Size
|
Age (years)
Mean, (SD)
|
Gender
(female)
(%)
|
Diagnoses
|
Inclusion
Criteria
|
Type
|
Modality
|
Nº of sessions
|
Duration
(m)
|
Staff qualification
|
Measure
|
Period (w)
|
N
|
IG
|
CG
|
Adler et al., 2004
USA
|
RCT
|
16
|
533
|
268
|
265
|
42.3 (13.9)
|
71.80
|
MDD ± PDD
|
≥ 18 years
MDD and/or PDD (DSM-IV)
English reading comprehension
|
CCM
|
Face-to-face
|
9
|
6
|
Doctoral-level clinical pharmacist
|
Correct medication intakes
|
Base
12
24
|
Akerblad et al., 2003
Sweden
|
Cluster RCT
|
24
|
1,031
|
366
|
339
|
48.4 (14.36)
|
28.10
|
MDD
|
≥ 18 years
MDD (DSM-IV)
SSRI prescription
|
Education + support (programme RHYTHMS)
|
Letters + telephone
|
5 letters + 4 telephone calls
|
6
|
GPs
|
Self-report
|
24
|
Serum levels
|
24
|
Appointments kept
|
24
|
Composite index
|
24
|
Aljumah and Hassali, 2015
Saudi Arabia
|
RCT
|
16
|
239
|
119
|
120
|
39.5 (NR)
|
58.16
|
MDD
|
18–60 years
MDD (DSM-IV)
AD prescription
|
SDM
|
Face-to-face
|
2
|
6
|
Pharmacist, psychiatrist and trained nurse
|
MMAS
|
12
|
Al-Saffar et al., 2008, 2005
Kuwait
|
RCT
|
20
|
300
|
100
|
100
|
NR
|
33.10
|
MDD
|
≥ 18years
Unipolar depression (ICD-10)
TCA or SSRI prescription
|
Counselling
|
Face-to-face + leaflet
|
1
|
NA
|
Trained pharmacist
|
Self-report + Pill count
|
20
6
|
100
|
Education + support
|
Leaflet
|
Correct medication intakes
|
6
|
Browne et al., 2002
Canada
|
RCT
|
24
|
707
|
212
|
196
|
42.4 (NR)
|
68.00
|
PDD ± MDD
|
18–75 years
PDD ± MDD (DSM-IV)
|
Interpersonal psychotherapy
|
Face-to-face
|
10
|
6
|
Masters-level therapist
|
Correct medication intakes
|
24
|
Capoccia et al., 2004
USA
|
RCT
|
52
|
74
|
41
|
33
|
38.7 (13.5)
|
57.00
|
Depressive episode
|
≥ 18 years
Depressive episode
New AD prescription
|
CCM
|
Telephone
|
16
|
12
|
Clinical pharmacist
|
Self-report
|
12
24
36
52
|
Chang et al., 2014
USA
|
Cluster RCT
|
24
|
915
|
503
|
411
|
46.03 (21.49)
|
66.30
|
MDD
|
≥ 18 years; MDD; newly prescribed antidepressant; capable of self-management and understand English.
|
Monitoring and feedback to physicians about the patient's symptom severity
|
Telephone
|
6
|
6
|
GPs or internal medicine doctors
|
Correct medication intakes and adapted questions from MMAS
|
12
24
|
de Jonghe et al.,
2001
Netherlands
|
RCT
|
24
|
167
|
83
|
84
|
34
(19–60)
|
62.00
|
PDD ± MDD
|
18–60 years; DSM-III criteria MDD with or without dysthymia; 17-item HDRS ≥ 14; written informed consent.
