1. Kazazian, H. H., Jr. Mobile elements: drivers of genome evolution. Science303, 1626-1632 (2004).
2. Bannert, N. & Kurth, R. Retroelements and the human genome: new perspectives on an old relation. Proc. Natl Acad. Sci. U. S. A.101 Suppl 2, 14572-14579 (2004).
3. Goodier, J. L. & Kazazian, H. H., Jr. Retrotransposons revisited: the restraint and rehabilitation of parasites. Cell135, 23-35 (2008).
4. Kazazian, H. H., Jr et al. Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man. Nature332, 164-166 (1988).
5. Morse, B., Rotherg, P. G., South, V. J., Spandorfer, J. M. & Astrin, S. M. Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature333, 87-90 (1988).
6. Miki, Y. et al. Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res.52, 643-645 (1992).
7. De Cecco, M. et al. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature566, 73-78 (2019).
8. Hohjoh, H. & Singer, M. F. Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA. EMBO J.15, 630-639 (1996).
9. Goodier, J. L., Zhang, L., Vetter, M. R. & Kazazian, H. H., Jr. LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol. Cell. Biol.27, 6469-6483 (2007).
10. Mathias, S. L., Scott, A. F., Kazazian, H. H., Jr, Boeke, J. D. & Gabriel, A. Reverse transcriptase encoded by a human transposable element. Science254, 1808-1810 (1991).
11. Feng, Q., Moran, J. V., Kazazian, H. H., Jr & Boeke, J. D. Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition. Cell87, 905-916 (1996).
12. Babushok, D. V. & Kazazian, H. H., Jr. Progress in understanding the biology of the human mutagen LINE-1. Hum. Mutat.28, 527-539 (2007).
13. Gasior, S. L., Wakeman, T. P., Xu, B. & Deininger, P. L. The human LINE-1 retrotransposon creates DNA double-strand breaks. J. Mol. Biol.357, 1383-1393 (2006).
14. Okudaira, N. et al. Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct. Proc. Natl Acad. Sci. U. S. A.107, 18487-18492 (2010).
15. Okudaira, N. et al. Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor. Oncogene32, 4903-4912 (2013).
16. Ishizaka, Y. et al. Modes of retrotransposition of long interspersed element-1 by environmental factors. Front. Microbiol.3, 191 (2012).
17. Okudaira, N. et al. Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate. Cancer Sci.102, 2000-2006 (2011).
18. Okudaira, N., Ishizaka, Y. & Nishio, H. Retrotransposition of long interspersed element 1 induced by methamphetamine or cocaine. J. Biol. Chem.289, 25476-25485 (2014).
19. Okudaira, N., Ishizaka, Y., Nishio, H. & Sakagami, H. Morphine and fentanyl citrate induce retrotransposition of long interspersed element-1. In Vivo30, 113-118 (2016).
20. Whitlock, N. C. & Baek, S. J. The anticancer effects of resveratrol: modulation of transcription factors. Nutr. Cancer64, 493-502 (2012).
21. Wang, Q. et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res.958, 439-447 (2002).
22. Sinha, K., Chaudhary, G. & Gupta, Y. K. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci.71, 655-665 (2002).
23. Burns, J., Yokota, T., Ashihara, H., Lean, M. E. & Crozier, A. Plant foods and herbal sources of resveratrol. J. Agric. Food Chem.50, 3337-3340 (2002).
24. Van Meter, M. et al. SIRT6 represses. Nat. Commun.5, 5011 (2014).
25. Simon, M. et al. Derepression in aged wild-type and SIRT6-deficient mice drives inflammation. Cell Metab.30, 1-15 (2019).
26. Vazquez, B. N. et al. SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina. Nucleic Acids Res.47, 7870-7885 (2019).
27. Baillie, J. K. et al. Somatic retrotransposition alters the genetic landscape of the human brain. Nature479, 534-537 (2011).
28. Kazazian, H. H., Jr. Mobile DNA transposition in somatic cells. BMC Biol.9, 62 (2011).
29. Sajish, M. & Schimmel, P. A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Nature519, 370-373 (2015).
30. Goodier, J. L., Zhang, L., Vetter, M. R. & Kazazian, H. H., Jr. LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol. Cell. Biol.27, 6469-6483 (2007).
31. Goodier, J. L. Restricting retrotransposons: a review. Mob. DNA7, 16 (2016).
32. Gu, J., Hu, W. & Zhang, D. D. Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity. J. Cell. Mol. Med.19, 2324-2328 (2015).
33. Shi, Y. et al. Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway. Sci. Rep.6, 24744 (2016).
34. Zhou, Y., Lin, S., Zhang, L. & Li, Y. Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway. Mol. Cell. Biochem.411, 143-150 (2016).
35. Kano, H. et al. L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism. Genes Dev.23, 1303-1312 (2009).
36. Ariumi, Y. Guardian of the human genome: Host Defense Mechanisms against LINE-1 Retrotransposition: host defense mechanisms against LINE-1 Retrotransposition. Front. Chem.4, 28 (2016).
37. Ting, D. T. et al. Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science331, 593-596 (2011).
38. Morrish, T. A. et al. DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Nat. Genet.31, 159-165 (2002).
39. Wallerath, T. et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation106, 1652-1658 (2002).
40. Cook, P. R., Jones, C. E. & Furano, A. V. Phosphorylation of ORF1p is required for L1 retrotransposition. Proc. Natl Acad. Sci. U. S. A.112, 4298-4303 (2015).
41. Furano, A. V. & Cook, P. R. The challenge of ORF1p phosphorylation: effects on L1 activity and its host. Mob. Genet. Elem.6, e1119927 (2015)
42. Takizawa, Y. et al. The 4′-hydroxyl group of resveratrol is functionally important for direct activation of PPARα. PLOS ONE10, e0120865 (2015).
43. Cea, M. et al. Evidence for a role of the histone deacetylase DNA damage response of multiple myeloma cells. Blood127, 1138-1150 (2016)
44. Oberg, M., Bergander, L., Håkansson, H., Rannug, U. & Rannug, A. Identification of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activity. Toxicol. Sci.85, 935-943 (2005).
45. Scott, K. A., Turesky, R. J., Wainman, B. C. & Josephy, P. D. Hplc/electrospray ionization mass spectrometric analysis of the heterocyclic aromatic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human milk. Chem. Res. Toxicol.20, 88-94 (2007).
46. Li, W. et al. Activation of transposable elements during aging and neuronal decline in Drosophila. Nat. Neurosci.16, 529-531 (2013).
47. Wood, J. G. et al. Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila. Proc. Natl Acad. Sci. U. S. A.113, 11277-11282 (2016).
48. Jarrett, S. G. et al. Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage. J. Biol. Chem.293, 19025-19037 (2018).