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Research article
Effect of dexmedetomidine on prevention of postoperative nausea and vomiting in pediatric strabismus surgery: A randomized controlled study
Jie Jia
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Background
Postoperative nausea and vomiting (PONV) are common side-effects following strabismus surgery. The present study aimed to compare the effects of different doses of dexmedetomidine (DEX) on PONV incidence in pediatric patients undergoing strabismus surgery.
Methods
In this prospective randomized double-blinded study, 126 pediatric patients undergoing strabismus surgery were randomized into one of three groups: Placebo group, normal saline; DEX1 group, 0.3 ug/kg dexmedetomidine, and DEX2 group, 0.5 ug/kg dexmedetomidine. Oculocardiac reflex (OCR) events were recorded during surgery. PONV or postoperative vomiting (POV) was recorded for 24 hours in the ward. Pediatric anesthesia emergence delirium (PAED) scale and emergence agitation (EA) scale were recorded in the recovery room.
Results
Intraoperative OCR was significantly reduced in DEX2 group (41.5%) as compared to that of Placebo group (68.3%) (p=0.026). During the first 24 hours post-op, the overall incidence of PONV was significantly lower in DEX2 group (9.8%) than that of Placebo group (31.7%) (p=0.029). There was no significant difference in POV among the three groups. PAED or EA scores among the three groups were similar during recovery time.
Conclusion
Dexmedetomidine (0.5 ug/kg) reduced OCX and PONV without lengthening extubation time or recovery time in pediatric patients undergoing strabismus surgery.
Keywords
Dexmedetomidine, Postoperative nausea and vomiting, Strabismus surgery, Oculocardiac reflex, Emergence Agitation
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CURRENT STATUS: Under Review
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On 27 Feb, 2020
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On 26 Feb, 2020
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On 26 Feb, 2020
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Editorial decision: Minor revision
On 25 Feb, 2020
Review #1 received
Received 24 Feb, 2020
Reviewers invited
Invitations sent on 20 Feb, 2020
Reviewer #1 agreed
On 20 Feb, 2020
Editor assigned
On 04 Feb, 2020
Submission checks complete
On 03 Feb, 2020
Editor invited
On 03 Feb, 2020
No comments provided
Editorial decision: Minor revision
On 28 Jan, 2020
Review #1 received
Received 22 Jan, 2020
Editor assigned
On 20 Jan, 2020
Reviewers invited
Invitations sent on 20 Jan, 2020
Reviewer #1 agreed
On 20 Jan, 2020
Submission checks complete
On 19 Jan, 2020
Editor invited
On 19 Jan, 2020
No comments provided
Editorial decision: Major revision
On 11 Jan, 2020
Review #1 received
Received 31 Dec, 2019
Reviewers invited
Invitations sent on 23 Dec, 2019
Reviewer #1 agreed
On 23 Dec, 2019
Editor assigned
On 20 Dec, 2019
Editor invited
On 19 Dec, 2019
Submission checks complete
On 18 Dec, 2019
Version 1
Posted 07 May, 2019
No comments provided
Editorial decision: Major revision
On 26 Nov, 2019
Review #3 received
Received 20 Nov, 2019
Reviewer #3 agreed
On 14 Nov, 2019
Reviewer #2 agreed
On 27 Aug, 2019
Review #2 received
Received 27 Aug, 2019
Review #1 received
Received 16 Jun, 2019
Reviewer #1 agreed
On 12 Jun, 2019
Reviewers invited
Invitations sent on 09 Jun, 2019
Editor assigned
On 21 May, 2019
Submission checks complete
On 05 May, 2019
Editor invited
On 05 May, 2019
First submitted
On 19 Apr, 2019
Metrics
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PDF Downloads: ...
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Subject Areas
Ophthalmology
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This preprint is under consideration at BMC Ophthalmology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Effect of dexmedetomidine on prevention of postoperative nausea and vomiting in pediatric strabismus surgery: A randomized controlled study
Jie Jia
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
No community comments so far
Editor assigned
On 27 Feb, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 26 Feb, 2020
No comments provided
Editorial decision: Minor revision
On 25 Feb, 2020
Review #1 received
Received 24 Feb, 2020
Reviewers invited
Invitations sent on 20 Feb, 2020
Reviewer #1 agreed
On 20 Feb, 2020
Editor assigned
On 04 Feb, 2020
Submission checks complete
On 03 Feb, 2020
Editor invited
On 03 Feb, 2020
No comments provided
Editorial decision: Minor revision
On 28 Jan, 2020
Review #1 received
Received 22 Jan, 2020
Editor assigned
On 20 Jan, 2020
Reviewers invited
Invitations sent on 20 Jan, 2020
Reviewer #1 agreed
On 20 Jan, 2020
Submission checks complete
On 19 Jan, 2020
Editor invited
On 19 Jan, 2020
No comments provided
Editorial decision: Major revision
On 11 Jan, 2020
Review #1 received
Received 31 Dec, 2019
Reviewers invited
Invitations sent on 23 Dec, 2019
Reviewer #1 agreed
On 23 Dec, 2019
Editor assigned
On 20 Dec, 2019
Editor invited
On 19 Dec, 2019
Submission checks complete
On 18 Dec, 2019
Version 1
Posted 07 May, 2019
No comments provided
Editorial decision: Major revision
On 26 Nov, 2019
Review #3 received
Received 20 Nov, 2019
Reviewer #3 agreed
On 14 Nov, 2019
Reviewer #2 agreed
On 27 Aug, 2019
Review #2 received
Received 27 Aug, 2019
Review #1 received
Received 16 Jun, 2019
Reviewer #1 agreed
On 12 Jun, 2019
Reviewers invited
Invitations sent on 09 Jun, 2019
Editor assigned
On 21 May, 2019
Submission checks complete
On 05 May, 2019
Editor invited
On 05 May, 2019
First submitted
On 19 Apr, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Background
Postoperative nausea and vomiting (PONV) are common side-effects following strabismus surgery. The present study aimed to compare the effects of different doses of dexmedetomidine (DEX) on PONV incidence in pediatric patients undergoing strabismus surgery.
Methods
In this prospective randomized double-blinded study, 126 pediatric patients undergoing strabismus surgery were randomized into one of three groups: Placebo group, normal saline; DEX1 group, 0.3 ug/kg dexmedetomidine, and DEX2 group, 0.5 ug/kg dexmedetomidine. Oculocardiac reflex (OCR) events were recorded during surgery. PONV or postoperative vomiting (POV) was recorded for 24 hours in the ward. Pediatric anesthesia emergence delirium (PAED) scale and emergence agitation (EA) scale were recorded in the recovery room.
Results
Intraoperative OCR was significantly reduced in DEX2 group (41.5%) as compared to that of Placebo group (68.3%) (p=0.026). During the first 24 hours post-op, the overall incidence of PONV was significantly lower in DEX2 group (9.8%) than that of Placebo group (31.7%) (p=0.029). There was no significant difference in POV among the three groups. PAED or EA scores among the three groups were similar during recovery time.
Conclusion
Dexmedetomidine (0.5 ug/kg) reduced OCX and PONV without lengthening extubation time or recovery time in pediatric patients undergoing strabismus surgery.
Figure 1