|
Short Psychodynamic Supportive Psychotherapy
|
Face-to-face
|
16
|
6
|
Psychiatrist ± fully trained psychotherapist
|
Pharmacotherapy dropout rates
|
24
|
Desplenter et al.,
2013
Belgium
|
Cluster
NRCT
|
52
|
99
|
41
|
58
|
46.10 (11.10)
|
62.60
|
MDD
|
≥ 18 years; MDD according to DSM-IV-TR criteria; antidepressant medicine; Dutch speaking; could be reached by telephone for follow-up
|
Tailoring counselling or
counselling intervention
|
Telephone
|
1
|
1 day
|
Pharmacist
|
MMAS
|
4
12
|
Dietrich et al., 2004
USA
|
Cluster RCT
|
24
|
405
|
224
|
181
|
42.0 (20.80)*
|
79.80
|
MDD or PDD
|
≥ 18 years
MDD or PDD (DSM-IV)
Patients who had a telephone
Hopkins symptom checklist-20 score ≥ 0.5
|
CCM
|
Telephone
|
6
|
6
|
Mental health and primary care professionals
|
Correct medication intakes
|
12
24
|
Gervasoni et al., 2010
Switzerland
|
NRCT
|
2
|
131
|
81
|
50
|
36.24 (19–62)
|
59.54
|
Moderate or severe depressive episode
|
18–65 years; ICD-1 criteria for moderate or severe depressive episode without psychotic characteristics and MADRS scale ≥ 25
|
Monitoring and motivational support
|
Telephone
|
3
|
2 weeks
|
Psychiatrist and research nurse
|
AD plasma level
|
2
|
Guo et al.,
2015
China
|
RCT
|
24
|
81
|
44
|
37
|
41.10 (12.10)
|
64.16
|
Moderate to severe MDD
|
Outpatients; 18–65 years; non-psychotic MDD according to DSM-IV criteria; HAM-D ≥ 17
|
Measurement-based care
|
Face-to-face
|
NA
|
NA
|
Psychiatrist and raters
|
NR
|
12
|
Hammonds et al., 2015
USA
|
RCT
|
4
|
57
|
30
|
27
|
20.6 (4.3)
|
85.96
|
MDD (89,4%)
|
18–30 years
AD prescription
English speaking
Patients who had an Android or iPhone smartphone
|
Medication reminder app
|
Smartphone
|
Until study termination
|
1
|
Trained research assistant
|
Correct medication intakes
|
4
|
Interian et al., 2013
USA
|
RCT
|
20
|
50
|
26
|
24
|
40.6 (16.90)*
|
76.00
|
MDD or PDD
|
≥ 18 years
MDD or PDD (DSM-IV)
AD prescription
|
Motivational Enhancement Therapy
|
Face-to-face
|
3
|
5
|
Clinical psychologist and psychology doctoral students
|
Pill Count
|
5
20
|
John et al.,
2016
India
|
RCT
|
6
|
39
|
17
|
22
|
34 (21–46)
|
61.53
|
Mild depression, moderate depression or PDD.
|
ICD-10 criteria; diagnosed by psychiatry residents and confirmed by a senior member; 18–60 years; residence within the catchment area of the hospital; were able to sit through a 30–60 min interview; AD monotherapy; 12–23 HAM-D) score.
|
Educational
|
Face-to-face
|
NR
|
NR
|
Clinicians
|
Correct medication intakes
|
6
|
Katon et al.,
2002
USA
|
RCT
|
112
|
171
|
NR
|
NR
|
46.95 (18–80)
|
74.55
|
MDD
|
18–80 years; new AD; ≥11 SCL-20 and > 4 DSM-IV or < 4 DSMIV and ≥ 11,5 SCL-20.
