1. Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V (2019) Diabetic neuropathy. Nature reviews Disease primers 5 (1):42. doi:10.1038/s41572-019-0097-9
2. Albers JW, Pop-Busui R (2014) Diabetic neuropathy: mechanisms, emerging treatments, and subtypes. Current neurology and neuroscience reports 14 (8):473. doi:10.1007/s11910-014-0473-5
3. Tousoulis D, Papageorgiou N, Androulakis E, Siasos G, Latsios G, Tentolouris K, Stefanadis C (2013) Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches. Journal of the American College of Cardiology 62 (8):667-676. doi:10.1016/j.jacc.2013.03.089
4. Dewanjee S, Das S, Das AK, Bhattacharjee N, Dihingia A, Dua TK, Kalita J, Manna P (2018) Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets. European journal of pharmacology 833:472-523. doi:10.1016/j.ejphar.2018.06.034
5. Sifuentes-Franco S, Pacheco-Moisés FP, Rodríguez-Carrizalez AD, Miranda-Díaz AG (2017) The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy. Journal of diabetes research 2017:1673081. doi:10.1155/2017/1673081
6. Feldman EL, Nave KA, Jensen TS, Bennett DLH (2017) New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain. Neuron 93 (6):1296-1313. doi:10.1016/j.neuron.2017.02.005
7. Akinpelu OV, Ibrahim F, Waissbluth S, Daniel SJ (2014) Histopathologic changes in the cochlea associated with diabetes mellitus--a review. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 35 (5):764-774. doi:10.1097/mao.0000000000000293
8. Rance G, Chisari D, O'Hare F, Roberts L, Shaw J, Jandeleit-Dahm K, Szmulewicz D (2014) Auditory neuropathy in individuals with Type 1 diabetes. Journal of neurology 261 (8):1531-1536. doi:10.1007/s00415-014-7371-2
9. Doostkam A, Mirkhani H, Iravani K, Karbalay-Doust S, Zarei K (2020) Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model. Clinical and experimental otorhinolaryngology. doi:10.21053/ceo.2019.02068
10. Yilmaz M, Aktug H, Oltulu F, Erbas O (2016) Neuroprotective effects of folic acid on experimental diabetic peripheral neuropathy. Toxicology and industrial health 32 (5):832-840. doi:10.1177/0748233713511513
11. Wang D, Zhai JX, Liu DW (2017) Serum folate, vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes: A meta-analysis. Molecular and cellular endocrinology 443:72-79. doi:10.1016/j.mce.2017.01.006
12. Han Y, Wang M, Shen J, Zhang Z, Zhao M, Huang J, Chen Y, Chen Z, Hu Y, Wang Y (2018) Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy. Minerva endocrinologica 43 (1):11-18. doi:10.23736/s0391-1977.16.02505-0
13. Várkonyi T, Körei A, Putz Z, Martos T, Keresztes K, Lengyel C, Nyiraty S, Stirban A, Jermendy G, Kempler P (2017) Advances in the management of diabetic neuropathy. Minerva medica 108 (5):419-437. doi:10.23736/s0026-4806.17.05257-0
14. Enderami A, Zarghami M, Darvishi-Khezri H (2018) The effects and potential mechanisms of folic acid on cognitive function: a comprehensive review. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 39 (10):1667-1675. doi:10.1007/s10072-018-3473-4
15. Couto MR, Gonçalves P, Catarino T, Araújo JR, Correia-Branco A, Martel F (2012) The effect of oxidative stress upon the intestinal uptake of folic acid: in vitro studies with Caco-2 cells. Cell biology and toxicology 28 (6):369-381. doi:10.1007/s10565-012-9228-8
16. Ferrazzi E, Tiso G, Di Martino D (2020) Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy. European journal of obstetrics, gynecology, and reproductive biology 253:312-319. doi:10.1016/j.ejogrb.2020.06.012
17. Imbard A, Benoist JF, Blom HJ (2013) Neural tube defects, folic acid and methylation. International journal of environmental research and public health 10 (9):4352-4389. doi:10.3390/ijerph10094352
18. Field MS, Stover PJ (2018) Safety of folic acid. Annals of the New York Academy of Sciences 1414 (1):59-71. doi:10.1111/nyas.13499
19. van Gool JD, Hirche H, Lax H, De Schaepdrijver L (2018) Folic acid and primary prevention of neural tube defects: A review. Reproductive toxicology (Elmsford, NY) 80:73-84. doi:10.1016/j.reprotox.2018.05.004
20. Helzner EP, Contrera KJ (2016) Type 2 Diabetes and Hearing Impairment. Current diabetes reports 16 (1):3. doi:10.1007/s11892-015-0696-0
21. Mursleen MT, Riaz S (2017) Implication of homocysteine in diabetes and impact of folate and vitamin B12 in diabetic population. Diabetes & metabolic syndrome 11 Suppl 1:S141-s146. doi:10.1016/j.dsx.2016.12.023
22. Koller A, Szenasi A, Dornyei G, Kovacs N, Lelbach A, Kovacs I (2018) Coronary Microvascular and Cardiac Dysfunction Due to Homocysteine Pathometabolism; A Complex Therapeutic Design. Current pharmaceutical design 24 (25):2911-2920. doi:10.2174/1381612824666180625125450
