Modulebrown&clusster1
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TNF signaling pathway
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CXCL1, FOS, ICAM1, IL6, PTGS2, SOCS3, JUN, MAP3K8, CXCL2, IL1B, NFKBIA, BIRC3, JUNB
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3.00E-08
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Malaria
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HBA-A1, CSF3, ICAM1, SELP, IL6, IL1B, HBB-B1, HBA1, HBB
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1.51E-05
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HTLV-I infection
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EGR1, ZFP36, IL1R2, ICAM1, IL6, EGR2, CREM, NFKBIA, FOS, ATF3, JUN, ETS2, MYC, FOSL1
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2.56E-04
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African trypanosomiasis
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HBA-A1, ICAM1, IL6, IL1B, HBB-B1, HBA1, HBB
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4.41E-04
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MAPK signaling pathway
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DUSP5, MAP3K6, FOS, DUSP2, DUSP1, JUN, GADD45G, MAP3K8, IL1B, MYC, CDC25B
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0.027356
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Salmonella infection
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CXCL1, FOS, IL6, JUN, CXCL2, IL1B, NOS2
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0.046022
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Moduleturquoise&cluster2
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Lysosome
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CLTA, GM2A, LITAF, LGMN, HEXA, HEXB, AP3S1, ACP2, PPT1, CTSA, CLTC, ASAH1, GLB1, SLC11A1, AP1S1, CD68, LAPTM5, GALC, MAN2B1, AP3B1, TCIRG1, CTSS, CD63, M6PR, DNASE2, GNS, CTSL, NPC1, LAMP2, NPC2, CTSD, CTSC, CTSB
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1.58E-09
|
Phagosome
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RAB7B, MSR1, TUBB2A, RAB5C, TLR2, C1R, ITGB2, TLR4, RT1-DMA, RT1-DMB, ATP6V1B2, TLR6, CALR, CANX, ITGAM, ACTG1, FCGR1A, TUBB5, TUBB6, SCARB1, TUBA1A, TUBA1B, SEC61A1, TCIRG1, ACTB, MRC1, NCF2, NCF4, COLEC12, CTSS, M6PR, ATP6V1A, CYBA, CTSL, CORO1A, LAMP2, SEC61B, FCGR2B, ITGA5, CD14
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9.67E-09
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Fc gamma R-mediated phagocytosis
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PTPRC, PLD1, VAV3, LYN, PIK3CB, HCK, ASAP1, ARPC4, ARPC5, PRKCD, VAV1, WAS, PRKCB, RAC2, FCGR2B, ARPC3, ARPC2, FCGR1A, CFL1, MAPK3, PIK3R5, INPP5D, SYK
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3.29E-06
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Natural killer cell-mediated cytotoxicity
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BID, PTPN6, CD244, VAV3, PIK3CB, ITGB2, VAV1, PRKCB, IFNAR1, HCST, CD48, NRAS, CASP3, RAC2, FYN, MAPK3, FCER1G, SHC1, PIK3R5, IFNGR1, LCP2, TYROBP, SH3BP2, SYK
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1.11E-05
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Osteoclast differentiation