|
CCM
|
Face-to-face
|
0–7
|
28
|
GPs and psychiatrist
|
Adequate prescription refills
|
24
48
72
96
112
|
Katon et al., 2001
USA
|
RCT
|
52
|
386
|
194
|
192
|
46.0 (17.85)*
|
73.70
|
MDD or PDD
|
18–80 years
MDD or PDD
AD prescription
|
CCM
|
Mail + website
|
4 mailings + 3 telephone calls
|
12
|
GPs, psychologists, nurse practitioners and social worker
|
Automated data on refill
|
12
24
36
52
|
Katon et al., 1999
USA
|
RCT
|
24
|
228
|
114
|
114
|
46.9 (19.38)*
|
74.50
|
MDD or PDD or anxiety
|
18–80 years
MDD or PDD
≥ 4 DSM- III-R major depressive symptoms + SCL-20 score ≥ 1.0 or < 4 major depressive symptoms + SCL-20 score ≥ 1.5
|
CCM
|
Book + videotape + face-to-face
|
≤ 7
|
6
|
GPs and psychiatrist
|
Automated data on refill
|
4
12
24
|
Katon et al., 1996
USA
|
RCT
|
12
|
153
|
31
|
34
|
44.4 (26.88)*
|
73.86
|
MDD
|
18–75 years
Definite or probable MDD or PDD
SCL-20 score ≥ 0.75
Willingness to take AD
|
CCM
|
Book + videotape + face-to-face
|
4–6 sessions + 4 telephone calls
|
6
|
GPs and psychologist
|
Automated data on refill
|
4
12
|
Katon et al., 1995
USA
|
RCT
|
12
|
217
|
108
|
109
|
35.9 (28.83)*
|
77.60
|
MDD or PDD
|
18–780 years
Definite or probable MDD or PDD
SCL-20 score ≥ 0.75
Willingness to take AD
|
CCM
|
Book + videotape + face-to-face
|
4
|
1
|
GPs, therapists and psychiatrists
|
Automated data on refill
|
4
12
|
Keeley et al.,
2014
USA
|
Cluster RCT
|
NR
|
175
|
85
|
86
|
33.40 (38–60)
|
38.05
|
Depression
|
English speakers; ≥118 years; consenting patients; positive Patient Health Questionnaire; ≥10 PHQ-9 score; newly diagnosed.
|
Motivational Interviewing
|
Face-to-face
|
4
|
13
|
GPs
|
NR
|
|
Klang et al., 2015
Israel
|
nRCT
|
24
|
NR
|
173
|
12,746
|
50.5 (25.96)*
|
68.05
|
Depressive episode
|
≥ 18 years
Depressive episode(DSM-IV)
escitalopram prescription
|
Pharmacist adherence support
|
Face-to-face
|
6
|
NR
|
Community Pharmacist
|
Correct medication intakes
|
4
24
|
Klutcher et al., 2002
Canada
|
RCT
|
29
|
269
|
131
|
138
|
NR
|
NR
|
MDD
|
MDD
(DSM-IV)
Contraceptive method in females of childbearing years.
|
Education + support (programme RHYTHMS)
|
Letters + telephone
|
5 letters + 4 telephone calls
|
6
|
Research nurses
|
Pill count
|
NR
|
LeBlanc et al., 2015
USA
|
Cluster RCT
|
24
|
297
|
138
|
139
|
43.5 (43.54)*
|
66.92
|
Moderate to severe depression
|
≥ 18 years
Moderate/Severe depression PHQ-9 score ≥ 10
|
SDM
|
Face-to-face
|
2
|
6
|
Clinicians
|
Automated data on refill
|
24
|
Lin et al., 2003
USA
|
RCT
|
52
|
386
|
194
|
192
|
46.0 (17.85)*
|
26.40
|
High risk for recurrent depression
|
18–80 years
AD prescription
Improvement of depressive episode
(≥ 4 DSM- III-R major depressive symptoms or 4 major depressive symptoms + SCL-20 score ≥ 1.5)
High risk of relapse (≥ 3 lifetime depressive episodes or a history of dysthymia)
|
CBT + motivational interviewing + education
|
Face-to-face + telephone
|
2 sessions + 3 telephone calls
|
12
|
Psychologist, psychiatric nurse and social worker
|
% of days covered
|
52
|
Lin et al., 1999
USA
|
RCT
|
19
|
156
|
63
|
53
|
44.10 (13.60)
|
81.00
|
MDD
|
SCL-20 score ≥ 0.75; 18–80 years; AD
|
CCM
|
Face-to-face
|
4 + 2 optional
|
4.75
|
GPs and psychologists
|
Self-reported and adequate pharmacotherapy according to pharmacy data
|
19
|
Mantani et al.,
2017
Japan
|
