Four species of invasive carp from Asia are advancing up the Mississippi River through its locks and dams and threatening to damage to its ecosystems. It has been hypothesized that sensory stimuli could be projected into locks to block the movement of these carp. Sound has garnered attention because carp are hearing specialists, so they might be targetable. A recent study demonstrated that when a broadband cyclic sound was projected into an air curtain to create an ensonified bubble curtain (EBC), it was especially effective at blocking bighead and common carp and less effective at blocking a native species that lacked hearing specializations, while sound alone was generally less effective. However, whether an EBC might be similarly and uniquely effective at blocking all species of carp, and what its effects might be on other fishes in general, has not yet been addressed. To answer these questions, this study examined the responses of 10 species of fishes including 4 carps, 2 native hearing specialists, and 4 native non-specialists in a darkened laboratory flume while either a cyclic sound was played on its own or projected into an air curtain. The EBC blocked all 4 carps 9297% of the time without habituation, but 5 native fish were also partially blocked. In contrast, sound alone only blocked 2 carps and affected the other fishes in ways not related to their hearing abilities. An EBC appears well suited to blocking carp invasions, especially if native fish movement is a secondary concern.