Effect of dexmedetomidine on prevention of postoperative nausea and vomiting in pediatric strabismus surgery: A randomized controlled study
Background
Postoperative nausea and vomiting (PONV) are common side-effects following strabismus surgery. The present study aimed to compare the effects of different doses of dexmedetomidine (DEX) on PONV incidence in pediatric patients undergoing strabismus surgery.
Methods
In this prospective randomized double-blinded study, 126 pediatric patients undergoing strabismus surgery were randomized into one of three groups: Placebo group, normal saline; DEX1 group, 0.3 ug/kg dexmedetomidine, and DEX2 group, 0.5 ug/kg dexmedetomidine. Oculocardiac reflex (OCR) events were recorded during surgery. PONV or postoperative vomiting (POV) was recorded for 24 hours in the ward. Pediatric anesthesia emergence delirium (PAED) scale and emergence agitation (EA) scale were recorded in the recovery room.
Results
Intraoperative OCR was significantly reduced in DEX2 group (41.5%) as compared to that of Placebo group (68.3%) (p=0.026). During the first 24 hours post-op, the overall incidence of PONV was significantly lower in DEX2 group (9.8%) than that of Placebo group (31.7%) (p=0.029). There was no significant difference in POV among the three groups. PAED or EA scores among the three groups were similar during recovery time.
Conclusion
Dexmedetomidine (0.5 ug/kg) reduced OCX and PONV without lengthening extubation time or recovery time in pediatric patients undergoing strabismus surgery.
Figure 1
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Effect of dexmedetomidine on prevention of postoperative nausea and vomiting in pediatric strabismus surgery: A randomized controlled study
On 27 Feb, 2020
On 26 Feb, 2020
On 26 Feb, 2020
On 25 Feb, 2020
Received 24 Feb, 2020
Invitations sent on 20 Feb, 2020
On 20 Feb, 2020
On 04 Feb, 2020
On 03 Feb, 2020
On 03 Feb, 2020
On 28 Jan, 2020
Received 22 Jan, 2020
On 20 Jan, 2020
Invitations sent on 20 Jan, 2020
On 20 Jan, 2020
On 19 Jan, 2020
On 19 Jan, 2020
On 11 Jan, 2020
Received 31 Dec, 2019
Invitations sent on 23 Dec, 2019
On 23 Dec, 2019
On 20 Dec, 2019
On 19 Dec, 2019
On 18 Dec, 2019
Posted 07 May, 2019
On 26 Nov, 2019
Received 20 Nov, 2019
On 14 Nov, 2019
On 27 Aug, 2019
Received 27 Aug, 2019
Received 16 Jun, 2019
On 12 Jun, 2019
Invitations sent on 09 Jun, 2019
On 21 May, 2019
On 05 May, 2019
On 05 May, 2019
On 19 Apr, 2019
Background
Postoperative nausea and vomiting (PONV) are common side-effects following strabismus surgery. The present study aimed to compare the effects of different doses of dexmedetomidine (DEX) on PONV incidence in pediatric patients undergoing strabismus surgery.
Methods
In this prospective randomized double-blinded study, 126 pediatric patients undergoing strabismus surgery were randomized into one of three groups: Placebo group, normal saline; DEX1 group, 0.3 ug/kg dexmedetomidine, and DEX2 group, 0.5 ug/kg dexmedetomidine. Oculocardiac reflex (OCR) events were recorded during surgery. PONV or postoperative vomiting (POV) was recorded for 24 hours in the ward. Pediatric anesthesia emergence delirium (PAED) scale and emergence agitation (EA) scale were recorded in the recovery room.
Results
Intraoperative OCR was significantly reduced in DEX2 group (41.5%) as compared to that of Placebo group (68.3%) (p=0.026). During the first 24 hours post-op, the overall incidence of PONV was significantly lower in DEX2 group (9.8%) than that of Placebo group (31.7%) (p=0.029). There was no significant difference in POV among the three groups. PAED or EA scores among the three groups were similar during recovery time.
Conclusion
Dexmedetomidine (0.5 ug/kg) reduced OCX and PONV without lengthening extubation time or recovery time in pediatric patients undergoing strabismus surgery.
Figure 1