Despite the emerging influence of anthropogenic climate change on the global water cycle, at regional scales the combination of observational uncertainty, large internal variability, and modeling uncertainty undermine robust statements regarding the human influence on precipitation. Here, we propose a novel approach to regional detection and attribution (D&A) for precipitation, starting with the contiguous United States (CONUS) where observational uncertainty is minimized. In a single framework, we simultaneously detect systematic trends in mean and extreme precipitation, attribute trends to anthropogenic forcings, compute the effects of forcings as a function of time, and map the effects of individual forcings. We use output from global climate models in a perfect-data sense to conduct a set of tests that yield a parsimonious representation for characterizing seasonal precipitation over the CONUS for the historical record (1900 to present day). In doing so, we turn an apparent limitation into an opportunity by using the diversity of responses to short-lived climate forcers across the CMIP6 multi-model ensemble to ensure our D&A is insensitive to structural uncertainty. Our framework is developed using a Pearl-causal perspective, but forthcoming research now underway will apply the framework to in situ measurements using a Granger-causal perspective. While the hypothesis-based framework and accompanying generalized D&A formula we develop should be widely applicable, we include a strong caution that the hypothesis-guided simplification of the formula for the historical climatic record of CONUS as described in this paper will likely fail to hold in other geographic regions and under future warming.