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LILRB3A, LILRB3B, SPI1, TGFB1, BTK, LILRB3L, TNFRSF1A, FCGR1A, PIK3R5, IFNGR1, TYROBP, SYK, CSF1R, BLNK, NCF2, PIK3CB, NCF4, SIRPA, IFNAR1, TYK2, CYBA, CYBB, FCGR2B, FYN, MAPK3, TREM2, LCP2
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3.58E-05
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Tuberculosis
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BID, RAB5C, IL18, TLR2, ITGB2, TLR4, RT1-DMA, RT1-DMB, TLR6, TGFB1, ITGAM, IRAK4, TNFRSF1A, CASP3, IL10RB, FCGR1A, IL10RA, FCER1G, IFNGR1, SYK, TCIRG1, MRC1, CTSS, LSP1, CORO1A, LAMP2, FCGR2B, MAPK3, CTSD, JAK2, CD14
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3.56E-04
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Leukocyte transendothelial migration
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ACTB, VAV3, GNAI3, GNAI2, ACTN4, NCF2, PIK3CB, NCF4, SIPA1, ACTN1, ITGB2, CTNNA1, VAV1, CXCL12, ITGAM, PRKCB, ACTG1, CYBA, EZR, RAC2, PIK3R5, RAP1B, MSN
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0.001492
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Regulation of actin cytoskeleton
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FGF7, DIAPH3, ARPC4, ITGB2, ARPC5, IQGAP1, ITGAM, ACTG1, PFN1, EZR, PAK2, RAC2, ARPC3, TIAM1, ARPC2, PIK3R5, MSN, FN1, ACTB, VAV3, ACTN4, PIK3CB, BAIAP2, NCKAP1L, ACTN1, VAV1, WAS, NRAS, ITGA5, CFL1, MAPK3, PDGFRA, PIP4K2A
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0.001869
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Cell cycle
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CDK1, YWHAZ, RBL1, YWHAB, TTK, CDK6, CDK4, MCM3, MCM4, TGFB1, MCM5, MCM6, CCNB1, CDKN1A, CCNB2, YWHAH, MAD2L1, HDAC1, PLK1, CDKN2C, PCNA, BUB1, CCNA2
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0.006191
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Chemokine signaling pathway
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GNAI3, GNAI2, FGR, PREX1, PF4, CXCL12, CCL7, CCL6, CCL24, RAC2, TIAM1, PIK3R5, SHC1, VAV3, LYN, PIK3CB, HCK, PRKCD, VAV1, WAS, NRAS, GNGT2, CCR5, ARRB2, GNB1, MAPK3, RAP1B, JAK2
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0.006592
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Moduleblue&cluster3
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Carbon metabolism
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ME3, ECHS1, PGAM2, OGDH, ACSS2, ACAT1, PDHB, HADHA, PGP, ACSS1, TPI1, IDH3G, GOT1, MCEE, PDHA1, SUCLA2, GPT2, FH, ALDH6A1, ACADM, ACO2, ACADS, SUCLG1, CS, IDH3B, DLAT, PFKM, FBP2, IDH3A, SDHA, SDHB, SDHC, SDHD, GPT, PCCB, MDH2, PCCA, MDH1
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3.48E-27
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Metabolic pathways
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PGAM2, OGDH, ACSS2, COX5B, HIBADH, PDHB, CMBL, ACSS1, PGP, GOT1, IDH3G, TRAK2, PDHA1, HADH, GPT2, ACAA2, ALDH6A1, SUCLG1, FBP2, CHPT1, COX6C, NNT, AKR1B10, PGM1, ADSL, PCCB, PCCA, MDH2, MDH1, HSD17B10, ME3, NT5C1A, COX7B, ACAT1, HADHA, QRSL1, TPI1, IVD, FH, COX8B, IDH3B, DLAT, IDH3A, TST, NDUFV1, ST8SIA5, NDUFV2, ATP5D, UQCRC2, UQCRC1, CYC1, NDUFS7, MCCC2, NDUFS4, MCEE, NDUFS8, ATP5O, ATP5I, SUCLA2, NDUFS3, NDUFS2, NDUFS1, NDUFB11, ACADM, ACO2, ACADS, ALDH5A1, WBSCR17, NDUFC2, PFKM, COQ7, NDUFA10, LPIN1, NDUFA12, NDUFA11, ACADVL, COQ3, PANK1, ADK, NDUFB5, NDUFB6, NDUFB8, NFS1, ECHS1, ATP5G1, ATP5G3, ACSL1, PLCD4, ACSL6, AGL, NDUFA5, NDUFA8, NDUFA9, BCKDHB, CS, ATP5F1, SDHA, SDHB, GANC, SDHC, SDHD, GPT
