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Inverse Association Between Triglyceride Glucose Index and Muscle Mass in Korean Adults: 2008–2011 KNHANES
JI WON LEE
Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2666-4249
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Lipids in Health and Disease.
Aim: The early detection and prevention of sarcopenia is increasingly emphasized considering that sarcopenia is an important risk factor for falls or cardiovascular disease. Recently, there have been emerging evidences that support the relationship between sarcopenia, insulin resistance, and inflammation. The TyG index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been verified for an association with sarcopenia. This study aimed to examine the relationship between the TyG index and muscle mass in Korean adults.
Methods: This study included 15,741 non-diabetic adults over 19 years old using data from the 2008–2011 Korea National Health and Nutrition Examination Survey. Participants were divided into three groups according to tertiles of the TyG index. Low skeletal muscle mass index (LMSI) was defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project criteria. Weighted multivariate logistic regression model was used to analyze the relationship between TyG index tertiles and LSMI.
Results: The ORs (95% CIs) for LSMI of the second and third tertiles, compared to first tertile, were 1.300 (1.001–1.689) and 1.448 (1.104–1.900), respectively, after adjusting for confounding factors. Higher TyG index was also associated with increased odds of LSMI in subgroups such as adults under 65-year old who did not exercise regularly, who consumed less than 30g alcohol per day, who did not currently smoke, and who ate less than 1.5g protein/kg/day.
Conclusion: The TyG index was significantly and positively associated with LSMI in Korean adults.
Keywords
TyG index, sarcopenia, low skeletal muscle index, insulin resistance, chronic inflammation
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CURRENT STATUS: Published
Version 1
Posted 22 Sep, 2020
Published
On 22 Nov, 2020
Published
On 22 Nov, 2020
No community comments so far
Editorial decision: Major revision
On 12 Oct, 2020
Review #4 received
Received 30 Sep, 2020
Review #3 received
Received 29 Sep, 2020
Review #2 received
Received 29 Sep, 2020
Review #1 received
Received 29 Sep, 2020
Reviewer #4 agreed
On 27 Sep, 2020
Reviewer #5 agreed
On 27 Sep, 2020
Review #5 received
Received 27 Sep, 2020
Reviewer #2 agreed
On 26 Sep, 2020
Reviewer #3 agreed
On 26 Sep, 2020
Reviewer #1 agreed
On 21 Sep, 2020
Reviewers invited
Invitations sent on 18 Sep, 2020
First submitted
On 16 Sep, 2020
Editor assigned
On 16 Sep, 2020
Submission checks complete
On 15 Sep, 2020
Editor invited
On 15 Sep, 2020
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This preprint is under consideration at Lipids in Health and Disease. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Inverse Association Between Triglyceride Glucose Index and Muscle Mass in Korean Adults: 2008–2011 KNHANES
JI WON LEE
Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2666-4249
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 1
Posted 22 Sep, 2020
Published
On 22 Nov, 2020
Published
On 22 Nov, 2020
No community comments so far
Editorial decision: Major revision
On 12 Oct, 2020
Review #4 received
Received 30 Sep, 2020
Review #3 received
Received 29 Sep, 2020
Review #2 received
Received 29 Sep, 2020
Review #1 received
Received 29 Sep, 2020
Reviewer #4 agreed
On 27 Sep, 2020
Reviewer #5 agreed
On 27 Sep, 2020
Review #5 received
Received 27 Sep, 2020
Reviewer #2 agreed
On 26 Sep, 2020
Reviewer #3 agreed
On 26 Sep, 2020
Reviewer #1 agreed
On 21 Sep, 2020
Reviewers invited
Invitations sent on 18 Sep, 2020
First submitted
On 16 Sep, 2020
Editor assigned
On 16 Sep, 2020
Submission checks complete
On 15 Sep, 2020
Editor invited
On 15 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Lipids in Health and Disease.
Aim: The early detection and prevention of sarcopenia is increasingly emphasized considering that sarcopenia is an important risk factor for falls or cardiovascular disease. Recently, there have been emerging evidences that support the relationship between sarcopenia, insulin resistance, and inflammation. The TyG index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been verified for an association with sarcopenia. This study aimed to examine the relationship between the TyG index and muscle mass in Korean adults.
Methods: This study included 15,741 non-diabetic adults over 19 years old using data from the 2008–2011 Korea National Health and Nutrition Examination Survey. Participants were divided into three groups according to tertiles of the TyG index. Low skeletal muscle mass index (LMSI) was defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project criteria. Weighted multivariate logistic regression model was used to analyze the relationship between TyG index tertiles and LSMI.
Results: The ORs (95% CIs) for LSMI of the second and third tertiles, compared to first tertile, were 1.300 (1.001–1.689) and 1.448 (1.104–1.900), respectively, after adjusting for confounding factors. Higher TyG index was also associated with increased odds of LSMI in subgroups such as adults under 65-year old who did not exercise regularly, who consumed less than 30g alcohol per day, who did not currently smoke, and who ate less than 1.5g protein/kg/day.
Conclusion: The TyG index was significantly and positively associated with LSMI in Korean adults.
Figure 1
Figure 2