The Sudano-Sahelian region of Cameroon is mainly drained by the Benue, Chari and Logone rivers, which are very useful for water resources, especially for irrigation, hydropower generation, and navigation. Long-term changes in mean and extreme rainfall events in the region may be of crucial importance in understanding the impact of climate change. Daily and monthly rainfall data from twenty-five synoptic stations in the study area from 1980 to 2019 and extreme indices from the Expert Team on Climate Change Detection and Indices (ETCCDI) measurements were estimated using the non-parametric Modified Mann-Kendall test and the Sen slope estimator. The precipitation concentration index (PCI), the precipitation concentration degree (PCD), and the precipitation concentration period (PCP) were used to explore the spatio-temporal variations in the characteristics of rainfall concentrations. An increase in extreme rainfall events was observed, leading to an upward trend in mean annual. Trends in consecutive dry days (CDD) are significantly increasing in most parts of the study area. This could mean that the prevalence of drought risk is higher in the study area. Overall, the increase in annual rainfall could benefit the hydro-power sector, agricultural irrigation, the availability of potable water sources, and food security.