The enormous impact of SARS-CoV2 continues and scientific community is seeking to discover the tactics to impede the spread of virus. The essential result is attenuated, and genetically engineered vaccines are being driven into the market with the general effectiveness being around 80%. Therefore, vaccination is not the sole answer for combat this pandemic. The substitute methodology is adapted to target on this virus with a medication in blend with existing vaccines. Papain like protease (nsp-3; nonstructural protein) and Mpro (nsp-5; nonstructural protein) of novel corona virus are the ideal target to develop drugs as they play different roles that are essential for viral development and replication. Utilizing computational methodology, we plan to distinguish a plausible microbial metabolite as analogue of GRL0617 (the well-established inhibitor of PLpro) and X77 (the well-established inhibitor of Mpro) from the pool of known antiviral compounds of endophytic microbes to interact and inhibit PLpro and Mpro as dual inhibitors. In the wake of collecting known antiviral compounds of endophytic microbes and screened them through pharmacophore hypothesis, molecular docking, and dynamics simulation, we perceive Cytonic acid A and Cytonic acid B to be seen as the potent PLpro and Mpro dual inhibitors using rigorous computational methods.