RCT
|
17
|
164
|
81
|
83
|
40.90 (NR)
|
53.05
|
MDD ± anxiety
|
25–59 years; MDD without psychotic features (DSM-5 and PRIME-MD); antidepressant-resistant, BDI-II score ≥ 10 for ≥ 4 weeks; AD in monotherapy (not antipsychotics or mood stabilizers); smartphones users; being an outpatient; no plan to transfer within 4 months
|
Smartphone CBT
|
Smartphone
|
8
|
2.25
|
Psychiatrists
|
Discontinuation of protocol antidepressant treatment by week 9
|
17
|
Meglic et al.,
2010
Slovenia
|
NRCT
|
24
|
19
|
10
|
9
|
35.71 (12.11)
|
86.00
|
Depression or mixed anxiety and depression disorder
|
ICD10 group F32 or F41.2; first time or after a remission > 6 months; newly AD; internet and mobile phone; BDI-II score ≥ 14
|
CCM
|
Telephone + website
|
NR
|
6
|
GPs and psychologist
|
Correct medication intakes
|
24
|
Mundt et al., 2001
USA
|
RCT
|
30
|
246
|
124
|
122
|
40.5 (16.57)*
|
82.83
|
MDD
|
MDD (DSM-IV)
Symptom duration of ≥ 1 month
AD prescription
Hamilton Depression score ≥ 18
|
Education + support (programme RHYTHMS)
|
Mail + telephone
|
1mailing + telephone calls
|
7
|
NR
|
Medication days
|
30
|
Myers and Calvert, 1984
UK
|
RCT
|
NR
|
120
|
40
|
40
|
41.7 (29.79)
|
74.20
|
Depression
|
Depression, reactive or endogenous
Dothiepin prescription
|
Education
|
Leaflet
|
1
|
NA
|
NA
|
Correct medication intakes
|
3
6
|
Myers and Calvert, 1976
UK
|
nRCT
|
NR
|
89
|
46
|
43
|
47.8 NR
|
66.30
|
Depression
|
21–77 years
≥Attack of primary depression, reactive or endogenous
Dothiepin prescription
|
Education
|
Leaflet
|
1
|
NA
|
NA
|
Correct medication intakes
|
NR
|
Nwokeji et al., 2012
USA
|
RCT
|
52
|
166
|
101
|
65
|
47.8 (12.01)*
|
88.00
|
MDD
|
MDD
AD prescription
|
Enhanced care
|
Mail + telephone
|
NR
|
12
|
Nurses and social worker
|
% of days covered
|
52
|
Perahia et al., 2008
11 European countries
|
RCT
|
4
|
962
|
485
|
477
|
46.2 (18.46)*
|
64.20
|
MDD
|
≥ 18 years
MDD (DSM-IV)
Hamilton Depression score ≥ 15
Access to a telephone
|
Education
|
Telephone
|
3
|
12
|
GPs or psychiatrists
|
Pill count
|
2
6
12
|
Perlis et al., 2002
USA
|
RCT
|
28
|
132
|
66
|
66
|
39.9 (14.57)*
|
54.60
|
MDD
|
18–65 years
MDD (DSM-III-R)
Hamilton Depression score ≥ 16
History of ≥ 3 major depressive episodes, diagnosis of current episode as chronic; history of poor interepisode recovery; or both MDD and PDD
|
CBT
|
Face-to-face
|
19
|
28
|
Clinicians and psychologists
|
Correct medication intakes
|
28
|
Pradeep et al., 2014
India
|
Cluster RCT
|
24
|
260
|
122
|
138
|
NR
|
100.00
|
MDD + PD, social phobia or GAD
|
Women
≥ 18 years
MDD (DSM-IV-TR)
|
Education + support
|
Face-to-face
|
2
|
4
|
Health workers
|
Duration of compliance (days)
|
28
|
Richards et al., 2016
UK
|
Cluster RCT
|
52
|
581
|
276
|
305
|
NR
|
71.94
|
Depressive episode
|
≥ 18 years
Depressive episode (ICD-10)
|
CCM
|
Face-to-face
|
6–12
|
≥ 3
|
Trained care managers, GPs and mental health worker
|
Self-report
|
16
52
|
Rickles et al., 2006, 2005
USA
|
RCT
|
24
|
63
|
31
|
32
|
37.6 (17.15)*
|
84.10
|
Depressive symptoms
|
≥ 18 years
BDI-II score ≥ 16
Willingness to take AD
|
Education + monitoring
|
Telephone
|
3
|
3
|
Trained pharmacist
|
Medication intakes
|
12
24
|
Salkovskis et al.,
2006
UK
|
RCT
|
26
|
77
|
39
|
38
|
40.5 (NR)
|
81.82
|
Depressive disorder
|
AD prescription and 17–70 years.
