The support point layout of the machine tool has an important influence on the working performance of the machine tool, when the material, manufacturing process and internal structure of machine bed are determined. In order to ensure that the precision machine tool has good leveling performance, stability and anti-interference, this paper presents an optimized design method of three-point support for T-shape bed of precision horizontal machining center. This article first establishes the statics model of the T-shape bed and analyzes grillage beam model used to characterize the main static deformation trend of the bed based on the singular function method. After verifying the rationality of the model through simulation, the optimized three-point support position can be obtained. Then this paper measured the deformation of the upper surface of a simple bed due to gravity. The deviation between the experimental results and the simulation results is less than 20%, which verifies the reliability of the simulation and theoretical results. Based on the ISIGHT multi-disciplinary optimization platform, this paper completes the multi-objective optimization of the support point layout of the bed, and the optimization results prove the accuracy of the theoretical model. This paper takes the bed of M800H precision horizontal machining center as an example to illustrate the application process of the proposed method. Finally, this paper compares the optimization effect of the static characteristics of the bed and the whole machine. The maximum deformation of the bed has reduced by 27.1%. In the whole machine status, the deformation of the spindle end has reduced by 50.8%, and the maximum deformation of the workpiece end have reduced by 50.0%.