Background Epidermal cysts are common skin tumors that are composed of a keratinocytic cyst wall and central keratin material, which can occur anywhere in the body, especially on the face. However, there are no relevant reports of multiple epidermal cysts coexisting at the same location.
Case presentation Here, we report one rare case of facial multiple epidermal cysts, who underwent sequential resection of all cysts. A 45-year-old male presented with facial multiple masses for over 2 years. Physical examination showed multiple cysts with varied sizes on the face. All cysts were smooth, dome-shaped, freely movable, and some of them were attached to the skin by a central pore. The histopathology revealed cysts in the dermis, the wall of which were composed of stratified squamous epithelium, and the cavity were filled with keratin. Therefore, the patient was diagnosed as facial multiple epidermal cysts.
Conclusions This is the first well-documented case of multiple epidermal cysts on the face. We report this rare case to highlight that although epidermal cysts usually appear single, they may also appear multiple in the same location, especially in those patients with vigorous sebaceous gland function. Surgical excision is the first-line effective treatment for epidermal cysts.