isoform 1
|
gi|350595422
|
2
|
1.834
|
identical protein binding
|
|
long-chain 3-ketoacyl-CoA thiolase
|
gi|6165556
|
7
|
3.162
|
NAD binding and long-chain- enoyl-CoA hydratase activity
|
|
Similar to serpin A3-8
|
gi|350587171
|
10
|
4.428
|
serine-type endopeptidase inhibitor activity
|
|
Similar to hydroxyacid-oxoacid transhydrogenase, mitochondrial-like
|
gi|311253769
|
2
|
5.101
|
hydroxyacid-oxoacid transhydrogenase activity
|
|
Similar to adenylate kinase 2, mitochondrial-like isoform 1
|
gi|335309396
|
4
|
9.89
|
adenylate kinase activity and ATP binding
|
|