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Research article
Components of metabolic syndrome in patients with multiple myeloma and smoldering multiple myeloma
Elena Izkhakov
Tel Aviv Sourasky Medical Center
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4742-878X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among patients with smoldering MM (SMM).
Methods: Changes in various components of metabolic syndrome were investigated during the follow-up of patients with either MM or SMM compared to healthy controls. The data of 153 patients (105 with MM and 48 with SMM) and 138 controls were accessed from our medical center’s records between 2008-2015. We analyzed the patients’ data at diagnosis (baseline) and after 1, 3, and 5 years of follow-up.
Results: Patients with SMM had a significantly higher prevalence of diabetes, hypertension, and dyslipidemia at baseline compared to controls. A multivariate Cox regression analysis revealed a higher risk to develop dyslipidemia after 1, 3, and 5 years of follow-up among the SMM patients. The MM patients had a higher risk to develop diabetes after 1 year, hypertension after 5 years, and dyslipidemia after 1, 3, and 5 years of follow-up.
Conclusions: These data demonstrate that patients with SMM and those with MM are more prone to develop various components of metabolic syndrome, and they stress the importance of following-up metabolic syndrome components in both groups of patients.
Keywords
Smoldering multiple myeloma, hyperlipidemia, metabolic changes
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CURRENT STATUS: Under Review
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Posted 19 May, 2020
No community comments so far
Editorial decision: Minor revision
On 08 May, 2020
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On 15 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 06 May, 2020
Reviewers invited
Invitations sent on 17 Apr, 2020
Reviewer #1 agreed
On 17 Apr, 2020
Review #1 received
Received 17 Apr, 2020
Editor assigned
On 16 Apr, 2020
Submission checks complete
On 15 Apr, 2020
Editor invited
On 15 Apr, 2020
No comments provided
Editorial decision: Major revision
On 12 Mar, 2020
Review #3 received
Received 11 Mar, 2020
Reviewer #3 agreed
On 09 Mar, 2020
Review #1 received
Received 26 Feb, 2020
Reviewer #2 agreed
On 21 Feb, 2020
Review #2 received
Received 21 Feb, 2020
Reviewer #1 agreed
On 18 Feb, 2020
Reviewers invited
Invitations sent on 18 Feb, 2020
Editor assigned
On 14 Feb, 2020
Submission checks complete
On 13 Feb, 2020
Editor invited
On 13 Feb, 2020
No comments provided
Review #1 received
Received 29 Jan, 2020
Editorial decision: Minor revision
On 29 Jan, 2020
Review #2 received
Received 24 Jan, 2020
Reviewer #2 agreed
On 17 Jan, 2020
Reviewer #1 agreed
On 14 Jan, 2020
Reviewers invited
Invitations sent on 22 Nov, 2019
Editor assigned
On 20 Nov, 2019
Submission checks complete
On 19 Nov, 2019
Editor invited
On 17 Nov, 2019
First submitted
On 11 Nov, 2019
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This preprint is under consideration at BMC Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Components of metabolic syndrome in patients with multiple myeloma and smoldering multiple myeloma
Elena Izkhakov
Tel Aviv Sourasky Medical Center
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4742-878X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 4
Posted 19 May, 2020
No community comments so far
Editorial decision: Minor revision
On 08 May, 2020
Submission checks complete
On 15 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 06 May, 2020
Reviewers invited
Invitations sent on 17 Apr, 2020
Reviewer #1 agreed
On 17 Apr, 2020
Review #1 received
Received 17 Apr, 2020
Editor assigned
On 16 Apr, 2020
Submission checks complete
On 15 Apr, 2020
Editor invited
On 15 Apr, 2020
No comments provided
Editorial decision: Major revision
On 12 Mar, 2020
Review #3 received
Received 11 Mar, 2020
Reviewer #3 agreed
On 09 Mar, 2020
Review #1 received
Received 26 Feb, 2020
Reviewer #2 agreed
On 21 Feb, 2020
Review #2 received
Received 21 Feb, 2020
Reviewer #1 agreed
On 18 Feb, 2020
Reviewers invited
Invitations sent on 18 Feb, 2020
Editor assigned
On 14 Feb, 2020
Submission checks complete
On 13 Feb, 2020
Editor invited
On 13 Feb, 2020
No comments provided
Review #1 received
Received 29 Jan, 2020
Editorial decision: Minor revision
On 29 Jan, 2020
Review #2 received
Received 24 Jan, 2020
Reviewer #2 agreed
On 17 Jan, 2020
Reviewer #1 agreed
On 14 Jan, 2020
Reviewers invited
Invitations sent on 22 Nov, 2019
Editor assigned
On 20 Nov, 2019
Submission checks complete
On 19 Nov, 2019
Editor invited
On 17 Nov, 2019
First submitted
On 11 Nov, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among patients with smoldering MM (SMM).
Methods: Changes in various components of metabolic syndrome were investigated during the follow-up of patients with either MM or SMM compared to healthy controls. The data of 153 patients (105 with MM and 48 with SMM) and 138 controls were accessed from our medical center’s records between 2008-2015. We analyzed the patients’ data at diagnosis (baseline) and after 1, 3, and 5 years of follow-up.
Results: Patients with SMM had a significantly higher prevalence of diabetes, hypertension, and dyslipidemia at baseline compared to controls. A multivariate Cox regression analysis revealed a higher risk to develop dyslipidemia after 1, 3, and 5 years of follow-up among the SMM patients. The MM patients had a higher risk to develop diabetes after 1 year, hypertension after 5 years, and dyslipidemia after 1, 3, and 5 years of follow-up.
Conclusions: These data demonstrate that patients with SMM and those with MM are more prone to develop various components of metabolic syndrome, and they stress the importance of following-up metabolic syndrome components in both groups of patients.
Figure 1
Figure 2