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1.46E-25
|
Oxidative phosphorylation
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ATP5D, UQCRC2, NDUFB5, NDUFB6, UQCRC1, NDUFB8, COX7B, CYC1, ATP5G1, COX5B, ATP5G3, NDUFS7, NDUFS4, NDUFS8, ATP5O, ATP5I, NDUFS3, NDUFS2, NDUFS1, NDUFA5, NDUFB11, COX7A2, NDUFA8, COX8B, NDUFA9, NDUFC2, ATP5F1, NDUFA10, NDUFA12, NDUFA11, COX6C, SDHA, SDHB, SDHC, NDUFV1, NDUFV2, SDHD
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5.93E-23
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Parkinson's disease
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ATP5D, UQCRC2, NDUFB5, NDUFB6, UQCRC1, NDUFB8, COX7B, CYC1, PINK1, ATP5G1, COX5B, ATP5G3, NDUFS7, NDUFS4, NDUFS8, ATP5O, NDUFS3, NDUFS2, NDUFS1, NDUFA5, NDUFB11, COX7A2, NDUFA8, COX8B, NDUFA9, NDUFC2, ATP5F1, NDUFA10, NDUFA12, NDUFA11, COX6C, SDHA, SDHB, SDHC, NDUFV1, NDUFV2, SDHD
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4.58E-22
|
Alzheimer's disease
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ATP5D, UQCRC2, HSD17B10, NDUFB5, NDUFB6, UQCRC1, NDUFB8, COX7B, CYC1, ATP5G1, COX5B, ATP5G3, NDUFS7, NDUFS4, NDUFS8, PPP3CB, ATP5O, NDUFS3, NDUFS2, NDUFS1, NDUFA5, NDUFB11, COX7A2, NDUFA8, COX8B, NDUFA9, NDUFC2, ATP5F1, NDUFA10, NDUFA12, NDUFA11, COX6C, SDHA, SDHB, SDHC, NDUFV1, NDUFV2, SDHD
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3.05E-20
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Biosynthesis of antibiotics
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HSD17B10, ECHS1, PGAM2, OGDH, ACSS2, ACAT1, PDHB, HADHA, CMBL, PGP, ACSS1, TPI1, IDH3G, GOT1, PDHA1, SUCLA2, HADH, FH, ACAA2, ACADM, ACO2, SUCLG1, BCKDHB, CS, IDH3B, DLAT, PFKM, FBP2, IDH3A, SDHA, SDHB, SDHC, PGM1, SDHD, ADSL, PCCB, MDH2, PCCA, MDH1
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2.76E-18
|
Non-alcoholic fatty liver disease (NAFLD)
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UQCRC2, PPARA, NDUFB5, UQCRC1, NDUFB6, NDUFB8, COX7B, CYC1, COX5B, NDUFS7, NDUFS4, NDUFS8, PRKAA2, NDUFS3, NDUFS2, NDUFS1, NDUFA5, NDUFB11, COX7A2, NDUFA8, COX8B, NDUFA9, NDUFC2, NDUFA10, IRS1, NDUFA12, NDUFA11, COX6C, SDHA, SDHB, SDHC, NDUFV1, NDUFV2, SDHD
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8.50E-18
|
Huntington's disease
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ATP5D, UQCRC2, NDUFB5, NDUFB6, UQCRC1, NDUFB8, COX7B, CYC1, ATP5G1, COX5B, ATP5G3, NDUFS7, NDUFS4, NDUFS8, ATP5O, NDUFS3, NDUFS2, NDUFS1, NDUFA5, NDUFB11, COX7A2, NDUFA8, COX8B, NDUFA9, NDUFC2, ATP5F1, NDUFA10, PPARGC1A, NDUFA12, NDUFA11, COX6C, SDHA, SDHB, SDHC, NDUFV1, NDUFV2, SDHD
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1.64E-17
|
Citrate cycle (TCA cycle)
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ACO2, SUCLG1, CS, IDH3B, DLAT, OGDH, IDH3A, PDHB, SDHA, SDHB, IDH3G, SDHC, SDHD, PDHA1, SUCLA2, MDH2, FH, MDH1
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3.23E-16
|
Valine, leucine and isoleucine degradation
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ACAA2, HSD17B10, ALDH6A1, ACADM, ACADS, BCKDHB, ECHS1, ACAT1, HADHA, HIBADH, MCCC2, IVD, OXCT1, MCEE, HADH, PCCB, PCCA
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4.13E-10
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