23. Damanik J, Mayza A, Rachman A, Sauriasari R, Kristanti M, Agustina PS, Angianto AR, Prawiroharjo P, Yunir E (2019) Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients. PloS one 14 (11):e0224611. doi:10.1371/journal.pone.0224611
24. Wang Y, Branicky R, Noë A, Hekimi S (2018) Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling. The Journal of cell biology 217 (6):1915-1928. doi:10.1083/jcb.201708007
25. Islam MT (2017) Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurological research 39 (1):73-82. doi:10.1080/01616412.2016.1251711
26. Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R, Cheng D, Knight AR, Taylor EL, Oettrich J, Ruskovska T, Gasparovic AC, Cuadrado A, Weber D, Poulsen HE, Grune T, Schmidt HH, Ghezzi P (2015) Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants & redox signaling 23 (14):1144-1170. doi:10.1089/ars.2015.6317
27. Rostami S, Momeni Z, Behnam-Rassouli M, Rooholamin S (2013) A comparative study on the effects of type I and type II diabetes on learning and memory deficit and hippocampal neuronal loss in rat. Minerva endocrinologica 38 (3):289-295
28. Kuse H, Ogawa T, Nakamura N, Nakayama Y, Nakakarumai A, Komori C, Tsuda Y, Matsushima K, Nakamura A, Tamura K (2011) Changes in auditory brainstem response (ABR) in Kanamycin-induced auditory disturbance model rats. The Journal of toxicological sciences 36 (6):835-841. doi:10.2131/jts.36.835
29. Márquez-Gamiño S, Sotelo F, Sosa M, Caudillo C, Holguín G, Ramos M, Mesa F, Bernal J, Córdova T (2008) Pulsed electromagnetic fields induced femoral metaphyseal bone thickness changes in the rat. Bioelectromagnetics 29 (5):406-409. doi:10.1002/bem.20396
30. Rusznák Z, Szucs G (2009) Spiral ganglion neurones: an overview of morphology, firing behaviour, ionic channels and function. Pflugers Archiv : European journal of physiology 457 (6):1303-1325. doi:10.1007/s00424-008-0586-2
31. Kristiansen SL, Nyengaard JR (2012) Digital stereology in neuropathology. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 120 (4):327-340. doi:10.1111/j.1600-0463.2012.02889.x
32. Schettino AE, Lauer AM (2013) The efficiency of design-based stereology in estimating spiral ganglion populations in mice. Hearing research 304:153-158. doi:10.1016/j.heares.2013.07.007
33. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Møller A, Nielsen K, Nyengaard JR, Pakkenberg B, et al. (1988) The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 96 (10):857-881. doi:10.1111/j.1699-0463.1988.tb00954.x
34. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Møller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sørensen FB, Vesterby A, et al. (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 96 (5):379-394. doi:10.1111/j.1699-0463.1988.tb05320.x
35. Baiduc RR, Helzner EP (2019) Epidemiology of Diabetes and Hearing Loss. Seminars in hearing 40 (4):281-291. doi:10.1055/s-0039-1697643
36. Tsuda J, Sugahara K, Hori T, Kanagawa E, Takaki E, Fujimoto M, Nakai A, Yamashita H (2016) A study of hearing function and histopathologic changes in the cochlea of the type 2 diabetes model Tsumura Suzuki obese diabetes mouse. Acta oto-laryngologica 136 (11):1097-1106. doi:10.1080/00016489.2016.1195012
37. Alvarado JC, Fuentes-Santamaría V, Jareño-Flores T, Blanco JL, Juiz JM (2012) Normal variations in the morphology of auditory brainstem response (ABR) waveforms: a study in Wistar rats. Neuroscience research 73 (4):302-311. doi:10.1016/j.neures.2012.05.001
38. Meyer zum Gottesberge AM, Massing T, Sasse A, Palma S, Hansen S (2015) Zucker diabetic fatty rats, a model for type 2 diabetes, develop an inner ear dysfunction that can be attenuated by losartan treatment. Cell and tissue research 362 (2):307-315. doi:10.1007/s00441-015-2215-7
39. Muzurović E, Kraljević I, Solak M, Dragnić S, Mikhailidis DP (2021) Homocysteine and diabetes: Role in macrovascular and microvascular complications. Journal of diabetes and its complications 35 (3):107834. doi:10.1016/j.jdiacomp.2020.107834
40. Jamwal S, Sharma S (2018) Vascular endothelium dysfunction: a conservative target in metabolic disorders. Inflammation research : official journal of the European Histamine Research Society [et al] 67 (5):391-405. doi:10.1007/s00011-018-1129-8
41. Esse R, Barroso M, Tavares de Almeida I, Castro R (2019) The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art. International journal of molecular sciences 20 (4). doi:10.3390/ijms20040867
42. Zaric BL, Obradovic M, Bajic V, Haidara MA, Jovanovic M, Isenovic ER (2019) Homocysteine and Hyperhomocysteinaemia. Current medicinal chemistry 26 (16):2948-2961. doi:10.2174/0929867325666180313105949
43. He L, He T, Farrar S, Ji L, Liu T, Ma X (2017) Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 44 (2):532-553. doi:10.1159/000485089