|
Self-help programme
|
Telephone
|
NR
|
6.5
|
GPs
|
Length of time medication
|
26
|
Simon et al.,
2011
USA
|
RCT
|
24
|
197
|
104
|
93
|
45.5 (NR)
|
72.12
|
Depressive disorder
|
≥ 18 years new AD; no AD ≥ 270 days before; online messaging
|
Support
|
Telephone
|
4
|
4
|
GPs, psychiatrist and nurse
|
Using antidepressant for over 90 days
|
24
|
Simon et al., 2006
USA
|
RCT
|
24
|
207
|
103
|
104
|
43.0 (21.21)*
|
65.00
|
MDD or PDD
|
≥ 18 years
MDD or PDD
New AD prescription
|
Support
|
Telephone
|
3
|
3
|
Nurses
|
Automated data on refill
|
12
|
Smit et al., 2005
Netherlands
|
RCT
|
52
|
267
|
112
|
72
|
42.8 (19.39)*
|
63.20
|
MDD
|
18–70 years
MDD (DSM-IV)
|
Education
|
Face-to-face + telephone
|
3
|
3
|
GPs
|
Correct medication intakes
|
12
24
36
52
|
39
|
Education
+ psychiatric consultation
|
4
|
3
|
GPs and psychiatrist
|
44
|
Education
+ CBT
|
15
|
3
|
GPs and clinical psychologist
|
Vannachavee, 2016
Thailand
|
RCT
|
6
|
60
|
30
|
30
|
45.3 (22.70)*
|
84.00
|
MDD
|
≥ 18 years
MDD (DSM-IV-TR)
A new AD prescription
Thai speaking
|
Educational, motivational and cognitive intervention
|
Face-to-face
|
4
|
1,5
|
Candidate master degree researcher and nurses
|
Self-Medication Intake Record Form
|
6
|
Vergouwen et al., 2009, 2005
Netherlands
|
Cluster RCT
|
26
|
211
|
101
|
110
|
43.0 (20.29)*
|
67.40
|
MDD
|
≥ 18 years
MDD (DSM-IV)
|
Education + support + active participation in treatment process with discussion on AD
|
Mail + face-to-face
|
7 visits
|
6,5
|
GPs
|
Self-report + pill counts
|
10
26
|
Wiles et al., 2014, 2013
UK
|
RCT
|
52
|
469
|
234
|
235
|
49.6 (11.7)
|
72.30
|
MDD + PD, social phobia or GAD
|
18–75 years
AD prescription
Patients’ adherence to the prescribed AD
Beck Depression Inventory score ≥ 14
|
CBT
|
Face-to-face
|
12–18
|
12
|
Trained CBT therapist
|
4-item MMAS (80%)
|
48
|
Wiles et al.,
2008
UK
|
RCT
|
16
|
25
|
14
|
11
|
45.3 (NR)
|
84
|
Depressive disorder
|
18–65 years; AD;
≥ 15 BDI-II; positive Morisky-Green-Levine test; ICD-10 criteria.
|
CBT
|
Face-to-face
|
12–20
|
4
|
GPs, psychiatrist and psychologist
|
4-item MMAS (80%)
|
16
|