A systematic review of surgical margins utilized for removal of cutaneous mast cell tumors in dogs
Background Traditionally, wide lateral surgical margins of 3cm and one fascial plane deep have been recommended for resection of canine cutaneous mast cell tumor (MCT). Several studies have been published assessing surgical margins of less than this traditional recommendation. The objective of this systematic review was to determine if resection MCT with lateral surgical margins < 3cm results in low rates of incomplete resection and local tumor recurrence. Systematic searches of digital bibliographic databases were performed with two authors screening abstracts to identify relevant scientific articles. Studies regarding surgical treatment of dogs with cutaneous MCT were reviewed. Data abstraction was performed and the quality of individual studies and the strength of the body of evidence for utilization of surgical margins < 3cm for removal of MCTs was assessed.Results From the initial 78 citations identified through the database searches, four articles were retained for data abstraction after both relevance screenings were performed. Two studies were retrospective observational studies, one was a prospective case series and one was a prospective clinical trial. Assessment of the quality level of the body of evidence identified using the GRADE system was low. Excision of MCT at 2cm and 3cm was associated with comparably low rates of incomplete excision and recurrence.Conclusions Despite the low quality of the overall body of evidence, a recommendation can be made that resection of canine cutaneous MCTs (< 4cm) of Patnaik grade I and II with 2cm lateral margins and 1 fascial plane deep results in low rates of incomplete excision and local tumor recurrence.
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Posted 27 Dec, 2019
On 06 Jan, 2020
On 24 Dec, 2019
On 22 Dec, 2019
On 21 Dec, 2019
On 21 Dec, 2019
On 19 Dec, 2019
Received 12 Dec, 2019
Received 05 Dec, 2019
Invitations sent on 02 Dec, 2019
On 02 Dec, 2019
On 02 Dec, 2019
On 28 Nov, 2019
On 27 Nov, 2019
On 27 Nov, 2019
On 27 Nov, 2019
A systematic review of surgical margins utilized for removal of cutaneous mast cell tumors in dogs
Posted 27 Dec, 2019
On 06 Jan, 2020
On 24 Dec, 2019
On 22 Dec, 2019
On 21 Dec, 2019
On 21 Dec, 2019
On 19 Dec, 2019
Received 12 Dec, 2019
Received 05 Dec, 2019
Invitations sent on 02 Dec, 2019
On 02 Dec, 2019
On 02 Dec, 2019
On 28 Nov, 2019
On 27 Nov, 2019
On 27 Nov, 2019
On 27 Nov, 2019
Background Traditionally, wide lateral surgical margins of 3cm and one fascial plane deep have been recommended for resection of canine cutaneous mast cell tumor (MCT). Several studies have been published assessing surgical margins of less than this traditional recommendation. The objective of this systematic review was to determine if resection MCT with lateral surgical margins < 3cm results in low rates of incomplete resection and local tumor recurrence. Systematic searches of digital bibliographic databases were performed with two authors screening abstracts to identify relevant scientific articles. Studies regarding surgical treatment of dogs with cutaneous MCT were reviewed. Data abstraction was performed and the quality of individual studies and the strength of the body of evidence for utilization of surgical margins < 3cm for removal of MCTs was assessed.Results From the initial 78 citations identified through the database searches, four articles were retained for data abstraction after both relevance screenings were performed. Two studies were retrospective observational studies, one was a prospective case series and one was a prospective clinical trial. Assessment of the quality level of the body of evidence identified using the GRADE system was low. Excision of MCT at 2cm and 3cm was associated with comparably low rates of incomplete excision and recurrence.Conclusions Despite the low quality of the overall body of evidence, a recommendation can be made that resection of canine cutaneous MCTs (< 4cm) of Patnaik grade I and II with 2cm lateral margins and 1 fascial plane deep results in low rates of incomplete excision and local tumor recurrence.
Figure 1