[1] Vincent A, Huda S, Cao M, et al.Serological and experimental studies in different forms of myasthenia gravis [J].Annals of the New York Academy of Sciences,2018,1413(1):143-153.
[2] Leite MI, Ströbel P, Jones M, et al.Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG [J].Ann Neurol,2005,57(3):444-448.
[3] Cron MA, Maillard S, Villegas J, et al.Thymus involvement in early-onset myasthenia gravis [J].Annals of the New York Academy of Sciences,2018,1412(1):137-145.
[4] A. Marx, F. Pfister, B. Schalke, et al.The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes [J].Autoimmun Rev,2013,12(9):875-884.
[5] F. Romi, Y. Hong, N. E. Gilhus.Pathophysiology and immunological profile of myasthenia gravis and its subgroups [J].Curr Opin Immunol,2017,49(9-13.
[6] P. Cufi, P. Soussan, F. Truffault, et al.Thymoma-associated myasthenia gravis: On the search for a pathogen signature [J].Journal of autoimmunity,2014,52(29-35.
[7] S. Berrih-Aknin, R. Le Panse.Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms [J].Journal of autoimmunity,2014,52(90-100.
[8] Mantegazza R, Antozzi C.When myasthenia gravis is deemed refractory: clinical signposts and treatment strategies [J].Therapeutic advances in neurological disorders,2018,11(undefined):1756285617749134.
[9] S. Ikehara, M. Inaba, R. Yasumizu, et al.Autoimmune diseases as stem cell disorders [J].Tohoku J Exp Med,1994,173(1):141-155.
[10] T. Otsuka, S. Okamura, M. Harada, et al.Multipotent hemopoietic progenitor cells in patients with systemic lupus erythematosus [J].J Rheumatol,1988,15(7):1085-1090.
[11] A. J. Nauta, W. E. Fibbe.Immunomodulatory properties of mesenchymal stromal cells [J].Blood,2007,110(10):3499-3506.
[12] C. Porta, R. Caporali, O. Epis, et al.Impaired bone marrow hematopoietic progenitor cell function in rheumatoid arthritis patients candidated to autologous hematopoietic stem cell transplantation [J].Bone Marrow Transplant,2004,33(7):721-728.
[13] H. A. Papadaki, H. D. Kritikos, C. Gemetzi, et al.Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect [J].Blood,2002,99(5):1610-1619.
[14] H. A. Papadaki, J. C. Marsh, G. D. Eliopoulos.Bone marrow stem cells and stromal cells in autoimmune cytopenias [J].Leuk Lymphoma,2002,43(4):753-760.
[15] McKinney EF, Lee JC, Jayne DR, et al.T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection [J].Nature,2015,523(7562):612-616.
[16] Jaretzki A, Barohn RJ, Ernstoff RM, et al.Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America [J].The Annals of thoracic surgery,2000,70(1):327-334.
[17] Chen S, Zhou Y, Chen Y, et al.fastp: an ultra-fast all-in-one FASTQ preprocessor [J].Bioinformatics (Oxford, England),2018,34(17):i884-i890.
[18] B. Langmead, S. L. Salzberg.Fast gapped-read alignment with Bowtie 2 [J].Nature methods,2012,9(4):357-359.
[19] Kim D, Pertea G, Trapnell C, et al.TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions [J].Genome biology,2013,14(4):R36.
[20] Trapnell C, Roberts A, Goff L, et al.Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks [J].Nature protocols,2012,7(3):562-578.
[21] B. Li, C. N. Dewey.RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome [J].BMC bioinformatics,2011,12(323.
[22] Nawrocki EP, Eddy SR.Infernal 1.1: 100-fold faster RNA homology searches [J].Bioinformatics (Oxford, England),2013,29(22):2933-2935.
[23] Szydłowski M, Jabłońska E, Juszczyński P.FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development [J].International reviews of immunology,2014,33(2):146-157.
[24] Meshaal S, El Hawary R, Elsharkawy M, et al.Mutations in Recombination Activating Gene 1 and 2 in patients with severe combined immunodeficiency disorders in Egypt [J].Clinical immunology (Orlando, Fla),2015,158(2):167-173.
[25] Avila EM, Uzel G, Hsu A, et al.Highly variable clinical phenotypes of hypomorphic RAG1 mutations [J].Pediatrics,2010,126(5):e1248-1252.
[26] Chen K, Wu W, Mathew D, et al.Autoimmunity due to RAG deficiency and estimated disease incidence in RAG1/2 mutations [J].The Journal of allergy and clinical immunology,2014,133(3):880-882.e810.
[27] Niehues T, Perez-Becker R, Schuetz C.More than just SCID--the phenotypic range of combined immunodeficiencies associated with mutations in the recombinase activating genes (RAG) 1 and 2 [J].Clinical immunology (Orlando, Fla),2010,135(2):183-192.
[28] Brauer PM, Pessach IM, Clarke E, et al.Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies [J].Blood,2016,128(6):783-793.
[29] Akiyama T, Tanaka S.Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology [J].Archivum immunologiae et therapiae experimentalis,2011,59(4):277-287.
[30] Ludwinski MW, Sun J, Hilliard B, et al.Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice [J].The Journal of clinical investigation,2009,119(6):1706-1713.
[31] Wang YM, Zhang GY, Wang Y, et al.Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2-interacting mediator knock-out mice [J].Clinical and experimental immunology,2017,188(2):195-207.
[32] Bouillet P, Metcalf D, Huang DC, et al.Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity [J].Science (New York, NY),1999,286(5445):1735-1738.
[33] Chen M, Huang L, Wang J.Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity [J].Blood,2007,109(10):4360-4367.
[34] Soldati C, Caramanica P, Burney MJ, et al.RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro [J].Journal of neuroscience research,2015,93(8):1203-1214.
[35] Covey MV, Streb JW, Spektor R, et al.REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells [J].Development (Cambridge, England),2012,139(16):2878-2890.
[36] Menzel L, Paterka M, Bittner S, et al.Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury [J].Acta neuropathologica,2016,132(5):703-720.
[37] Bergsland M, Covacu R, Perez Estrada C, et al.Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cells [J].Stem cells (Dayton, Ohio),2014,32(9):2539-2549.