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Research article
A systematic review of surgical margins utilized for removal of cutaneous mast cell tumors in dogs
Laura Elizabeth Selmic
Ohio State University College of Veterinary Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6695-6273
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Veterinary Research.
Background Traditionally, wide lateral surgical margins of 3cm and one fascial plane deep have been recommended for resection of canine cutaneous mast cell tumor (MCT). Several studies have been published assessing surgical margins of less than this traditional recommendation. The objective of this systematic review was to determine if resection MCT with lateral surgical margins < 3cm results in low rates of incomplete resection and local tumor recurrence. Systematic searches of digital bibliographic databases were performed with two authors screening abstracts to identify relevant scientific articles. Studies regarding surgical treatment of dogs with cutaneous MCT were reviewed. Data abstraction was performed and the quality of individual studies and the strength of the body of evidence for utilization of surgical margins < 3cm for removal of MCTs was assessed.Results From the initial 78 citations identified through the database searches, four articles were retained for data abstraction after both relevance screenings were performed. Two studies were retrospective observational studies, one was a prospective case series and one was a prospective clinical trial. Assessment of the quality level of the body of evidence identified using the GRADE system was low. Excision of MCT at 2cm and 3cm was associated with comparably low rates of incomplete excision and recurrence.Conclusions Despite the low quality of the overall body of evidence, a recommendation can be made that resection of canine cutaneous MCTs (< 4cm) of Patnaik grade I and II with 2cm lateral margins and 1 fascial plane deep results in low rates of incomplete excision and local tumor recurrence.
Keywords
dog, mast cell tumor, surgical margin, surgery
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CURRENT STATUS: Published
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Posted 27 Dec, 2019
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On 06 Jan, 2020
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Editorial decision: Accept
On 24 Dec, 2019
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On 22 Dec, 2019
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On 21 Dec, 2019
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Editorial decision: Minor revision
On 19 Dec, 2019
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Invitations sent on 02 Dec, 2019
Reviewer #1 agreed
On 02 Dec, 2019
Reviewer #2 agreed
On 02 Dec, 2019
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On 28 Nov, 2019
First submitted
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This preprint is under consideration at BMC Veterinary Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
A systematic review of surgical margins utilized for removal of cutaneous mast cell tumors in dogs
Laura Elizabeth Selmic
Ohio State University College of Veterinary Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6695-6273
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 27 Dec, 2019
Published
On 06 Jan, 2020
No community comments so far
Editorial decision: Accept
On 24 Dec, 2019
Editor assigned
On 22 Dec, 2019
Submission checks complete
On 21 Dec, 2019
Editor invited
On 21 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 19 Dec, 2019
Review #2 received
Received 12 Dec, 2019
Review #1 received
Received 05 Dec, 2019
Reviewers invited
Invitations sent on 02 Dec, 2019
Reviewer #1 agreed
On 02 Dec, 2019
Reviewer #2 agreed
On 02 Dec, 2019
Editor assigned
On 28 Nov, 2019
First submitted
On 27 Nov, 2019
Submission checks complete
On 27 Nov, 2019
Editor invited
On 27 Nov, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Small Animal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Veterinary Research.
Background Traditionally, wide lateral surgical margins of 3cm and one fascial plane deep have been recommended for resection of canine cutaneous mast cell tumor (MCT). Several studies have been published assessing surgical margins of less than this traditional recommendation. The objective of this systematic review was to determine if resection MCT with lateral surgical margins < 3cm results in low rates of incomplete resection and local tumor recurrence. Systematic searches of digital bibliographic databases were performed with two authors screening abstracts to identify relevant scientific articles. Studies regarding surgical treatment of dogs with cutaneous MCT were reviewed. Data abstraction was performed and the quality of individual studies and the strength of the body of evidence for utilization of surgical margins < 3cm for removal of MCTs was assessed.Results From the initial 78 citations identified through the database searches, four articles were retained for data abstraction after both relevance screenings were performed. Two studies were retrospective observational studies, one was a prospective case series and one was a prospective clinical trial. Assessment of the quality level of the body of evidence identified using the GRADE system was low. Excision of MCT at 2cm and 3cm was associated with comparably low rates of incomplete excision and recurrence.Conclusions Despite the low quality of the overall body of evidence, a recommendation can be made that resection of canine cutaneous MCTs (< 4cm) of Patnaik grade I and II with 2cm lateral margins and 1 fascial plane deep results in low rates of incomplete excision and local tumor recurrence.
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