Inverse Association Between Triglyceride Glucose Index and Muscle Mass in Korean Adults: 2008–2011 KNHANES
Aim: The early detection and prevention of sarcopenia is increasingly emphasized considering that sarcopenia is an important risk factor for falls or cardiovascular disease. Recently, there have been emerging evidences that support the relationship between sarcopenia, insulin resistance, and inflammation. The TyG index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been verified for an association with sarcopenia. This study aimed to examine the relationship between the TyG index and muscle mass in Korean adults.
Methods: This study included 15,741 non-diabetic adults over 19 years old using data from the 2008–2011 Korea National Health and Nutrition Examination Survey. Participants were divided into three groups according to tertiles of the TyG index. Low skeletal muscle mass index (LMSI) was defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project criteria. Weighted multivariate logistic regression model was used to analyze the relationship between TyG index tertiles and LSMI.
Results: The ORs (95% CIs) for LSMI of the second and third tertiles, compared to first tertile, were 1.300 (1.001–1.689) and 1.448 (1.104–1.900), respectively, after adjusting for confounding factors. Higher TyG index was also associated with increased odds of LSMI in subgroups such as adults under 65-year old who did not exercise regularly, who consumed less than 30g alcohol per day, who did not currently smoke, and who ate less than 1.5g protein/kg/day.
Conclusion: The TyG index was significantly and positively associated with LSMI in Korean adults.
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Posted 22 Sep, 2020
On 22 Nov, 2020
On 22 Nov, 2020
On 12 Oct, 2020
Received 30 Sep, 2020
Received 29 Sep, 2020
Received 29 Sep, 2020
Received 29 Sep, 2020
On 27 Sep, 2020
On 27 Sep, 2020
Received 27 Sep, 2020
On 26 Sep, 2020
On 26 Sep, 2020
On 21 Sep, 2020
Invitations sent on 18 Sep, 2020
On 16 Sep, 2020
On 16 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
Inverse Association Between Triglyceride Glucose Index and Muscle Mass in Korean Adults: 2008–2011 KNHANES
Posted 22 Sep, 2020
On 22 Nov, 2020
On 22 Nov, 2020
On 12 Oct, 2020
Received 30 Sep, 2020
Received 29 Sep, 2020
Received 29 Sep, 2020
Received 29 Sep, 2020
On 27 Sep, 2020
On 27 Sep, 2020
Received 27 Sep, 2020
On 26 Sep, 2020
On 26 Sep, 2020
On 21 Sep, 2020
Invitations sent on 18 Sep, 2020
On 16 Sep, 2020
On 16 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
Aim: The early detection and prevention of sarcopenia is increasingly emphasized considering that sarcopenia is an important risk factor for falls or cardiovascular disease. Recently, there have been emerging evidences that support the relationship between sarcopenia, insulin resistance, and inflammation. The TyG index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been verified for an association with sarcopenia. This study aimed to examine the relationship between the TyG index and muscle mass in Korean adults.
Methods: This study included 15,741 non-diabetic adults over 19 years old using data from the 2008–2011 Korea National Health and Nutrition Examination Survey. Participants were divided into three groups according to tertiles of the TyG index. Low skeletal muscle mass index (LMSI) was defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project criteria. Weighted multivariate logistic regression model was used to analyze the relationship between TyG index tertiles and LSMI.
Results: The ORs (95% CIs) for LSMI of the second and third tertiles, compared to first tertile, were 1.300 (1.001–1.689) and 1.448 (1.104–1.900), respectively, after adjusting for confounding factors. Higher TyG index was also associated with increased odds of LSMI in subgroups such as adults under 65-year old who did not exercise regularly, who consumed less than 30g alcohol per day, who did not currently smoke, and who ate less than 1.5g protein/kg/day.
Conclusion: The TyG index was significantly and positively associated with LSMI in Korean adults.
Figure 1
Figure 2